Probiotic Pearls Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Probiotic Pearls against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Probiotic Pearls is a dietary supplement by Integrative Therapeutics with 2 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are HOWARU Lactobacillus acidophilus NCFM, Bifidobacterium longum BB536. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Probiotic Pearls by Integrative Therapeutics
Ask about any prescription or over-the-counter medication and we check it for interactions with Probiotic Pearls by Integrative Therapeutics — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Probiotic Pearls by Integrative Therapeutics
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Probiotic Pearls contains two active probiotic ingredients: Lactobacillus acidophilus NCFM and Bifidobacterium longum BB536. Both are live-culture bacterial strains meant to support your gut health.
The capsules also contain several inactive ingredients — palm oil, fish gelatin, glycerin, sunflower lecithin, pectin, and soy lecithin — that serve as the delivery system and stabilizers.
Does it work?
Moderate evidence
The evidence for Lactobacillus acidophilus shows it's possibly effective for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis. For Bifidobacterium longum, the data we hold don't establish effectiveness for the conditions listed — they're rated as insufficient reliable evidence.
If you're considering this product for a specific condition, it's worth discussing with your doctor whether the evidence supports its use for your situation.
How safe is it?
Well-documented data
Both probiotic strains are generally well tolerated in healthy adults and children. However, there are a few cautions.
Live probiotic organisms can rarely cause serious infections — mainly in people who are critically ill, have compromised immune systems, or are very young infants — so check with your doctor before use if you fall into those groups. Orally, some people report mild gastrointestinal side effects like abdominal discomfort, bloating, flatulence, or diarrhea, but these are uncommon.
There's no pregnancy or lactation safety data on file for Lactobacillus acidophilus; Bifidobacterium longum is rated possibly safe in both, though the data are limited, so talk with your doctor or pharmacist for personalized advice.
Meds to double-check
Moderate interaction found
Before taking Probiotic Pearls, double-check any antibiotic drugs you're on. Antibiotics can kill off the live organisms in the supplement, making it less effective, so you'll want to separate when you take them.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Probiotic Pearls may help if you're dealing with IBS, antibiotic-associated diarrhea, or certain infections — the evidence is strongest for L. acidophilus in these areas. Be aware that antibiotics will interfere with the probiotics' effectiveness, so space them apart.
If you're critically ill, immune-compromised, or a very young infant, check with your doctor first. Run your exact medications through the checker below before you start.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Probiotic Pearls, straight from the product label.
| Brand | Integrative Therapeutics |
|---|---|
| Barcode (UPC) | 871791000018 |
| Net contents | 30 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jul 25, 2024 |
| DSLD ID | 317367 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Probiotic Pearls by Integrative Therapeutics, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Probiotic Blend | 11 mg | -- |
| HOWARU Lactobacillus acidophilus NCFM | 0 NP | -- |
| Bifidobacterium longum BB536 | 0 NP | -- |
Other ingredients: Palm Oil, Fish Gelatin, Glycerin, Sunflower Lecithin, Pectin, Soy Lecithin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Guaranteed Delivery
Contains no salt, wheat, or artificial colors.
Product of Japan
Formula
Active Cultures
FDA Statement of Identity
Dietary Supplement
General Statements
For more information, please visit integrativepro.com
Precautions
Keep out of reach of children.
This product has a tamper-evident foil pouch. Do not use if foil or plastic is punctured.
Contains milk, soy, fish (Tilapia).
Do not chew or crush.
If you are pregnant, nursing, or taking any medications, consult a healthcare professional before use.
Storage
Store at room temperature. Avoid excessive heat and direct sunlight.
Brand IP Statement(s)
Howaru Probiotic Quality You Can Feel Howaru is a registered trademark of IFF and is used under license.
Copyright 2023
Suggested/Recommended/Usage/Directions
Recommendation: Adults swallow 1 capsule daily with water or your favorite beverage, or as recommended by a healthcare professional. May be taken with or without food. Do not chew or crush.
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Probiotic Pearls by Integrative Therapeutics label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Probiotic Pearls by Integrative Therapeutics
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Probiotic Blend
Other (inactive) ingredients: Palm Oil, Fish Gelatin, Glycerin, Sunflower Lecithin, Pectin, Soy Lecithin. These complete the product’s ingredient list but are not active constituents.
Probiotic Pearls by Integrative Therapeutics Drug Interactions
HelloPharmacist Interaction Report
Probiotic Pearls from Integrative Therapeutics contains two live probiotic strains, and both have documented interactions with antibiotic drugs.
The most serious concern is Moderate-severity: when you take either Lactobacillus acidophilus or Bifidobacterium longum alongside antibiotics, the antibiotics may kill a significant number of the live organisms in the supplement, reducing its effectiveness. Altogether, these interactions span 182 individual medications.
Read the full breakdown — every affected drug type, severity by severity
To protect the probiotics, you'll want to separate when you take them from your antibiotics — your pharmacist or doctor can help you space them out so they don't interfere with each other. Since both strains share this same interaction with antibiotic drugs, the advice is the same for either one.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Probiotic Pearls?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Probiotic Pearls interact with 182 drugs. Click any drug to see the details.
2 of the 2 ingredients in Probiotic Pearls interact with drugs. Each result below shows which ingredient is responsible. HOWARU Lactobacillus acidophilus NCFM Bifidobacterium longum BB536
AmikacinAmikin, Arikayce
How Amikacin interacts with Probiotic Pearls — through 2 ingredients. Tap an ingredient for the detail:
Bifidobacterium Longum Bb536Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bb536 + Amikacin interactionHowaru Lactobacillus Acidophilus NcfmAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Howaru Lactobacillus Acidophilus Ncfm + Amikacin interactionAmoxicillinAmix, Amoram, Amoxident, Amoxil Capsules, Amoxil Injection, Galenamox +3 more
How Amoxicillin interacts with Probiotic Pearls — through 2 ingredients. Tap an ingredient for the detail:
Howaru Lactobacillus Acidophilus NcfmAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Howaru Lactobacillus Acidophilus Ncfm + Amoxicillin interactionBifidobacterium Longum Bb536Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bb536 + Amoxicillin interactionAmoxicillin VeterinaryBiomox
How Amoxicillin Veterinary interacts with Probiotic Pearls — through 2 ingredients. Tap an ingredient for the detail:
Howaru Lactobacillus Acidophilus NcfmAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Howaru Lactobacillus Acidophilus Ncfm + Amoxicillin Veterinary interactionBifidobacterium Longum Bb536Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bb536 + Amoxicillin Veterinary interactionAmoxicillin, Clavulanate PotassiumAugmentin, Augmentin '125/31 SF', Augmentin '250/62 SF', Augmentin XR, Augmentin-Duo 400/57, Clavulin
How Amoxicillin, Clavulanate Potassium interacts with Probiotic Pearls — through 2 ingredients. Tap an ingredient for the detail:
Howaru Lactobacillus Acidophilus NcfmAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Howaru Lactobacillus Acidophilus Ncfm + Amoxicillin, Clavulanate Potassium interactionBifidobacterium Longum Bb536Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bb536 + Amoxicillin, Clavulanate Potassium interactionAmoxicillin, Omeprazole Magnesium, RifabutinTalicia
How Amoxicillin, Omeprazole Magnesium, Rifabutin interacts with Probiotic Pearls — through 2 ingredients. Tap an ingredient for the detail:
Howaru Lactobacillus Acidophilus NcfmAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Howaru Lactobacillus Acidophilus Ncfm + Amoxicillin, Omeprazole Magnesium, Rifabutin interactionBifidobacterium Longum Bb536Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bb536 + Amoxicillin, Omeprazole Magnesium, Rifabutin interactionAmphotericin, TetracyclineMysteclin-F
How Amphotericin, Tetracycline interacts with Probiotic Pearls — through 2 ingredients. Tap an ingredient for the detail:
Bifidobacterium Longum Bb536Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bb536 + Amphotericin, Tetracycline interactionHowaru Lactobacillus Acidophilus NcfmAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Howaru Lactobacillus Acidophilus Ncfm + Amphotericin, Tetracycline interactionAmpicillinOmnipen, Omnipen-N, Penbritin, Principen, Rimacillin
How Ampicillin interacts with Probiotic Pearls — through 2 ingredients. Tap an ingredient for the detail:
Howaru Lactobacillus Acidophilus NcfmAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Howaru Lactobacillus Acidophilus Ncfm + Ampicillin interactionBifidobacterium Longum Bb536Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bb536 + Ampicillin interactionAmpicillin, SulbactamUnasyn
How Ampicillin, Sulbactam interacts with Probiotic Pearls — through 2 ingredients. Tap an ingredient for the detail:
Howaru Lactobacillus Acidophilus NcfmAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Howaru Lactobacillus Acidophilus Ncfm + Ampicillin, Sulbactam interactionBifidobacterium Longum Bb536Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bb536 + Ampicillin, Sulbactam interactionAvibactam Sodium, CeftazidimeAvycaz
How Avibactam Sodium, Ceftazidime interacts with Probiotic Pearls — through 2 ingredients. Tap an ingredient for the detail:
Bifidobacterium Longum Bb536Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bb536 + Avibactam Sodium, Ceftazidime interactionHowaru Lactobacillus Acidophilus NcfmAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Howaru Lactobacillus Acidophilus Ncfm + Avibactam Sodium, Ceftazidime interactionAzithromycinAzasite, Zithromax, Zmax
How Azithromycin interacts with Probiotic Pearls — through 2 ingredients. Tap an ingredient for the detail:
Howaru Lactobacillus Acidophilus NcfmAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Howaru Lactobacillus Acidophilus Ncfm + Azithromycin interactionBifidobacterium Longum Bb536Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bb536 + Azithromycin interactionAztreonamAzactam
How Aztreonam interacts with Probiotic Pearls — through 2 ingredients. Tap an ingredient for the detail:
Bifidobacterium Longum Bb536Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bb536 + Aztreonam interactionHowaru Lactobacillus Acidophilus NcfmAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Howaru Lactobacillus Acidophilus Ncfm + Aztreonam interactionBacampicillinPenglobe
How Bacampicillin interacts with Probiotic Pearls — through 2 ingredients. Tap an ingredient for the detail:
Howaru Lactobacillus Acidophilus NcfmAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Howaru Lactobacillus Acidophilus Ncfm + Bacampicillin interactionBifidobacterium Longum Bb536Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bb536 + Bacampicillin interactionBacitracinBaci-IM, Baciguent, Bacitracin Ointment
How Bacitracin interacts with Probiotic Pearls — through 2 ingredients. Tap an ingredient for the detail:
Howaru Lactobacillus Acidophilus NcfmAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Howaru Lactobacillus Acidophilus Ncfm + Bacitracin interactionBifidobacterium Longum Bb536Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bb536 + Bacitracin interactionBenznidazoleBenznidazole
How Benznidazole interacts with Probiotic Pearls — through 2 ingredients. Tap an ingredient for the detail:
Bifidobacterium Longum Bb536Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bb536 + Benznidazole interactionHowaru Lactobacillus Acidophilus NcfmAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Howaru Lactobacillus Acidophilus Ncfm + Benznidazole interactionBismuth Subsalicylate, Metronidazole, TetracyclineHelidac
How Bismuth Subsalicylate, Metronidazole, Tetracycline interacts with Probiotic Pearls — through 2 ingredients. Tap an ingredient for the detail:
Howaru Lactobacillus Acidophilus NcfmAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Howaru Lactobacillus Acidophilus Ncfm + Bismuth Subsalicylate, Metronidazole, Tetracycline interactionBifidobacterium Longum Bb536Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bb536 + Bismuth Subsalicylate, Metronidazole, Tetracycline interactionCapreomycinCapastat
How Capreomycin interacts with Probiotic Pearls — through 2 ingredients. Tap an ingredient for the detail:
Bifidobacterium Longum Bb536Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bb536 + Capreomycin interactionHowaru Lactobacillus Acidophilus NcfmAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Howaru Lactobacillus Acidophilus Ncfm + Capreomycin interactionCarbenicillin Indanyl SodiumGeocillin
How Carbenicillin Indanyl Sodium interacts with Probiotic Pearls — through 2 ingredients. Tap an ingredient for the detail:
Howaru Lactobacillus Acidophilus NcfmAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Howaru Lactobacillus Acidophilus Ncfm + Carbenicillin Indanyl Sodium interactionBifidobacterium Longum Bb536Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bb536 + Carbenicillin Indanyl Sodium interactionCefaclorCeclor, Ceclor CD
How Cefaclor interacts with Probiotic Pearls — through 2 ingredients. Tap an ingredient for the detail:
Howaru Lactobacillus Acidophilus NcfmAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Howaru Lactobacillus Acidophilus Ncfm + Cefaclor interactionBifidobacterium Longum Bb536Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bb536 + Cefaclor interactionCefadroxilCef-Tab, Duricef, Ultracef
How Cefadroxil interacts with Probiotic Pearls — through 2 ingredients. Tap an ingredient for the detail:
Howaru Lactobacillus Acidophilus NcfmAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Howaru Lactobacillus Acidophilus Ncfm + Cefadroxil interactionBifidobacterium Longum Bb536Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bb536 + Cefadroxil interactionCefamandoleMandol
How Cefamandole interacts with Probiotic Pearls — through 2 ingredients. Tap an ingredient for the detail:
Howaru Lactobacillus Acidophilus NcfmAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Howaru Lactobacillus Acidophilus Ncfm + Cefamandole interactionBifidobacterium Longum Bb536Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bb536 + Cefamandole interactionCefazolinAncef
How Cefazolin interacts with Probiotic Pearls — through 2 ingredients. Tap an ingredient for the detail:
Bifidobacterium Longum Bb536Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bb536 + Cefazolin interactionHowaru Lactobacillus Acidophilus NcfmAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Howaru Lactobacillus Acidophilus Ncfm + Cefazolin interactionCefdinirOmnicef
How Cefdinir interacts with Probiotic Pearls — through 2 ingredients. Tap an ingredient for the detail:
Howaru Lactobacillus Acidophilus NcfmAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Howaru Lactobacillus Acidophilus Ncfm + Cefdinir interactionBifidobacterium Longum Bb536Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bb536 + Cefdinir interactionCefditoren PivoxilSpectracef
How Cefditoren Pivoxil interacts with Probiotic Pearls — through 2 ingredients. Tap an ingredient for the detail:
Howaru Lactobacillus Acidophilus NcfmAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Howaru Lactobacillus Acidophilus Ncfm + Cefditoren Pivoxil interactionBifidobacterium Longum Bb536Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bb536 + Cefditoren Pivoxil interactionCefepimeMaxipime
How Cefepime interacts with Probiotic Pearls — through 2 ingredients. Tap an ingredient for the detail:
Bifidobacterium Longum Bb536Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bb536 + Cefepime interactionHowaru Lactobacillus Acidophilus NcfmAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Howaru Lactobacillus Acidophilus Ncfm + Cefepime interactionCefiderocol Sulfate TosylateFetroja
How Cefiderocol Sulfate Tosylate interacts with Probiotic Pearls — through 2 ingredients. Tap an ingredient for the detail:
Howaru Lactobacillus Acidophilus NcfmAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Howaru Lactobacillus Acidophilus Ncfm + Cefiderocol Sulfate Tosylate interactionBifidobacterium Longum Bb536Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bb536 + Cefiderocol Sulfate Tosylate interactionCefiximeSuprax
How Cefixime interacts with Probiotic Pearls — through 2 ingredients. Tap an ingredient for the detail:
Howaru Lactobacillus Acidophilus NcfmAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Howaru Lactobacillus Acidophilus Ncfm + Cefixime interactionBifidobacterium Longum Bb536Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bb536 + Cefixime interactionCefmetazoleZefazone
How Cefmetazole interacts with Probiotic Pearls — through 2 ingredients. Tap an ingredient for the detail:
Howaru Lactobacillus Acidophilus NcfmAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Howaru Lactobacillus Acidophilus Ncfm + Cefmetazole interactionBifidobacterium Longum Bb536Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bb536 + Cefmetazole interactionCefonicidMonocid
How Cefonicid interacts with Probiotic Pearls — through 2 ingredients. Tap an ingredient for the detail:
Bifidobacterium Longum Bb536Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bb536 + Cefonicid interactionHowaru Lactobacillus Acidophilus NcfmAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Howaru Lactobacillus Acidophilus Ncfm + Cefonicid interactionCefoperazoneCefobid
How Cefoperazone interacts with Probiotic Pearls — through 2 ingredients. Tap an ingredient for the detail:
Howaru Lactobacillus Acidophilus NcfmAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Howaru Lactobacillus Acidophilus Ncfm + Cefoperazone interactionBifidobacterium Longum Bb536Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bb536 + Cefoperazone interactionCefotaximeClaforan
How Cefotaxime interacts with Probiotic Pearls — through 2 ingredients. Tap an ingredient for the detail:
Bifidobacterium Longum Bb536Antibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Longum Bb536 + Cefotaxime interactionHowaru Lactobacillus Acidophilus NcfmAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L.
Read the full Howaru Lactobacillus Acidophilus Ncfm + Cefotaxime interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Probiotic Pearls with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
HOWARU Lactobacillus acidophilus NCFM
Antibiotic Drugs
Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.
Bifidobacterium longum BB536
Antibiotic Drugs
Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B. longum.
Since B. longum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. longum preparations by at least 2 hours.
Brand information
Manufacturer and brand details for Probiotic Pearls, from the product label.
Integrative Therapeutics
See all Integrative Therapeutics products- Name
- Integrative Therapeutics, LLC
- City
- Green Bay
- State
- WI
- ZipCode
- 54311
- Phone Number
- 800-931-1709
- Web Address
- integrativepro.com
Probiotic Pearls by Integrative Therapeutics: Common Questions
Does Probiotic Pearls by Integrative Therapeutics interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Probiotic Pearls’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Lactobacillus Acidophilus
Interacts with 182 drugsLactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...
Read the full Lactobacillus Acidophilus monograph → Herb & supplement monographBifidobacterium Longum
Interacts with 182 drugsBifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most studied for digestive issues, though evi...
Read the full Bifidobacterium Longum monograph →Sources & How We Checked
Probiotic Pearls's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 36 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Lactobacillus Acidophilus 15 references
- Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
- Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
- Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
- Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
- Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
- Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
- Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
- Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
- Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
- Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
- Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
- Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
- Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
- Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
- Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.
See these in context on the Lactobacillus Acidophilus monograph →
Bifidobacterium Longum 21 references
- Ha GY, Yang CH, Kim H, Chong Y. Case of sepsis caused by Bifidobacterium longum. J Clin Microbiol 1999;37:1227-8.
- Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
- Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
- Rautava S, Kainonen E, Salminen S, Isolauri E. Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant. J Allergy Clin Immunol. 2012;130(6):1355-60. PubMed
- Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
- Pellonperä O, Vahlberg T, Mokkala K, et al. Weight gain and body composition during pregnancy: a randomised pilot trial with probiotics and/or fish oil. Br J Nutr. 2020 Nov 4:1-11. PubMed
- Pellonperä O, Mokkala K, Houttu N, et al. Efficacy of fish oil and/or probiotic intervention on the incidence of gestational diabetes mellitus in an at-risk group of overweight and obese women: A randomized, placebo-controlled, double-blind clinical trial PubMed
- Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
- Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
- Enomoto T, Sowa M, Nishimori K, et al. Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota. Allergol Int 2014;63(4):575-85. PubMed
- US Food and Drug Administration (FDA). Dear Healthcare Provider Letter: Warning Regarding Use of Probiotics in Preterm Infants. September 2023. Available at: https://www.fda.gov/media/172606/download?attachment. Accessed November 1, 2023.
- Pillai A, Tan J, Paquette V, Panczuk J. Does probiotic bacteremia in premature infants impact clinically relevant outcomes? A case report and updated review of literature. Clin Nutr ESPEN. 2020;39:255-259. PubMed
- Sabaté JM, Iglicki F. Effect of Bifidobacterium longum 35624 on disease severity and quality of life in patients with irritable bowel syndrome. World J Gastroenterol 2022;28(7):732-744.
- Malaguarnera M, Greco F, Barone G, Gargante MP, Malaguarnera M, Toscano MA. Bifidobacterium longum with fructo-oligosaccharide (FOS) treatment in minimal hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. Dig Dis Sci 2007;52(11) PubMed
- Zbinden A, Zbinden R, Berger C, Arlettaz R. Case series of Bifidobacterium longum bacteremia in three preterm infants on probiotic therapy. Neonatology 2015;107(1):56-9.
- Tamaki H, Nakase H, Inoue S, et al. Efficacy of probiotic treatment with Bifidobacterium longum 536 for induction of remission in active ulcerative colitis: A randomized, double-blinded, placebo-controlled multicenter trial. Dig Endosc 2016;28(1):67-74.
- Bertelli C, Pillonel T, Torregrossa A, et al. Bifidobacterium longum bacteremia in preterm infants receiving probiotics. Clin Infect Dis 2015;60(6):924-7. PubMed
- Esaiassen E, Cavanagh P, Hjerde E, Simonsen GS, Støen R, Klingenberg C. Bifidobacterium longum subspecies infantis bacteremia in 3 extremely preterm infants receiving probiotics. Emerg Infect Dis 2016;22(9):1664-6.
- Tena D, Losa C, Medina MJ, Sáez-Nieto JA. Peritonitis caused by Bifidobacterium longum: case report and literature review. Anaerobe 2014;27:27-30. PubMed
- Sangkanjanavanich S, Pradubpongsa P, Mitthamsiri W, Sangasapaviliya A, Boonpiyathad T. Bifidobacterium infantis 35624 efficacy in patients with uncontrolled asthma: A randomized placebo-controlled trial. Ann Allergy Asthma Immunol 2022;129(6):790-792. PubMed
- Wilson HL, Ong CW. Bifidobacterium longum vertebrodiscitis in a patient with cirrhosis and prostate cancer. Anaerobe 2017;47:47-50. PubMed
See these in context on the Bifidobacterium Longum monograph →
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC