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Dietary supplement

Probiotic Solutions Prenatal 20 Billion CFUs Ingredients & Drug Interactions

by GNC Probiotic Solutions

Probiotic Solutions Prenatal 20 Billion CFUs label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Probiotic Solutions Prenatal 20 Billion CFUs against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Probiotic Solutions Prenatal 20 Billion CFUs is a dietary supplement by GNC Probiotic Solutions with 5 active ingredients. Its ingredients are commonly taken for digestive health and regularity, constipation relief, immune support.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bifidobacterium animalis subsp. lactis (CUL 34 ), Bifidobacterium bifidum (CUL 20). Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Probiotic Solutions Prenatal 20 Billion CFUs by GNC Probiotic Solutions

Ask about any prescription or over-the-counter medication and we check it for interactions with Probiotic Solutions Prenatal 20 Billion CFUs by GNC Probiotic Solutions — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Probiotic Solutions Prenatal 20 Billion CFUs by GNC Probiotic Solutions

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.
  • “LAB4B Probiotics” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

This prenatal formula contains 5 active probiotic ingredients, each a live bacterial strain chosen for digestive and immune support during pregnancy. The two we can cross-check for interactions are Bifidobacterium animalis subsp. lactis (CUL 34) and Bifidobacterium bifidum (CUL 20).

Three others—Lactobacillus salivarius (CUL 61), Lactobacillus paracasei (CUL 08), and Lactobacillus rhamnosus GG—are included but we hold no interaction data for them. The capsule also contains inactive ingredients: vegetarian capsule shell, microcrystalline cellulose, corn maltodextrin, silicon dioxide, magnesium stearate, and titanium dioxide.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: prenatal probiotic support.
  • We looked for evidence on: Antibiotic-associated diarrhea, Constipation, Pregnancy-induced nausea and vomiting, Prematurity, Neonatal jaundice, Necrotizing enterocolitis (NEC) — and 4 related terms.
  • The strongest evidence on file: Bifidobacterium Animalis Subsp. Lactis is rated "Possibly Effective" for Constipation (Natural Medicines).
  • Also on file: Bifidobacterium Animalis Subsp. Lactis is rated "Possibly Effective" for Colic.
  • Also on file: Bifidobacterium Animalis Subsp. Lactis is rated "Insufficient Reliable Evidence To Rate" for Antibiotic-associated diarrhea, Postpartum depression, Pregnancy-induced nausea and vomiting, Necrotizing enterocolitis (NEC), and more.

Bifidobacterium animalis subsp. lactis is rated possibly effective for respiratory tract infections, irritable bowel syndrome (IBS), and constipation. Bifidobacterium bifidum is possibly effective for IBS and respiratory tract infections, though there isn't enough reliable evidence to rate it for hay fever (allergic rhinitis), Alzheimer disease, or generalized anxiety disorder.

We don't have effectiveness ratings for the other three probiotic strains in this formula.

The evidence, ingredient by ingredient Bifidobacterium Animalis Subsp. Lactis Bifidobacterium Bifidum

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bifidobacterium animalis subsp. lactis is generally well tolerated by most healthy people when taken as directed, though evidence is limited—check with your doctor first. The most common side effect is diarrhea; bloating, flatulence, abdominal pain, constipation, and stomach burn have been reported rarely.

In one clinical study, two cases of rash (one with itching) occurred in patients taking a combination that included this strain, though it's unclear whether B. lactis itself was responsible. Bifidobacterium bifidum is generally well tolerated in healthy people, though those with weakened immune systems should be cautious and check with their doctor before use.

Bloating and flatulence have been reported with probiotic use generally, though not specifically from B. bifidum. One case of vomiting and fever was reported in a child taking B. bifidum with another probiotic, though it's unclear if the probiotics caused it.

Rare cases of Bifidobacterium sepsis have occurred in critically ill patients, though none have been linked to B. bifidum specifically. For pregnancy, B. bifidum is rated possibly safe; no lactation data is on file.

Side effects, ingredient by ingredient Bifidobacterium Animalis Subsp. Lactis Bifidobacterium Bifidum

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Bifidobacterium Animalis Subsp. Lactis, Bifidobacterium Bifidum.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, check with your doctor or pharmacist if you take antibiotic drugs—both Bifidobacterium strains in this product can lose effectiveness if taken at the same time. You'll want to separate the doses by a few hours.

We could not check the other three probiotic strains for medication interactions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This prenatal probiotic may help with respiratory health, IBS, and constipation through its Bifidobacterium strains, though evidence is still developing. The main caution is timing with antibiotics—they can interfere with each other, so space them apart and ask your doctor or pharmacist how.

If you have a weakened immune system or take antibiotics regularly, talk it over with your healthcare provider before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 26, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Probiotic Solutions Prenatal 20 Billion CFUs, straight from the product label.

Brand GNC Probiotic Solutions
Net contents 30 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Feb 26, 2020
DSLD ID 214405
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Pregnant Women, Lactating, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Probiotic Solutions Prenatal 20 Billion CFUs by GNC Probiotic Solutions, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
IngredientAmount% DV
LAB4B Probiotics0 NP--
Bifidobacterium animalis subsp. lactis (CUL 34 )0 NP--
Lactobacillus salivarius (CUL 61)0 NP--
Lactobacillus paracasei (CUL 08)0 NP--
Bifidobacterium bifidum (CUL 20)0 NP--
Lactobacillus rhamnosus GG0 NP--

Other ingredients: Vegetarian Capsule Shell, Microcrystalline Cellulose, Corn Maltodextrin, Silicon Dioxide, Magnesium Stearate, Titanium Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Keep out of reach of children.

Storage

Store in a cool, dry place. No refrigeration required.

Formulation

Guaranteed potency at the time of expiration.

Gluten free

Potency Guaranteed

General Statements

Made in the UK

Seals/Symbols

Gluten free

Formula

Lactobacillus rhamnosus GG, along with Bifidobacterium lactis BB12, was taken throughout pregnancy and during breastfeeding. Pregnant women also received dietary counseling focusing on dietary fat intake. LAB4B strains were taken beginning in the last trimester of pregnancy until delivery. Clinically studied strains in pregnant & breastfeeding women 20 Billion Active Cultures

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one serving daily with food. You may take this product throughout pregnancy and breastfeeding.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Probiotic Solutions Prenatal 20 Billion CFUs by GNC Probiotic Solutions label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Probiotic Solutions Prenatal 20 Billion CFUs label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Probiotic Solutions Prenatal 20 Billion CFUs by GNC Probiotic Solutions

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

LAB4B Probiotics

0 NP per serving

Lactobacillus rhamnosus GG

0 NP per serving

Other (inactive) ingredients: Vegetarian Capsule Shell, Microcrystalline Cellulose, Corn Maltodextrin, Silicon Dioxide, Magnesium Stearate, Titanium Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Probiotic Solutions Prenatal 20 Billion CFUs by GNC Probiotic Solutions Drug Interactions

Want to check YOUR meds against Probiotic Solutions Prenatal 20 Billion CFUs?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Bifidobacterium animalis subsp. lactis (CUL 34 ) 182
Bifidobacterium bifidum (CUL 20) 182

Individual Drug Interactions

The ingredients in Probiotic Solutions Prenatal 20 Billion CFUs interact with 182 drugs. Click any drug to see the details.

2 of the 5 ingredients in Probiotic Solutions Prenatal 20 Billion CFUs interact with drugs. Each result below shows which ingredient is responsible. Bifidobacterium animalis subsp. lactis (CUL 34 ) Bifidobacterium bifidum (CUL 20)

Each ingredient & the kinds of drugs it affects

For each ingredient in Probiotic Solutions Prenatal 20 Billion CFUs with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bifidobacterium animalis subsp. lactis (CUL 34 )1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium lactis with antibiotic drugs might decrease the effectiveness of B. lactis.
Since B. lactis preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. lactis preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium animalis subsp. lactis (CUL 34 ) full monograph & interactions

Bifidobacterium bifidum (CUL 20)1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium. bifidum with antibiotic drugs might decrease the effectiveness of B. bifidum.
Since B. bifidum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. bifidum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium bifidum (CUL 20) full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Probiotic Solutions Prenatal 20 Billion CFUs, from the product label.

GNC Probiotic Solutions

See all GNC Probiotic Solutions products
Name
General Nutrition Corporation
City
Pittsburgh
State
PA
ZipCode
15222
Phone Number
1-888-462-2548
Web Address
gnc.com
Pharmacist Counseling Corner

Probiotic Solutions Prenatal 20 Billion CFUs by GNC Probiotic Solutions: Common Questions

Does Probiotic Solutions Prenatal 20 Billion CFUs by GNC Probiotic Solutions interact with any medications?
Yes. Based on its ingredients, Probiotic Solutions Prenatal 20 Billion CFUs has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Probiotic Solutions Prenatal 20 Billion CFUs contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this prenatal probiotic while pregnant?
Bifidobacterium bifidum is rated possibly safe in pregnancy. The data on Bifidobacterium animalis subsp. lactis during pregnancy isn't on file, and we have no pregnancy information for the other three strains—so talk with your doctor or midwife about whether this formula is right for you specifically.
What's the most common side effect?
Diarrhea is the most common reported side effect from Bifidobacterium animalis subsp. lactis. Bloating, gas, and other digestive complaints can occur with probiotics in general, though they're typically mild and temporary.
Will this help my IBS?
Both Bifidobacterium animalis subsp. lactis and Bifidobacterium bifidum are rated possibly effective for IBS. That means there's some evidence they may help, but more research is still needed. Talk with your doctor about whether it's worth trying for your situation.
Can I take this with antibiotics?
You can, but not at the same time. Antibiotics can kill the live probiotic organisms before they work. Separate your antibiotic and this supplement by a few hours, and let your doctor or pharmacist know you're taking both so they can help you time them right.
Does this product have fillers?
Yes—it contains several inactive ingredients, including microcrystalline cellulose, corn maltodextrin, silicon dioxide, magnesium stearate, and titanium dioxide, along with the vegetarian capsule shell. These are standard excipients used to form and stabilize the capsule.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Probiotic Solutions Prenatal 20 Billion CFUs is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Probiotic Solutions Prenatal 20 Billion CFUs label
Go deeper

The Full Monographs Behind Probiotic Solutions Prenatal 20 Billion CFUs’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bifidobacterium Animalis Subsp. Lactis

Interacts with 182 drugs

Bifidobacterium animalis subsp. lactis is a well-studied probiotic bacterium commonly added to supplements and yogurts to support digestion and gut health. It appears generally safe for most...

Read the full Bifidobacterium Animalis Subsp. Lactis monograph → Herb & supplement monograph

Bifidobacterium Bifidum

Interacts with 182 drugs

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance. Some evidence suggests probiotics may he...

Read the full Bifidobacterium Bifidum monograph →
Sources

Sources & How We Checked

Probiotic Solutions Prenatal 20 Billion CFUs's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bifidobacterium Animalis Subsp. Lactis 8 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Phuapradit P, Varavithya W, Vathanophas K, et al. Reduction of rotavirus infection in children receiving bifidobacteria-supplemented formula. J Med Assoc Thai 1999;82:S43-8.
  3. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  4. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  5. Taipale TJ, Pienihäkkinen K, Isolauri E, Jokela JT, Söderling EM. Bifidobacterium animalis subsp. lactis BB-12 in reducing the risk of infections in early childhood. Pediatr Res. 2016;79(1-1):65-9. PubMed
  6. Amat-Bou M, Garcia-Ribera S, Climent E, et al. Effects of Bifidobacterium animalis Subsp. lactis (BPL1) supplementation in children and adolescents with prader-willi syndrome: A randomized crossover trial. Nutrients. 2020;12(10):3123. PubMed
  7. Mäkelä SM, Forssten SD, Kailajärvi M, et al. Effects of Bifidobacterium animalis ssp. lactis 420 on gastrointestinal inflammation induced by a nonsteroidal anti-inflammatory drug: A randomized, placebo-controlled, double-blind clinical trial. Br J Clin Ph
  8. Wildt S, Munck LK, Vinter-Jensen L, et al. Probiotic treatment of collagenous colitis: a randomized, double-blind, placebo-controlled trial with Lactobacillus acidophilus and Bifidobacterium animalis subsp. Lactis. Inflamm Bowel Dis 2006;12(5):395-401. PubMed

See these in context on the Bifidobacterium Animalis Subsp. Lactis monograph →

Bifidobacterium Bifidum 7 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed
  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

See these in context on the Bifidobacterium Bifidum monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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