Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Probiotic Solutions Weight Management Support 25 Billion CFUs Ingredients & Drug Interactions

by GNC Probiotic Solutions

Probiotic Solutions Weight Management Support 25 Billion CFUs label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Probiotic Solutions Weight Management Support 25 Billion CFUs against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Probiotic Solutions Weight Management Support 25 Billion CFUs is a dietary supplement by GNC Probiotic Solutions with 2 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 385 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Morosil Sicilian Red Orange (Citrus sinensis L. Osbeck) (fruit juice) extract, Probiotic LAB4P Blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Probiotic Solutions Weight Management Support 25 Billion CFUs by GNC Probiotic Solutions

Ask about any prescription or over-the-counter medication and we check it for interactions with Probiotic Solutions Weight Management Support 25 Billion CFUs by GNC Probiotic Solutions — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Probiotic Solutions Weight Management Support 25 Billion CFUs by GNC Probiotic Solutions

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 6 active ingredients.
  • “Probiotic LAB4P Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

This product contains 6 active ingredients: four probiotic bacterial strains (Bifidobacterium animalis subsp. lactis, two different strains of Lactobacillus acidophilus, and Bifidobacterium bifidum), plus Lactobacillus plantarum and a proprietary probiotic blend. It also includes Morosil Sicilian Red Orange extract.

The probiotics are meant to support digestive and gut health; the red orange extract is included for weight management support. The capsule also contains inactive ingredients including maltodextrin, microcrystalline cellulose, and anti-caking agents.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: weight management and body composition support.
  • We looked for evidence on: Metabolic syndrome, Obesity, weight loss, body weight regulation, overweight.
  • The closest evidence on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Obesity (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Metabolic syndrome.
  • Also on file: Bifidobacterium Animalis Subsp. Lactis is rated "Insufficient Reliable Evidence To Rate" for Obesity, Metabolic syndrome.

The probiotic strains in this product have been studied for several uses. Bifidobacterium animalis and both Lactobacillus acidophilus strains are possibly effective for irritable bowel syndrome (IBS), and the Lactobacillus acidophilus strains are possibly effective for antibiotic-associated diarrhea and bacterial vaginosis.

Bifidobacterium animalis is also possibly effective for constipation and respiratory tract infections, while Bifidobacterium bifidum is possibly effective for respiratory tract infections. For the red orange extract, we don't have evidence in our data to rate its effectiveness for weight management or any other condition.

The evidence, ingredient by ingredient Lactobacillus Acidophilus Bifidobacterium Animalis Subsp. Lactis Bifidobacterium Bifidum Sweet Orange

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The probiotic strains are generally well tolerated by most healthy people when taken as directed. Bifidobacterium lactis may cause diarrhea in some people, and gastrointestinal side effects including bloating, flatulence, abdominal pain, and diarrhea have been reported rarely with these probiotics, though they're uncommon.

A small number of trial participants taking a combination of these probiotics reported rash with itching, though it's unclear if the probiotics were responsible. There is rare concern that probiotics might cause infection in people with weakened immune systems.

The red orange extract is likely safe in normal fruit amounts, but concentrated extracts haven't been well studied, so caution is advised. In pregnancy, Lactobacillus acidophilus is possibly safe, and the red orange extract is likely safe; for Bifidobacterium bifidum, the data shows it's possibly safe in pregnancy.

Talk with your doctor or pharmacist for personalized advice about taking this during pregnancy or breastfeeding.

Side effects, ingredient by ingredient Lactobacillus Acidophilus Bifidobacterium Animalis Subsp. Lactis Bifidobacterium Bifidum Sweet Orange

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Lactobacillus Acidophilus, Bifidobacterium Animalis Subsp. Lactis, Sweet Orange, Bifidobacterium Bifidum.
  • The most serious interaction on file is rated Major.
  • For scale: 385 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take antibiotic drugs, because taking them at the same time as these probiotics might reduce the probiotics' effectiveness — you may need to space them apart. Also watch for major interactions: fexofenadine (Allegra), ivermectin (Stromectol), celiprolol (Celicard), pravastatin (Pravachol), organic anion-transporting polypeptide substrate drugs, P-glycoprotein substrates, and quinolone antibiotics.

All of these can have their absorption changed or blood levels affected by the red orange extract in this product. Use the medication search tool below to check your exact drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

This product might help with IBS, antibiotic-associated diarrhea, or respiratory health if you're not on medications that interact with it — especially blood pressure drugs, cholesterol medications, allergy drugs, antiparasitic medications, or antibiotics. If you take any prescription or over-the-counter medications, check them against the interaction tool on this page before you start.

Talk with your doctor or pharmacist about whether this product is right for you, especially if you have a weakened immune system.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Probiotic Solutions Weight Management Support 25 Billion CFUs, straight from the product label.

Brand GNC Probiotic Solutions
Net contents 30 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jun 24, 2020
DSLD ID 228100
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Probiotic Solutions Weight Management Support 25 Billion CFUs by GNC Probiotic Solutions, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
IngredientAmount% DV
Bifidobacterium animalis subsp. lactis (CUL 34 )0 NP--
Lactobacillus acidophilus (CUL 60)0 NP--
Bifidobacterium bifidum (CUL 20)0 NP--
Lactobacillus acidophilus (CUL 21)0 NP--
Lactobacillus plantarum (CUL 66)0 NP--
Probiotic LAB4P Blend0 NP--
Morosil Sicilian Red Orange (Citrus sinensis L. Osbeck) (fruit juice) extract400 mg--

Other ingredients: Maltodextrin, Vegetarian Capsule Shell, Microcrystalline Cellulose, Anti-Caking Agents

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one capsule daily with food.

Precautions

Warning: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition.

Discontinue use two weeks prior to surgery.

Keep out of reach of children.

Formulation

Gluten free.

Potency guaranteed Clinically studied support for weight management & body composition

Formula

Why GNC Probiotic Solutions Weight Management Support? Multiple strains of live, active probiotic cultures Includes polyphenol-rich Morosil red orange extract, which is clinically studied to support weight management and body composition Guaranteed potency thru expiration date

Multi-strain probiotic with clinically studied strains 25 billion active cultures

Guaranteed Potency Probiotic Solutions Weight Management Support has been tested to ensure the full 25 billion cultures in each dose are live and active when used by the expiration date.

Storage

No refrigeration necessary

Store in a cool, dry place. No refrigeration required.

Brand IP Statement(s)

Morosil is a trademark of Bionap S.R.L.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Probiotic Solutions Weight Management Support 25 Billion CFUs by GNC Probiotic Solutions label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Probiotic Solutions Weight Management Support 25 Billion CFUs label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Probiotic Solutions Weight Management Support 25 Billion CFUs by GNC Probiotic Solutions

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Probiotic LAB4P Blend

Interacts with
182 drugs
0 NP per serving

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...

Probiotic LAB4P Blend monograph & interactions

Morosil Sicilian Red Orange (Citrus sinensis L. Osbeck) (fruit juice) extract

Interacts with
246 drugs
400 mg per serving

Sweet orange is a common citrus fruit that is a good source of vitamin C, fiber, and antioxidants, and is enjoyed as a food worldwide. Its peel and es...

Morosil Sicilian Red Orange (Citrus sinensis L. Osbeck) (fruit juice) extract monograph & interactions

Other (inactive) ingredients: Maltodextrin, Vegetarian Capsule Shell, Microcrystalline Cellulose, Anti-Caking Agents. These complete the product’s ingredient list but are not active constituents.

Interaction report

Probiotic Solutions Weight Management Support 25 Billion CFUs by GNC Probiotic Solutions Drug Interactions

Want to check YOUR meds against Probiotic Solutions Weight Management Support 25 Billion CFUs?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
385Drugs
48 Major 337 Moderate

Ingredients driving the most interactions

Morosil Sicilian Red Orange (Citrus sinensis L. Osbeck) (fruit juice) extract 246
Probiotic LAB4P Blend 182

Individual Drug Interactions

The ingredients in Probiotic Solutions Weight Management Support 25 Billion CFUs interact with 385 drugs. Click any drug to see the details.

2 of the 2 ingredients in Probiotic Solutions Weight Management Support 25 Billion CFUs interact with drugs. Each result below shows which ingredient is responsible. Morosil Sicilian Red Orange (Citrus sinensis L. Osbeck) (fruit juice) extract Probiotic LAB4P Blend

Each ingredient & the kinds of drugs it affects

For each ingredient in Probiotic Solutions Weight Management Support 25 Billion CFUs with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Morosil Sicilian Red Orange (Citrus sinensis L. Osbeck) (fruit juice) extract7 drug types · 246 drugs

Celiprolol (Celicard)

Consuming sweet orange with celiprolol can decrease oral absorption of celiprolol.
A pharmacokinetic study in healthy volunteers shows that celiprolol levels, after a single dose of 100 mg, are decreased by up to 90% in people who drink sweet orange juice 200 mL three times daily. It's not known if lower consumption of sweet orange juice will have the same effect. Theoretically, this occurs due to short-term inhibition of organic anion transporting polypeptide (OATP). Recommend separating drug administration and consumption of sweet orange by at least 4 hours.

Likelihood Likely Evidence B
Ivermectin (Stromectol, Others)

Consuming sweet orange juice with ivermectin can decrease the oral absorption of ivermectin.
A pharmacokinetic study in healthy volunteers shows that taking ivermectin orally with sweet orange juice 750 mL over 4 hours reduces the bioavailability of ivermectin. This effect does not seem to be related to effects on P-glycoprotein. The effect on ivermectin is more pronounced in males compared to females.

Likelihood Likely Evidence B
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Consuming sweet orange juice can decrease oral absorption of OATP substrates. Separate administration by at least 4 hours.
Clinical research shows that consuming sweet orange juice inhibits OATP, which reduces bioavailability of oral drugs that are substrates of OATP. For example, sweet orange juice decreases bioavailability of fexofenadine, a substrate of OATP, by about 72% and of celiprolol, another OATP substrate, by up to 90%. Since sweet orange juice seems to affect OATP for a short time, recommend separating drug administration and consumption of sweet orange juice by at least 4 hours.

Likelihood Likely Evidence B
Pravastatin (Pravachol)

Consuming sweet orange juice with pravastatin can increase the absorption of pravastatin.
A small pharmacokinetic study in healthy volunteers shows that consuming sweet orange juice 800 mL over 3 hours, including before, during, and after taking pravastatin 10 mg, increases pravastatin levels by about 149%, without affecting pravastatin elimination. Theoretically this effect might be due to modulation of organic anion transporting polypeptides (OATPs) by sweet orange juice. Sweet orange juice does not seem to affect simvastatin levels, but it is not known if sweet orange affects any of the other statins.

Likelihood Likely Evidence B
Fexofenadine (Allegra)

Consuming sweet orange juice with fexofenadine can decrease oral absorption of fexofenadine.
Clinical research shows that coadministration of sweet orange juice 1200 mL decreases bioavailability of fexofenadine by about 72%. In an animal model, sweet orange juice decreased bioavailability of fexofenadine by 31%. Fexofenadine manufacturer data indicates that concomitant administration of sweet orange juice and fexofenadine results in larger wheal and flare sizes in research models. This suggests that sweet orange reduces the clinical response to fexofenadine. Theoretically, this occurs due to short-term inhibition of organic anion transporting polypeptide (OATP). Recommend separating drug administration and consumption of sweet orange by at least 4 hours.

Likelihood Likely Evidence B
P-Glycoprotein Substrates

Sweet orange juice seems to modulate P-glycoprotein (P-gp), which might affect the blood levels of P-gp substrates.
Animal and in vitro research suggest that orange juice extract inhibits drug efflux by P-gp, increasing absorption and levels of P-gp substrates. In contrast, pharmacokinetic research in humans shows that drinking large amounts of sweet orange juice decreases absorption and levels of the P-gp substrate celiprolol. This suggests that orange juice actually induces drug efflux by P-gp or affects drug levels by another mechanism such as inhibiting the gut drug transporter called organic anion transporting polypeptide (OATP). Until more is known, sweet orange juice should be used cautiously in people taking P-gp substrates.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium-fortified sweet orange juice might reduce quinolone absorption.
Calcium binds to quinolones in the gut. Theoretically, the calcium in certain fortified orange juices can also bind to quinolone antibiotics and reduce their absorption and levels.

Likelihood Possible Evidence D
Morosil Sicilian Red Orange (Citrus sinensis L. Osbeck) (fruit juice) extract full monograph & interactions

Probiotic LAB4P Blend1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Probiotic LAB4P Blend full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Probiotic Solutions Weight Management Support 25 Billion CFUs, from the product label.

GNC Probiotic Solutions

See all GNC Probiotic Solutions products
Name
General Nutrition Corporation
City
Pittsburgh
State
PA
ZipCode
15222
Phone Number
1-888-462-2548
Web Address
gnc.com
Pharmacist Counseling Corner

Probiotic Solutions Weight Management Support 25 Billion CFUs by GNC Probiotic Solutions: Common Questions

Does Probiotic Solutions Weight Management Support 25 Billion CFUs by GNC Probiotic Solutions interact with any medications?
Yes. Based on its ingredients, Probiotic Solutions Weight Management Support 25 Billion CFUs has a known interaction with 385 medications, including 48 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Probiotic Solutions Weight Management Support 25 Billion CFUs contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this probiotic with my antibiotic?
Not at the same time. Since antibiotics can kill the beneficial bacteria in this product, you'll want to separate them — talk with your pharmacist about the best timing. Taking them a few hours apart might help the probiotics work better.
What's Morosil red orange extract doing in a weight management probiotic?
The product includes it for weight management support, but we don't have evidence in our data showing it works for that purpose. It is a concentrate of red orange fruit, so it carries some drug interactions that the plain fruit wouldn't.
Will this probiotic give me diarrhea?
Diarrhea is the most commonly reported side effect with Bifidobacterium lactis, and gastrointestinal complaints like bloating, gas, and diarrhea can happen with these probiotics, though they're rare. Most people tolerate them well.
Is it safe to take during pregnancy?
Lactobacillus acidophilus is rated possibly safe in pregnancy, and Bifidobacterium bifidum is also possibly safe, but there isn't enough data to be certain. Talk with your doctor or pharmacist for personalized advice before taking it while pregnant.
What do these probiotics actually do?
The strains in this product are possibly effective for IBS, antibiotic-associated diarrhea, bacterial vaginosis, constipation, and respiratory tract infections based on available evidence. Results vary from person to person.
Can I take this if I have a weakened immune system?
The safety data advises caution — talk with your doctor or pharmacist first. There's rare concern that probiotics might cause infection in people with compromised immunity, so personalized advice is important.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Probiotic Solutions Weight Management Support 25 Billion CFUs is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Probiotic Solutions Weight Management Support 25 Billion CFUs label
Go deeper

The Full Monographs Behind Probiotic Solutions Weight Management Support 25 Billion CFUs’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Bifidobacterium Animalis Subsp. Lactis

Interacts with 182 drugs

Bifidobacterium animalis subsp. lactis is a well-studied probiotic bacterium commonly added to supplements and yogurts to support digestion and gut health. It appears generally safe for most...

Read the full Bifidobacterium Animalis Subsp. Lactis monograph → Herb & supplement monograph

Bifidobacterium Bifidum

Interacts with 182 drugs

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance. Some evidence suggests probiotics may he...

Read the full Bifidobacterium Bifidum monograph → Herb & supplement monograph

Sweet Orange

Interacts with 246 drugs

Sweet orange is a common citrus fruit that is a good source of vitamin C, fiber, and antioxidants, and is enjoyed as a food worldwide. Its peel and essential oil are used in aromatherapy and...

Read the full Sweet Orange monograph →
Sources

Sources & How We Checked

Probiotic Solutions Weight Management Support 25 Billion CFUs's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 47 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bifidobacterium Animalis Subsp. Lactis 8 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Phuapradit P, Varavithya W, Vathanophas K, et al. Reduction of rotavirus infection in children receiving bifidobacteria-supplemented formula. J Med Assoc Thai 1999;82:S43-8.
  3. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  4. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  5. Taipale TJ, Pienihäkkinen K, Isolauri E, Jokela JT, Söderling EM. Bifidobacterium animalis subsp. lactis BB-12 in reducing the risk of infections in early childhood. Pediatr Res. 2016;79(1-1):65-9. PubMed
  6. Amat-Bou M, Garcia-Ribera S, Climent E, et al. Effects of Bifidobacterium animalis Subsp. lactis (BPL1) supplementation in children and adolescents with prader-willi syndrome: A randomized crossover trial. Nutrients. 2020;12(10):3123. PubMed
  7. Mäkelä SM, Forssten SD, Kailajärvi M, et al. Effects of Bifidobacterium animalis ssp. lactis 420 on gastrointestinal inflammation induced by a nonsteroidal anti-inflammatory drug: A randomized, placebo-controlled, double-blind clinical trial. Br J Clin Ph
  8. Wildt S, Munck LK, Vinter-Jensen L, et al. Probiotic treatment of collagenous colitis: a randomized, double-blind, placebo-controlled trial with Lactobacillus acidophilus and Bifidobacterium animalis subsp. Lactis. Inflamm Bowel Dis 2006;12(5):395-401. PubMed

See these in context on the Bifidobacterium Animalis Subsp. Lactis monograph →

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Bifidobacterium Bifidum 7 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed
  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
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  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

See these in context on the Bifidobacterium Bifidum monograph →

Sweet Orange 17 references
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  2. FDA, CFSAN. FDA-approved potassium health claim notification for potassium containing foods. 2000. Available at: www.cfsan.fda.gov/~dms/hclm-k.html.
  3. Kurowska EM, Spence JD, Jordan J, et al. HDL-cholesterol-raising effect of orange juice in subjects with hypercholesterolemia. Am J Clin Nutr 2000;72:1095-100. PubMed
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  7. Lilja JJ, Juntti-Patinen L, Neuvonen PJ. Orange juice substantially reduces the bioavailability of the beta-adrenergic-blocking agent celiprolol. Clin Pharmacol Ther 2004;75:184-90.
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  9. Vanapalli SR, Chen Y, Ellingrod VL, et al. Orange juice decreases the oral bioavailability of ivermectin in health volunteers. Clin Pharmacol Ther 2003;73 (Abstract PDII-A-10):P94.
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See these in context on the Sweet Orange monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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