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Dietary supplement

Probiotics + Prebiotics Return to Regular Ingredients & Drug Interactions

by Renew Life

Probiotics + Prebiotics Return to Regular label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Probiotics + Prebiotics Return to Regular against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Probiotics + Prebiotics Return to Regular is a dietary supplement by Renew Life with 3 active ingredients.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Probiotics + Prebiotics Return to Regular by Renew Life

Ask about any prescription or over-the-counter medication and we check it for interactions with Probiotics + Prebiotics Return to Regular by Renew Life — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Probiotics + Prebiotics Return to Regular by Renew Life

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 9 active ingredients.
  • “Total Bifido Probiotic Cultures” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Total Lacto Probiotic Cultures” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Return to Regular Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

This product has 9 active ingredients: a mix of six Lactobacillus strains (paracasei, rhamnosus, acidophilus, salivarius, plantarum, and casei) and two Bifidobacterium strains (animalis lactis and bifidum), plus xylooligosaccharides, a type of prebiotic (a food source for beneficial bacteria). The inactive ingredients are a vegetable capsule and organic rice hull concentrate.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Support digestive health and occasional constipation.
  • We looked for evidence on: Antibiotic-associated diarrhea, Clostridioides difficile infection, Constipation, Inflammatory bowel disease (IBD), Irritable bowel syndrome (IBS), Lactose intolerance — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Bifidobacterium Bifidum is rated "Possibly Effective" for Irritable bowel syndrome (IBS).

The evidence for this product's effectiveness comes from data on Lactobacillus acidophilus and Bifidobacterium bifidum. L. acidophilus is possibly effective for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis.

B. bifidum is possibly effective for IBS and respiratory tract infections. The evidence for other uses — hay fever, Alzheimer disease, and anxiety — isn't yet established.

The other strains in this blend have no effectiveness ratings on file.

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus and Bifidobacterium bifidum are generally well tolerated in healthy adults and children, though people with weakened immune systems should talk with their doctor first. Gastrointestinal side effects like bloating, flatulence, abdominal discomfort, and diarrhea can occur when taking probiotics in combination, but they're uncommon.

Rarely, these live organisms can cause serious infections in vulnerable patients — cases of sepsis and other deep infections have been reported, though most are thought to stem from bacteria that already exist elsewhere in the body. There's no pregnancy or lactation safety data on file for these ingredients; talk with your pharmacist or doctor for personalized guidance if you're pregnant or breastfeeding.

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Lactobacillus Acidophilus, Bifidobacterium Bifidum.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

The main concern here is antibiotic drugs — they can reduce how well this product's probiotics work if taken at the same time. Altogether, these interactions span 182 individual medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic blend may help with IBS, antibiotic-associated diarrhea, or certain infections — but the evidence is still developing. If you take antibiotics, separate them from this product by several hours.

Those with a weakened immune system should check with their doctor first. Run your exact medications through our checker to be sure.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Probiotics + Prebiotics Return to Regular, straight from the product label.

Brand Renew Life
Barcode (UPC) 631257159830
Net contents 60 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Jun 24, 2019
DSLD ID 203476
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Organic, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Probiotics + Prebiotics Return to Regular by Renew Life, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
631257159830
IngredientAmount% DV
Total Carbohydrates1 Gram(s)1%
Lactobacillus paracasei0 NP--
Lactobacillus rhamnosus0 NP--
Lactobacillus acidophilus0 NP--
Bifidobacterium animalis lactis0 NP--
Lactobacillus salivarius0 NP--
Lactobacillus plantarum0 NP--
Bifidobacterium bifidum0 NP--
Lactobacillus casei0 NP--
organic Xylooligosaccharides1300 mg--
Total Bifido Probiotic Cultures0 NP--
Total Lacto Probiotic Cultures0 NP--
Return to Regular Blend0 NP--

Other ingredients: Vegetable Capsule, organic Rice hull concentrate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Nourish your gut!

10 Strains 20 billion live cultures guaranteed

New! Occasional constipation, plus digestive & immune support

20 billion live cultures

Quality, purity and potency guaranteed through expiration.

Is Return to Regular right for me?

Formula

Renew Life Probiotics + Organic Prebiotics provide an effective and wholesome way to help support your health from the core every day.

Each daily formula is made with multiple strains of clinically studied probiotics to reflect the gut's natural diversity, plus an organic XOS prebiotic to help stimulate the growth of healthy bacteria, all in convenient vegetable capsules.

Contains 3 strains of Bifidobacterium lactis.

Renew Life Return to Regular is a clinically formulated daily probiotic with multiple strains of Bifidobacteria and Lactobacilli, plus prebiotics to: Support digestive and immune health Help improve regularity when taken daily Relieve occasional constipation by optimizing the normal speed that food moves through the digestive tract Reduce occasional bloating Promote healthy stool consistency Help stimulate the growth of healthy bacteria in the gut

Formulation

Non-GMO No gluten, dairy or soy

Gluten, dairy & soy free

Gluten free Dairy free Soy free

Certified organic by SCS Global Services.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Made with organic prebiotics

Non GMO Project Verified nongmoproject.org

Certified organic SCS Global Services

FDA Statement of Identity

Probiotic Supplement

Suggested/Recommended/Usage/Directions

Directions: For best results, take two (2) capsules once a day, with or without food.

Storage

Store at 41(0)F (5(0)C) or below. Keep refrigerated.

Precautions

Keep out of reach of children.

Consult your healthcare professional before using this or any product if you are pregnant, nursing or under medical supervision.

Tamper Evident: Do not use if safety seal on bottle is broken or missing.

Brand IP Statement(s)

2017 Made in USA of global ingredients

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Probiotics + Prebiotics Return to Regular by Renew Life label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Probiotics + Prebiotics Return to Regular label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Probiotics + Prebiotics Return to Regular by Renew Life

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Organic Xylooligosaccharides

1300 mg per serving

Return to Regular Blend

0 NP per serving
  • › Total Bifido Probiotic Cultures
  • › Total Lacto Probiotic Cultures

Other (inactive) ingredients: Vegetable Capsule, Organic Rice hull concentrate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Probiotics + Prebiotics Return to Regular by Renew Life Drug Interactions

Want to check YOUR meds against Probiotics + Prebiotics Return to Regular?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Individual Drug Interactions

The ingredients in Probiotics + Prebiotics Return to Regular interact with 182 drugs. Click any drug to see the details.

0 of the 3 ingredients in Probiotics + Prebiotics Return to Regular interact with drugs. Each result below shows which ingredient is responsible.

Each ingredient & the kinds of drugs it affects

For each ingredient in Probiotics + Prebiotics Return to Regular with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

The maker

Brand information

Manufacturer and brand details for Probiotics + Prebiotics Return to Regular, from the product label.

Renew Life

Name
Renew Life Formulas, Inc.
City
Palm Harbor
State
FL
ZipCode
34683
Phone Number
1-800-830-1800
Web Address
www.renewlife.com
Pharmacist Counseling Corner

Probiotics + Prebiotics Return to Regular by Renew Life: Common Questions

Does Probiotics + Prebiotics Return to Regular by Renew Life interact with any medications?
Yes. Based on its ingredients, Probiotics + Prebiotics Return to Regular has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Probiotics + Prebiotics Return to Regular contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this with my antibiotics?
Not at the same time. Antibiotics can kill off the live organisms in this probiotic, making it less effective. Space them several hours apart — your pharmacist can help you time them right.
What are the side effects I should watch for?
Gas, bloating, belly discomfort, and diarrhea are the most common, though they're uncommon overall. In rare cases, if you have a very weak immune system, these live bacteria could cause a serious infection — talk with your doctor if that's a concern for you.
Is this safe if I have a compromised immune system?
People with weakened immune systems should be cautious and check with their doctor before taking it. There have been rare cases of serious infections from these probiotic strains in critically ill patients.
Can I take this while pregnant or breastfeeding?
We don't have safety data on file for these ingredients during pregnancy or breastfeeding. Talk with your pharmacist or doctor — they can give you personalized guidance based on your situation.
Does this actually work for IBS or diarrhea?
The evidence shows L. acidophilus and B. bifidum are possibly effective for IBS and antibiotic-associated diarrhea, but it's not a guarantee — results vary by person. Other uses like hay fever and anxiety don't yet have solid evidence.
What's the difference between the probiotics and the prebiotic in here?
The probiotics (Lactobacillus and Bifidobacterium strains) are live beneficial bacteria. The prebiotic (xylooligosaccharides) is a type of fiber that feeds those bacteria so they can thrive in your gut.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Probiotics + Prebiotics Return to Regular is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Probiotics + Prebiotics Return to Regular label
Sources

Sources & How We Checked

Probiotics + Prebiotics Return to Regular's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 22 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Bifidobacterium Bifidum 7 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed
  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

See these in context on the Bifidobacterium Bifidum monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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