Interactions on record — worth a quick check against your medications. Based on 4 of 5 ingredients. Check your meds →
Dietary supplement

Prosaic By Nature Ingredients & Drug Interactions

by Amazon Therapeutics

Liquid Category: Botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Prosaic By Nature is a dietary supplement by Amazon Therapeutics with 5 active ingredients. Its ingredients are commonly taken for fatigue and low energy, stress and coping (adaptogen), mental performance and focus.Based on those ingredients, 1,271 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Rhodiola, Damiana. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Prosaic By Nature by Amazon Therapeutics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.

Prosaic By Nature is a liquid supplement with 5 active ingredients: rhodiola, maca, damiana, muira puama, and tayuya. Rhodiola is traditionally used to help with stress and energy; maca is commonly used for sexual function and energy; damiana has been used for sexual desire and mood; and muira puama and tayuya are botanical ingredients with traditional uses.

The liquid also contains inactive ingredients — 35–40% organic alcohol and distilled water — to preserve and deliver the active botanicals.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Promotes emotional well-being.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence for what this product can do isn't established in our data. All six uses we track for rhodiola — including altitude sickness, anxiety, heart rhythm, athletic performance, and bladder cancer — have insufficient reliable evidence.

The same is true for maca's tracked uses (amenorrhea, anemia, sexual dysfunction, athletic performance, and osteoporosis), damiana's uses (sexual dysfunction, asthma, headache, cognition, constipation, and depression), and muira puama's tracked uses (sexual dysfunction and erectile dysfunction). This doesn't mean the ingredients don't work; it means the clinical evidence hasn't yet established a clear benefit for these conditions.

The evidence, ingredient by ingredient Rhodiola Maca Damiana Muira Puama

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Rhodiola is generally well tolerated for short-term use, but long-term safety hasn't been well studied. The most common side effects are dizziness and changes in saliva production (either dry mouth or excessive saliva).

Damiana can cause stomach pain, especially uncooked fresh damiana, and at very high doses (200 grams of extract) has caused serious neurological effects in one case. Maca is generally well tolerated as a food, though supplement safety long-term is unclear.

Regarding pregnancy and breastfeeding: the safety data advise against rhodiola, damiana, maca, and muira puama during pregnancy and breastfeeding because there isn't enough data to know either way. Talk with your doctor or pharmacist about whether this product is right for you in these situations.

Side effects, ingredient by ingredient Rhodiola Maca Damiana Muira Puama

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 4 matched ingredients can interact with medications — Damiana, Rhodiola.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,272 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Prosaic By Nature, double-check with your doctor or pharmacist if you take blood pressure medications (antihypertensives) or losartan — rhodiola may lower your blood pressure further or raise losartan levels. Diabetes medications are also a concern with both rhodiola and damiana, as they may increase low blood sugar risk.

If you take drugs broken down by your liver (including CYP2C9, P-glycoprotein, CYP1A2, or CYP3A4 metabolic pathways) or immunosuppressants, run those by your healthcare provider as well.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Prosaic By Nature may interest people exploring traditional botanical supplements for energy or vitality, but the clinical evidence for its uses isn't yet established. If you take blood pressure medications, diabetes drugs, losartan, immunosuppressants, or drugs that rely on liver metabolism, you should check your exact medications with your doctor or pharmacist before starting this product — rhodiola's interactions with these drug types are documented.

Avoid it during pregnancy or while breastfeeding unless your doctor advises otherwise.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 27, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Prosaic By Nature, straight from the product label.

Brand Amazon Therapeutics
Barcode (UPC) 838451008173
Net contents 2 Fluid Ounce(s); 60 mL
Market status On market
Date entered into DSLD Jul 27, 2021
DSLD ID 248381
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Prosaic By Nature by Amazon Therapeutics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
10 Drop(s)
Maximum serving Sizes:
15 Drop(s)
UPC/BARCODE
838451008173
IngredientAmount% DV
Rhodiola0 NP--
Maca0 NP--
Damiana0 NP--
Muira Puama0 NP--
Tayuya0 NP--

Other ingredients: 35-40% organic Alcohol, distilled Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Your Selection You hold in your hands the finest traditional botanical available. This botanical is a long-standing favorite of South America where it has been empirically selected for its effectiveness over many generations.

Traditional Ethnobotanical Information Amazon Therapeutics works for the preservation of rainforests and to uphold the intellectual property rights of native healers and their traditional medicines.

Suggested/Recommended/Usage/Directions

Suggested Directions Take 10-15 drops two or three times daily or as recommended by a health care practitioner.

Precautions

Cautions: Information provided on this label should not be used as medical advice. Not intended for long-term use.

Not intended for pregnant or nursing women.

Keep out of the reach of children.

Formulation

Promotes emotional well-being

Direct from the source

Gluten free

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Wild Crafted Sustainable Harvest

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

See for yourself

Prosaic By Nature by Amazon Therapeutics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Prosaic By Nature by Amazon Therapeutics

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size10 Drop(s) Dosage formLiquid Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Rhodiola

Interacts with
1,271 drugs
0 NP per serving

Rhodiola is an herb traditionally used to fight fatigue and help the body cope with stress. Some small studies suggest it may modestly reduce fatigue...

Rhodiola monograph & interactions

Maca

No known
interactions
0 NP per serving

Maca is a nutrient-rich Andean root often used for energy, libido, and menopause symptoms. Early studies suggest it may modestly help sexual desire an...

Maca monograph & interactions

Damiana

Interacts with
86 drugs
0 NP per serving

Damiana is a traditional herb most famous as an aphrodisiac and mild mood-lifter, but solid human evidence for any of its uses is very limited. It is...

Damiana monograph & interactions

Muira Puama

No known
interactions
0 NP per serving

Muira puama is a Brazilian plant traditionally used as an aphrodisiac and general tonic, often nicknamed 'potency wood.' Human research is very limite...

Muira Puama monograph & interactions

Tayuya

0 NP per serving

Other (inactive) ingredients: 35-40% organic Alcohol, Distilled Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Prosaic By Nature by Amazon Therapeutics Drug Interactions

Want to check YOUR meds against Prosaic By Nature?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
1,271Drugs
624 Moderate 647 Minor

Ingredients driving the most interactions

Rhodiola 1,271
Damiana 86

Each ingredient & the kinds of drugs it affects

For each ingredient in Prosaic By Nature with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Rhodiola10 drug types · 1,271 drugs

Antidiabetes Drugs

Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.
In vitro and animal research shows that rhodiola extract can decrease blood glucose due to alpha-glucosidase activity.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.
In vitro and animal research shows that rhodiola extract inhibits angiotensin-converting enzyme (ACE) and might lower blood pressure.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP2C9.
In vitro research shows that rhodiola inhibits CYP2C9. This effect is highly variable and appears to be dependent on the rhodiola product studied. Also, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.

Likelihood Possible Evidence B
Immunosuppressants

Theoretically, rhodiola use might interfere with immunosuppressive therapy.
In vitro and animal research show that rhodiola has immunostimulatory effects.

Likelihood Possible Evidence D
Losartan (Cozaar)

Rhodiola might increase the levels and adverse effects of losartan.
A clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.

Likelihood Probable Evidence B
P-Glycoprotein Substrates

Theoretically, rhodiola might increase levels of P-glycoprotein substrates.
In vitro research shows that rhodiola inhibits P-glycoprotein. Theoretically, using rhodiola with P-glycoprotein substrates might increase drug levels and potentially increase the risk of adverse effects.

Likelihood Possible Evidence D
Antidepressant Drugs

Theoretically, rhodiola might increase the risk of adverse effects when taken with antidepressants.
A review of adverse event reports in Poland identified cases of tachyarrhythmias, myalgia, arthralgia, gum pain, restless leg syndrome, swallowing disorders, and changes in consciousness when rhodiola was taken in combination with paroxetine, escitalopram, fluoxetine, sertraline, trazodone, and/or duloxetine.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
A review of adverse event reports in Poland identified cases of excessive sedation, myoclonus, hypotension, and hallucinations when rhodiola was taken with haloperidol, diazepam, or alprazolam.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that rhodiola inhibits CYP1A2. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of caffeine, a CYP1A2 substrate.

Likelihood Possible Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that rhodiola inhibits CYP3A4. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of midazolam, a CYP3A4 substrate.

Likelihood Possible Evidence B

Damiana1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking damiana with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that taking damiana lowers blood glucose level.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Prosaic By Nature, from the product label.

Amazon Therapeutics

See all Amazon Therapeutics products
Name
Herbs America
Street Address
PO Box 446
City
Murphy
State
OR
ZipCode
97533
Phone Number
541-846-6222
Web Address
www.amazonmedicine.com
Pharmacist Counseling Corner

Prosaic By Nature by Amazon Therapeutics: Common Questions

Does Prosaic By Nature by Amazon Therapeutics interact with any medications?
Yes. Based on its ingredients, Prosaic By Nature has a known interaction with 1,271 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Prosaic By Nature contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
The safety data advise against it — there isn't enough information on any of the active ingredients in this product to know they're safe in pregnancy or while breastfeeding. Talk with your doctor or pharmacist about your specific situation before using it.
What are the most common side effects?
Rhodiola, the main ingredient with side effect data, most commonly causes dizziness and changes in saliva (either dry mouth or too much saliva). Damiana at high doses can cause stomach pain. Most people tolerate the product without side effects, but the long-term safety profile hasn't been well studied.
Does this product have any proven benefits?
The clinical evidence for its benefits hasn't been established yet in the data we hold. The ingredients have traditional uses, but we don't have reliable studies showing they work for the conditions they're often used for — like sexual function, energy, or mood.
Is it safe to take with my blood pressure medication?
Rhodiola in this product may lower blood pressure further, which could be risky. Check with your doctor or pharmacist before starting — they can tell you whether it's safe for your specific medication and dosage.
What is tayuya, and does it interact with any drugs?
Tayuya is one of the five botanicals in this product, but we don't hold interaction data for it, so we can't check it. Your pharmacist can look into it further if you're concerned.
Why is there alcohol in this liquid?
Alcohol is a common preservative and extraction solvent in liquid herbal supplements — it helps keep the product stable and deliver the active botanicals. This product contains 35–40% organic alcohol by volume.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Prosaic By Nature is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Prosaic By Nature label
Sources

Sources & How We Checked

Prosaic By Nature's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 18 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Rhodiola 13 references
  1. Kim SH, Hyun SH, Choung SY. Antioxidative effects of Cinnamomi cassiae and Rhodiola rosea extracts in liver of diabetic mice. Biofactors 2006;26:209-19.
  2. Kwon YI, Jang HD, Shetty K. Evaluation of Rhodiola crenulata and Rhodiola rosea for management of type II diabetes and hypertension. Asia Pac J Clin Nutr 2006;15:425-32.
  3. Bystritsky A, Kerwin L, Feusner JD. A pilot study of Rhodiola rosea (Rhodax) for generalized anxiety disorder (GAD). J Altern Complement Med 2008;14:175-80.
  4. Shevtsov VA, Zholus BI, Shervarly VI, et al. A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine 2003;10:95-105. PubMed
  5. Apostolidis E, Kwon YI, Shetty K. Potential of cranberry-based herbal synergies for diabetes and hypertension management. Asia Pac J Clin Nutr 2006;15:433-41.
  6. Hellum BH, Tosse A, Hoybakk K, et al. Potent in vitro inhibition of CYP3A4 and P-glycoprotein by Rhodiola rosea. Planta Med 2010;76:331-8.
  7. Skopriska-Rozewska E, Wojcik R, Siwicki AK, et al. The effect of Rhodiola quadrifida extracts on cellular immunity in mice and rats. Pol J Vet Sci 2008;11:105-11.
  8. Mishra KP, Chanda S, Shukla K, Ganju L. Adjuvant effect of aqueous extract of Rhodiola imbricate rhizome on the immune responses to tetanus toxoid and ovalbumin in rats. Immunopharmacol Immunotoxicol 2010;32:141-6.
  9. Li HX, Sze SC, Tong Y, Ng TB. Production of Th1- and Th2-dependent cytokines induced by the Chinese medicine herb, Rhodiola algida, on human peripheral blood monocytes. J Ethnopharmacol 2009;123:257-66. PubMed
  10. Mishra KP, Ganju L, Chanda S, et al. Aqueous extract of Rhodiola imbricate rhizome stimulates Toll-like receptor 4, granzyme-B and Th1 cytokines in vitro. Immunobiology 2009;214:27-31.
  11. Thu OK, Nilsen OG, Hellum B. In vitro inhibition of cytochrome P-450 activities and quantification of constituents in a selection of commercial Rhodiola rosea products. Pharm Bio. 2016 Dec;54(12):3249-3256.
  12. Thu OK, Spigset O, Nilsen OG, Hellum B. Effect of commercial Rhodiola rosea on CYP enzyme activity in humans. Eur J Clin Pharmacol. 2016 Mar;72(3):295-300. PubMed
  13. Woron J, Siwek M. Unwanted effects of psychotropic drug interactions with medicinal products and diet supplements containing plant extracts. Psychiatr Pol 2018;52(6):983-96. PubMed

See these in context on the Rhodiola monograph →

Maca 1 reference
  1. Valerio, L. G., Jr. and Gonzales, G. F. Toxicological aspects of the South American herbs cat's claw (Uncaria tomentosa) and Maca (Lepidium meyenii) : a critical synopsis. Toxicol.Rev 2005;24(1):11-35. PubMed

See these in context on the Maca monograph →

Damiana 2 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Alarcon-Aquilar FJ, Roman-Ramos R, Perez-Gutierrez S, et al. Study of the anti-hyperglycemic effect of plants used as antidiabetics. J Ethnopharmacol 1998;61:101-10. PubMed

See these in context on the Damiana monograph →

Muira Puama 2 references
  1. Waynberg, J. and Brewer, S. Effects of Herbal vX on libido and sexual activity in premenopausal and postmenopausal women. Adv Ther 2000;17(5):255-262. PubMed
  2. Nguyen S, Rajfer J, Shaheen M. Safety and efficacy of daily Revactin in men with erectile dysfunction: a 3-month pilot study. Transl Androl Urol. 2018;7(2):266-73. PubMed

See these in context on the Muira Puama monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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