Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Agaricus Ingredients & Drug Interactions

by Amazon Therapeutics

Agaricus label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Agaricus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Agaricus is a dietary supplement by Amazon Therapeutics with 3 active ingredients. Its ingredients are commonly taken for immune support, general wellness and antioxidant, adjunct interest during cancer care.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Agaricus Sun Supreme Top. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Agaricus by Amazon Therapeutics

Ask about any prescription or over-the-counter medication and we check it for interactions with Agaricus by Amazon Therapeutics — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Agaricus by Amazon Therapeutics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.

This product contains 3 ingredients total. The active ingredient is agaricus mushroom (Agaricus Sun Supreme Top), which is a medicinal fungus used in traditional medicine.

The other two ingredients — distilled water and organic alcohol — are inactive, used to extract and preserve the mushroom material in liquid form.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Agaricus Mushroom product and its label doesn't state a use — see Agaricus Mushroom's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for agaricus mushroom is limited. Our data shows insufficient reliable evidence to rate it for allergic rhinitis (hay fever), osteoporosis, cancer, cardiovascular disease, chemotherapy side effects, and Crohn disease.

This means trials either haven't been done, are too small, or results are unclear — not that it doesn't work, but that we can't say it does based on the science we have.

The evidence, ingredient by ingredient Agaricus Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Agaricus mushroom is generally well tolerated when taken by mouth. The most common side effects are abdominal discomfort, diarrhea, and nausea — mild and fairly typical for mushroom supplements.

Rare serious effects have been reported, including allergic reactions, liver damage, and a lung condition called interstitial lung disease (ILD). Three cases of severe liver damage occurred in women with ovarian or breast cancer who were also undergoing chemotherapy; two were fatal.

For pregnancy, there isn't enough safety data, so it's best to avoid supplement doses. Same goes for breastfeeding — the data isn't there to say it's safe.

Side effects, ingredient by ingredient Agaricus Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Agaricus Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check this product before starting if you take antidiabetes drugs — agaricus mushroom can increase the risk of low blood sugar. We weren't able to check the alcohol and water components, so mention those to your pharmacist too.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Agaricus mushroom may interest people looking for traditional immune or antioxidant support, but the evidence for specific health claims is thin. If you take diabetes medications, talk with your pharmacist before adding this — the risk of low blood sugar is real.

Anyone with liver disease, a history of hepatitis B, or plans to become pregnant should check with their doctor first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Agaricus, straight from the product label.

Brand Amazon Therapeutics
Barcode (UPC) 838451001112
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Apr 23, 2020
DSLD ID 217623
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Agaricus by Amazon Therapeutics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
10 Drop(s)
Maximum serving Sizes:
15 Drop(s)
UPC/BARCODE
838451001112
IngredientAmount% DV
distilled Water0 NP--
35-40% organic Alcohol0 NP--
Agaricus Sun Supreme Top0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Your Selection You hold in your hands the finest traditional botanical available. This botanical is a long-standing favorite in South America where it has been empirically selected for its effectiveness over many generations.

Wild crafted sustainable harvest

Gluten free

Suggested/Recommended/Usage/Directions

Suggested Directions Use 10-15 drops once or twice a day in water or as recommended by a health care practitioner.

Precautions

Cautions: Information provided on this label should not be used as medical advice. Not intended for long-term use.

Not intended for pregnant or nursing women.

Keep out of the reach of children.

Formula

Agaricus brasilianesis Sun Supreme

EarthKosher

FDA Statement of Identity

Dietary Supplement

General Statements

Direct from the source

Traditional ethnobotanical information Amazon Therapeutics works for the preservation of rainforests and to uphold the intellectual property rights of native healers and their traditional medicines.

Seals/Symbols

EarthKosher

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Agaricus by Amazon Therapeutics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Agaricus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Agaricus by Amazon Therapeutics

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size10 Drop(s) Dosage formLiquid Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Distilled Water

0 NP per serving

35-40% organic Alcohol

0 NP per serving

Agaricus Sun Supreme Top

Interacts with
86 drugs
0 NP per serving

Agaricus mushroom (often Agaricus blazei/subrufescens) is a culinary and medicinal mushroom studied mostly for possible immune and antioxidant effects...

Agaricus Sun Supreme Top monograph & interactions
Interaction report

Agaricus by Amazon Therapeutics Drug Interactions

Want to check YOUR meds against Agaricus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Agaricus Sun Supreme Top 86

Individual Drug Interactions

The ingredients in Agaricus interact with 86 drugs. Click any drug to see the details.

1 of the 3 ingredients in Agaricus interact with drugs. Each result below shows which ingredient is responsible. Agaricus Sun Supreme Top

Each ingredient & the kinds of drugs it affects

For each ingredient in Agaricus with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Agaricus Sun Supreme Top1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
In one clinical study in patients with type 2 diabetes who are stabilized on conventional oral hypoglycemic agents, 3 of 29 patients taking an agaricus mushroom extract 500 mg three times daily for 12 weeks reported hypoglycemia, compared to one of 29 patients in the placebo group.

Likelihood Possible Evidence D
Agaricus Sun Supreme Top full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Agaricus, from the product label.

Amazon Therapeutics

See all Amazon Therapeutics products
Name
Herbs America
Street Address
PO Box 446
City
Murphy
State
OR
ZipCode
97533
Phone Number
541-846-6222
Web Address
www.amazonmedicine.com
Pharmacist Counseling Corner

Agaricus by Amazon Therapeutics: Common Questions

Does Agaricus by Amazon Therapeutics interact with any medications?
Yes. Based on its ingredients, Agaricus has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Agaricus contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What are the most common side effects of agaricus mushroom?
The mild ones you might see are abdominal discomfort, diarrhea, and nausea. Serious side effects are rare, but allergic reactions, liver damage, and a lung condition called interstitial lung disease have been reported. If you develop a rash, yellowing of the skin, or shortness of breath, stop and contact your doctor.
Is this safe to take while pregnant?
There isn't enough safety data for agaricus mushroom in pregnancy, so it's best to avoid supplement doses. Talk with your doctor or pharmacist if you're pregnant or planning to become pregnant.
Is this safe while breastfeeding?
Not enough safety data exists for breastfeeding either, so avoid supplement doses if you're nursing. Your pharmacist or doctor can discuss other options with you.
Does agaricus mushroom actually work for cancer or other diseases listed here?
The evidence is too limited to say. For the conditions listed — cancer, heart disease, hay fever, osteoporosis, and others — we have insufficient reliable evidence to rate whether it works. That doesn't mean it's useless, but claims aren't backed by solid science yet.
What's the alcohol content of this liquid?
The product contains 35–40% organic alcohol, which is used to extract and preserve the mushroom. If you need to avoid alcohol, this may not be the right choice for you — ask your pharmacist about alcohol-free alternatives.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Agaricus is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Agaricus label
Go deeper

The Full Monographs Behind Agaricus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Agaricus Mushroom

Interacts with 86 drugs

Agaricus mushroom (often Agaricus blazei/subrufescens) is a culinary and medicinal mushroom studied mostly for possible immune and antioxidant effects. The human evidence is limited and not...

Read the full Agaricus Mushroom monograph →
Sources

Sources & How We Checked

Agaricus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Agaricus Mushroom 5 references
  1. Hsu CH, Liao YL, Lin SC, et al. The mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial. J Altern Complement Med 2
  2. Mukai H, Watanabe T, Ando M, Katsumata N. An alternative medicine, Agaricus blazei, may have induced severe hepatic dysfunction in cancer patients. Jpn J Clin Oncol 2006;36:808-10. PubMed
  3. Ohno S, Sumiyoshi Y, Hashine K, et al. Phase I clinical study of the dietary supplement, Agaricus blazei Murill, in cancer patients in remission. Evid Based Complement Alternat Med 2011, doi 10.1155/2011/192381.
  4. Suehiro M, Katoh N, Kishimoto S. Chelitis due to Agaricus blazei Murill mushroom extract. Contact Dermatitis 2007;56(5):293-4.
  5. Iwai N, Okuda T, Sawada R, et al. Interstitial lung disease associated with Agaricus blazei Murill in a patient with pancreatic ductal adenocarcinoma receiving gemcitabine-based therapy. Case Rep Gastroenterol 2022;16(1):229-234.

See these in context on the Agaricus Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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