Interactions on record — worth a quick check against your medications. Based on 3 of 7 ingredients. Check your meds →
Dietary supplement

PUMP Fun Sweets Cotton Candy Cherry Berry Ingredients & Drug Interactions

by Core Nutritionals

PUMP Fun Sweets Cotton Candy Cherry Berry label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking PUMP Fun Sweets Cotton Candy Cherry Berry against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

PUMP Fun Sweets Cotton Candy Cherry Berry is a dietary supplement by Core Nutritionals with 7 active ingredients. Its ingredients are commonly taken for athletic performance and endurance, high-intensity exercise capacity, reducing muscle fatigue.Based on those ingredients, 194 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Citrulline, Alpha-GPC. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against PUMP Fun Sweets Cotton Candy Cherry Berry by Core Nutritionals

Ask about any prescription or over-the-counter medication and we check it for interactions with PUMP Fun Sweets Cotton Candy Cherry Berry by Core Nutritionals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of PUMP Fun Sweets Cotton Candy Cherry Berry by Core Nutritionals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 7 of its 7 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This powder contains 7 active ingredients designed to support blood flow and athletic performance. Beta-Alanine and L-Citrulline are amino acids that may help with exercise performance.

Alpha-GPC is a compound that supports brain function. The product also includes Betaine Nitrate, VasoDrive-AP, Hydromax, and AstraGin—proprietary or branded ingredients intended to enhance delivery and nutrient absorption.

The inactive ingredients are flavoring, sweeteners (Sucralose and Acesulfame Potassium), Malic Acid, Silicon Dioxide, and Red Boot Powder.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: athletic and exercise performance support.
  • We looked for evidence on: Athletic performance, Physical performance, Exercise-induced muscle breakdown, Muscle strength, Endurance, Muscle fatigue — and 1 related terms.
  • The strongest evidence on file: Beta-alanine is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Beta-alanine is rated "Possibly Effective" for Physical performance.
  • Also on file: L-citrulline is rated "Possibly Effective" for Athletic performance.

Beta-Alanine is rated Possibly Effective for athletic performance and physical performance. L-Citrulline is also rated Possibly Effective for athletic performance.

Alpha-GPC is rated Possibly Effective for Alzheimer disease. For other claims—cognitive function, heart health, or blood sugar control—the evidence we hold is either insufficient to rate or the ingredient isn't studied for that purpose.

We have no effectiveness data on file for Betaine Nitrate, VasoDrive-AP, Hydromax, or AstraGin.

The evidence, ingredient by ingredient Beta-alanine L-citrulline Alpha-gpc

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Beta-Alanine and L-Citrulline are generally well tolerated in healthy adults. Beta-Alanine commonly causes a harmless tingling sensation (paresthesia) and skin flushing, usually on the scalp within 20 minutes, spreading across the body for about an hour—mild at lower doses, more noticeable at higher ones.

L-Citrulline may cause gastrointestinal discomfort or heartburn in some users. Alpha-GPC is also generally well tolerated, though rarely it's been associated with dizziness, headache, and insomnia.

Orally, alpha-GPC used for 2 months or longer has rarely been linked to an elevated stroke risk compared with non-users. For pregnancy and breastfeeding: the safety data advises against Beta-Alanine, L-Citrulline, and Alpha-GPC during pregnancy and lactation because there isn't enough information.

Talk with your doctor or pharmacist before using this product if you're pregnant, nursing, or planning either.

Side effects, ingredient by ingredient Beta-alanine L-citrulline Alpha-gpc

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Alpha-gpc, L-citrulline.
  • The most serious interaction on file is rated Moderate.
  • For scale: 194 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications against these types before you start: blood pressure drugs (Moderate), ED medications like sildenafil and tadalafil (Moderate), and motion-sickness patches containing scopolamine (Minor). We could not check Betaine Nitrate, VasoDrive-AP, Hydromax, or AstraGin for interactions.

Use the search tool below to verify your exact prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you take blood pressure medication or ED drugs, talk to your pharmacist before starting this product—L-Citrulline can interact with both. It's aimed at people seeking athletic performance support, but the evidence for most ingredients is limited.

Long-term safety isn't fully established for several components, so this isn't a long-term daily supplement without checking first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about PUMP Fun Sweets Cotton Candy Cherry Berry, straight from the product label.

Brand Core Nutritionals
Barcode (UPC) 850051031191
Net contents 15.8 Ounce(s); 448 Gram(s)
Market status On market
Date entered into DSLD Feb 23, 2025
DSLD ID 320920
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for PUMP Fun Sweets Cotton Candy Cherry Berry by Core Nutritionals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
11.2 Gram(s)
Maximum serving Sizes:
22.4 Gram(s)
Servings per container
20
UPC/BARCODE
850051031191
IngredientAmount% DV
Beta-Alanine3200 mg, 1600 mg--
L-Citrulline6000 mg, 3000 mg--
Betaine Nitrate2500 mg, 1250 mg--
Alpha-GPC600 mg, 300 mg--
VasoDrive-AP254 mg, 127 mg--
Hydromax2000 mg, 1000 mg--
AstraGin50 mg, 25 mg--

Other ingredients: Natural and Artificial flavors, Silicon Dioxide, Malic Acid, Sucralose, Red Boot, Powder, Acesulfame Potassium

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Servings Per Container 20 (40 scoops)

Formula

Love cotton candy? Want a taste of nostalgia? Try our Core PUMP with the authentic flavor systems of Fun Sweets! With Core PUMP, we've redefined the non-stimulant, pre-work-out category with more than just a "pump" product, but a true performance pump. Core PUMP contains cutting edge and trademarked ingredients to maximize all performance aspects of your workout, without stimulants or jitters, and, now, with the delicious experience of real cotton candy in each and every sip.

Cherry Berry naturally and artificially flavored Dietary Supplement

Precautions

Warning: Consuming this product can expose you to chemicals including lead, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Warning: This product is only intended for use in healthy adults 18 years of age or older.

Pregnant or nursing women should not use this product. Consult your healthcare provider before using this product, especially if you are taking any prescription, over the counter medication, dietary supplement product, or if you have any pre-existing medical condition including but not limited to: high or low blood pressure, cardiac arrhythmia, stroke, heart, liver, kidney or thyroid disease, seizure disorder, psychiatric disease, diabetes, difficulty urinating due to a prostate enlargement or if you are taking a MAOI (Monoamine Oxidase Inhibitor), PDE5 inhibitor, nitrates for chest pain, or any other medication.

Immediately discontinue use and consult your health care professional if you experience adverse reaction to this product. Do not exceed recommended serving. Do not use if safety seal is broken or missing.

Keep out of reach of children.

Allergen information: Contains milk.

Suggested/Recommended/Usage/Directions

Directions: Mix 2 scoops with 12-16 ounces of water and consume approximately 15-30 minutes prior to your workout.

Brand IP Statement(s)

Core Nutritionals Crush it!

NO3T Nitrate Technology NO3-T.com/Patents NO3-T is a registered trademark of ThermoLife International LLC, this mark covers the use of one or more patents listed at www.NO3-T.com/patents HydroMax HydroMax is a registered trademark of Glanbia plc. VasoDrive-AP VasoDrive-AP is the registered trademark of Nova Nutra LLC AstraGin AstraGin is a registered trademark of NuLiv Science USA Inc. Fun Sweets is a trademark of Fun Sweets LLC and is being used under license Copyright Fun Sweets LLC. 2023

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Smiles guaranteed It has been scientifically proven that it is impossible for someone to eat Fun Sweets cotton candy without cracking a smile. In fact we're so confident of this fact, that we guarantee it. Disclaimer The Fun Sweets smile guarantee applies to typically pleasant individuals. If you are a major grouch that doesn't smile at a puppy or a rainbow that even we can't help you.

Full-Spectrum Non-Stimulant Pre-Workout

Manufactured in a U.S. cGMP Facility

FDA Statement of Identity

Cherry Berry naturally and artificially flavored Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

PUMP Fun Sweets Cotton Candy Cherry Berry by Core Nutritionals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

PUMP Fun Sweets Cotton Candy Cherry Berry label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in PUMP Fun Sweets Cotton Candy Cherry Berry by Core Nutritionals

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size11.2 Gram(s) Dosage formPowder Servings per container20 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Beta-Alanine

No known
interactions
3200 mg per serving

Beta-alanine is an amino acid taken mostly by athletes to raise muscle carnosine, which may help buffer acid and reduce fatigue during short, high-int...

Beta-Alanine monograph & interactions

L-Citrulline

Interacts with
178 drugs
6000 mg per serving

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. I...

L-Citrulline monograph & interactions

Betaine Nitrate

2500 mg per serving

Alpha-GPC

Interacts with
16 drugs
600 mg per serving

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition...

Alpha-GPC monograph & interactions

VasoDrive-AP

254 mg per serving

Hydromax

2000 mg per serving Form: Glycerol, Powder

AstraGin

50 mg per serving Form: Astragalus membranaceous Root Extract, Panax notoginseng

Other (inactive) ingredients: Natural and Artificial flavors, Silicon Dioxide, Malic Acid, Sucralose, Red Boot, Powder, Acesulfame Potassium. These complete the product’s ingredient list but are not active constituents.

Interaction report

PUMP Fun Sweets Cotton Candy Cherry Berry by Core Nutritionals Drug Interactions

Want to check YOUR meds against PUMP Fun Sweets Cotton Candy Cherry Berry?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
194Drugs
178 Moderate 16 Minor

Ingredients driving the most interactions

L-Citrulline 178
Alpha-GPC 16

Individual Drug Interactions

The ingredients in PUMP Fun Sweets Cotton Candy Cherry Berry interact with 194 drugs. Click any drug to see the details.

2 of the 7 ingredients in PUMP Fun Sweets Cotton Candy Cherry Berry interact with drugs. Each result below shows which ingredient is responsible. L-Citrulline Alpha-GPC

Each ingredient & the kinds of drugs it affects

For each ingredient in PUMP Fun Sweets Cotton Candy Cherry Berry with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Citrulline2 drug types · 178 drugs

Antihypertensive Drugs

Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.

Likelihood Possible Evidence B
Phosphodiesterase-5 Inhibitors

Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
L-Citrulline full monograph & interactions

Alpha-GPC1 drug type · 16 drugs

Scopolamine (Transderm Scop)

Theoretically, alpha-GPC might decrease the effects of scopolamine.
A small clinical study shows that alpha-GPC can partially counteract the attention and memory impairment effects caused by scopolamine given intramuscularly. Whether alpha-GPC can decrease the beneficial anti-motion sickness effects of the scopolamine patch (Transderm Scop) is unclear.

Likelihood Possible Evidence B
Alpha-GPC full monograph & interactions
The maker

Brand information

Manufacturer and brand details for PUMP Fun Sweets Cotton Candy Cherry Berry, from the product label.

Core Nutritionals

See all Core Nutritionals products
Name
Core Nutritionals, LLC
City
Statesville
State
NC
ZipCode
28625
Phone Number
(888) 978-2332
Web Address
corenutritionals.com
Pharmacist Counseling Corner

PUMP Fun Sweets Cotton Candy Cherry Berry by Core Nutritionals: Common Questions

Does PUMP Fun Sweets Cotton Candy Cherry Berry by Core Nutritionals interact with any medications?
Yes. Based on its ingredients, PUMP Fun Sweets Cotton Candy Cherry Berry has a known interaction with 194 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
PUMP Fun Sweets Cotton Candy Cherry Berry contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's the tingling feeling I've heard about with this product?
That's Beta-Alanine causing paresthesia—a harmless pins-and-needles sensation, usually starting on your scalp within 20 minutes and spreading to your body for about an hour. It's milder at lower doses and more noticeable at higher ones. It goes away on its own and isn't dangerous.
Can I take this if I'm on blood pressure medication?
Not without checking with your pharmacist first. L-Citrulline in this powder can lower blood pressure, so combined with your medication, you could drop too low. Talk to your pharmacist or doctor before starting.
Is this safe to use while pregnant or breastfeeding?
No, not based on the safety data we have. There isn't enough information about the key ingredients during pregnancy and breastfeeding, so the data advises against use. Talk with your doctor or pharmacist for personalized advice if you're pregnant, nursing, or planning either.
Does this really improve athletic performance?
Beta-Alanine and L-Citrulline are rated Possibly Effective for athletic performance and physical performance—meaning the evidence suggests they may help, but it's not definitive. The other ingredients don't have established effectiveness data in our system.
What are VasoDrive-AP, Hydromax, and AstraGin?
Those are branded or proprietary ingredients meant to enhance blood flow and nutrient absorption, but we don't hold interaction or effectiveness data on them in our system. If you have specific questions, ask your pharmacist or check the brand's website.
Can I take this with my ED medication?
No—there's a Moderate interaction risk. L-Citrulline works similarly to ED drugs like sildenafil (Viagra) and tadalafil (Cialis) by dilating blood vessels. Together, they could lower your blood pressure dangerously. Talk to your pharmacist or doctor before using.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if PUMP Fun Sweets Cotton Candy Cherry Berry is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

PUMP Fun Sweets Cotton Candy Cherry Berry label
Go deeper

The Full Monographs Behind PUMP Fun Sweets Cotton Candy Cherry Berry’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Beta-alanine

Beta-alanine is an amino acid taken mostly by athletes to raise muscle carnosine, which may help buffer acid and reduce fatigue during short, high-intensity exercise. The evidence is moderat...

Read the full Beta-alanine monograph → Herb & supplement monograph

L-citrulline

Interacts with 178 drugs

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. It is popular for exercise performance an...

Read the full L-citrulline monograph → Herb & supplement monograph

Alpha-gpc

Interacts with 16 drugs

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition in people with dementia, but evidence i...

Read the full Alpha-gpc monograph →
Sources

Sources & How We Checked

PUMP Fun Sweets Cotton Candy Cherry Berry's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 25 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Beta-alanine 13 references
  1. Harris RC, Tallon MJ, Dunnett M, et al. The absorption of orally supplied beta-alanine and its effect on muscle carnosine synthesis in human vastus lateralis. Amino Acids 2006;30:279-89.
  2. Hill CA, Harris RC, Kim HJ, et al. Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity. Amino Acids 2007;32:225-33.
  3. Bellinger PM, Minahan CL. The effect of ß-alanine supplementation on cycling time trials of different length. Eur J Sport Sci 2016;16(7):829-36.
  4. Chung W, Shaw G, Anderson ME, et al. Effect of 10 week beta-alanine supplementation on competition and training performance in elite swimmers. Nutrients 2012;4(10):1441-53. PubMed
  5. Glenn JM, Gray M, Stewart R, et al. Incremental effects of 28 days of beta-alanine supplementation on high-intensity cycling performance and blood lactate in masters female cyclists. Amino Acids 2015;47(12):2593-600. PubMed
  6. Gross M, Bieri K, Hoppeler H, Norman B, Vogt M. Beta-alanine supplementation improves jumping power and affects severe-intensity performance in professional alpine skiers. Int J Sport Nutr Exerc Metab 2014;24(6):665-73. PubMed
  7. Howe ST, Bellinger PM, Driller MW, Shing CM, Fell JW. The effect of beta-alanine supplementation on isokinetic force and cycling performance in highly trained cyclists. Int J Sport Nutr Exerc Metab 2013;23(6):562-70. PubMed
  8. Sweeney KM, Wright GA, Glenn Brice A, Doberstein ST. The effect of beta-alanine supplementation on power performance during repeated sprint activity. J Strength Cond Res 2010;24(1):79-87.
  9. Décombaz J, Beaumont M, Vuichoud J, Bouisset F, Stellingwerff T. Effect of slow-release ß-alanine tablets on absorption kinetics and paresthesia. Amino Acids 2012;43(1):67-76. Erratum in: Amino Acids 2013;45(4):1015.
  10. Stellingwerff T, Anwander H, Egger A, et al. Effect of two ß-alanine dosing protocols on muscle carnosine synthesis and washout. Amino Acids 2012;42(6):2461-72. PubMed
  11. da Silva RP, de Oliveira LF, Saunders B, et al. Effects of ß-alanine and sodium bicarbonate supplementation on the estimated energy system contribution during high-intensity intermittent exercise. Amino Acids. 2019;51(1):83-96. PubMed
  12. Varanoske AN, Hoffman JR, Church DD, et al. Comparison of sustained-release and rapid-release ß-alanine formulations on changes in skeletal muscle carnosine and histidine content and isometric performance following a muscle-damaging protocol. Amino Acids. PubMed
  13. Perim P, Gobbi N, Duarte B, et al. Beta-alanine did not improve high-intensity performance throughout simulated road cycling. Eur J Sport Sci 2021. PubMed

See these in context on the Beta-alanine monograph →

L-citrulline 8 references
  1. Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
  2. Schwedhelm E, Maas R, Freese R, et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. Br J Clin Pharmacol 2008;65:51-9. PubMed
  3. Romero MJ, Platt DH, Caldwell RB, Caldwell RW. Therapeutic use of citrulline in cardiovascular disease. Cardiovasc Drug Rev 2006;24:275-90. PubMed
  4. Balderas-Munoz K, Castillo-Martínez L, Orea-Tejeda A, et al. Improvement of ventricular function in systolic heart failure patients with oral L-citrulline supplementation. Cardiol J 2012;19:612-7. PubMed
  5. Sharif Kashani B, Tahmaseb Pour P, Malekmohammad M, et al. Oral l-citrulline malate in patients with idiopathic pulmonary arterial hypertension and Eisenmenger Syndrome: a clinical trial. J Cardiol 2014;64:231-5. PubMed
  6. Pérez-Guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res 2010;24:1215-22. PubMed
  7. Mirenayat MS, Moradi S, Mohammadi H, Rouhani MH. Effect of L-citrulline supplementation on blood pressure: a systematic review and meta-analysis of clinical trials. Curr Hypertens Rep. 2018;20(11):98. PubMed
  8. Xu Z, Liu C, Liu S, Zhou Z. Comparison of efficacy and safety of daily oral L-arginine and PDE5Is alone or combination in treating erectile dysfunction: A systematic review and meta-analysis of randomised controlled trials. Andrologia. 2021:e14007. PubMed

See these in context on the L-citrulline monograph →

Alpha-gpc 4 references
  1. Di Perri R, Coppola G, Ambrosio LA, et al. A multicentre trial to the evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia. J Int Med Res 1991;19:330-41.
  2. Barbagallo Sangiorgi G, Barbagallo M, Giordano M, et al. Alpha-glycerophosphocholine in the mental recovery of cerebral ischemic attacks: An Italian multicenter clinical trial. Ann N Y Acad Sci 1994;717:253-69. PubMed
  3. Canal N, Franceschi M, Alberoni M, et al. Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine. Int J Clin Pharmacol Ther Toxicol 1991;29:103-7.
  4. Lee G, Choi S, Chang J, et al. Association of L-a glycerylphosphorylcholine with subsequent stroke risk after 10 Years. JAMA Netw Open 2021;4(11):e2136008.

See these in context on the Alpha-gpc monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team