Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

PumpPills Ingredients & Drug Interactions

by Do Vitamins

PumpPills label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking PumpPills against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

PumpPills is a dietary supplement by Do Vitamins with 4 active ingredients. Its ingredients are commonly taken for high blood pressure, erectile dysfunction, athletic performance.Based on those ingredients, 407 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Arginine, L-Citrulline, L-Malic Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against PumpPills by Do Vitamins

Ask about any prescription or over-the-counter medication and we check it for interactions with PumpPills by Do Vitamins — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of PumpPills by Do Vitamins

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

PumpPills contains 4 active ingredients: L-arginine and L-citrulline, both amino acids that your body uses to make nitric oxide (a molecule that relaxes blood vessels); CarnoSyn (beta-alanine), an amino acid that builds up in muscle tissue; and L-malic acid, an organic acid found naturally in fruits. The capsule itself is made from vegetarian material, and the product includes inactive rice extract and rice concentrate as excipients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: increase nitric oxide production and muscular endurance.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle breakdown, Muscle strength, Physical performance, muscle fatigue, blood flow — and 1 related terms.
  • The strongest evidence on file: Beta-alanine is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Beta-alanine is rated "Possibly Effective" for Physical performance.
  • Also on file: L-citrulline is rated "Possibly Effective" for Athletic performance.

L-arginine and L-citrulline show possibly effective evidence for athletic performance. Beta-alanine (CarnoSyn) is also possibly effective for athletic and physical performance.

The data we hold does not establish effectiveness for L-arginine or L-citrulline for heart or metabolic conditions, and evidence is insufficient for beta-alanine in cognitive function, COPD, or menopausal symptoms. L-malic acid is possibly effective for dry mouth but evidence is insufficient for other uses listed in our data.

The evidence, ingredient by ingredient L-arginine L-citrulline Beta-alanine Malic Acid

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-arginine and beta-alanine are generally well tolerated, though both can cause side effects. L-arginine may cause abdominal pain, bloating, nausea, diarrhea, headache, insomnia, and flushing when taken by mouth.

Beta-alanine commonly causes harmless skin tingling (paresthesia) and flushing, usually starting on the scalp within 20 minutes and lasting about an hour — intensity depends on dose. L-citrulline is generally well tolerated but may cause heartburn or gastrointestinal discomfort.

L-malic acid is generally well tolerated in food amounts; supplement safety is not well studied. Regarding pregnancy and breastfeeding: L-citrulline and beta-alanine should be avoided during pregnancy and lactation because there is not enough safety data.

L-arginine is rated possibly safe in pregnancy but lactation data is not on file. L-malic acid is rated likely safe in pregnancy and lactation.

If you are pregnant or nursing, talk with your doctor or pharmacist about whether this product is right for you.

Side effects, ingredient by ingredient L-arginine L-citrulline Beta-alanine Malic Acid

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 4 matched ingredients can interact with medications — L-arginine, L-citrulline, Malic Acid.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 407 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking PumpPills, check with your doctor or pharmacist if you take blood pressure medications (including ACE inhibitors and ARBs), blood thinners or antiplatelet drugs, diabetes medications, potassium-sparing water pills, or sildenafil (Viagra) — all carry moderate-severity interaction risks with L-arginine, L-citrulline, or both.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

PumpPills may appeal to athletes looking to boost performance, but it's not a casual supplement — three of its four ingredients can lower blood pressure and interact with common heart and blood pressure medications. If you take any medications for blood pressure, heart condition, diabetes, or blood thinning, or if you take potassium-sparing diuretics or sildenafil, check with your doctor or pharmacist before starting.

Pregnant or nursing people should discuss it with their healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about PumpPills, straight from the product label.

Brand Do Vitamins
Barcode (UPC) 859572003083
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 269526
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for PumpPills by Do Vitamins, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Capsule(s)
Maximum serving Sizes:
4 Capsule(s)
Servings per container
30
UPC/BARCODE
859572003083
IngredientAmount% DV
L-Arginine1000 mg--
L-Citrulline1000 mg--
CarnoSyn800 mg--
L-Malic Acid300 mg--

Other ingredients: Vcaps Plus vegetarian capsule, organic Rice extract, organic Rice concentrate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Premium, pure, third-party tested ingredients you can trust.

KQ Kyowa Quality

Pure pre-workout booster

Contains no: wheat, gluten, soy, dairy, preservatives, artificial sweeteners, colors, or flavors.

Suitable for vegans and vegetarians.

Precautions

No sugar No fillers No gluten No GMO No banned substances No artificial colors, flavors or sweeteners.

Warning: If you have any medical condition, are pregnant or nursing, are under the age of 18, or take any medications, over-the-counter products, or other dietary supplements, please consult your healthcare practitioner before using this product. Keep out of reach of children.

If you have any medical condition, are pregnant or nursing, are under the age of 18, or take any medications, over-the-counter products, or other dietary supplements, please consult your healthcare practitioner before using this product.

Immediately discontinue use if you experience any adverse reaction. Do not eat freshness packet; keep in bottle.

Suggested/Recommended/Usage/Directions

How to use Take up to four (4) capsules 30 minutes before training. PumpPills is two supplements in one: Take PumpPill alone or stack with PurePump for the ultimate pre-workout boost.

Suggested use: As a dietary supplement, Take up to four (4) capsules 30 minutes before training.

Formula

What to expect Nutrition you need for a clean pre-workout boost without stimulants. Increase nitric oxide production and support muscular endurance for optimal performance and enhanced workouts.

Seals/Symbols

labdoor tested for purity labdoor tested for sport PF Certified Paleo Friendly V Certified Vegan vegan.org This product is Keto Certified Ketocertified.com

GMP Quality Good Manufacturing Practice Certification Manufactured in a cGMP facility

General Statements

Vitamin Angels

dovitamins.com @dovitamins.com

Brand IP Statement(s)

Natural Alternatives International (NAI) is the owner of patents as listed on www.carnosyn.com and registered trademark CarnoSyn.

Copyright 2020 Do Vitamins. All rights reserved.

Do Vitamins Purity and Performance; No Pollutants.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

PumpPills by Do Vitamins label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

PumpPills label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in PumpPills by Do Vitamins

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size4 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Arginine

Interacts with
403 drugs
1000 mg per serving

L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for bl...

L-Arginine monograph & interactions

L-Citrulline

Interacts with
178 drugs
1000 mg per serving

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. I...

L-Citrulline monograph & interactions

CarnoSyn

No known
interactions
800 mg per serving Form: Beta-Alanine

Beta-alanine is an amino acid taken mostly by athletes to raise muscle carnosine, which may help buffer acid and reduce fatigue during short, high-int...

CarnoSyn monograph & interactions

L-Malic Acid

Interacts with
172 drugs
300 mg per serving

Malic acid is a natural acid found in apples and other fruits, often combined with magnesium in supplements marketed for fibromyalgia and muscle pain....

L-Malic Acid monograph & interactions

Other (inactive) ingredients: Vcaps Plus vegetarian capsule, Organic Rice extract, Organic Rice concentrate. These complete the product’s ingredient list but are not active constituents.

Interaction report

PumpPills by Do Vitamins Drug Interactions

Want to check YOUR meds against PumpPills?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
407Drugs
399 Moderate 8 Minor

Ingredients driving the most interactions

L-Arginine 403
L-Citrulline 178
L-Malic Acid 172

Individual Drug Interactions

The ingredients in PumpPills interact with 407 drugs. Click any drug to see the details.

3 of the 4 ingredients in PumpPills interact with drugs. Each result below shows which ingredient is responsible. L-Arginine L-Citrulline L-Malic Acid

Each ingredient & the kinds of drugs it affects

For each ingredient in PumpPills with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Arginine9 drug types · 403 drugs

Ace Inhibitors (Aceis)

Theoretically, concomitant use of L-arginine and ACE inhibitors may increase the risk for hypotension and hyperkalemia.
Combining L-arginine with some antihypertensive drugs, especially ACE inhibitors, seems to have additive vasodilating and blood pressure-lowering effects. Furthermore, ACE inhibitors can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ACE inhibitors with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Angiotensin Receptor Blockers (Arbs)

Theoretically, concomitant use of L-arginine and ARBs may increase the risk of hypotension and hyperkalemia.
L-arginine increases nitric oxide, which causes vasodilation. Combining L-arginine with ARBs seems to increase L-arginine-induced vasodilation. Furthermore, ARBs can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients. Theoretically, concomitant use of ARBs with L-arginine may increases the risk of hyperkalemia.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of L-arginine with anticoagulant and antiplatelet drugs might have additive effects and increase the risk of bleeding.
Preliminary research suggests that L-arginine infusions reduce platelet aggregation in humans. The clinical significance of this effect is unclear.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.
Preliminary clinical research shows that L-arginine decreases blood glucose levels in patients with type 2 diabetes.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concomitant use of L-arginine and antihypertensive drugs may increase the risk of hypotension.
L-arginine increases nitric oxide, which causes vasodilation. Clinical evidence shows that L-arginine can reduce blood pressure in some individuals with hypertension. Furthermore, combining L-arginine with some antihypertensive drugs seems to have additive vasodilating and blood pressure-lowering effects.

Likelihood Probable Evidence D
Isoproterenol (Isuprel)

Theoretically, concurrent use of isoproterenol and L-arginine might result in additive effects and hypotension.
Preliminary clinical evidence suggests that L-arginine enhances isoproterenol-induced vasodilation in patients with essential hypertension or a family history of essential hypertension.

Likelihood Probable Evidence D
Potassium-Sparing Diuretics

Theoretically concomitant use of potassium-sparing diuretics with L-arginine may increases the risk of hyperkalemia.
Potassium-sparing diuretics can increase potassium levels. Use of L-arginine has been associated with hyperkalemia in some patients.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, concurrent use of sildenafil and L-arginine might increase the risk for hypotension.
In vivo, concurrent use of L-arginine and sildenafil has resulted in increased vasodilation. Theoretically, concurrent use might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
Testosterone

Theoretically, concomitant use of L-arginine and testosterone might have additive effects.
In clinical research, L-arginine increases the level of testosterone in male patients with erectile dysfunction. The clinical significance of this finding is unclear.

Likelihood Possible Evidence D
L-Arginine full monograph & interactions

L-Citrulline2 drug types · 178 drugs

Antihypertensive Drugs

Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.

Likelihood Possible Evidence B
Phosphodiesterase-5 Inhibitors

Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
L-Citrulline full monograph & interactions

L-Malic Acid1 drug type · 172 drugs

Antihypertensive Drugs

Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research shows that malic acid isolated from tagetes roots can reduce mean arterial blood pressure.

Likelihood Possible Evidence D
L-Malic Acid full monograph & interactions
The maker

Brand information

Manufacturer and brand details for PumpPills, from the product label.

Do Vitamins

See all Do Vitamins products
Name
Do Vitamins, LLC.
City
Newark
State
DE
ZipCode
19702
Phone Number
1-800-380-1283
Web Address
dovitamins.com
Pharmacist Counseling Corner

PumpPills by Do Vitamins: Common Questions

Does PumpPills by Do Vitamins interact with any medications?
Yes. Based on its ingredients, PumpPills has a known interaction with 407 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
PumpPills contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this make me tingle or flush?
Beta-alanine (CarnoSyn) commonly causes a harmless tingling sensation (paresthesia) and skin flushing, usually starting on your scalp within 20 minutes and lasting about an hour. How strong it is depends on the dose — higher doses cause more tingling. This effect is not dangerous, just noticeable.
Is it safe to take while pregnant or breastfeeding?
L-citrulline and beta-alanine should be avoided during pregnancy and breastfeeding because there isn't enough safety data. L-arginine is rated possibly safe in pregnancy but we don't have lactation data for it. L-malic acid is rated likely safe in both. Talk with your doctor or pharmacist about your individual situation.
What does each ingredient do?
L-arginine and L-citrulline are amino acids your body converts to nitric oxide, which relaxes blood vessels and improves blood flow. Beta-alanine builds up in muscle tissue and is used for athletic performance. L-malic acid is an organic acid that may help with dry mouth.
Does it actually work for athletic performance?
L-arginine, L-citrulline, and beta-alanine are all rated possibly effective for athletic performance in the data we hold. That means some evidence supports their use, but more research would help confirm the effect.
What side effects might I notice?
L-arginine may cause abdominal pain, bloating, nausea, diarrhea, headache, insomnia, or flushing. Beta-alanine commonly causes tingling and flushing. L-citrulline may cause heartburn or stomach discomfort. L-malic acid is generally well tolerated. Most are mild, but contact your doctor if anything bothers you.
Can I take this with my blood pressure medication?
Not without checking first. L-arginine, L-citrulline, and L-malic acid all lower blood pressure theoretically, and combining them with blood pressure medications — especially ACE inhibitors and ARBs — may drop your pressure too low or raise your potassium dangerously. Talk with your doctor or pharmacist before taking this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

PumpPills label
Go deeper

The Full Monographs Behind PumpPills’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

L-arginine

Interacts with 403 drugs

L-arginine is an amino acid that the body uses to make nitric oxide, a substance that helps blood vessels relax and widen. It is popularly used for blood pressure, erectile dysfunction, and...

Read the full L-arginine monograph → Herb & supplement monograph

L-citrulline

Interacts with 178 drugs

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. It is popular for exercise performance an...

Read the full L-citrulline monograph → Herb & supplement monograph

Beta-alanine

Beta-alanine is an amino acid taken mostly by athletes to raise muscle carnosine, which may help buffer acid and reduce fatigue during short, high-intensity exercise. The evidence is moderat...

Read the full Beta-alanine monograph → Herb & supplement monograph

Malic Acid

Interacts with 172 drugs

Malic acid is a natural acid found in apples and other fruits, often combined with magnesium in supplements marketed for fibromyalgia and muscle pain. The evidence for its health benefits is...

Read the full Malic Acid monograph →
Sources

Sources & How We Checked

PumpPills's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 94 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

L-arginine 66 references
  1. Sapienza MA, Kharitonov SA, Horvath I, et al. Effect of inhaled L-arginine on exhaled nitric oxide in normal and asthmatic subjects. Thorax 1998;53:172-5.
  2. Clarkson P, Adams MR, Powe AJ, et al. Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults. J Clin Invest 1996;97:1989-94. PubMed
  3. Tenenbaum A, Fisman EZ, Motro M. L-arginine: Rediscovery in progress. Cardiology 1998;90:153-9.
  4. Brittenden J, Park KGM, Heys SD, et al. L-Arginine stimulates host defenses in patients with breast cancer. Surgery 1994;115:205-12.
  5. Korting GE, Smith SD, Wheeler MA, et al. A randomized double-blind trial of oral L-arginine for treatment of interstitial cystitis. J Urol 1999;161:558-65. DOI
  6. Rector TS, Bank AJ, Mullen KA, et al. Randomized, double-blind, placebo-controlled study of supplemental oral L-arginine in patients with heart failure. Circulation 1996;93:2135-41.
  7. Siani A, Pagano E, Iacone R, et al. Blood pressure and metabolic changes during dietary L-arginine supplementation in humans. Am J Hypertens 2000;13:547-51. PubMed
  8. Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
  9. Wallace AW, Tom WL. Interaction of L-arginine and phosphodiesterase inhibitors in vasodilation of the porcine internal mammary artery. Anesth Analg 2000;90:840-6. DOI
  10. Huynh NT, Tayek JA. Oral arginine reduces systemic blood pressure in type 2 diabetes: its potential role in nitric oxide generation. J Am Coll Nutr 2002;21:422-7.. PubMed
  11. Staff AC, Berge L, Haugen G, et al. Dietary supplementation with L-arginine or placebo in women with pre-eclampsia. Acta Obstet Gynecol Scand 2004;83:103-7.
  12. Resnick DJ, Softness B, Murphy AR, et al. Case report of an anaphylactoid reaction to arginine. Ann Allergy Asthma Immunol 2002;88:67-8. PubMed
  13. Anon. Arginine hydrochloride injection (marketed as R-Gene 10). FDA Drug Safety Newsletter 2009;2(2):16-18. Available at: www.fda.gov/Drugs/DrugSafety/DrugSafetyNewsletter/default.htm.
  14. Higashi Y, Oshima T, Sasaki S, et. al. Angiotensin-converting enzyme inhibition, but not calcium antagonism, improves a response of the renal vasculature to L-arginine in patients with essential hypertension. Hypertension. 1998 Jul;32(1):16-24.
  15. Facchinetti, F., Longo, M., Piccinini, F., Neri, I., and Volpe, A. L-arginine infusion reduces blood pressure in preeclamptic women through nitric oxide release. J Soc Gynecol.Investig. 1999;6(4):202-207. DOI
  16. de Gouw, H. W., Verbruggen, M. B., Twiss, I. M., and Sterk, P. J. Effect of oral L-arginine on airway hyperresponsiveness to histamine in asthma. Thorax 1999;54(11):1033-1035. PubMed
  17. Komers, R., Komersova, K., Kazdova, L., Ruzickova, J., and Pelikanova, T. Effect of ACE inhibition and angiotensin AT1 receptor blockade on renal and blood pressure response to L-arginine in humans. J Hypertens. 2000;18(1):51-59. PubMed
  18. Cartledge, J. J., Davies, A. M., and Eardley, I. A randomized double-blind placebo-controlled crossover trial of the efficacy of L-arginine in the treatment of interstitial cystitis. BJU.Int. 2000;85(4):421-426.
  19. Sozykin, A. V., Noeva, E. A., Balakhonova, T. V., Pogorelova, O. A., and Men'shikov, M. I. [Effect of L-arginine on platelet aggregation, endothelial function adn exercise tolerance in patients with stable angina pectoris]. Ter.Arkh. 2000;72(8):24-27.
  20. Nagaya, N., Uematsu, M., Oya, H., Sato, N., Sakamaki, F., Kyotani, S., Ueno, K., Nakanishi, N., Yamagishi, M., and Miyatake, K. Short-term oral administration of L-arginine improves hemodynamics and exercise capacity in patients with precapillary pulmona
  21. Stokes, G. S., Barin, E. S., Gilfillan, K. L., and Kaesemeyer, W. H. Interactions of L-arginine, isosorbide mononitrate, and angiotensin II inhibitors on arterial pulse wave. Am J Hypertens. 2003;16(9 Pt 1):719-724.
  22. Park, K. G., Heys, S. D., Blessing, K., Kelly, P., McNurlan, M. A., Eremin, O., and Garlick, P. J. Stimulation of human breast cancers by dietary L-arginine. Clin.Sci.(Lond) 1992;82(4):413-417.
  23. Palloshi, A., Fragasso, G., Piatti, P., Monti, L. D., Setola, E., Valsecchi, G., Galluccio, E., Chierchia, S. L., and Margonato, A. Effect of oral L-arginine on blood pressure and symptoms and endothelial function in patients with systemic hypertension,
  24. Schlaich, M. P., Ahlers, B. A., Parnell, M. M., and Kaye, D. M. beta-Adrenoceptor-mediated, nitric-oxide-dependent vasodilatation is abnormal in early hypertension: restoration by L-arginine. J Hypertens. 2004;22(10):1917-1925. PubMed
  25. Neri, I., Blasi, I., and Facchinetti, F. Effects of acute L-arginine infusion on non-stress test in hypertensive pregnant women. J Matern.Fetal Neonatal Med. 2004;16(1):23-26. PubMed
  26. Rytlewski, K., Olszanecki, R., Korbut, R., and Zdebski, Z. Effects of prolonged oral supplementation with l-arginine on blood pressure and nitric oxide synthesis in preeclampsia. Eur.J Clin.Invest 2005;35(1):32-37.
  27. Mansoor, J. K., Morrissey, B. M., Walby, W. F., Yoneda, K. Y., Juarez, M., Kajekar, R., Severinghaus, J. W., Eldridge, M. W., and Schelegle, E. S. L-arginine supplementation enhances exhaled NO, breath condensate VEGF, and headache at 4,342 m. High Alt.M
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L-citrulline 8 references
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Beta-alanine 13 references
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Malic Acid 7 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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