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Dietary supplement

Pure NR Ingredients & Drug Interactions

by DoNotAge.org

Pure NR label
See full label image
Capsule Category: Vitamin
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pure NR against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Pure NR is a dietary supplement by DoNotAge.org with 1 active ingredient. Its ingredients are commonly taken for healthy aging, boosting cellular energy, supporting metabolism.Based on those ingredients, 172 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Nicotinamide Riboside. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pure NR by DoNotAge.org

Ask about any prescription or over-the-counter medication and we check it for interactions with Pure NR by DoNotAge.org — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Pure NR by DoNotAge.org

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: nicotinamide riboside, a form of vitamin B3 that your cells use to make energy and support various repair processes. The capsule itself is made with cellulose, an inert filler.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Nicotinamide Riboside's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: healthy aging and cellular energy support.
  • We looked for evidence on: Athletic performance, Physical performance, Cellular vitality, NAD+ metabolism, Longevity.
  • The closest evidence on file: Nicotinamide Riboside is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Nicotinamide Riboside is rated "Insufficient Reliable Evidence To Rate" for Physical performance.

The evidence for nicotinamide riboside isn't established yet for most conditions we have data on. For age-related macular degeneration, Alzheimer disease, athletic performance, nonalcoholic fatty liver disease, and heart failure, the research is too limited or conflicting to rate whether it works.

We're holding insufficient evidence for all of these.

The evidence, ingredient by ingredient Nicotinamide Riboside

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Nicotinamide riboside is generally well tolerated in short-term studies, though long-term safety isn't fully known. The most common side effects reported are mild: bloating, muscle pain, nausea, itching, sweating, and temporary changes in bowel habits.

One person in a trial reported leg cramps, and some have noted mild muscle soreness. Gastrointestinal discomfort, diarrhea, and indigestion have been reported with combination products containing nicotinamide riboside, though it's unclear whether nicotinamide riboside alone caused those.

There isn't enough safety data in pregnancy or while breastfeeding, so the safety data advises against use in both situations. Talk with your doctor or pharmacist about whether this is right for you if you're pregnant, planning pregnancy, or nursing.

Side effects, ingredient by ingredient Nicotinamide Riboside

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Nicotinamide Riboside.
  • The most serious interaction on file is rated Minor.
  • For scale: 172 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take any blood pressure medication (antihypertensive drugs), check your exact medications with the tool below — nicotinamide riboside may theoretically add to their blood pressure-lowering effect.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

Pure NR is a single-ingredient supplement of nicotinamide riboside, a form of B3 that's generally well tolerated but with unclear long-term effects. If you take blood pressure medication, check your specific drugs before starting.

Pregnant or breastfeeding people should talk with their pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pure NR, straight from the product label.

Brand DoNotAge.org
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jul 25, 2024
DSLD ID 315492
Product type Vitamin
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pure NR by DoNotAge.org, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
IngredientAmount% DV
Nicotinamide Riboside700 mg--

Other ingredients: Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions Take 2 capsules per day, with or without food.

Precautions

Warning Pregnant or nursing mothers, children under the age of 18 and individuals with a known medical condition should consult a physician before using

Warning Pregnant or nursing mothers, children under the age of 18 and individuals with a known medical condition should consult a physician before using

Storage

Store in a cool, dry place

Seals/Symbols

GMP Good Manufacturing Practice Quality Guarantee

Formulation

UK Supplier

Contains no artificial ingredients, wheat, gluten, yeast, soy, corn, milk or preservatives

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pure NR by DoNotAge.org label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pure NR label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pure NR by DoNotAge.org

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Nicotinamide Riboside

Interacts with
172 drugs
700 mg per serving

Nicotinamide riboside (NR) is a form of vitamin B3 that the body converts into NAD+, a molecule involved in cellular energy and repair. Early human st...

Nicotinamide Riboside monograph & interactions

Other (inactive) ingredients: Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pure NR by DoNotAge.org Drug Interactions

Want to check YOUR meds against Pure NR?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
172Drugs
172 Minor

Ingredients driving the most interactions

Nicotinamide Riboside 172

Individual Drug Interactions

The ingredients in Pure NR interact with 172 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pure NR interact with drugs. Each result below shows which ingredient is responsible. Nicotinamide Riboside

Each ingredient & the kinds of drugs it affects

For each ingredient in Pure NR with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Nicotinamide Riboside1 drug type · 172 drugs

Antihypertensive Drugs

Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
One small clinical study suggests that nicotinamide riboside can modestly reduce blood pressure in hypertensive patients. However, other clinical research did not find a reduction in blood pressure when compared with control.

Likelihood Possible Evidence D
Nicotinamide Riboside full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pure NR, from the product label.

DoNotAge.org

See all DoNotAge.org products
Name
DoNotAge.org
Pharmacist Counseling Corner

Pure NR by DoNotAge.org: Common Questions

Does Pure NR by DoNotAge.org interact with any medications?
Yes. Based on its ingredients, Pure NR has a known interaction with 172 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pure NR contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is nicotinamide riboside and what does it do?
Nicotinamide riboside is a form of vitamin B3 that your cells use to create energy and support repair processes in your body. It's different from the niacin you might know from a standard B-complex; your body converts it into a molecule called NAD+ that's involved in aging and metabolism.
Does this product actually work for any of the conditions it's marketed for?
The evidence isn't established yet. The research on nicotinamide riboside for age-related macular degeneration, Alzheimer disease, athletic performance, nonalcoholic fatty liver disease, and heart failure is too limited to say whether it works, so we rate all of these as insufficient evidence.
Is nicotinamide riboside safe to take long-term?
Short-term studies show it's generally well tolerated, but long-term safety data is missing. That's something to keep in mind if you're thinking about taking this for months or years — talk with your pharmacist about what we know and don't know.
Can I take this if I'm pregnant or breastfeeding?
There isn't enough safety data to know either way, so the safety data advises against use in both pregnancy and breastfeeding. Have a conversation with your doctor or pharmacist about your individual situation before starting.
What side effects might I experience?
The most common ones are mild: bloating, muscle pain or soreness, nausea, itching, sweating, and temporary changes in your bowel habits. One person reported leg cramps in a trial. Stomach discomfort, diarrhea, or indigestion have been reported with combination products, though it's unclear if nicotinamide riboside alone caused those.
Are there any inactive ingredients or fillers I should know about?
The capsule is made with cellulose, which is an inert filler that helps hold the supplement together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pure NR is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pure NR label
Go deeper

The Full Monographs Behind Pure NR’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Nicotinamide Riboside

Interacts with 172 drugs

Nicotinamide riboside (NR) is a form of vitamin B3 that the body converts into NAD+, a molecule involved in cellular energy and repair. Early human studies show it can reliably raise NAD+ le...

Read the full Nicotinamide Riboside monograph →
Sources

Sources & How We Checked

Pure NR's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Nicotinamide Riboside 7 references
  1. Martens CR, Denman BA, Mazzo MR, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun 2018;9(1):1286. PubMed
  2. Dollerup OL, Christensen B, Svart M, et al. A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects. Am J Clin Nutr 2018;108(2):343-53. PubMed
  3. Dellinger RW, Santos SR, Morris M, et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safety and sustainably: a randomized, double-blind, placebo-controlled study. NPJ J Aging Mech Dis 2017;3:17.
  4. Conze D, Brenner C, Kruger CL. Safety and metabolism of long-term administration of NIAGEN (nicotinamide riboside chloride) in a randomized, double-blind, placebo-controlled clinical trial of healthy overweight adults. Sci Rep 2019;9(1):9772. PubMed
  5. Remie CME, Roumans KHM, Moonen MPB, et al. Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans. Am J Clin Nutr. 2020;112(2):413-426. PubMed
  6. Turck D, Castenmiller J, de Henauw S, et al. Safety of nicotinamide riboside chloride as a novel food pursuant to Regulation (EU) 2015/2283 and bioavailability of nicotinamide from this source, in the context of Directive 2002/46/EC. EFSA J. 2019;17(8):e0
  7. EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, et al. Extension of use of nicotinamide riboside chloride as a novel food pursuant to Regulation (EU) 2015/2283. EFSA J 2021;19(11):e06843.

See these in context on the Nicotinamide Riboside monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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