Purple Mushroom Defense Ingredients & Drug Interactions
by Enzymatic Therapy
What is this page for?
First and foremost: checking Purple Mushroom Defense against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Purple Mushroom Defense is a dietary supplement by Enzymatic Therapy with 4 active ingredients. Its ingredients are commonly taken for immune support, blood sugar support in diabetes, high blood pressure.Based on those ingredients, 375 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Reishi Antler Mushroom, organic Maitake Mushroom, organic Agaricus Mushroom. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Purple Mushroom Defense by Enzymatic Therapy
Ask about any prescription or over-the-counter medication and we check it for interactions with Purple Mushroom Defense by Enzymatic Therapy — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Purple Mushroom Defense by Enzymatic Therapy
Four independent checks of what is known — a summary of the available information, not a grade of the product itself.
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
The stated purpose hasn't been mapped to our evidence data yet.
Why this rating?
- We haven't mapped this product's purpose to our evidence data yet — it'll be graded on the next content refresh.
Every active ingredient lists its own amount on the label.
Why this rating?
- The label discloses an exact amount for 4 of its 4 active ingredients.
- “Exclusive Purple PowerBlend(TM)” is a proprietary blend — the label gives one combined amount (1.40 Gram(s)) without saying how much of each component you get.
The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.
Why this rating?
- 3 of the 3 matched ingredients can interact with medications — Maitake Mushroom, Reishi Mushroom, Agaricus Mushroom.
- The most serious interaction on file is rated Moderate.
- Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
- For scale: 375 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.
Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.
Why this rating?
- We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
- Pregnancy & breastfeeding safety ratings cover 3 of 3.
- General safety write-ups exist for 3 of 3.
- Remember: this measures how much safety information exists. Thin data is not the same as being safe.
HelloPharmacist summaryFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2013.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Purple Mushroom Defense, straight from the product label.
| Brand | Enzymatic Therapy |
|---|---|
| Net contents | 120 Veg Capsule(s) |
| Market status | Off market |
| Date entered into DSLD | Aug 23, 2013 |
| DSLD ID | 24817 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years), Organic, Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Purple Mushroom Defense by Enzymatic Therapy, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 5 {Calories} | -- |
| Total Carbohydrates | 1 Gram(s) | 1% |
| organic Maitake Mushroom | 446 mg | -- |
| Exclusive Purple PowerBlend(TM) | 1.4 Gram(s) | -- |
| organic Agaricus Mushroom | 446 mg | -- |
| organic Trametes Mushroom | 290 mg | -- |
| organic Reishi Antler Mushroom | 218 mg | -- |
Other ingredients: Vegetable Polysaccharide Capsule, Cellulose, Magnesium Stearate, Silicon Dioxide
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols
Enzymatic Therapy(R)
QUALITY ASSURANCE INTERNATIONAL CERTIFIED ORGANIC
LABORATORY TESTED PURITY, SAFETY & PERFORMANCE
VEGETARIAN
Formula
Made with Organic Mushrooms
General Statements
Dramatically intensifies natural killer-cell activity
DEEP IMMUNE HEALTH
This product contains natural ingredients; color variations are normal.
Purple Power Protection Makes All the difference
The organic Purple Kculli Corn, a non-GMO heirloom strain of corn, is sustainably grown in the coastal plains of Peru. It actively serves as a nutritional growth medium, nourishing the four organically-grown powerhouse mushrooms and infusing them with its naturally abundant antioxidant power--for maximum deep immune support.
As the troop scavenges free radicals, it profoundly enhances your body's natural defenses. Cell Forte Purple Mushroom Defense delivers more than 5x's the super antioxidant power of the three antioxidant-rich fruits, including raisins, blueberries and strawberries! When you want to leave nothing to chance, make Cell Forte Purple Mushroom Defense your first line of defense. Values based on independent laboratory tests. Results may vary.
In addition, antioxidant-rich Purple Kculli Corn provides the perfect growth medium, generating ultimate antioxidant and immune power.
Delivers more than 3x's the Antioxidant Power than the leading competitor!
Leave Nothing to Chance
FDA Statement of Identity
DIETARY SUPPLEMENT
FDA Disclaimer Statement
THIS STATEMENT HAS NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT ANY DISEASE.
Formulation
ETI is certified organic by Quality Assurance International and is an FDA-registered Drug Establishment
Contains no sugar, salt, yeast, wheat, gluten, soy, dairy products, artificial coloring, artificial flavoring, preservatives, or ingredients of animal origin.
Suggested/Recommended/Usage/Directions
Recommendations: Four capsules daily. May be taken as two capsules twice daily.
Precautions
If pregnant, nursing, or taking prescription drugs, consult your healthcare practitioner prior to use.
Brand IP Statement(s)
No other mushroom formula contains the unique blend of powerful, antioxidant-rich ingredients as found in Cell Forte(R) Purple Mushroom Defense(TM).
Synergistically, the exclusive Purple PowerBlend(TM) activates antioxidant power to amplify your immune functions and mobilize your natural killer-cell "minutemen" into action.
Cell Forte(R) Purple Mushroom Defense(TM), your first line of defense, supports proactive deep immune health naturally with efficacious levels of the four powerhouse mushrooms.
The Exclusive Purple PowerBlend(TM): ~Is clinically proven to intensify natural killer (NK) cell activity ~Boosts the body's natural defenses against harmful free radicals
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Purple Mushroom Defense by Enzymatic Therapy label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Purple Mushroom Defense by Enzymatic Therapy
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size4 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Exclusive Purple PowerBlend(TM)
- › Organic Maitake Mushroom
- › Organic Agaricus Mushroom
- › Organic Trametes Mushroom
- › Organic Reishi Antler Mushroom
Other (inactive) ingredients: Vegetable Polysaccharide Capsule, Cellulose, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.
Purple Mushroom Defense by Enzymatic Therapy Drug Interactions
Purple Mushroom Defense contains 4 ingredients, and 3 of them have known drug interactions. Altogether they interact with 375 medications. Here’s the picture, then you can look up your own drug.
Want to check YOUR meds against Purple Mushroom Defense?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Purple Mushroom Defense interact with 375 drugs. Click any drug to see the details.
3 of the 4 ingredients in Purple Mushroom Defense interact with drugs. Each result below shows which ingredient is responsible. organic Reishi Antler Mushroom organic Maitake Mushroom organic Agaricus Mushroom
AbciximabReoPro
How Abciximab interacts with Purple Mushroom Defense — through 1 ingredient. Tap an ingredient for the detail:
Organic Reishi Antler MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Organic Reishi Antler Mushroom + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Purple Mushroom Defense — through 1 ingredient. Tap an ingredient for the detail:
Organic Reishi Antler MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Organic Reishi Antler Mushroom + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Purple Mushroom Defense — through 3 ingredients. Tap an ingredient for the detail:
Organic Reishi Antler MushroomAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Read the full Organic Reishi Antler Mushroom + Acarbose interactionOrganic Agaricus MushroomAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Organic Agaricus Mushroom + Acarbose interactionOrganic Maitake MushroomAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Organic Maitake Mushroom + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Purple Mushroom Defense — through 2 ingredients. Tap an ingredient for the detail:
Organic Maitake MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Organic Maitake Mushroom + Acebutolol interactionOrganic Reishi Antler MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Organic Reishi Antler Mushroom + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Purple Mushroom Defense — through 1 ingredient. Tap an ingredient for the detail:
Organic Reishi Antler MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Organic Reishi Antler Mushroom + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Purple Mushroom Defense — through 1 ingredient. Tap an ingredient for the detail:
Organic Reishi Antler MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Organic Reishi Antler Mushroom + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Purple Mushroom Defense — through 1 ingredient. Tap an ingredient for the detail:
Organic Reishi Antler MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Organic Reishi Antler Mushroom + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Purple Mushroom Defense — through 1 ingredient. Tap an ingredient for the detail:
Organic Reishi Antler MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Organic Reishi Antler Mushroom + Acetaminophen, Ibuprofen interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Purple Mushroom Defense — through 2 ingredients. Tap an ingredient for the detail:
Organic Maitake MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Organic Maitake Mushroom + Acetazolamide interactionOrganic Reishi Antler MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Organic Reishi Antler Mushroom + Acetazolamide interactionAcetohexamideDymelor
How Acetohexamide interacts with Purple Mushroom Defense — through 3 ingredients. Tap an ingredient for the detail:
Organic Reishi Antler MushroomAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Read the full Organic Reishi Antler Mushroom + Acetohexamide interactionOrganic Agaricus MushroomAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Organic Agaricus Mushroom + Acetohexamide interactionOrganic Maitake MushroomAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Organic Maitake Mushroom + Acetohexamide interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with Purple Mushroom Defense — through 1 ingredient. Tap an ingredient for the detail:
Organic Reishi Antler MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Organic Reishi Antler Mushroom + Acetylsalicylic Acid interactionAlbiglutideTanzeum
How Albiglutide interacts with Purple Mushroom Defense — through 3 ingredients. Tap an ingredient for the detail:
Organic Maitake MushroomAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Organic Maitake Mushroom + Albiglutide interactionOrganic Agaricus MushroomAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Organic Agaricus Mushroom + Albiglutide interactionOrganic Reishi Antler MushroomAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Read the full Organic Reishi Antler Mushroom + Albiglutide interactionAliskirenTekturna
How Aliskiren interacts with Purple Mushroom Defense — through 2 ingredients. Tap an ingredient for the detail:
Organic Maitake MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Organic Maitake Mushroom + Aliskiren interactionOrganic Reishi Antler MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Organic Reishi Antler Mushroom + Aliskiren interactionAlogliptinNesina
How Alogliptin interacts with Purple Mushroom Defense — through 3 ingredients. Tap an ingredient for the detail:
Organic Maitake MushroomAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Organic Maitake Mushroom + Alogliptin interactionOrganic Reishi Antler MushroomAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Read the full Organic Reishi Antler Mushroom + Alogliptin interactionOrganic Agaricus MushroomAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Organic Agaricus Mushroom + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Purple Mushroom Defense — through 3 ingredients. Tap an ingredient for the detail:
Organic Agaricus MushroomAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Organic Agaricus Mushroom + Alogliptin, Metformin interactionOrganic Maitake MushroomAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Organic Maitake Mushroom + Alogliptin, Metformin interactionOrganic Reishi Antler MushroomAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Read the full Organic Reishi Antler Mushroom + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Purple Mushroom Defense — through 3 ingredients. Tap an ingredient for the detail:
Organic Reishi Antler MushroomAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Read the full Organic Reishi Antler Mushroom + Alogliptin, Pioglitazone interactionOrganic Agaricus MushroomAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Organic Agaricus Mushroom + Alogliptin, Pioglitazone interactionOrganic Maitake MushroomAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Organic Maitake Mushroom + Alogliptin, Pioglitazone interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with Purple Mushroom Defense — through 1 ingredient. Tap an ingredient for the detail:
Organic Reishi Antler MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Organic Reishi Antler Mushroom + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Purple Mushroom Defense — through 1 ingredient. Tap an ingredient for the detail:
Organic Reishi Antler MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Organic Reishi Antler Mushroom + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Purple Mushroom Defense — through 1 ingredient. Tap an ingredient for the detail:
Organic Reishi Antler MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Organic Reishi Antler Mushroom + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Purple Mushroom Defense — through 2 ingredients. Tap an ingredient for the detail:
Organic Maitake MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Organic Maitake Mushroom + Ambrisentan interactionOrganic Reishi Antler MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Organic Reishi Antler Mushroom + Ambrisentan interactionAmilorideAmilamont, Midamor
How Amiloride interacts with Purple Mushroom Defense — through 2 ingredients. Tap an ingredient for the detail:
Organic Reishi Antler MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Organic Reishi Antler Mushroom + Amiloride interactionOrganic Maitake MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Organic Maitake Mushroom + Amiloride interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Purple Mushroom Defense — through 2 ingredients. Tap an ingredient for the detail:
Organic Maitake MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Organic Maitake Mushroom + Amiloride, Hydrochlorothiazide interactionOrganic Reishi Antler MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Organic Reishi Antler Mushroom + Amiloride, Hydrochlorothiazide interactionAmlodipineNorliqva
How Amlodipine interacts with Purple Mushroom Defense — through 2 ingredients. Tap an ingredient for the detail:
Organic Reishi Antler MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Organic Reishi Antler Mushroom + Amlodipine interactionOrganic Maitake MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Organic Maitake Mushroom + Amlodipine interactionAmlodipine BenzoateKaterzia
How Amlodipine Benzoate interacts with Purple Mushroom Defense — through 2 ingredients. Tap an ingredient for the detail:
Organic Maitake MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Organic Maitake Mushroom + Amlodipine Benzoate interactionOrganic Reishi Antler MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Organic Reishi Antler Mushroom + Amlodipine Benzoate interactionAmlodipine BesilateIstin
How Amlodipine Besilate interacts with Purple Mushroom Defense — through 2 ingredients. Tap an ingredient for the detail:
Organic Reishi Antler MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Organic Reishi Antler Mushroom + Amlodipine Besilate interactionOrganic Maitake MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Organic Maitake Mushroom + Amlodipine Besilate interactionAmlodipine BesylateNorvasc
How Amlodipine Besylate interacts with Purple Mushroom Defense — through 2 ingredients. Tap an ingredient for the detail:
Organic Maitake MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Organic Maitake Mushroom + Amlodipine Besylate interactionOrganic Reishi Antler MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Organic Reishi Antler Mushroom + Amlodipine Besylate interactionAmlodipine Besylate, BenazeprilLotrel
How Amlodipine Besylate, Benazepril interacts with Purple Mushroom Defense — through 2 ingredients. Tap an ingredient for the detail:
Organic Reishi Antler MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Organic Reishi Antler Mushroom + Amlodipine Besylate, Benazepril interactionOrganic Maitake MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Organic Maitake Mushroom + Amlodipine Besylate, Benazepril interactionAmlodipine, CelecoxibConsensi
How Amlodipine, Celecoxib interacts with Purple Mushroom Defense — through 2 ingredients. Tap an ingredient for the detail:
Organic Maitake MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Organic Maitake Mushroom + Amlodipine, Celecoxib interactionOrganic Reishi Antler MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Organic Reishi Antler Mushroom + Amlodipine, Celecoxib interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with Purple Mushroom Defense — through 2 ingredients. Tap an ingredient for the detail:
Organic Reishi Antler MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Organic Reishi Antler Mushroom + Ammonium Chloride interactionOrganic Maitake MushroomAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Read the full Organic Maitake Mushroom + Ammonium Chloride interactionAnacaulase-bcdbNexoBrid
How Anacaulase-bcdb interacts with Purple Mushroom Defense — through 1 ingredient. Tap an ingredient for the detail:
Organic Reishi Antler MushroomAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
Read the full Organic Reishi Antler Mushroom + Anacaulase-bcdb interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Purple Mushroom Defense with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
organic Reishi Antler Mushroom
Anticoagulant/Antiplatelet Drugs
Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
A dose of 1.5 grams daily of reishi mushroom does not seem to decrease platelet aggregation, but a higher dose of 3 grams daily does.
Antidiabetes Drugs
Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Animal research suggests that reishi mushroom decreases blood sugar. However, in patients with type 2 diabetes, taking reishi mushroom does not reduce fasting glucose levels, and its effects on glycated hemoglobin are inconsistent.
Antihypertensive Drugs
Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Reishi mushroom has shown hypotensive activity in animal research. Clinical evidence suggests that reishi mushroom reduces blood pressure in some, but not all, patients with hypertension.
organic Maitake Mushroom
Antidiabetes Drugs
Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking maitake mushroom polysaccharide (MMP) can lower blood glucose levels in patients with types 2 diabetes.
Antihypertensive Drugs
Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that maitake mushroom can lower blood pressure.
Warfarin (Coumadin)
There is limited evidence that maitake mushroom may increase the anticoagulant effects of warfarin.
In a case report, a patient previously stabilized on warfarin developed an elevated international normalized ratio (INR) of 5.1 after taking maitake mushroom (Grifron-Pro Maitake D-Fraction) 1 drop/kg daily in three divided doses for one week. The elevated INR resolved after holding warfarin for two days, then reducing the dose by 11%. It is thought that the beta-glucan constituent of maitake mushroom might cause warfarin dissociation from proteins, resulting in increased free warfarin levels and increased warfarin effects.
organic Agaricus Mushroom
Antidiabetes Drugs
Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
In one clinical study in patients with type 2 diabetes who are stabilized on conventional oral hypoglycemic agents, 3 of 29 patients taking an agaricus mushroom extract 500 mg three times daily for 12 weeks reported hypoglycemia, compared to one of 29 patients in the placebo group.
Brand information
Manufacturer and brand details for Purple Mushroom Defense, from the product label.
Enzymatic Therapy
- Name
- Enzymatic Therapy, Inc.
- City
- Green Bay
- State
- WI
- ZipCode
- 54311
- Phone Number
- 1.800.783.2286
- Web Address
- enzy.com
Purple Mushroom Defense by Enzymatic Therapy: Common Questions
Does Purple Mushroom Defense by Enzymatic Therapy interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Purple Mushroom Defense’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Maitake Mushroom
Interacts with 260 drugsMaitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and blood pressure effects. The human evidence...
Read the full Maitake Mushroom monograph → Herb & supplement monographAgaricus Mushroom
Interacts with 86 drugsAgaricus mushroom (often Agaricus blazei/subrufescens) is a culinary and medicinal mushroom studied mostly for possible immune and antioxidant effects. The human evidence is limited and not...
Read the full Agaricus Mushroom monograph → Herb & supplement monographReishi Mushroom
Interacts with 375 drugsReishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits is limited or low-quality, so it should...
Read the full Reishi Mushroom monograph →Sources & How We Checked
Purple Mushroom Defense's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 30 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Maitake Mushroom 8 references
- Kabir Y, Kimura S. Dietary mushrooms reduce blood pressure in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol (Tokyo) 1989;35:91-4. PubMed
- Kabir Y, Yamaguchi M, Kimura S. Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo) 1987;33:341-6. PubMed
- Konno S, Tortorelis DG, Fullerton SA, et al. A possible hypoglycaemic effect of maitake mushroom on Type 2 diabetic patients. Diabet Med 2001;18:1010. PubMed
- Chen JT, Tominaga K, Sato Y, et al. Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with first-line clomiphene citrate. J Altern Compl
- Hanselin MR, Vande Griend JP, Linnebur SA. INR elevation with maitake extract in combination with warfarin. Ann Pharmacother 2010;44:223-4. PubMed
- Talpur, N. A., Echard, B. W., Fan, A. Y., Jaffari, O., Bagchi, D., and Preuss, H. G. Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains. Mol.Cell Biochem. 2002;237(1-2):129-136. PubMed
- Deng, G., Lin, H., Seidman, A., Fornier, M., D'Andrea, G., Wesa, K., Yeung, S., Cunningham-Rundles, S., Vickers, A. J., and Cassileth, B. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: i
- Wesa KM, Cunningham-Rundles S, Klimek VM, et al. Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study. Cancer Immunol Immunother 2015;64(2):237-47. PubMed
Agaricus Mushroom 5 references
- Hsu CH, Liao YL, Lin SC, et al. The mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial. J Altern Complement Med 2
- Mukai H, Watanabe T, Ando M, Katsumata N. An alternative medicine, Agaricus blazei, may have induced severe hepatic dysfunction in cancer patients. Jpn J Clin Oncol 2006;36:808-10. PubMed
- Ohno S, Sumiyoshi Y, Hashine K, et al. Phase I clinical study of the dietary supplement, Agaricus blazei Murill, in cancer patients in remission. Evid Based Complement Alternat Med 2011, doi 10.1155/2011/192381.
- Suehiro M, Katoh N, Kishimoto S. Chelitis due to Agaricus blazei Murill mushroom extract. Contact Dermatitis 2007;56(5):293-4.
- Iwai N, Okuda T, Sawada R, et al. Interstitial lung disease associated with Agaricus blazei Murill in a patient with pancreatic ductal adenocarcinoma receiving gemcitabine-based therapy. Case Rep Gastroenterol 2022;16(1):229-234.
Reishi Mushroom 17 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Tao J, Feng KY. Experimental and clinical studies on inhibitory effect of ganoderma lucidum on platelet aggregation. J Tongji Med Univ 1990;10:240-3. PubMed
- Singh AB, Gupta SK, Pereira BM, Prakash D. Sensitization to Ganoderma lucidum in patients with respiratory allergy in India. Clin Exp Allergy 1995;25:440-7.
- Lee SY, Rhee HM. Cardiovascular effects of mycelium extract of Ganoderma lucidum: inhibition of sympathetic outflow as a mechanism of its hypotensive action. Chem Pharm Bull (Tokyo) 1990;38:1359-64. PubMed
- Kwok Y, Ng KFJ, Li, CCF, et al. A prospective, randomized, double-blind, placebo-controlled study of the platelet and global hemostatic effects of Ganoderma lucidum (Ling-Zhi) in healthy volunteers. Anesth Analg 2005;101:423-6. PubMed
- Wanmuang, H., Leopairut, J., Kositchaiwat, C., Wananukul, W., and Bunyaratvej, S. Fatal fulminant hepatitis associated with Ganoderma lucidum (Lingzhi) mushroom powder. J Med Assoc Thai. 2007;90(1):179-181.
- Seto, S. W., Lam, T. Y., Tam, H. L., Au, A. L., Chan, S. W., Wu, J. H., Yu, P. H., Leung, G. P., Ngai, S. M., Yeung, J. H., Leung, P. S., Lee, S. M., and Kwan, Y. W. Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db
- Chu, T. T., Benzie, I. F., Lam, C. W., Fok, B. S., Lee, K. K., and Tomlinson, B. Study of potential cardioprotective effects of Ganoderma lucidum (Lingzhi): results of a controlled human intervention trial. Br.J.Nutr. 2012;107(7):1017-1027.
- Jin, X., Ruiz, Beguerie J., Sze, D. M., and Chan, G. C. Ganoderma lucidum (Reishi mushroom) for cancer treatment. Cochrane.Database.Syst.Rev. 2012;6:CD007731.
- Kabir, Y., Kimura, S., and Tamura, T. Dietary effect of Ganoderma lucidum mushroom on blood pressure and lipid levels in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol.(Tokyo) 1988;34(4):433-438. PubMed
- Kanmatsuse, K., Kajiwara, N., Hayashi, K., Shimogaichi, S., Fukinbara, I., Ishikawa, H., and Tamura, T. [Studies on Ganoderma lucidum. I. Efficacy against hypertension and side effects]. Yakugaku Zasshi 1985;105(10):942-947. PubMed
- Gao, Y., Lan, J., Dai, X., Ye, J., and Zhou, S. A Phase I/II Study of Ling Zhi Mushroom Ganoderma lucidum(W.Curt: Fr.) Lloyd (Aphyllophoromycetideae) Extract in Patients with Type II Diabetes Mellitus. International Journal of Medicinal Mushrooms 2004;6. DOI
- Jin H, Zhang G, Cao X, and et al. Treatment of hypertension by linzhi combined with hypotensor and its effects on arterial, arteriolar and capillary pressure and microcirculation. In: Niimi H, Xiu RJ, Sawada T, and et al. Microcirculatory Approach to Asi
- Klupp NL, Chang D, Hawke F, Kiat H, Cao H, Grant SJ, Bensoussan A. Ganoderma lucidum mushroom for the treatment of cardiovascular risk factors. Cochrane Database Syst Rev. 2015 Feb 17;2:CD007259. PubMed
- Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X. Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial. Evid Based Complement Alternat Med. 2012;2012:809614.
- Pazzi F, Adsuar JC, Domínguez-Muñoz FJ, García-Gordillo MA, Gusi N, Collado-Mateo D. Ganoderma lucidum effects on mood and health-related quality of life in women with fibromyalgia. Healthcare (Basel) 2020;8(4):520. PubMed
- Kogure T, Koiwai A, Fukushi D, et al. Hypereosinophilia with hepatic nodule formation caused by Ganoderma lucidum. Intern Med 2021;60(24):3897-3903.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC