Pycnogenol 100 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Pycnogenol 100 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Pycnogenol 100 mg is a dietary supplement by Healthy Origins with 1 active ingredient. Its ingredients are commonly taken for circulation and vein health, antioxidant support, skin health and aging.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are French Maritime Pine Bark Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Pycnogenol 100 mg by Healthy Origins
Ask about any prescription or over-the-counter medication and we check it for interactions with Pycnogenol 100 mg by Healthy Origins — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Pycnogenol 100 mg by Healthy Origins
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product is straightforward: one active ingredient, French Maritime Pine Bark Extract, standardized to deliver 100 mg of pycnogenol per capsule. Pycnogenol is a natural compound from pine bark that's been studied for joint health, circulation, and a few other uses.
The capsule itself is vegetarian, and the formula includes calcium palmitate as a binder.
Does it work?
Moderate evidence
The extract shows some promise. Research rates it possibly effective for osteoarthritis and chronic venous insufficiency — that's the swelling and heaviness you get from poor circulation in the legs.
For asthma, the evidence also suggests it might help, though more solid studies would be reassuring. On the flip side, it does not appear to help with cholesterol (hyperlipidemia), so don't count on it for that.
How safe is it?
Well-documented data
Maritime pine bark extract is generally well tolerated in the studies we have, but long-term safety hasn't been fully worked out yet. The most common side effects are stomach upset, dizziness, and vertigo.
A few rare cases of headache, chest pain, and heart failure problems have been reported in people taking the standardized Pycnogenol extract, though it's unclear whether the extract caused them. During pregnancy, there isn't enough safety data, so the advice is to avoid it.
The same goes for breastfeeding — we don't have enough information to say it's safe, so it's best to skip it.
Meds to double-check
Moderate interaction found
Before you start, check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (like warfarin or aspirin) — the extract may increase bleeding risk. Also double-check if you're on diabetes medications, since it might lower your blood sugar.
And if you take immunosuppressants, let your provider know so they can monitor how well they're working.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
If you have osteoarthritis or leg swelling from poor circulation, this extract might be worth a try based on current evidence. But you'll want to talk it over with your doctor or pharmacist first — especially if you take blood thinners, diabetes medications, or immunosuppressants.
They can help you decide whether it's right for you and watch for any problems.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 21, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Pycnogenol 100 mg, straight from the product label.
| Brand | Healthy Origins |
|---|---|
| Barcode (UPC) | 603573413712 |
| Net contents | 60 Veggie Cap(s) |
| Market status | On market |
| Date entered into DSLD | Jul 21, 2022 |
| DSLD ID | 269452 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Pycnogenol 100 mg by Healthy Origins, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| French Maritime Pine Bark Extract | 100 mg | -- |
Other ingredients: Vegetarian Capsule, Calcium Palmitate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Directions: As a dietary supplement for adults, take one (1) vegetarian capsule once or twice daily, preferably with a meal, or as directed by a physician.
Formula
Pycnogenol is a natural extract originating from the bark of the maritime pine tree that grows along the coast of southwestern France. Pycnogenol contains a unique combination of procyanidins, bioflavonoids and phenolic acids, which offer an extensive range of support for the body.
Clinically studied French maritime pine bark extract
Formulation
Pycnogenol may help to support joint health, skin health, circulatory health and eye health. Over the past 40 years, Pycnogenol has been the subject of over 135 clinical studies and 300 scientific papers, making it one of the most clinically studied ingredients in the world.
Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish, peanut, or tree nut derived ingredients. Non GMO
Manufactured in a cGMP facility.
Suitable for vegans
Brand IP Statement(s)
Pycnogenol is a registered trademark of Horphag Research Ltd. Use of this product may be protected by one or more U.S. and/or foreign patents.
Healthy Origins Since 1996
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
General Statements
New look Nature's super antioxidant Look, feel, and live better
Pycnogenol is extracted from the bark of pine trees grown exclusively in the Les Landes de Gascogne forest in southwest France.
FDA Statement of Identity
Dietary Supplement
Seals/Symbols
3rd Party Tested
Storage
Store in a cool, dry place.
Precautions
Keep out of reach of children
Caution: Consult a physician before use if you are pregnant, nursing, taking medication or have a medical condition.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Pycnogenol 100 mg by Healthy Origins label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Pycnogenol 100 mg by Healthy Origins
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
French Maritime Pine Bark Extract
Interacts with327 drugs
Maritime pine bark extract (often sold as Pycnogenol) is a plant-based antioxidant most studied for circulation, vein, and skin health. Some research...
French Maritime Pine Bark Extract monograph & interactionsOther (inactive) ingredients: Vegetarian Capsule, Calcium Palmitate. These complete the product’s ingredient list but are not active constituents.
Pycnogenol 100 mg by Healthy Origins Drug Interactions
HelloPharmacist Interaction Report
Healthy Origins Pycnogenol 100 mg contains French Maritime Pine Bark Extract, which interacts with three major medication categories.
The most serious concern is with blood thinners and antiplatelet drugs (anticoagulants/antiplatelet agents): the extract may slow down clotting and raise your bleeding risk, though we don't yet know how much of a real-world problem this is in people.
Read the full breakdown — every affected drug type, severity by severity
It also may lower blood sugar when combined with diabetes medications, so if you take those, your doctor will want to monitor your glucose levels closely — you might need a dose adjustment. Additionally, the extract theoretically could reduce how well immunosuppressant drugs work, though this effect has only been seen in lab and animal studies, not in people yet.
Altogether, these interactions span 327 individual medications. Use the medication checker below to see if any of yours are affected before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Pycnogenol 100 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Pycnogenol 100 mg interact with 327 drugs. Click any drug to see the details.
1 of the 1 ingredient in Pycnogenol 100 mg interact with drugs. Each result below shows which ingredient is responsible. French Maritime Pine Bark Extract
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full French Maritime Pine Bark Extract + 6-mercaptopurine interactionAbciximabReoPro
How Abciximab interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full French Maritime Pine Bark Extract + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAnticoagulant/antiplatelet Drugs, Immunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full French Maritime Pine Bark Extract + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full French Maritime Pine Bark Extract + Acarbose interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full French Maritime Pine Bark Extract + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full French Maritime Pine Bark Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full French Maritime Pine Bark Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full French Maritime Pine Bark Extract + Acetaminophen, Ibuprofen interactionAcetohexamideDymelor
How Acetohexamide interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full French Maritime Pine Bark Extract + Acetohexamide interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full French Maritime Pine Bark Extract + Acetylsalicylic Acid interactionAdalimumabHumira
How Adalimumab interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full French Maritime Pine Bark Extract + Adalimumab interactionAdalimumab-adazHyrimoz
How Adalimumab-adaz interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full French Maritime Pine Bark Extract + Adalimumab-adaz interactionAdalimumab-adbmCyltezo
How Adalimumab-adbm interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full French Maritime Pine Bark Extract + Adalimumab-adbm interactionAdalimumab-afzbAbrilada
How Adalimumab-afzb interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full French Maritime Pine Bark Extract + Adalimumab-afzb interactionAdalimumab-attoAmjevita
How Adalimumab-atto interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full French Maritime Pine Bark Extract + Adalimumab-atto interactionAdalimumab-bwwdHadlima
How Adalimumab-bwwd interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full French Maritime Pine Bark Extract + Adalimumab-bwwd interactionAdalimumab-fkjpHulio
How Adalimumab-fkjp interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full French Maritime Pine Bark Extract + Adalimumab-fkjp interactionAlbiglutideTanzeum
How Albiglutide interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full French Maritime Pine Bark Extract + Albiglutide interactionAlefaceptAmevive
How Alefacept interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full French Maritime Pine Bark Extract + Alefacept interactionAlemtuzumabCampath
How Alemtuzumab interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full French Maritime Pine Bark Extract + Alemtuzumab interactionAlogliptinNesina
How Alogliptin interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full French Maritime Pine Bark Extract + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full French Maritime Pine Bark Extract + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full French Maritime Pine Bark Extract + Alogliptin, Pioglitazone interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full French Maritime Pine Bark Extract + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full French Maritime Pine Bark Extract + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full French Maritime Pine Bark Extract + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAnacaulase-bcdbNexoBrid
How Anacaulase-bcdb interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full French Maritime Pine Bark Extract + Anacaulase-bcdb interactionAnagrelideAgrylin
How Anagrelide interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full French Maritime Pine Bark Extract + Anagrelide interactionAnifrolumab-fniaSaphnelo
How Anifrolumab-fnia interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full French Maritime Pine Bark Extract + Anifrolumab-fnia interactionAnisindioneMiradon
How Anisindione interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full French Maritime Pine Bark Extract + Anisindione interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Pycnogenol 100 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
French Maritime Pine Bark Extract
Anticoagulant/Antiplatelet Drugs
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Clinical research suggests that maritime pine bark extract inhibits platelet aggregation. However, the clinical significance of this effect is unclear.
Antidiabetes Drugs
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
One clinical study shows that maritime pine bark extract decreases blood sugar in patients with diabetes being treated with antidiabetes agents. Monitor blood glucose levels closely. Dose adjustments might be necessary.
Immunosuppressants
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
In vitro and animal research suggests that maritime pine bark extract has immunostimulant activity. This effect has not been reported in humans.
Brand information
Manufacturer and brand details for Pycnogenol 100 mg, from the product label.
Healthy Origins
See all Healthy Origins products- Name
- Healthy Origins
- City
- Pittsburgh
- State
- PA
- ZipCode
- 15241
- Phone Number
- 1-888-228-6650
Pycnogenol 100 mg by Healthy Origins: Common Questions
Does Pycnogenol 100 mg by Healthy Origins interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Pycnogenol 100 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Pycnogenol 100 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Pycnogenol 100 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 14 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Maritime Pine 14 references
- Rice-Evans CA, Packer L, eds. Flavonoids in Health and Disease. Manhattan, NY: Marcel Dekker, Inc., 1998.
- Liu FJ, Zhang YX, Lau BH. Pycnogenol enhances immune and haemopoietic functions in senescence-accelerated mice. Cell Mol Life Sci 1998;54:1168-72. PubMed
- Putter M, Grotemeyer KH, Wurthwein G, et al. Inhibition of smoking-induced platelet aggregation by aspirin and pycnogenol. Thromb Res 1999;95:155-61. PubMed
- Kohama T, Inoue M. Pycnogenol alleviates pain associated with pregnancy. Phytother Res 2006;20:232-4.
- Liu X, Zhou HJ, Rohdewald P. French maritime pine bark extract pycnogenol dose-dependently lowers glucose in type 2 diabetic patients (letter). Diabetes Care 2004;27:839. PubMed
- Liu X, Wei J, Tan F, et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci 2004;75:2505-13. PubMed
- Wilson D, Evans M, Guthrie N et al. A randomized, double-blind, placebo-controlled exploratory study to evaluate the potential of pycnogenol for improving allergic rhinitis symptoms. Phytother Res 2010;24:1115-9.
- Araghi-Niknam, M., Hosseini, S., Larson, D., Rohdewald, P., and Watson, R. R. Pine bark extract reduces platelet aggregation. Integr.Med. 3-21-2000;2(2):73-77. PubMed
- Trebaticka, J., Kopasova, S., Hradecna, Z., Cinovsky, K., Skodacek, I., Suba, J., Muchova, J., Zitnanova, I., Waczulikova, I., Rohdewald, P., and Durackova, Z. Treatment of ADHD with French maritime pine bark extract, Pycnogenol. Eur.Child Adolesc.Psychi PubMed
- Suzuki, N., Uebaba, K., Kohama, T., Moniwa, N., Kanayama, N., and Koike, K. French maritime pine bark extract significantly lowers the requirement for analgesic medication in dysmenorrhea: a multicenter, randomized, double-blind, placebo-controlled study
- Cisar, P., Jany, R., Waczulikova, I., Sumegova, K., Muchova, J., Vojtassak, J., Durackova, Z., Lisy, M., and Rohdewald, P. Effect of pine bark extract (Pycnogenol) on symptoms of knee osteoarthritis. Phytother.Res. 2008;22(8):1087-1092.
- Enseleit, F., Sudano, I., Periat, D., Winnik, S., Wolfrum, M., Flammer, A. J., Frohlich, G. M., Kaiser, P., Hirt, A., Haile, S. R., Krasniqi, N., Matter, C. M., Uhlenhut, K., Hogger, P., Neidhart, M., Luscher, T. F., Ruschitzka, F., and Noll, G. Effects
- Schoonees, A., Visser, J., Musekiwa, A., and Volmink, J. Pycnogenol(R) (extract of French maritime pine bark) for the treatment of chronic disorders. Cochrane.Database.Syst.Rev. 2012;4:CD008294.
- Wang S, Tan D Zhao Y et al. The effect of pycnogenol on the microcirculation, platelet function and ischemic myocardium in patients with coronary artery diseases. Eur Bull Drug Res 1999;7:19-25.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC