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Dietary supplement

D-Ribose Ingredients & Drug Interactions

by Healthy Origins

D-Ribose label
See full label image
Powder Category: Fiber And Other Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking D-Ribose against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

D-Ribose is a dietary supplement by Healthy Origins with 1 active ingredient. Its ingredients are commonly taken for energy and fatigue, athletic performance and recovery, fibromyalgia symptoms.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are D-Ribose. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against D-Ribose by Healthy Origins

Ask about any prescription or over-the-counter medication and we check it for interactions with D-Ribose by Healthy Origins — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of D-Ribose by Healthy Origins

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

D-Ribose by Healthy Origins is a single-ingredient powder. Ribose is a five-carbon sugar (pentose) your cells naturally produce as part of energy metabolism.

The product contains no other active ingredients and no inactive fillers.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Ribose's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: energy production and ATP support.
  • We looked for evidence on: Athletic performance, Chronic fatigue syndrome (CFS), Fibromyalgia, Congestive heart failure (CHF), Coronary heart disease (CHD), Coronary artery bypass graft (CABG) surgery — and 4 related terms.
  • The closest evidence on file: Ribose is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).
  • Also on file: Ribose is rated "Possibly Ineffective" for McArdle disease.
  • Also on file: Ribose is rated "Insufficient Reliable Evidence To Rate" for Coronary heart disease (CHD), Chronic fatigue syndrome (CFS), Congestive heart failure (CHF), Fibromyalgia, and more.

The evidence for D-Ribose is mixed. For athletic performance and McArdle disease (a rare muscle-sugar metabolism disorder), it's rated possibly ineffective.

For restless legs syndrome, muscle soreness, heart failure after bypass surgery, and general heart function, there isn't enough reliable evidence in our data to rate it either way. If you're considering it for any of these reasons, talk with your doctor about what the current research actually shows for your specific situation.

The evidence, ingredient by ingredient Ribose

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

D-Ribose is generally well tolerated in the short term—up to about a month—but long-term safety hasn't been well studied. The most common side effects when taken by mouth are diarrhea, nausea, gastrointestinal discomfort, headache, and low blood sugar.

Some people report lightheadedness, anxiety, or increased appetite; lowering the dose has resolved nausea and anxiety in some cases. Because it can lower blood sugar and safety data are limited, D-Ribose is not recommended during pregnancy or while breastfeeding.

Talk with your doctor or pharmacist if you are pregnant, planning pregnancy, or nursing.

Side effects, ingredient by ingredient Ribose

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Ribose.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antidiabetes drugs or insulin, check your exact medications with the search tool on this page before using D-Ribose. Both drug categories carry a Moderate interaction risk for low blood sugar when combined with this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

D-Ribose may be worth a conversation if you're researching it for athletic recovery or heart health, but the evidence for most uses is thin or unclear. The real concern is low blood sugar if you take diabetes or insulin medications—you absolutely need to check your exact drugs before starting.

Talk it over with your doctor or pharmacist before adding this to your routine.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about D-Ribose, straight from the product label.

Brand Healthy Origins
Barcode (UPC) 603573370107
Net contents 10.6 Ounce(s); 300 Gram(s)
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 269305
Product type Fiber And Other Nutrients
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for D-Ribose by Healthy Origins, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
5 Gram(s)
Maximum serving Sizes:
5 Gram(s)
Servings per container
60
UPC/BARCODE
603573370107
IngredientAmount% DV
Calories20 Calorie(s)--
Total Carbohydrate5 Gram(s)2%
Total Sugars5 Gram(s)--
added Sugars5 Gram(s)10%
D-Ribose5 Gram(s)--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement for adults, take one (1) scoop once or twice daily with juice or water. Take with or without food. Consider healthy Origins Natural CoQ10 or Ubiquinol in combination with D-Ribose for enhanced cardiovascular support.

Formulation

Healthy Origins D-Ribose is a naturally occurring pentose (5-carbon) sugar, which is a primary building block in the production of Adenosine Triphosphate (ATP), the body's main energy source. ATP levels can become severely depressed following periods of rigorous exercise and metabolic stress. Supplementing with D-Ribose may help replenish depressed levels of ATP and improve workout recovery.

Non GMO

Suitable for vegans

Natural Supports muscle recovery and cardiovascular health

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish, peanut or tree nut derived ingredients.

Manufactured in a cGMP facility.

Brand IP Statement(s)

Use of BioEnergy Ribose is licensed by BioEnergy Life Science, Inc. under U.S. and foreign patents issued or pending.

Healthy Origins Since 1996

Precautions

Caution: Consult a physician before use if you are pregnant, nursing, diabetic, arthritic, taking medication or have a medical condition.

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

Store in a cool, dry place.

Seals/Symbols

3rd Party Tested

General Statements

New look

Formula

Bioenergy Ribose

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

D-Ribose by Healthy Origins label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

D-Ribose label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in D-Ribose by Healthy Origins

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size5 Gram(s) Dosage formPowder Servings per container60 Amounts shown are per serving.

D-Ribose

Interacts with
86 drugs
5 Gram(s) per serving

Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalg...

D-Ribose monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

D-Ribose by Healthy Origins Drug Interactions

Want to check YOUR meds against D-Ribose?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

D-Ribose 86

Individual Drug Interactions

The ingredients in D-Ribose interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in D-Ribose interact with drugs. Each result below shows which ingredient is responsible. D-Ribose

Each ingredient & the kinds of drugs it affects

For each ingredient in D-Ribose with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

D-Ribose2 drug types · 86 drugs

Antidiabetes Drugs

Theoretically, taking ribose in combination with antidiabetes drugs might increase the risk of hypoglycemia.
In clinical research, ribose decreases serum glucose levels in a dose-dependent manner.

Likelihood Probable Evidence B
Insulin

Theoretically, taking ribose with insulin could increase the hypoglycemic effect of insulin.
In clinical pharmacokinetic studies, oral administration of ribose modestly increased serum insulin levels.

Likelihood Possible Evidence B
D-Ribose full monograph & interactions
The maker

Brand information

Manufacturer and brand details for D-Ribose, from the product label.

Healthy Origins

See all Healthy Origins products
Name
Healthy Origins
City
Pittsburgh
State
PA
ZipCode
15241
Phone Number
1-888-228-6650
Pharmacist Counseling Corner

D-Ribose by Healthy Origins: Common Questions

Does D-Ribose by Healthy Origins interact with any medications?
Yes. Based on its ingredients, D-Ribose has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
D-Ribose contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take D-Ribose if I have diabetes or take insulin?
Not without checking with your doctor or pharmacist first. D-Ribose can lower blood sugar and may increase the risk of low blood sugar (hypoglycemia) when combined with diabetes medications or insulin. Your healthcare provider needs to review your specific drugs and may need to adjust dosing if you do take it together.
Is D-Ribose safe to take long-term?
Short-term use—up to about a month—appears generally well tolerated. But long-term safety hasn't been well studied, so we don't have solid data on what happens if you take it for months or years. Talk with your doctor about whether long-term use makes sense for you.
What are the most common side effects?
When taken by mouth, diarrhea, nausea, gastrointestinal discomfort, headache, and low blood sugar are the most frequently reported. Some people also experience lightheadedness, increased appetite, or mild anxiety. In studies, lowering the dose resolved nausea and anxiety in some cases.
Can I take D-Ribose while pregnant or breastfeeding?
No, D-Ribose is not recommended during pregnancy or while breastfeeding because there isn't enough safety information. Talk with your doctor or pharmacist about other options if you're pregnant, planning pregnancy, or nursing.
Does D-Ribose really improve athletic performance or muscle recovery?
The evidence doesn't support that. For athletic performance, D-Ribose is rated possibly ineffective based on the data we hold. For muscle soreness, there's just not enough reliable evidence to say either way.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if D-Ribose is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

D-Ribose label
Go deeper

The Full Monographs Behind D-Ribose’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Ribose

Interacts with 86 drugs

Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalgia, exercise recovery, or heart conditio...

Read the full Ribose monograph →
Sources

Sources & How We Checked

D-Ribose's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ribose 8 references
  1. Segal S, Foley J. The metabolism of D-ribose in man. J Clin Invest 1958;37:719-35. PubMed
  2. Perlmutter NS, Wilson RA, Angello DA, et al. Ribose facilitates thallium-201 redistribution in patients with coronary artery disease. J Nucl Med 1991;32:193-200.
  3. Hegewald MG, Palac RT, Angello DA, et al. Ribose infusion accelerates thallium redistribution with early imaging compared with late 24-hour imaging without ribose. J Am Coll Cardiol 1991;18:1671-81. PubMed
  4. Pliml W, von Arnim T, Stalein A, et al. Effects of ribose on excercise-induced ischaemia in stable coronary artery disease. Lancet 1992;340:507-10.
  5. Burke ER. D-Ribose What You Need To Know. Garden City Park, NY: Avery Publishing Group 1999;1-43.
  6. Gross M, Reiter S, Zollner N. Metabolism of D-ribose administered continuously to healthy persons and to patients with myoadenylate deaminase deficiency. Klin Wochenschr 1989;67:1205-13. PubMed
  7. Teitelbaum JE, Johnson C, St Cyr J. The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study. J Altern Complement Med 2006;12:857-62. PubMed
  8. Thompson J, Neutel J, Homer K, Tempero K, Shah A, Khankari R. Evaluation of D-ribose pharmacokinetics, dose proportionality, food effect, and pharmacodynamics after oral solution administration in healthy male and female subjects. J Clin Pharmacol 2014;54 PubMed

See these in context on the Ribose monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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