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Dietary supplement

D-Ribose SAP Ingredients & Drug Interactions

by NFH

D-Ribose SAP label
See full label image
Powder Category: Fiber And Other Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking D-Ribose SAP against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

D-Ribose SAP is a dietary supplement by NFH with 1 active ingredient. Its ingredients are commonly taken for energy and fatigue, athletic performance and recovery, fibromyalgia symptoms.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are D-Ribose. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against D-Ribose SAP by NFH

Ask about any prescription or over-the-counter medication and we check it for interactions with D-Ribose SAP by NFH — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of D-Ribose SAP by NFH

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

D-Ribose SAP is a single-ingredient powder containing D-Ribose, a naturally occurring five-carbon sugar. The product has no inactive ingredients listed.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: athletic support and energy metabolism.
  • We looked for evidence on: Athletic performance, Chronic fatigue syndrome (CFS), Fibromyalgia, Muscle soreness, Heart function, Exercise recovery.
  • The closest evidence on file: Ribose is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).
  • Also on file: Ribose is rated "Insufficient Reliable Evidence To Rate" for Chronic fatigue syndrome (CFS), Fibromyalgia, Muscle soreness.

The evidence for D-Ribose in most conditions we hold data for is limited. For athletic performance and McArdle disease (a genetic muscle disorder), ribose is rated possibly ineffective.

For restless legs syndrome, muscle soreness, congestive heart failure, and recovery after coronary artery bypass graft surgery, there isn't enough reliable evidence in our data to rate whether it works.

The evidence, ingredient by ingredient Ribose

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

D-Ribose is generally well tolerated for short-term use (up to about a month in studies), but long-term safety hasn't been well studied. The most common side effects when taken by mouth are diarrhea, gastrointestinal discomfort, headache, nausea, and low blood sugar (hypoglycemia).

A few people have reported lightheadedness, increased appetite, and mild to moderate anxiety — though lowering the dose resolved the anxiety and nausea in those cases. The safety data advises against using D-Ribose during pregnancy or while breastfeeding because there isn't enough information to know whether it's safe in those situations.

Talk with your doctor or pharmacist about whether this product is right for you if you're pregnant, planning to become pregnant, or breastfeeding.

Side effects, ingredient by ingredient Ribose

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Ribose.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking D-Ribose if you use insulin or antidiabetes drugs (like metformin, sulfonylureas, or GLP-1 agonists). Ribose can increase the risk of low blood sugar (hypoglycemia) with these medications and may require dose adjustments or closer monitoring.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

D-Ribose may be worth considering if you're interested in potential muscle or energy support, though the evidence for most uses is limited or absent. If you take insulin or any blood-sugar medication, you need to check with your doctor or pharmacist first — this product can lower blood sugar.

Avoid it if you're pregnant or breastfeeding unless your healthcare provider says otherwise.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about D-Ribose SAP, straight from the product label.

Brand NFH
Barcode (UPC) 856711011176
Net contents 17.6 Ounce(s); 500 Gram(s)
Market status On market
Date entered into DSLD Jan 23, 2023
DSLD ID 273373
Product type Fiber And Other Nutrients
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for D-Ribose SAP by NFH, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
10 Gram(s)
Maximum serving Sizes:
10 Gram(s)
Servings per container
50
UPC/BARCODE
856711011176
IngredientAmount% DV
Calories40 Calorie(s)--
Total Carbohydrates10 Gram(s)4%
D-Ribose10 Gram(s)--
Total Sugars10 Gram(s)--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

D-Ribose SAP provides athletic support.

All ingredients listed for this product lot number have been tested by a third-party laboratory for identity, potency, and purity.

Contains no: Gluten, soy, wheat, corn, eggs, dairy, yeast, citrus, preservatives, artificial flavor or color, or starch.

This product is non-GMO and vegan friendly.

This product is non-GMO and vegan friendly.

Color and smell may vary from one lot to another.

Energy support

Formula

Ribose is a factor in energy metabolism and production.

Suggested/Recommended/Usage/Directions

Directions for use: Adults: Take 2 teaspoons daily or as directed by your healthcare practitioner.

Precautions

Contraindications: Consult a healthcare practitioner prior to use if you are pregnant or breast-feeding.

Ensure to dink enough fluid before, during, and after exercise.

Do not use if seal is broken.

Keep out of reach of children.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

General Statements

NPN 80063441

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

D-Ribose SAP by NFH label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

D-Ribose SAP label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in D-Ribose SAP by NFH

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size10 Gram(s) Dosage formPowder Servings per container50 Amounts shown are per serving.

D-Ribose

Interacts with
86 drugs
10 Gram(s) per serving

Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalg...

D-Ribose monograph & interactions
Interaction report

D-Ribose SAP by NFH Drug Interactions

Want to check YOUR meds against D-Ribose SAP?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

D-Ribose 86

Individual Drug Interactions

The ingredients in D-Ribose SAP interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in D-Ribose SAP interact with drugs. Each result below shows which ingredient is responsible. D-Ribose

Each ingredient & the kinds of drugs it affects

For each ingredient in D-Ribose SAP with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

D-Ribose2 drug types · 86 drugs

Antidiabetes Drugs

Theoretically, taking ribose in combination with antidiabetes drugs might increase the risk of hypoglycemia.
In clinical research, ribose decreases serum glucose levels in a dose-dependent manner.

Likelihood Probable Evidence B
Insulin

Theoretically, taking ribose with insulin could increase the hypoglycemic effect of insulin.
In clinical pharmacokinetic studies, oral administration of ribose modestly increased serum insulin levels.

Likelihood Possible Evidence B
D-Ribose full monograph & interactions
The maker

Brand information

Manufacturer and brand details for D-Ribose SAP, from the product label.

NFH

See all NFH products
Name
NFH - Nutritional Fundamentals for Health, Inc.
Street Address
351 Joseph-Carrier
City
Vaudreuil
State
QC
ZipCode
J7V 5V5
Phone Number
1-866-510-3123
Web Address
nfh.ca
Pharmacist Counseling Corner

D-Ribose SAP by NFH: Common Questions

Does D-Ribose SAP by NFH interact with any medications?
Yes. Based on its ingredients, D-Ribose SAP has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
D-Ribose SAP contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will D-Ribose help me with athletic performance or muscle recovery?
The evidence doesn't support D-Ribose for athletic performance — it's rated possibly ineffective for that. For muscle soreness, there isn't enough reliable evidence in our data to say whether it works. Talk with your doctor or a sports medicine specialist if you're looking for evidence-based recovery strategies.
What are the most common side effects?
When taken by mouth, D-Ribose most often causes diarrhea, gastrointestinal discomfort, headache, nausea, and low blood sugar (hypoglycemia). Less commonly, some people report lightheadedness, increased appetite, or mild anxiety — though reducing the dose has resolved these symptoms in cases where they occurred.
How long can I safely take D-Ribose?
In clinical studies, ribose has been shown to be generally well tolerated for up to about a month. Long-term safety beyond that hasn't been well studied, so talk with your pharmacist or doctor if you're considering using it longer.
Is D-Ribose safe during pregnancy or breastfeeding?
No — there isn't enough safety information, so the data advises against using it during pregnancy or while breastfeeding. If you're pregnant, planning pregnancy, or nursing, talk with your doctor or pharmacist before considering this product.
Can I take D-Ribose if I have diabetes or take blood-sugar medication?
You'll need to check with your doctor or pharmacist first. D-Ribose can lower blood sugar and may increase the risk of hypoglycemia (low blood sugar) if you're also taking insulin or antidiabetes drugs. Your healthcare provider can help you determine whether it's safe and whether monitoring or dose adjustments are needed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if D-Ribose SAP is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

D-Ribose SAP label
Go deeper

The Full Monographs Behind D-Ribose SAP’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Ribose

Interacts with 86 drugs

Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalgia, exercise recovery, or heart conditio...

Read the full Ribose monograph →
Sources

Sources & How We Checked

D-Ribose SAP's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ribose 8 references
  1. Segal S, Foley J. The metabolism of D-ribose in man. J Clin Invest 1958;37:719-35. PubMed
  2. Perlmutter NS, Wilson RA, Angello DA, et al. Ribose facilitates thallium-201 redistribution in patients with coronary artery disease. J Nucl Med 1991;32:193-200.
  3. Hegewald MG, Palac RT, Angello DA, et al. Ribose infusion accelerates thallium redistribution with early imaging compared with late 24-hour imaging without ribose. J Am Coll Cardiol 1991;18:1671-81. PubMed
  4. Pliml W, von Arnim T, Stalein A, et al. Effects of ribose on excercise-induced ischaemia in stable coronary artery disease. Lancet 1992;340:507-10.
  5. Burke ER. D-Ribose What You Need To Know. Garden City Park, NY: Avery Publishing Group 1999;1-43.
  6. Gross M, Reiter S, Zollner N. Metabolism of D-ribose administered continuously to healthy persons and to patients with myoadenylate deaminase deficiency. Klin Wochenschr 1989;67:1205-13. PubMed
  7. Teitelbaum JE, Johnson C, St Cyr J. The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study. J Altern Complement Med 2006;12:857-62. PubMed
  8. Thompson J, Neutel J, Homer K, Tempero K, Shah A, Khankari R. Evaluation of D-ribose pharmacokinetics, dose proportionality, food effect, and pharmacodynamics after oral solution administration in healthy male and female subjects. J Clin Pharmacol 2014;54 PubMed

See these in context on the Ribose monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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