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Dietary supplement

Relax+ Ultimate Calm Ingredients & Drug Interactions

by Natrol

Relax+ Ultimate Calm label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Relax+ Ultimate Calm against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Relax+ Ultimate Calm is a dietary supplement by Natrol with 4 active ingredients. Its ingredients are commonly taken for low mood or depression, anxiety and stress, sleep problems.Based on those ingredients, 1,376 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sensoril Ashwagandha root and leaf extract, L-Theanine, 5-HTP. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Relax+ Ultimate Calm by Natrol

Ask about any prescription or over-the-counter medication and we check it for interactions with Relax+ Ultimate Calm by Natrol — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Relax+ Ultimate Calm by Natrol

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Relax+ Ultimate Calm contains four active ingredients working together for calm and relaxation. 5-HTP is an amino acid your body naturally uses to make serotonin, a brain chemical linked to mood and sleep.

L-theanine is an amino acid from green tea that may support mental clarity and calm without drowsiness. Sensoril Ashwagandha is a standardized extract of ashwagandha root and leaf, an herb traditionally used to ease stress and support rest.

Lemon Balm extract comes from the leaves of lemon balm, another traditional herb for stress relief. The capsule also contains inactive ingredients: hypromellose, maltodextrin, magnesium stearate, and silicon dioxide.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Reduces stress, anxiety and tension; promotes calm.
  • We looked for evidence on: Anxiety, Generalized anxiety disorder (GAD), Panic disorder, Stress management, Relaxation, Emotional balance — and 1 related terms.
  • The strongest evidence on file: Lemon Balm is rated "Possibly Effective" for Stress (Natural Medicines).
  • Also on file: Ashwagandha is rated "Possibly Effective" for Anxiety, Generalized anxiety disorder (GAD), Stress.
  • Also on file: Lemon Balm is rated "Insufficient Reliable Evidence To Rate" for Anxiety.

Evidence for 5-HTP shows it's possibly effective for depression, though the data is limited. L-theanine is possibly effective for cognitive function but lacks solid evidence for anxiety or age-related memory decline.

Ashwagandha has the strongest data here—it's possibly effective for insomnia, anxiety, stress, and generalized anxiety disorder (GAD). Lemon balm is possibly effective for stress, depression, and cold sores.

The product combines ingredients with some research support, but the overall effectiveness for the blend as sold here isn't formally tested.

The evidence, ingredient by ingredient 5-htp Theanine Ashwagandha Lemon Balm

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

5-HTP is generally well tolerated short-term, but the safety data advises against use during pregnancy and breastfeeding. Common side effects include abdominal pain, nausea, vomiting, dizziness, drowsiness, diarrhea, and headache—these tend to be dose-related.

Rare serious effects include aggression, hallucinations, and mania. L-theanine is generally well tolerated in healthy adults for short-term use, though long-term safety hasn't been thoroughly studied.

The main reported side effect is headache; some people also report drowsiness or increased dream activity. Ashwagandha is generally well tolerated short-term but carries pregnancy warnings due to concern about miscarriage, and safety data during breastfeeding is limited.

Most common side effects are mild gastrointestinal upset; rare serious effects include acute liver failure. Lemon balm is generally well tolerated for short-term use.

There's limited safety information for pregnancy, and breastfeeding requires caution—talk to your doctor or pharmacist before use if you're nursing.

Side effects, ingredient by ingredient 5-htp Theanine Ashwagandha Lemon Balm

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Lemon Balm, 5-htp, Ashwagandha, Theanine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs; diabetes medications; Parkinson's medications.
  • For scale: 1,377 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this, double-check any serotonergic drugs like antidepressants (SSRIs, SNRIs) and certain pain relievers—5-HTP and L-theanine carry Moderate risk with these. Also check CNS depressants (sedatives, sleep aids, anxiety medications, opioids, alcohol)—all four ingredients can add to drowsiness at Moderate or Minor severity.

If you take antihypertensive drugs (blood pressure medications), benzodiazepines (like Valium or Klonopin), antidiabetes drugs, thyroid hormone, or immunosuppressants, run those through the checker too—ashwagandha has Moderate interactions with all of them, and theanine and lemon balm affect blood pressure drugs. Talk to your pharmacist or doctor before starting.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with stress and sleep if you're looking for a multi-ingredient herbal blend, but it's important to check it against any medications you take—especially blood pressure drugs, sedatives, antidepressants, diabetes medications, thyroid medications, or anti-anxiety prescriptions. If you're pregnant, planning to become pregnant, or breastfeeding, talk with your pharmacist or doctor first.

Start with the interaction checker on this page to see your specific medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Relax+ Ultimate Calm, straight from the product label.

Brand Natrol
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Nov 22, 2022
DSLD ID 274757
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Relax+ Ultimate Calm by Natrol, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
IngredientAmount% DV
5-HTP100 mg--
L-Theanine200 mg--
Sensoril Ashwagandha root and leaf extract125 mg--
Lemon Balm extract3 mg--

Other ingredients: Hypromellose, Maltodextrin, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Reduces occasional stress, anxiety & tension Feel calm and balanced

100% drug free

Natrol Relax+ helps you better manage your stress Reduce stress Relaxed mood Feel balanced Feel calm

No: Milk, Egg, Fish, Crustacean Shellfish, Tree Nuts, Peanuts, Wheat, Soybeans, Yeast, Artificial Colors or Flavors, Added Sugar or Preservatives.

Fast acting formula to manage daily stress

Non-habit forming

Vegetarian

General Statements

New name Same product Money back guarantee

Relax+ will get you on your way to a much better day.

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Suggested/Recommended/Usage/Directions

Directions: Take 1 capsule daily with or without food.

Storage

Store in a cool, dry place.

Precautions

Keep out of reach of children.

Warning: Consult your healthcare professional prior to use if you have or suspect a medical condition, are taking prescription drugs. Do not use if you are pregnant, lactating or under the age of 18 years.

Warning: Consult your healthcare professional prior to use if you have or suspect a medical condition, are taking prescription drugs. Do not use if you are pregnant, lactating or under the age of 18 years.

Brand IP Statement(s)

Sensoril is a registered trademark or Natreon, Inc.

Formula

Helps reduce occasional stress, anxiety and tension. It is specially formulated with a blend of calming herbals that help you feel calm and balanced throughout the day. Ashwagandha 5-HTP L-Theanine Lemon Balm

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Relax+ Ultimate Calm by Natrol label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Relax+ Ultimate Calm label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Relax+ Ultimate Calm by Natrol

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

5-HTP

Interacts with
398 drugs
100 mg per serving Form: Griffonia simplicifolia

5-HTP is a compound your body uses to make serotonin, and people take it as a supplement hoping to improve mood, sleep, and headaches. Some early rese...

5-HTP monograph & interactions

L-Theanine

Interacts with
565 drugs
200 mg per serving

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong dro...

L-Theanine monograph & interactions

Sensoril Ashwagandha root and leaf extract

Interacts with
1,372 drugs
125 mg per serving Form: Withanolides

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evid...

Sensoril Ashwagandha root and leaf extract monograph & interactions

Lemon Balm extract

Interacts with
264 drugs
3 mg per serving

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold so...

Lemon Balm extract monograph & interactions

Other (inactive) ingredients: Hypromellose, Maltodextrin, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Relax+ Ultimate Calm by Natrol Drug Interactions

Want to check YOUR meds against Relax+ Ultimate Calm?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,376Drugs
1,044 Moderate 332 Minor

Ingredients driving the most interactions

Sensoril Ashwagandha root and leaf extract 1,372
L-Theanine 565
5-HTP 398
Lemon Balm extract 264

Individual Drug Interactions

The ingredients in Relax+ Ultimate Calm interact with 1,376 drugs. Click any drug to see the details.

4 of the 4 ingredients in Relax+ Ultimate Calm interact with drugs. Each result below shows which ingredient is responsible. Sensoril Ashwagandha root and leaf extract L-Theanine 5-HTP Lemon Balm extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Relax+ Ultimate Calm with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sensoril Ashwagandha root and leaf extract10 drug types · 1,372 drugs

Antidiabetes Drugs

Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
There is preliminary clinical evidence suggesting that ashwagandha might lower blood glucose levels. Theoretically, ashwagandha might have additive effects when used with antidiabetes drugs and increase the risk of hypoglycemia.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.

Likelihood Possible Evidence D
Benzodiazepines

Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
There is preliminary evidence that ashwagandha might have an additive effect with diazepam (Valium) and clonazepam (Klonopin). This may also occur with other benzodiazepines.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Ashwagandha seems to have sedative effects. Theoretically, this may potentiate the effects of barbiturates, other sedatives, and anxiolytics.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Ashwagandha has been linked to cases of acute hepatitis, liver failure, hepatic encephalopathy, autoimmune hepatitis, the need for liver transplantation, and death due to liver failure.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Ashwagandha has demonstrated immunostimulant effects in humans. Animal research has shown that ashwagandha can attenuate the immunosuppression caused by cyclophosphamide.

Likelihood Possible Evidence D
Thyroid Hormone

Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Concomitant use of ashwagandha with thyroid hormones may cause additive therapeutic and adverse effects. Preliminary clinical research and animal studies suggest that ashwagandha boosts thyroid hormone synthesis and secretion. In one clinical study, ashwagandha increased triiodothyronine (T3) and thyroxine (T4) levels by 41.5% and 19.6%, respectively, and reduced serum TSH levels by 17.4% from baseline in adults with subclinical hypothyroidism.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that ashwagandha extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that ashwagandha extract induces CYP3A4 enzymes.

Likelihood Possible Evidence D
Serotonergic Drugs

Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors. However, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects, and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs. Nevertheless, due to the lack of extensive studies on the matter and the fact that ashwagandha appears to affect serotonergic pathways, it would be prudent to exercise caution when combining it with drugs that affect serotonin. [References: - Effects of Withania somnifera (Ashwaga ndha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021 Sep 14; 19: 1468–1495. - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/]

Likelihood Possible Evidence C
Sensoril Ashwagandha root and leaf extract full monograph & interactions

L-Theanine3 drug types · 565 drugs

Antihypertensive Drugs

Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.
Animal research shows that theanine can lower blood pressure in spontaneously hypertensive animals. Theoretically, concomitant use of theanine and antihypertensive drugs might potentiate the antihypertensive activity.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Theoretically, theanine may compete with glutamate and/or increase plasma gamma-aminobutyric acid (GABA) levels, which could cause CNS depression. In one clinical study, some subjects taking oral theanine reported drowsiness.

Likelihood Unlikely Evidence D
Serotonergic Drugs

Clinical studies regarding the effects of L-theanine on serotonin levels are conflicting. Some studies suggest it can increase serotonin levels in the brain while others report that it may decrease them. Nevertheless, there have been no reports of l-theanine being a causative agent in serotonergic-related side effects or serotonin syndrome.

Likelihood Unlikely Evidence C
L-Theanine full monograph & interactions

5-HTP3 drug types · 398 drugs

Carbidopa (Lodosyn)

Combining 5-HTP and carbidopa can increase the risk of serotonergic side effects.
Carbidopa is sometimes used with 5-HTP to minimize peripheral 5-HTP metabolism and boost the amount that reaches the brain. However, this combination might also increase the risk of some side effects including hypomania, restlessness, rapid speech, anxiety, insomnia, and aggressiveness. Combining carbidopa and 5-HTP might also increase the risk of scleroderma-like skin changes due to elevated serotonin levels.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
In clinical trials, 5-HTP has been associated with drowsiness and somnolence.

Likelihood Possible Evidence D
Serotonergic Drugs

Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
5-HTP can increase serotonin levels and cause serotonergic effects. Theoretically, combining serotonergic drugs with 5-HTP might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders. However, serotonin syndrome with 5-HTP has not yet been reported in humans. Monitor patients for signs of serotonin syndrome and other serotonergic side effects if using 5-HTP with serotonergic drugs.

Likelihood Possible Evidence D
5-HTP full monograph & interactions

Lemon Balm extract2 drug types · 264 drugs

Cns Depressants

Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Lemon balm seems to have CNS depressant activity in animals and in humans.

Likelihood Possible Evidence B
Thyroid Hormone

Theoretically, lemon balm might interfere with thyroid hormone replacement therapy.
In vitro, constituents of lemon balm extract bind to thyroid stimulating hormone (TSH), preventing TSH receptor-binding and leading to the inhibition of TSH-stimulated adenylate cyclase activity. In animals, lemon balm extract has been shown to decrease levels of circulating TSH and inhibit thyroid secretion.

Likelihood Possible Evidence D
Lemon Balm extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Relax+ Ultimate Calm, from the product label.

Natrol

See all Natrol products
Name
Natrol LLC
City
Chatsworth
State
CA
ZipCode
91311
Phone Number
1-800-262-8765
Web Address
www.natrol.com
Pharmacist Counseling Corner

Relax+ Ultimate Calm by Natrol: Common Questions

Does Relax+ Ultimate Calm by Natrol interact with any medications?
Yes. Based on its ingredients, Relax+ Ultimate Calm has a known interaction with 1,376 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Relax+ Ultimate Calm contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Not recommended. 5-HTP and L-theanine lack safety data and should be avoided in pregnancy. Ashwagandha carries a traditional concern about miscarriage. Lemon balm has limited pregnancy data. During breastfeeding, 5-HTP and ashwagandha should be avoided, and lemon balm requires caution—talk to your doctor or pharmacist for personalized advice.
What are the most common side effects?
From 5-HTP, you might experience stomach upset, nausea, diarrhea, dizziness, drowsiness, or headache—usually dose-related. L-theanine commonly causes headache and drowsiness. Ashwagandha and lemon balm may cause mild gastrointestinal upset. Most of these effects tend to be mild, but starting low and going slow can help.
Will this actually help with anxiety and sleep?
Ashwagandha has the strongest evidence—it's possibly effective for anxiety, stress, and insomnia. Lemon balm is possibly effective for stress. 5-HTP is possibly effective for depression. L-theanine is possibly effective for cognitive function. None of these are guaranteed to work for everyone, so give it time and talk to your pharmacist if you don't see a benefit.
What are these ingredients for?
5-HTP supports serotonin, a mood and sleep chemical. L-theanine is from green tea and may calm the mind. Ashwagandha is an adaptogenic herb used traditionally for stress and rest. Lemon balm is another traditional stress-relief herb. Together, they're meant to work synergistically for relaxation.
How long until this works?
The data we hold doesn't specify how quickly you should expect results. Effects may vary by person and ingredient. Give it consistent use over a few weeks, and if you see no benefit, talk to your pharmacist about whether it's right for you.
Is it safe to take long-term?
Long-term safety for most of these ingredients hasn't been thoroughly studied. All four have solid short-term safety data in healthy adults, but extended use hasn't been validated in clinical trials. Check in with your pharmacist regularly if you're taking this long-term.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Relax+ Ultimate Calm label
Go deeper

The Full Monographs Behind Relax+ Ultimate Calm’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

5-htp

Interacts with 398 drugs

5-HTP is a compound your body uses to make serotonin, and people take it as a supplement hoping to improve mood, sleep, and headaches. Some early research is promising, but the overall evide...

Read the full 5-htp monograph → Herb & supplement monograph

Theanine

Interacts with 565 drugs

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong drowsiness. Early research suggests it may...

Read the full Theanine monograph → Herb & supplement monograph

Ashwagandha

Interacts with 1,372 drugs

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evidence is still limited. It is generally w...

Read the full Ashwagandha monograph → Herb & supplement monograph

Lemon Balm

Interacts with 264 drugs

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold sores. Early studies are promising but gen...

Read the full Lemon Balm monograph →
Sources

Sources & How We Checked

Relax+ Ultimate Calm's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 82 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

5-htp 32 references
  1. Birdsall TC. 5-Hydroxytryptophan: A Clinically-Effective Serotonin Precursor. Altern Med Rev 1998;3:271-80.
  2. Michelson D, Page SW, Casey R, et al. An eosinophilia-myalgia syndrome related disorder associated with exposure to L-5-hydroxytryptophan. J Rheumatol 1994;21:2261-5.
  3. Cangiano C, Ceci F, Cancino A, et al. Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan. Am J Clin Nutr 1992;56:863-7. PubMed
  4. U.S. Food and Drug Administration. Impurities confirmed in dietary supplement 5-hydroxy-L-tryptophan. FDA Talk Paper, August 31, 1998; T98-48.
  5. Sternberg EM, Van Woert MH, Young SN, et al. Development of a scleroderma-like illness during therapy with L-5-hydroxytryptophan and carbidopa. N Engl J Med 1980;303:782-7. PubMed
  6. Poldinger W, Calanchini B, Schwarz W. A functional-dimensional approach to depression: serotonin deficiency as a target syndrome in a comparison of 5-hydroxytryptophan and fluvoxamine. Psychopathology 1991;24:53-81.
  7. Ribeiro CA. L-5-Hydroxytryptophan in the prophylaxis of chronic tension-type headache: a double-blind, randomized, placebo-controlled study. Headache 2000;40:451-6.
  8. U. S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Nutritional Products, Labeling, and Dietary Supplements. Information Paper on L-Tryptophan and 5-hydroxy-L-tryptophan, February 2001.
  9. Singhal AB, Caviness VS, Begleiter AF, et al. Cerebral vasoconstriction and stroke after use of serotonergic drugs. Neurology 2002;58:130-3. PubMed
  10. Johnson KL, Klarskov K, Benson LM, et al. Presence of peak X and related compounds: the reported contaminant in case related 5-hydroxy-L-tryptophan associated with eosinophilia-myalgia syndrome. J Rheumatol 1999;26:2714-7.
  11. Takahashi S, Kondo H, Kato N. Effect of l-5-hydroxytryptophan on brain monoamine metabolism and evaluation of its clinical effect in depressed patients. J Psychiatr Res 1975;12:177-87. PubMed
  12. Iovieno, N., Dalton, E. D., Fava, M., and Mischoulon, D. Second-tier natural antidepressants: review and critique. J Affect.Disord. 2011;130(3):343-357. PubMed
  13. den Boer JA, Westenberg HG. Behavioral, neuroendocrine, and biochemical effects of 5-hydroxytryptophan administration in panic disorder. Psychiatry Res 1990;31:267-78. PubMed
  14. Jangid P, Malik P, Singh P, Sharma M, Gulia AK. Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode. Asian J Psychiatr 2013;6:29-34. PubMed
  15. Ceci F, Cangiano C, Cairella M, et al. The effects of oral 5-hydroxytryptophan administration on feeding behavior in obese adult female subjects. J Neural Transm 1989;76:109-17. PubMed
  16. Angst J, Woggon B, Schoepf J. The treatment of depression with L-5-hydroxytryptophan versus imipramine. Results of two open and one double-blind study. Arch Psychiatr Nervenkr 1977;224:175-86. DOI
  17. Titus F, Dávalos A, Alom J, Codina A. 5-Hydroxytryptophan versus methysergide in the prophylaxis of migraine. Randomized clinical trial. Eur Neurol 1986;25:327-9. PubMed
  18. De Benedittis G, Massei R. Serotonin precursors in chronic primary headache. A double-blind cross-over study with L-5-hydroxytryptophan vs. placebo. J Neurosurg Sci 1985;29:239-48.
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Theanine 6 references
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Ashwagandha 32 references
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Lemon Balm 12 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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