Interactions on record — worth a quick check against your medications. Based on 4 of 5 ingredients. Check your meds →
Dietary supplement

Relaxia Day Calm Fruit Punch Ingredients & Drug Interactions

by Natrol

Relaxia Day Calm Fruit Punch label
See full label image
Gummy Or Jelly Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Relaxia Day Calm Fruit Punch against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Relaxia Day Calm Fruit Punch is a dietary supplement by Natrol with 5 active ingredients. Its ingredients are commonly taken for anxiety and stress, relaxation and calm, sleep support.Based on those ingredients, 617 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Theanine, 5-HTP, Lemon Balm extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Relaxia Day Calm Fruit Punch by Natrol

Ask about any prescription or over-the-counter medication and we check it for interactions with Relaxia Day Calm Fruit Punch by Natrol — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Relaxia Day Calm Fruit Punch by Natrol

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 3 of its 4 active ingredients.

Relaxia Day Calm Fruit Punch contains 4 active ingredients. L-theanine is an amino acid thought to support calm focus.

Sodium is an electrolyte the body needs in small amounts. Lemon balm extract comes from an herb traditionally used for relaxation.

5-HTP is a compound your body makes from the amino acid tryptophan and uses to produce serotonin, a brain chemical linked to mood. The product also contains inactive ingredients—pectin, elderberry, citric acid, natural flavors, sodium citrate, coconut oil, carnauba wax, organic tapioca syrup, and organic cane sugar—which serve as the gummy base, sweeteners, and thickeners.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Calm and reduce daytime stress.
  • We looked for evidence on: Anxiety, Generalized anxiety disorder (GAD), Panic disorder, Stress, Relaxation, Tension relief — and 2 related terms.
  • The strongest evidence on file: Lemon Balm is rated "Possibly Effective" for Stress (Natural Medicines).
  • Also on file: Lemon Balm is rated "Insufficient Reliable Evidence To Rate" for Anxiety.
  • Also on file: 5-htp is rated "Insufficient Reliable Evidence To Rate" for Anxiety, Panic disorder.

Evidence for this product's ingredients is mixed. L-theanine is possibly effective for cognitive function, though evidence for anxiety, age-related cognitive decline, and Alzheimer's disease is insufficient.

Lemon balm extract is possibly effective for cold sores and stress, and possibly effective for depression. 5-HTP is possibly effective for depression but possibly ineffective for Down syndrome, with insufficient evidence for Alzheimer's disease, ADHD, and cerebellar ataxia.

Sodium's effectiveness is rated for cystic fibrosis (likely effective) and amphotericin B–related kidney damage (possibly effective), but these are not typical uses for a daytime calm product.

The evidence, ingredient by ingredient Theanine Sodium Lemon Balm 5-htp

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-theanine is generally well tolerated in healthy adults for short-term use, though long-term safety hasn't been well studied; reported side effects include headaches, drowsiness, and increased dream activity. Sodium is well tolerated at normal dietary amounts, but excess intake is linked to high blood pressure and heart strain—avoid supplemental sodium or very high intake without medical advice.

Lemon balm extract is generally well tolerated for short-term use in healthy adults; dizziness and sedation are reported but don't occur more often than placebo. 5-HTP is generally well tolerated short-term but can cause abdominal pain, nausea, diarrhea, dizziness, drowsiness, headache, and other GI effects, with severity often dose-dependent.

Regarding pregnancy: L-theanine has insufficient safety data and is best avoided. Sodium is listed as possibly unsafe in pregnancy and possibly safe in lactation—talk with your doctor for personalized guidance.

Lemon balm extract has insufficient safety data and is best avoided unless your doctor advises otherwise; limited data exists for breastfeeding, so check with your doctor first. 5-HTP also has insufficient safety data and should be avoided during pregnancy and breastfeeding.

Side effects, ingredient by ingredient Theanine Sodium Lemon Balm 5-htp

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Lemon Balm, 5-htp, Theanine, Sodium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: lithium; Parkinson's medications.
  • For scale: 617 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Relaxia Day Calm Fruit Punch, check with your doctor or pharmacist if you take blood pressure medications (L-theanine and sodium may lower blood pressure further), antidepressants or other serotonergic drugs (5-HTP and L-theanine may interact), sedatives or other central nervous system depressants (L-theanine, lemon balm, and 5-HTP may add to drowsiness), thyroid hormone replacement (lemon balm may interfere), lithium (sodium changes can alter its levels), carbidopa for Parkinson's disease (5-HTP can heighten side effects), or corticosteroids, didanosine, sodium phosphate, tolvaptan, or other sodium-containing drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Relaxia Day Calm Fruit Punch may appeal to people looking for daytime relaxation support through herbal and amino-acid ingredients. However, it's not for you if you take blood pressure medications, antidepressants, sedatives, thyroid medication, lithium, or certain Parkinson's or HIV drugs—and it carries real sodium content that matters if you're managing blood pressure or taking certain other medications.

Talk with your doctor or pharmacist before starting, especially if you're pregnant, breastfeeding, or take any prescription drugs.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 18, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Relaxia Day Calm Fruit Punch, straight from the product label.

Brand Natrol
Barcode (UPC) 047469076900
Net contents 60 Gummy(ies)
Market status On market
Date entered into DSLD Dec 18, 2021
DSLD ID 257107
Product type Other Combinations
Supplement form Gummy Or Jelly
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Relaxia Day Calm Fruit Punch by Natrol, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Gummie(s)
Maximum serving Sizes:
2 Gummie(s)
Servings per container
30
UPC/BARCODE
047469076900
IngredientAmount% DV
Protein0 Gram(s)--
Total Fat0 Gram(s)--
L-Theanine100 mg--
Total Sugars3 Gram(s)--
added Sugars3 Gram(s)6%
Sodium0 mg--
Calories15 Calorie(s)--
Total Carbohydrate4 Gram(s)1%
Lemon Balm extract1 mg--
5-HTP25 mg--

Other ingredients: organic Tapioca Syrup, organic Cane Sugar, Pectin, Elderberry, Citric Acid, Natural Flavors, Sodium Citrate, Coconut Oil, Carnauba Wax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Fast acting formula for daytime stress Feel more calm and relaxed with a soothing blend of 5-HTP, L-Theanine and Lemon Balm. These great tasting gummies will get you on your way to a much better day. 100% drug-free Non-habit forming

Soothes daily stress & tension Promotes feelings of calm

No: milk, egg, fish, crustacean shellfish, tree nuts, wheat, yeast, artificial flavors, preservatives or synthetic dyes.

A sweeter way to get through your day

Non-GMO Gluten Free Gelatin Free No Synthetic dyes No artificial flavors, sweeteners or preservatives

Vegetarian

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Take 2 gummies as needed.

Storage

Store in a cool, dry place.

Precautions

Keep out of reach of children.

Warning: Consult your healthcare professional prior to use if you have or suspect a medical condition, are taking prescription drugs, are pregnant or lactating or under 18 years of age.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Relaxia Day Calm Fruit Punch by Natrol label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Relaxia Day Calm Fruit Punch label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Relaxia Day Calm Fruit Punch by Natrol

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Gummie(s) Dosage formGummy Or Jelly Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Protein

0 Gram(s) per serving

L-Theanine

Interacts with
565 drugs
100 mg per serving

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong dro...

L-Theanine monograph & interactions

Sodium

Interacts with
205 drugs
0 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Lemon Balm extract

Interacts with
264 drugs
1 mg per serving

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold so...

Lemon Balm extract monograph & interactions

5-HTP

Interacts with
398 drugs
25 mg per serving Form: Griffonia simplicifolia

5-HTP is a compound your body uses to make serotonin, and people take it as a supplement hoping to improve mood, sleep, and headaches. Some early rese...

5-HTP monograph & interactions

Other (inactive) ingredients: Organic Tapioca Syrup, Organic Cane Sugar, Pectin, Elderberry, Citric Acid, Natural Flavors, Sodium Citrate, Coconut Oil, Carnauba Wax. These complete the product’s ingredient list but are not active constituents.

Interaction report

Relaxia Day Calm Fruit Punch by Natrol Drug Interactions

Want to check YOUR meds against Relaxia Day Calm Fruit Punch?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
617Drugs
617 Moderate

Ingredients driving the most interactions

L-Theanine 565
5-HTP 398
Lemon Balm extract 264
Sodium 205

Individual Drug Interactions

The ingredients in Relaxia Day Calm Fruit Punch interact with 617 drugs. Click any drug to see the details.

4 of the 5 ingredients in Relaxia Day Calm Fruit Punch interact with drugs. Each result below shows which ingredient is responsible. L-Theanine 5-HTP Lemon Balm extract Sodium

Each ingredient & the kinds of drugs it affects

For each ingredient in Relaxia Day Calm Fruit Punch with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Theanine3 drug types · 565 drugs

Antihypertensive Drugs

Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.
Animal research shows that theanine can lower blood pressure in spontaneously hypertensive animals. Theoretically, concomitant use of theanine and antihypertensive drugs might potentiate the antihypertensive activity.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Theoretically, theanine may compete with glutamate and/or increase plasma gamma-aminobutyric acid (GABA) levels, which could cause CNS depression. In one clinical study, some subjects taking oral theanine reported drowsiness.

Likelihood Unlikely Evidence D
Serotonergic Drugs

Clinical studies regarding the effects of L-theanine on serotonin levels are conflicting. Some studies suggest it can increase serotonin levels in the brain while others report that it may decrease them. Nevertheless, there have been no reports of l-theanine being a causative agent in serotonergic-related side effects or serotonin syndrome.

Likelihood Unlikely Evidence C
L-Theanine full monograph & interactions

5-HTP3 drug types · 398 drugs

Carbidopa (Lodosyn)

Combining 5-HTP and carbidopa can increase the risk of serotonergic side effects.
Carbidopa is sometimes used with 5-HTP to minimize peripheral 5-HTP metabolism and boost the amount that reaches the brain. However, this combination might also increase the risk of some side effects including hypomania, restlessness, rapid speech, anxiety, insomnia, and aggressiveness. Combining carbidopa and 5-HTP might also increase the risk of scleroderma-like skin changes due to elevated serotonin levels.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.
In clinical trials, 5-HTP has been associated with drowsiness and somnolence.

Likelihood Possible Evidence D
Serotonergic Drugs

Combining serotonergic drugs with 5-HTP might cause additive serotonergic effects.
5-HTP can increase serotonin levels and cause serotonergic effects. Theoretically, combining serotonergic drugs with 5-HTP might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders. However, serotonin syndrome with 5-HTP has not yet been reported in humans. Monitor patients for signs of serotonin syndrome and other serotonergic side effects if using 5-HTP with serotonergic drugs.

Likelihood Possible Evidence D
5-HTP full monograph & interactions

Lemon Balm extract2 drug types · 264 drugs

Cns Depressants

Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Lemon balm seems to have CNS depressant activity in animals and in humans.

Likelihood Possible Evidence B
Thyroid Hormone

Theoretically, lemon balm might interfere with thyroid hormone replacement therapy.
In vitro, constituents of lemon balm extract bind to thyroid stimulating hormone (TSH), preventing TSH receptor-binding and leading to the inhibition of TSH-stimulated adenylate cyclase activity. In animals, lemon balm extract has been shown to decrease levels of circulating TSH and inhibit thyroid secretion.

Likelihood Possible Evidence D
Lemon Balm extract full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Relaxia Day Calm Fruit Punch, from the product label.

Natrol

See all Natrol products
Name
Natrol LLC
City
Chatsworth
State
CA
ZipCode
91311
Phone Number
1-800-262-8765
Web Address
www.natrol.com
Pharmacist Counseling Corner

Relaxia Day Calm Fruit Punch by Natrol: Common Questions

Does Relaxia Day Calm Fruit Punch by Natrol interact with any medications?
Yes. Based on its ingredients, Relaxia Day Calm Fruit Punch has a known interaction with 617 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Relaxia Day Calm Fruit Punch contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take while I'm pregnant?
The safety data for all four active ingredients—L-theanine, sodium, lemon balm extract, and 5-HTP—is not sufficient to recommend use during pregnancy. Talk with your doctor or pharmacist about whether this product is right for you while pregnant; they can weigh the risks and benefits for your specific situation.
Can I take this if I breastfeed?
L-theanine, lemon balm extract, and 5-HTP all have insufficient safety data for breastfeeding. Sodium has limited information as well. Check with your doctor or pharmacist before taking this product while breastfeeding to make sure it's safe for you and your baby.
Will this actually help me feel calm during the day?
L-theanine is possibly effective for cognitive function. Lemon balm extract is possibly effective for stress. 5-HTP is possibly effective for depression. The evidence for all three supporting daytime calm isn't definitive, so results may vary from person to person.
What are the most common side effects?
L-theanine may cause headaches, drowsiness, or increased dream activity. 5-HTP can cause nausea, diarrhea, dizziness, drowsiness, headache, or abdominal pain, especially at higher doses. Lemon balm typically causes no more dizziness or sedation than a placebo in studies.
How much sodium does this product contain?
The product facts provided don't specify the exact amount of sodium per serving. If sodium intake matters to you—for example, if you have high blood pressure or take blood pressure medication—check the label or contact the manufacturer to confirm the dose.
Is this product safe to use long-term?
Long-term safety for L-theanine, lemon balm extract, and 5-HTP is not well studied. The data we have focuses on short-term use in healthy adults. If you plan to take this regularly over weeks or months, talk with your doctor or pharmacist first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Relaxia Day Calm Fruit Punch label
Go deeper

The Full Monographs Behind Relaxia Day Calm Fruit Punch’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Theanine

Interacts with 565 drugs

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong drowsiness. Early research suggests it may...

Read the full Theanine monograph → Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Lemon Balm

Interacts with 264 drugs

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold sores. Early studies are promising but gen...

Read the full Lemon Balm monograph → Herb & supplement monograph

5-htp

Interacts with 398 drugs

5-HTP is a compound your body uses to make serotonin, and people take it as a supplement hoping to improve mood, sleep, and headaches. Some early research is promising, but the overall evide...

Read the full 5-htp monograph →
Sources

Sources & How We Checked

Relaxia Day Calm Fruit Punch's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 88 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Theanine 6 references
  1. Yokogoshi H, Kobayashi M. Hypotensive effect of gamma-glutamylethylamide in spontaneously hypertensive rats. Life Sci 1998;62:1065-8.
  2. Haskell, C. F., Kennedy, D. O., Milne, A. L., Wesnes, K. A., and Scholey, A. B. The effects of L-theanine, caffeine and their combination on cognition and mood. Biol.Psychol. 2008;77(2):113-122. PubMed
  3. Yokogoshi, H., Kato, Y., Sagesaka, Y. M., Takihara-Matsuura, T., Kakuda, T., and Takeuchi, N. Reduction effect of theanine on blood pressure and brain 5-hydroxyindoles in spontaneously hypertensive rats. Biosci.Biotechnol.Biochem. 1995;59(4):615-618. PubMed
  4. Lyon MR, Kapoor MP, Juneja LR. The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial. Altern Med Rev. 2011;16(4):348-
  5. Hidese S, Ota M, Wakabayashi C, et al. Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study. Acta Neuropsychiatr 2017;29(2):72-9.
  6. Tsuchiya T, Honda H, Oikawa M, et al. Oral administration of the amino acids cystine and theanine attenuates the adverse events of S-1 adjuvant chemotherapy in gastrointestinal cancer patients. Int J Clin Oncol 2016;21(6):1085-90. PubMed

See these in context on the Theanine monograph →

Sodium 38 references
  1. Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
  2. Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
  3. Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
  4. Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
  5. Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
  6. Alam S, Johnson AG. A meta-analysis of randomised controlled trials (RCT) among healthy normotensive and essential hypertensive elderly patients to determine the effect of high salt (NaCl) diet of blood pressure. J Hum Hypertens 1999;13(6):367-74.
  7. Boudville N, Ward S, Benaroia M, House AA. Increased sodium intake correlates with greater use of antihypertensive agents by subjects with chronic kidney disease. Am J Hypertens 2005;18(10):1300-5. PubMed
  8. Bennett WM. Drug interactions and consequences of sodium restriction. Am J Clin Nutr 1997;65(2 Suppl):678S-681S. PubMed
  9. Okusa MD, Crystal LJ. Clinical manifestations and management of acute lithium intoxication. Am J Med 1994;97(4):383-9. PubMed
  10. Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/openbook.php?record_id=10925. DOI
  11. D'Elia L, Rossi G, Ippolito R, Cappuccio FP, Strazzullo P. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr 2012;31(4):489-98. PubMed
  12. Goldsmith SR. Hyponatremia in heart failure: time for a trial. J Card Fail 2013;19(6):398-400. PubMed
  13. Willocks L, Brettle R, Keen J, Valentine C, Pinching AJ. Formulations of didanosine (ddI) and salt overload. Lancet 1992;339(8786):190.
  14. Chen L, Zhang Z, Chen W, Whelton PK, Appel LJ. Lower Sodium Intake and Risk of Headaches: Results From the Trial of Nonpharmacologic Interventions in the Elderly. Am J Public Health. 2016;106(7):1270-5. PubMed
  15. Cook NR, Appel LJ, Whelton PK. Lower levels of sodium intake and reduced cardiovascular risk. Circulation. 2014;129(9):981-9. PubMed
  16. Cook NR, Appel LJ, Whelton PK. Sodium Intake and All-Cause Mortality Over 20 Years in the Trials of Hypertension Prevention. J Am Coll Cardiol. 2016;68(15):1609-1617. PubMed
  17. Mente A, O'Donnell M, Rangarajan S, et al. Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies. Lancet. 2016;388(10043):465-75. PubMed
  18. Moosavian SP, Haghighatdoost F, Surkan PJ, Azadbakht L. Salt and obesity: a systematic review and meta-analysis of observational studies. Int J Food Sci Nutr. 2017;68(3):265-277. PubMed
  19. O'Donnell M, Mente A, Rangarajan S, et al. Urinary sodium and potassium excretion, mortality, and cardiovascular events. N Engl J Med. 2014;371(7):612-23. DOI
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