Major interaction on record — check this product against your medications before combining. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

RNA/DNA 100/100 Ingredients & Drug Interactions

by Solgar

RNA/DNA 100/100 label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking RNA/DNA 100/100 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

RNA/DNA 100/100 is a dietary supplement by Solgar with 3 active ingredients. Its ingredients are commonly taken for source of b vitamins, diarrhea (certain types), cold and flu support.Based on those ingredients, 136 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Debittered Brewer's Yeast. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against RNA/DNA 100/100 by Solgar

Ask about any prescription or over-the-counter medication and we check it for interactions with RNA/DNA 100/100 by Solgar — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of RNA/DNA 100/100 by Solgar

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 3 active ingredients: DNA, RNA, and debittered brewer's yeast. DNA and RNA are nucleic acids — the molecules that carry genetic instructions in cells.

Brewer's yeast is a type of fungus used as a nutritional supplement, usually debittered (processed to remove harsh flavor) and often rich in B vitamins and minerals. The tablet also contains inactive ingredients: vegetable cellulose, stearic acid, and silica, which are standard binders and fillers that help hold the tablet together.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Brewer's Yeast's overall clinical evidence instead.

Moderate

Some clinical evidence supports Brewer's Yeast for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Irritable bowel syndrome (IBS) — rated "Possibly Effective" (Natural Medicines).

For brewer's yeast, the evidence shows it's possibly effective for irritable bowel syndrome (IBS). For other conditions — Clostridioides difficile infection, influenza, high cholesterol (hypercholesterolemia), and hay fever (allergic rhinitis) — the evidence we hold is insufficient to rate whether it works.

We have no effectiveness data in our records for the DNA and RNA ingredients in this product.

The evidence, ingredient by ingredient Brewer's Yeast

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Brewer's yeast is generally well tolerated in food amounts, though it can cause gas and flatulence. In concentrated supplement doses, the most common side effects are flatulence and migraine-type headaches in sensitive people.

Rare but serious concerns include fungemia (a fungal infection in the bloodstream) and anaphylaxis in people with yeast sensitivity. The safety of concentrated brewer's yeast supplements during pregnancy and breastfeeding hasn't been well studied, so there isn't enough data to know either way — talk with your doctor or pharmacist about whether it's right for you if you're pregnant or nursing.

People with weakened immune systems should be cautious.

Side effects, ingredient by ingredient Brewer's Yeast

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Brewer's Yeast.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 136 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you're on an MAOI antidepressant (the most serious risk is a blood pressure spike), an antidiabetes medication (increased low blood sugar risk), lithium, or an antifungal drug. Also mention this product if you have a weakened immune system or a history of yeast sensitivity.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.

If you have IBS and want to try brewer's yeast as a supplement, this product may be worth discussing with your doctor. If you take an MAOI antidepressant, an antidiabetes drug, lithium, or an antifungal, check your specific medications before starting, because this product's brewer's yeast content can interact with them.

Talk it over with your doctor or pharmacist before you begin.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about RNA/DNA 100/100, straight from the product label.

Brand Solgar
Barcode (UPC) 033984023215
Net contents 250 Tablet(s)
Market status On market
Date entered into DSLD Mar 24, 2020
DSLD ID 214910
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for RNA/DNA 100/100 by Solgar, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
033984023215
IngredientAmount% DV
DNA100 mg--
RNA100 mg--
Debittered Brewer's Yeast525 mg--

Other ingredients: Vegetable Cellulose, Stearic Acid, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Solgar's RNA/DNA tablets are free of corn, soy and dairy products and are formulated without the use of artificial preservatives, flavors or colors.

Sugar, salt and starch free

Storage

To assure freshness and potency, store at room temperature 59 degrees-86 degrees F (15 degrees-30 degrees C). Store away from heat, light and moisture.

Precautions

Do not use if outer bottle seal is missing, torn or damaged in any way.

Contains fish and wheat. Brewer's Yeast is derived from wheat.

If you are pregnant, nursing, taking any medication or have a medical condition, please consult your healthcare practitioner before taking any dietary supplement.

Keep out of reach of children.

General Statements

Solgar since 1947

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement for adults, take one (1) tablet daily, preferably at mealtime, or as directed by a healthcare practitioner.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

RNA/DNA 100/100 by Solgar label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

RNA/DNA 100/100 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in RNA/DNA 100/100 by Solgar

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

DNA

100 mg per serving

RNA

100 mg per serving

Debittered Brewer's Yeast

Interacts with
136 drugs
525 mg per serving

Brewer's yeast is a nutrient-rich fungus that provides B vitamins, protein, and minerals, and a related yeast product (S. boulardii) is used for some...

Debittered Brewer's Yeast monograph & interactions

Other (inactive) ingredients: Vegetable Cellulose, Stearic Acid, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

RNA/DNA 100/100 by Solgar Drug Interactions

Want to check YOUR meds against RNA/DNA 100/100?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
136Drugs
9 Major 87 Moderate 40 Minor

Ingredients driving the most interactions

Debittered Brewer's Yeast 136

Individual Drug Interactions

The ingredients in RNA/DNA 100/100 interact with 136 drugs. Click any drug to see the details.

1 of the 3 ingredients in RNA/DNA 100/100 interact with drugs. Each result below shows which ingredient is responsible. Debittered Brewer's Yeast

Each ingredient & the kinds of drugs it affects

For each ingredient in RNA/DNA 100/100 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Debittered Brewer's Yeast4 drug types · 136 drugs

Monoamine Oxidase Inhibitors (Maois)

Theoretically, taking brewer's yeast with MAOIs might increase the risk of hypertension.
Brewer's yeast contains tyramine. Taking brewer's yeast with MAOIs might increase the risk for hypertensive crisis.

Likelihood Likely Evidence D
Antidiabetes Drugs

Taking brewer's yeast with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking chromium-containing brewer's yeast can decrease levels of blood glucose in diabetic patients being treated with antidiabetes drugs.

Likelihood Possible Evidence B
Lithium

Theoretically, taking brewer's yeast with lithium might cause additive effects and side effects.
Some brewer's yeast products contains lithium.

Likelihood Possible Evidence D
Antifungals

Theoretically, taking antifungals with some brewer's yeast products might decrease the effectiveness of brewer's yeast.
Some brewer's yeast products contain live yeast. Therefore, simultaneously taking antifungals might kill a significant number of the organisms.

Likelihood Possible Evidence D
Debittered Brewer's Yeast full monograph & interactions
The maker

Brand information

Manufacturer and brand details for RNA/DNA 100/100, from the product label.

Solgar

See all Solgar products
Name
Solgar Vitamin and Herb
City
Leonia
State
N.J.
ZipCode
07605
Phone Number
1-877-765-4274
Web Address
www.solgar.com
Pharmacist Counseling Corner

RNA/DNA 100/100 by Solgar: Common Questions

Does RNA/DNA 100/100 by Solgar interact with any medications?
Yes. Based on its ingredients, RNA/DNA 100/100 has a known interaction with 136 medications, including 9 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
RNA/DNA 100/100 contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product actually do anything?
Brewer's yeast in this product is possibly effective for irritable bowel syndrome (IBS). For other conditions like high cholesterol, hay fever, or fungal infections, we don't have enough evidence to know if it works. We have no effectiveness data on the DNA and RNA ingredients.
Will it give me gas?
Yes, flatulence and gas are the most common side effects people report with brewer's yeast supplements. A small number of people also get migraine-type headaches. These effects are usually mild, but if you're sensitive to yeast products, you might experience more intestinal discomfort.
Is it safe if I'm pregnant or breastfeeding?
We don't have enough data on how concentrated brewer's yeast supplements affect pregnancy and breastfeeding. Food amounts are likely fine, but supplement doses haven't been well studied. Talk with your doctor or pharmacist for personalized advice.
What's in this tablet besides the active ingredients?
The inactive ingredients are vegetable cellulose, stearic acid, and silica — standard binders and fillers that help hold the tablet together.
Why can't you check DNA and RNA for interactions?
We don't hold interaction data for those ingredients in our records, so we can't tell you whether they interact with medications. The brewer's yeast content is what we have information on.
What is debittered brewer's yeast?
Brewer's yeast is a fungus used in brewing beer and as a nutritional supplement. Debittered means it's been processed to remove the harsh, bitter flavor so it's easier to take as a supplement. It's naturally rich in B vitamins and minerals.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if RNA/DNA 100/100 is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

RNA/DNA 100/100 label
Go deeper

The Full Monographs Behind RNA/DNA 100/100’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Brewer's Yeast

Interacts with 136 drugs

Brewer's yeast is a nutrient-rich fungus that provides B vitamins, protein, and minerals, and a related yeast product (S. boulardii) is used for some types of diarrhea. Most other health cla...

Read the full Brewer's Yeast monograph →
Sources

Sources & How We Checked

RNA/DNA 100/100's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Brewer's Yeast 6 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Lewis SJ, Freedman AR. Review article: the use of biotherapeutic agents in the prevention and treatment of gastrointestinal disease. Aliment Pharmacol Ther 1998;12:807-22. PubMed
  3. Bahijiri, S. M., Mira, S. A., Mufti, A. M., and Ajabnoor, M. A. The effects of inorganic chromium and brewer's yeast supplementation on glucose tolerance, serum lipids and drug dosage in individuals with type 2 diabetes. Saudi.Med.J. 2000;21(9):831-837. DOI
  4. Schrauzer, G. N. and de, Vroey E. Effects of nutritional lithium supplementation on mood. A placebo-controlled study with former drug users. Biol.Trace Elem.Res. 1994;40(1):89-101. PubMed
  5. Gayathri R, Aruna T, Malar S, Shilpa B, Dhanasekar KR. Efficacy of Saccharomyces cerevisiae CNCM I-3856 as an add-on therapy for irritable bowel syndrome. Int J Colorectal Dis. 2020;35(1):139-145. PubMed
  6. Mourey F, Decherf A, Jeanne JF, et al. Saccharomyces cerevisiae I-3856 in irritable bowel syndrome with predominant constipation. World J Gastroenterol 2022;28(22):2509-2522.

See these in context on the Brewer's Yeast monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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