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Dietary supplement

Rutin 250 mg Ingredients & Drug Interactions

by KAL

Rutin 250 mg label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Rutin 250 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Rutin 250 mg is a dietary supplement by KAL with 1 active ingredient. Its ingredients are commonly taken for varicose veins and chronic venous insufficiency, hemorrhoids, easy bruising and fragile capillaries.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Rutin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Rutin 250 mg by KAL

Ask about any prescription or over-the-counter medication and we check it for interactions with Rutin 250 mg by KAL — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Rutin 250 mg by KAL

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: rutin, a flavonoid compound that occurs naturally in plants and some foods. The tablet also includes several inactive ingredients—cellulose, dicalcium phosphate, stearic acid, magnesium stearate, and silica—which serve as binders, fillers, and flow agents to hold the pill together and make it easy to swallow.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Rutin's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: capillary strength and vitamin C support.
  • We looked for evidence on: Hemorrhoids, Varicose veins, easy bruising, fragile capillaries, chronic venous insufficiency.
  • The closest evidence on file: Rutin is rated "Insufficient Reliable Evidence To Rate" for Hemorrhoids (Natural Medicines).
  • Also on file: Rutin is rated "Insufficient Reliable Evidence To Rate" for Varicose veins.

The evidence we hold does not establish that rutin works for any of the conditions people use it for, including aging skin, autism spectrum disorder, inflammatory bowel disease, diabetes, exercise-related respiratory infections, or hemorrhoids. For each of these uses, the rating is insufficient reliable evidence—meaning either very few studies exist, the studies are small or poor quality, or the results don't point in one direction.

That doesn't mean rutin is ineffective; it means we don't yet have solid proof either way.

The evidence, ingredient by ingredient Rutin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Rutin is generally well tolerated in food and when taken as a short-term supplement, but long-term safety data at supplement doses are limited. The most common side effects from oral rutin include headache in some people, and flushing or rashes in others.

Safety during pregnancy has a rating of likely safe, but not enough safety data exists for supplement doses during breastfeeding, so the recommendation is to avoid it unless your doctor advises otherwise.

Side effects, ingredient by ingredient Rutin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Rutin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take any antidiabetes drugs—including insulin, metformin, sulfonylureas, or other glucose-lowering medicines—check with your doctor or pharmacist before starting rutin. The moderate risk is that it could lower your blood sugar more than intended.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Rutin 250 mg may be worth considering if you're looking to experiment with a flavonoid that early research has touched on, but the evidence for any specific use is not established. The main caution is if you take diabetes medication—you'll need to talk with your doctor or pharmacist first, because rutin might lower your blood sugar further.

For any other health condition or medication question, check it over with your healthcare provider before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 23, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Rutin 250 mg, straight from the product label.

Brand KAL
Barcode (UPC) 021245883067
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD Oct 23, 2019
DSLD ID 103348
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Rutin 250 mg by KAL, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
021245883067
IngredientAmount% DV
Rutin250 mg--

Other ingredients: Cellulose, Dicalcium Phosphate, Stearic Acid, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Innovative quality Since 1932

ActivTab technology guarantees tablet disintegration within 30 minutes according to USP standards.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

1 Daily

Formulation

Wheat-Free

Vegetarian

Vegetarian formula.

KAL Guarantees that no ingredients other than those listed on this label have been added to this product.

Seals/Symbols

Clear Quality

Formula

Discussion: Rutin is a bioflavonoid that is intended to provide nutritive support for the strength of capillaries. It is also intended to provide nutritive support for proper absorption and usage of Vitamin C.

Brand IP Statement(s)

2009

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Rutin 250 mg by KAL label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Rutin 250 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Rutin 250 mg by KAL

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Rutin

Interacts with
86 drugs
250 mg per serving

Rutin is a plant flavonoid (often taken from buckwheat or citrus) that people use mainly for blood vessel and circulation problems like varicose veins...

Rutin monograph & interactions

Other (inactive) ingredients: Cellulose, Dicalcium Phosphate, Stearic Acid, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Rutin 250 mg by KAL Drug Interactions

Want to check YOUR meds against Rutin 250 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Rutin 86

Individual Drug Interactions

The ingredients in Rutin 250 mg interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Rutin 250 mg interact with drugs. Each result below shows which ingredient is responsible. Rutin

Each ingredient & the kinds of drugs it affects

For each ingredient in Rutin 250 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Rutin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking rutin with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that rutin has hypoglycemic effects.

Likelihood Possible Evidence D
Rutin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Rutin 250 mg, from the product label.

KAL

See all KAL products
Name
KAL
City
Park City
State
UT
ZipCode
84060
Phone Number
(800) 365-5966
Web Address
www.kalvitamins.com
Pharmacist Counseling Corner

Rutin 250 mg by KAL: Common Questions

Does Rutin 250 mg by KAL interact with any medications?
Yes. Based on its ingredients, Rutin 250 mg has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Rutin 250 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Pregnancy is rated likely safe, so you have some reassurance there. Breastfeeding safety is unknown at supplement doses, so the data suggests avoiding it unless your doctor advises otherwise. Either way, it's best to talk with your doctor or pharmacist before starting.
What side effects might I get from rutin?
Headache is the most common one we see in the data. Some people also report flushing (redness or warmth in the face and neck) or rashes. These aren't guaranteed—many people take it without trouble—but they're worth knowing about.
Does rutin actually work for any condition?
The evidence we hold doesn't establish that it works for aging skin, diabetes, hemorrhoids, inflammatory bowel disease, autism, or exercise-related infections. That means either very few studies exist, the studies are small, or the results aren't clear. It's an open question, but we can't say yet that it's proven.
Why does the label say to avoid this during breastfeeding?
There simply isn't enough safety data on rutin supplements during breastfeeding to know whether it's okay. To be cautious, the recommendation is to skip it at supplement doses unless your doctor tells you otherwise.
Is rutin safe to take long-term?
Rutin is generally well tolerated from food and in short-term supplement use, but we don't have high-quality safety data for long-term use at supplement doses. If you're thinking of taking it regularly, discuss that with your doctor or pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Rutin 250 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Rutin 250 mg label
Go deeper

The Full Monographs Behind Rutin 250 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Rutin

Interacts with 86 drugs

Rutin is a plant flavonoid (often taken from buckwheat or citrus) that people use mainly for blood vessel and circulation problems like varicose veins and hemorrhoids. The evidence is limite...

Read the full Rutin monograph →
Sources

Sources & How We Checked

Rutin 250 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Rutin 2 references
  1. Mehta DK (Ex Ed). British National Formulary, Number 37. British Medical Association and Royal Pharmaceutical Society of Great Britain: London, England, March 1999.
  2. Sun C, Wang L, Sun J, Wang Z, Tang Z. Hypoglycemic and hypolipidemic effects of rutin on hyperglycemic rats. J Tradit Chin Med. 2020;40(4):640-645.

See these in context on the Rutin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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