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Dietary supplement

Rutin 250 mg Ingredients & Drug Interactions

by KAL

Rutin 250 mg label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Rutin 250 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Rutin 250 mg is a dietary supplement by KAL with 1 active ingredient. Its ingredients are commonly taken for varicose veins and chronic venous insufficiency, hemorrhoids, easy bruising and fragile capillaries.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Rutin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Rutin 250 mg by KAL

Ask about any prescription or over-the-counter medication and we check it for interactions with Rutin 250 mg by KAL — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Rutin 250 mg by KAL

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: rutin 250 mg per tablet. Rutin is a bioflavonoid — a plant compound found in foods like apples, berries, and onions.

The tablet also includes inactive ingredients (cellulose, dicalcium phosphate, stearic acid, magnesium stearate, and silica) that help form and stabilize the pill.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Rutin's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: nutritive support for capillary strength and vitamin C usage.
  • We looked for evidence on: Hemorrhoids, Varicose veins, Postoperative swelling, capillary fragility, easy bruising, edema.
  • The closest evidence on file: Rutin is rated "Insufficient Reliable Evidence To Rate" for Hemorrhoids (Natural Medicines).
  • Also on file: Rutin is rated "Insufficient Reliable Evidence To Rate" for Lymphedema, Varicose veins, Postoperative swelling.

The evidence for rutin isn't established in the data we hold. The product has been studied for aging skin, autism spectrum disorder, inflammatory bowel disease, diabetes, exercise-induced respiratory infections, and hemorrhoids, but our data show insufficient reliable evidence to rate it for any of those uses.

That doesn't mean it doesn't work — it means the clinical evidence isn't there yet to say one way or the other.

The evidence, ingredient by ingredient Rutin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Rutin is generally well tolerated in food and short-term supplement use, though long-term safety data at supplement doses are limited. Some people may experience headache, flushing, or rashes when taking it orally.

Because safety data for supplement doses during pregnancy are limited, the data advise caution; for breastfeeding, there isn't enough information, so avoid supplement doses unless your doctor advises otherwise.

Side effects, ingredient by ingredient Rutin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Rutin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Antidiabetes drugs are the main category to double-check. If you take any medication to lower blood sugar — whether insulin, metformin, sulfonylureas, or another class — verify it with your pharmacist before you start, because rutin may increase the risk of low blood sugar.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Rutin may be worth considering if you're interested in exploring a bioflavonoid supplement, but the evidence for its effectiveness isn't established yet. If you take diabetes medication, talk to your pharmacist or doctor first — the interaction with blood sugar control is real and worth checking against your specific drugs.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 23, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Rutin 250 mg, straight from the product label.

Brand KAL
Barcode (UPC) 021245883067
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD Oct 23, 2019
DSLD ID 103348
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Rutin 250 mg by KAL, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
021245883067
IngredientAmount% DV
Rutin250 mg--

Other ingredients: Cellulose, Dicalcium Phosphate, Stearic Acid, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Innovative quality Since 1932

ActivTab technology guarantees tablet disintegration within 30 minutes according to USP standards.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

1 Daily

Formulation

Wheat-Free

Vegetarian

Vegetarian formula.

KAL Guarantees that no ingredients other than those listed on this label have been added to this product.

Seals/Symbols

Clear Quality

Formula

Discussion: Rutin is a bioflavonoid that is intended to provide nutritive support for the strength of capillaries. It is also intended to provide nutritive support for proper absorption and usage of Vitamin C.

Brand IP Statement(s)

2009

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Rutin 250 mg by KAL label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Rutin 250 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Rutin 250 mg by KAL

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Rutin

Interacts with
86 drugs
250 mg per serving

Rutin is a plant flavonoid (often taken from buckwheat or citrus) that people use mainly for blood vessel and circulation problems like varicose veins...

Rutin monograph & interactions

Other (inactive) ingredients: Cellulose, Dicalcium Phosphate, Stearic Acid, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Rutin 250 mg by KAL Drug Interactions

Want to check YOUR meds against Rutin 250 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Rutin 86

Individual Drug Interactions

The ingredients in Rutin 250 mg interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Rutin 250 mg interact with drugs. Each result below shows which ingredient is responsible. Rutin

Each ingredient & the kinds of drugs it affects

For each ingredient in Rutin 250 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Rutin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking rutin with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that rutin has hypoglycemic effects.

Likelihood Possible Evidence D
Rutin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Rutin 250 mg, from the product label.

KAL

See all KAL products
Name
KAL
City
Park City
State
UT
ZipCode
84060
Phone Number
(800) 365-5966
Web Address
www.kalvitamins.com
Pharmacist Counseling Corner

Rutin 250 mg by KAL: Common Questions

Does Rutin 250 mg by KAL interact with any medications?
Yes. Based on its ingredients, Rutin 250 mg has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Rutin 250 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
The safety data for rutin at supplement doses during pregnancy are limited, so there isn't enough information to say it's safe or unsafe. Talk with your doctor or pharmacist about whether it's right for you — that's an individual decision they can help you make.
Is it safe while breastfeeding?
There isn't enough data to know whether rutin is safe at supplement doses during breastfeeding. The advice is to avoid it unless your doctor advises otherwise. Check with your pharmacist or doctor for personalized guidance.
What side effects might I notice?
Some people experience headache, flushing, or rashes when taking rutin orally. These aren't guaranteed — many people tolerate it without problems — but if you notice any of those, let your pharmacist know.
Does rutin really work for diabetes?
We don't have enough reliable evidence to say whether rutin helps with diabetes. That's why it matters especially to talk with your doctor if you take diabetes medication — the interaction risk is documented even though its effectiveness isn't proven yet.
What is rutin, exactly?
Rutin is a bioflavonoid, a type of plant compound you'd naturally get from foods like apples, berries, and onions. This supplement gives you a concentrated dose in pill form.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Rutin 250 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Rutin 250 mg label
Go deeper

The Full Monographs Behind Rutin 250 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Rutin

Interacts with 86 drugs

Rutin is a plant flavonoid (often taken from buckwheat or citrus) that people use mainly for blood vessel and circulation problems like varicose veins and hemorrhoids. The evidence is limite...

Read the full Rutin monograph →
Sources

Sources & How We Checked

Rutin 250 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Rutin 2 references
  1. Mehta DK (Ex Ed). British National Formulary, Number 37. British Medical Association and Royal Pharmaceutical Society of Great Britain: London, England, March 1999.
  2. Sun C, Wang L, Sun J, Wang Z, Tang Z. Hypoglycemic and hypolipidemic effects of rutin on hyperglycemic rats. J Tradit Chin Med. 2020;40(4):640-645.

See these in context on the Rutin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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