Interactions on record — worth a quick check against your medications. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

SAMe with Vitamins B-6, B-12 and 5-MTHF Ingredients & Drug Interactions

by Designs for Health

SAMe with Vitamins B-6, B-12 and 5-MTHF label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking SAMe with Vitamins B-6, B-12 and 5-MTHF against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

SAMe with Vitamins B-6, B-12 and 5-MTHF is a dietary supplement by Designs for Health with 4 active ingredients. Its ingredients are commonly taken for treating or preventing b12 deficiency, pernicious anemia, low energy and fatigue.Based on those ingredients, 414 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin B-6, SAMe, Vitamin B12. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against SAMe with Vitamins B-6, B-12 and 5-MTHF by Designs for Health

Ask about any prescription or over-the-counter medication and we check it for interactions with SAMe with Vitamins B-6, B-12 and 5-MTHF by Designs for Health — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of SAMe with Vitamins B-6, B-12 and 5-MTHF by Designs for Health

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 4 active ingredients. Vitamin B-12 supports nerve and blood cell health and is used when your body can't absorb it well from food or has a deficiency.

Vitamin B-6 helps your body use amino acids and create neurotransmitters; it's important for brain function and immune health. Folate (the 5-MTHF form) is a B vitamin your body uses for DNA synthesis and cell division, and this form is already in the active shape your body uses.

SAMe (S-adenosylmethionine) is a compound your cells make naturally and use in hundreds of chemical reactions, particularly those involving mood, joint health, and liver function. The inactive ingredients are microcrystalline cellulose, vegetable stearate, calcium chloride anhydrous, and calcium oxide—these are fillers and capsule materials.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Sideroblastic anemia — rated "Effective" (Vitamin B6) (Natural Medicines).
  • On file: Imerslund-Grasbeck disease — rated "Effective" (Vitamin B12) (Natural Medicines).
  • On file: Vitamin B12 deficiency — rated "Effective" (Vitamin B12) (Natural Medicines).
  • On file: Vitamin B6 deficiency — rated "Effective" (Vitamin B6) (Natural Medicines).
  • On file: Pyridoxine-dependent epilepsy — rated "Effective" (Vitamin B6) (Natural Medicines).

Vitamin B-12 is effective for treating B-12 deficiency, a condition called Imerslund-Grasbeck disease, and cyanide poisoning; it's also possibly effective for canker sores and nerve pain after shingles. Vitamin B-6 is effective for sideroblastic anemia (a blood disorder), B-6 deficiency, and a seizure condition called pyridoxine-dependent epilepsy; it's likely effective for lowering homocysteine (a risk marker) and possibly effective for pregnancy-related nausea and vomiting.

SAMe is likely effective for osteoarthritis and possibly effective for depression and cholestasis (bile duct disease). For Alzheimer disease and ADHD, the evidence we hold on file is insufficient to rate whether it works.

Folate's effectiveness data is not on file with us.

The evidence, ingredient by ingredient Vitamin B12 Vitamin B6 Same

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B-12 is generally very safe—your body removes excess in the urine, and there's no established upper limit. It's safe at normal recommended amounts during pregnancy and breastfeeding.

Vitamin B-6 is well tolerated at doses under 100 mg daily, but high doses over time can damage nerves (sensory neuropathy). It's used during pregnancy for morning sickness but only under a doctor's guidance, and normal dietary amounts are fine during breastfeeding.

SAMe is often well tolerated short-term but can cause stomach upset (nausea, constipation, diarrhea, heartburn), dizziness, headache, insomnia, and nervousness, especially at higher doses. It may trigger mania in people with bipolar disorder.

Safety during pregnancy is possibly safe, but safety during breastfeeding is not well established. The safety profile of folate is not on file with us.

Side effects, ingredient by ingredient Vitamin B12 Vitamin B6 Same

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Same, Vitamin B12, Vitamin B6.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: Parkinson's medications.
  • For scale: 414 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check with your doctor or pharmacist before taking this product if you're on serotonergic drugs like antidepressants (risk of serotonin syndrome), antihypertensive medications (additive blood-pressure lowering), amiodarone (increased sun sensitivity), seizure medications like phenobarbital or phenytoin (reduced drug levels), levodopa for Parkinson disease, or metformin for diabetes. No interactions are documented for folate, the 5-MTHF form in this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help if you have B-12 or B-6 deficiency, osteoarthritis, or depression (though the depression evidence for SAMe is modest). If you take antidepressants, blood pressure medications, seizure medications, heart rhythm drugs, metformin, or levodopa, you need to check with your doctor or pharmacist before starting—interactions are real and could affect how your medications work.

Talk it over with your own healthcare provider to see if this is right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about SAMe with Vitamins B-6, B-12 and 5-MTHF, straight from the product label.

Brand Designs for Health
Barcode (UPC) 879452003781
Net contents 30 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jun 25, 2013
DSLD ID 22786
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for SAMe with Vitamins B-6, B-12 and 5-MTHF by Designs for Health, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
879452003781
IngredientAmount% DV
Vitamin B1250 mcg830%
Vitamin B-65 mg250%
Folate100 mcg25%
SAMe200 mg--

Other ingredients: Microcrystalline Cellulose, Vegetable Stearate, Calcium Chloride Anhydrous, Calcium Oxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General

SAM030

Seals/Symbols

MADE WITH NON-GMO INGREDIENTS

Guaranteed GMP COMPLIANT Products

General Statements

Notice: Color, size or shape may appear different between lots.

For Professional Use Only

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommended Use: As a dietary supplement, take one capsule per day, preferably on an empty stomach, or as directed by your health care practitioner.

Storage

STORE IN A COOL, DRY PLACE.

Formulation

Does not contain gluten.

Brand IP Statement(s)

Quatrefolic(R) is a registered trademark of Gnosis S.p.A.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

SAMe with Vitamins B-6, B-12 and 5-MTHF by Designs for Health label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

SAMe with Vitamins B-6, B-12 and 5-MTHF label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in SAMe with Vitamins B-6, B-12 and 5-MTHF by Designs for Health

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B12

Interacts with
20 drugs
50 mcg per serving Form: Methylcobalamin

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

Vitamin B-6

Interacts with
210 drugs
5 mg per serving Form: Pyridoxal 5-Phosphate

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B-6 monograph & interactions

Folate

100 mcg per serving Form: [6s]-5-Methyltetrahydrofolate, Glucosamine Salt

SAMe

Interacts with
189 drugs
200 mg per serving Form: S-Adenosyl-L-Methionine Disulfate P-Toluensulfate

SAM-e is a compound your body makes naturally that is sold as a supplement, most often for depression and osteoarthritis. Some research suggests it ma...

SAMe monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Vegetable Stearate, Calcium Chloride Anhydrous, Calcium Oxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

SAMe with Vitamins B-6, B-12 and 5-MTHF by Designs for Health Drug Interactions

Want to check YOUR meds against SAMe with Vitamins B-6, B-12 and 5-MTHF?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
414Drugs
394 Moderate 20 Minor

Ingredients driving the most interactions

Vitamin B-6 210
SAMe 189
Vitamin B12 20

Individual Drug Interactions

The ingredients in SAMe with Vitamins B-6, B-12 and 5-MTHF interact with 414 drugs. Click any drug to see the details.

3 of the 4 ingredients in SAMe with Vitamins B-6, B-12 and 5-MTHF interact with drugs. Each result below shows which ingredient is responsible. Vitamin B-6 SAMe Vitamin B12

Each ingredient & the kinds of drugs it affects

For each ingredient in SAMe with Vitamins B-6, B-12 and 5-MTHF with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B-65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B-6 full monograph & interactions

SAMe2 drug types · 189 drugs

Levodopa

SAMe might reduce the effectiveness of levodopa.
SAMe methylates levodopa, which might reduce its effectiveness for treating Parkinson disease.

Likelihood Possible Evidence D
Serotonergic Drugs

Taking SAMe with serotonergic drugs might increase the risk of serotonin syndrome and other serotonergic side effects.
SAMe has serotonergic effects. Theoretically, combining serotonergic drugs with SAMe might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders. In one case report, SAMe 100 mg intramuscularly was given daily with clomipramine (Anafranil) 25 mg per day. When the clomipramine dose was increased to 75 mg per day the patient experienced serotonin syndrome about 48-72 hours later, requiring hospitalization.

Likelihood Possible Evidence D
SAMe full monograph & interactions

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for SAMe with Vitamins B-6, B-12 and 5-MTHF, from the product label.

Designs for Health

See all Designs for Health products
Name
Designs for Health, Inc.
Street Address
980 South Street
City
Suffield
State
CT
ZipCode
06078
Web Address
www.designsforhealth.com
Pharmacist Counseling Corner

SAMe with Vitamins B-6, B-12 and 5-MTHF by Designs for Health: Common Questions

Does SAMe with Vitamins B-6, B-12 and 5-MTHF by Designs for Health interact with any medications?
Yes. Based on its ingredients, SAMe with Vitamins B-6, B-12 and 5-MTHF has a known interaction with 414 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
SAMe with Vitamins B-6, B-12 and 5-MTHF contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is it safe to take this if I'm pregnant or breastfeeding?
Vitamin B-12 and B-6 are considered likely safe at normal recommended amounts during pregnancy and breastfeeding. SAMe is possibly safe in pregnancy, but safety during breastfeeding isn't well established. Talk with your doctor or midwife before taking any supplement in pregnancy or while nursing—they can advise what's right for you.
What are the most common side effects?
SAMe most often causes digestive upset—nausea, diarrhea, constipation, heartburn, and loss of appetite—especially at higher doses. Vitamin B-6 can cause headache, nausea, and stomach pain at typical doses. Vitamin B-12 is generally very well tolerated by mouth.
Can high doses of B-6 in this product harm my nerves?
Vitamin B-6 is well tolerated at doses under 100 mg daily. High doses (especially over 1,000 mg daily or sustained over time) can cause sensory neuropathy—a type of nerve damage. The amount in this product and whether it poses nerve risk depends on your total daily B-6 intake from all sources—ask your pharmacist to check your label.
Will this help my depression?
SAMe is possibly effective for depression according to the evidence we hold, but the data isn't as strong as for some other treatments. If you're considering it for depression, discuss it with your doctor—especially if you're already on an antidepressant, because combining them carries a risk of serotonin syndrome.
What is SAMe and why is it in this product?
SAMe (S-adenosylmethionine) is a compound your body makes naturally and uses in hundreds of chemical reactions. It's included here because it's likely effective for osteoarthritis and possibly helpful for depression and liver health (cholestasis).
I'm on metformin for diabetes. Does this product affect it?
Vitamin B-12 in this product has a minor interaction with metformin—metformin can lower your B-12 levels over time by reducing how well you absorb it. If you're on metformin long-term, ask your doctor or pharmacist whether B-12 supplementation makes sense for you and how often you should have your B-12 level checked.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if SAMe with Vitamins B-6, B-12 and 5-MTHF is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

SAMe with Vitamins B-6, B-12 and 5-MTHF label
Go deeper

The Full Monographs Behind SAMe with Vitamins B-6, B-12 and 5-MTHF’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph → Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Same

Interacts with 189 drugs

SAM-e is a compound your body makes naturally that is sold as a supplement, most often for depression and osteoarthritis. Some research suggests it may help with these conditions, but the qu...

Read the full Same monograph →
Sources

Sources & How We Checked

SAMe with Vitamins B-6, B-12 and 5-MTHF's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 93 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B12 30 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  2. Hartman TJ, Woodson K, Stolzenberg-Solomon R, et al. Association of the B-vitamins pyridoxal 5'-phosphate (B6), B12, and folate with lung cancer risk in older men. Am J Epidemiol 2001;153:688-94.. DOI
  3. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  4. Lange H, Suryapranata H, De Luca G, et al. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med 2004;350:2673-81. PubMed
  5. Collin, S. M., Metcalfe, C., Refsum, H., Lewis, S. J., Zuccolo, L., Smith, G. D., Chen, L., Harris, R., Davis, M., Marsden, G., Johnston, C., Lane, J. A., Ebbing, M., Bonaa, K. H., Nygard, O., Ueland, P. M., Grau, M. V., Baron, J. A., Donovan, J. L., Nea
  6. Geissbuhler, P., Mermillod, B., and Rapin, C. H. Elevated serum vitamin B12 levels associated with CRP as a predictive factor of mortality in palliative care cancer patients: a prospective study over five years. J.Pain Symptom.Manage. 2000;20(2):93-103. PubMed
  7. Salles, N., Herrmann, F., Sakbani, K., Rapin, C. H., and Sieber, C. High vitamin B12 level: a strong predictor of mortality in elderly inpatients. J Am Geriatr.Soc 2005;53(5):917-918.
  8. Looker, H. C., Fagot-Campagna, A., Gunter, E. W., Pfeiffer, C. M., Sievers, M. L., Bennett, P. H., Nelson, R. G., Hanson, R. L., and Knowler, W. C. Homocysteine and vitamin B(12) concentrations and mortality rates in type 2 diabetes. Diabetes Metab Res R
  9. Uhl, W., Nolting, A., Golor, G., Rost, K. L., and Kovar, A. Safety of hydroxocobalamin in healthy volunteers in a randomized, placebo-controlled study. Clin Toxicol (Phila) 2006;44 Suppl 1:17-28. PubMed
  10. Borron, S. W., Baud, F. J., Barriot, P., Imbert, M., and Bismuth, C. Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation. Ann Emerg.Med 2007;49(6):794-801, 801. PubMed
  11. Borron, S. W., Baud, F. J., Megarbane, B., and Bismuth, C. Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation. Am J Emerg.Med 2007;25(5):551-558. PubMed
  12. Lewis, J. G. Gout, Steatorrhoea, and Megaloblastic Anaemia. Ann Rheum.Dis 1962;21(3):284-286. PubMed
  13. Tal, S., Shavit, Y., Stern, F., and Malnick, S. Association between vitamin B12 levels and mortality in hospitalized older adults. J Am Geriatr.Soc 2010;58(3):523-526. PubMed
  14. Baztan, J. J., Gavidia, J. J., Gomez-Pavon, J., Esteve, A., and Ruiperez, I. High vitamin B12 levels and in-hospital mortality. J Am Geriatr.Soc 2010;58(11):2237-2238. PubMed
  15. Omboni, E., Checchini, M., and Longoni, F. [Hypopotassemia and megaloblastic anemia. Presentation of a case]. Minerva Med 8-31-1987;78(16):1255-1257.
  16. Aalfs As, Scholvinck LH, Horvath B. Acneiform eruption in a 5-year old due to vitamin B12 supplementation. Eur J Dermatol 2013;23(5):726-7. PubMed
  17. Balta I, Ozuguz P. Vitamin B12-induced acneiform eruption. Cutan Ocul Toxicol 2014;33(2):94-5. PubMed
  18. Carman KB, Belgemen T, Yis U. Involuntary movements misdiagnosed as seizure during vitamin B12 treatment. Pediatr Emerg Care 2013;29(11):1223-4. PubMed
  19. Djuric V, Bogic M, Popadic AP, et al. Anaphylactic reaction to hydroxycobalamin with tolerance to cyanocobalamin. Ann Allergy Asthma Immunol 2012;108(3):207-8. PubMed
  20. Kartel O, Gulec M, Demirel F, et al. Vitamin B12 allergy and successful desensitization with cyanocobalamin: A case report. Allergol Immunopath (Madr) 2012;40(5):324-5.
  21. Patiroglu T, Unal E, Yildirim S. Infantile tremor syndrome associated with cobalamin therapy: A case report. Clin Neurol Neurosurg 2013;115(9):1903-5. PubMed
  22. Schulte S, Barkema LW, Kardaun SH. Long-lasting atypical acneiform eruption with prominent comedones induced by hydroxocobalamin (vitamin B12). J Dtsch Dermatol Ges 2014;12(6):502-3.
  23. Zanus C, Alberini E, Costa P, et al. Involuntary movements after correction of vitamin B12 deficiency: A video-case report. Epileptic Disord 2012;14(2):174-80. PubMed
  24. Fanidi A, Carreras-Torres R, Larose TL, et al. Is high vitamin B12 status a cause of lung cancer? Int J Cancer. 2019 Sep 15;145(6):1499-1503. PubMed
  25. Fujita Y, Mizukami T, Maya Y, et al. Vitamin B12 allergy manifesting as lymphomatoid contact dermatitis. Eur J Dermatol. 2020;30(3):304-305. PubMed
  26. Dépret F, Hoffmann C, Daoud L, et al. Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study. Crit Care. 2019;23(1):421. PubMed
  27. Khairan P, Sobue T, Eshak ES, et al. Association of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer: the Japan Public Health Center-based (JPHC) prospective study. BMC Cancer 2021;21(1):982. PubMed
  28. Evans J, Pandya A, Ding Y, Qunibi WY. Hydroxocobalamin-Induced Oxalate Nephropathy in a Patient With Smoke Inhalation. Kidney Int Rep 2021;6(8):2228-2231. PubMed
  29. Lacombe V, Chabrun F, Lacout C, et al. Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer. Sci Rep 2021;11(1):13361. PubMed
  30. Pegalajar-García MD, Cebolla-Verdugo M, Prados-Carmona Á, Llamas-Segura C, Navarro-Triviño FJ. Systemic allergic dermatitis to cobalt present in cyanocobalamin supplementation. Contact Dermatitis 2023;89(3):203-205. PubMed

See these in context on the Vitamin B12 monograph →

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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