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Dietary supplement

SereniSelect Ingredients & Drug Interactions

by Moss Nutrition

Capsule Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

SereniSelect is a dietary supplement by Moss Nutrition with 3 active ingredients. Its ingredients are commonly taken for anxiety and stress, relaxation and calm, sleep support.Based on those ingredients, 747 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Theanine, GABA, Holy Basil leaf extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of SereniSelect by Moss Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

SereniSelect contains 3 active ingredients. L-theanine is an amino acid thought to support calm focus without the jitters often linked to caffeine.

GABA (gamma-aminobutyric acid) is a chemical messenger in your brain involved in relaxation and sleep signaling. Holy basil leaf extract, also called tulsi, is an herb traditionally used to manage everyday stress.

The capsules also contain inactive ingredients—cellulose, microcrystalline cellulose, silicon dioxide, and vegetable stearate—which are standard binders and flow agents.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: natural support for calmness and relaxation.
  • We looked for evidence on: Anxiety, Generalized anxiety disorder (GAD), Stress, Insomnia, Post-traumatic stress disorder (PTSD), Sleep quality — and 2 related terms.
  • The closest evidence on file: Gamma-aminobutyric Acid (gaba) is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Gamma-aminobutyric Acid (gaba) is rated "Insufficient Reliable Evidence To Rate" for Hypertension, Insomnia, Post-traumatic stress disorder (PTSD).
  • Also on file: Theanine is rated "Insufficient Reliable Evidence To Rate" for Generalized anxiety disorder (GAD), Hypertension, Insomnia.

The evidence for what SereniSelect's ingredients do is limited. L-theanine is possibly effective for supporting cognitive function, but the data for anxiety, OCD, age-related cognitive changes, Alzheimer disease, and cancer support is insufficient.

GABA's effectiveness for anxiety, ADHD, athletic performance, cerebral palsy, and chronic bronchitis is not established in the data we hold. Holy basil's effectiveness for generalized anxiety disorder, asthma, headache, respiratory infections, dental plaque, and diabetes is also insufficient.

In short, we don't have reliable evidence that this product works for the conditions you might be considering it for.

The evidence, ingredient by ingredient Theanine Gamma-aminobutyric Acid (gaba) Holy Basil

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-theanine and GABA are generally well tolerated for short-term use, but long-term safety isn't well studied for either. L-theanine may cause headaches, drowsiness, increased sleep, or more vivid dreams; a rare pediatric case of facial tics was reported but not clearly linked to the ingredient.

GABA's most common side effects are drowsiness, nausea, gastric upset, minor throat burning, and muscle weakness. Holy basil is generally well tolerated short-term, with loose stools and nausea reported by a small number of trial participants.

For pregnancy, the safety data for L-theanine and GABA are insufficient—there isn't enough information to know either way, so talk with your doctor or pharmacist for personalized advice. Holy basil is rated possibly unsafe in pregnancy based on animal data, so it's best to avoid it if you're pregnant.

For breastfeeding, all three ingredients lack sufficient safety information, so discuss this with your doctor or pharmacist before use.

Side effects, ingredient by ingredient Theanine Gamma-aminobutyric Acid (gaba) Holy Basil

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Gamma-aminobutyric Acid (gaba), Theanine, Holy Basil.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 747 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start SereniSelect, check with your pharmacist or doctor about these medication types. Blood thinner and antiplatelet drugs (like warfarin or aspirin)—holy basil may increase bleeding risk.

Blood pressure medications—L-theanine and GABA might lower pressure further. Diabetes medications—holy basil may increase low blood sugar risk.

Sedatives, sleep aids, and opioids—all three ingredients could add to drowsiness. Also check if you take pentobarbital (Nembutal) or any serotonergic antidepressants.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

SereniSelect might appeal to someone seeking a multi-ingredient relaxation blend, but solid evidence that it works for anxiety or stress is lacking. If you take blood pressure medications, diabetes medications, blood thinners, or sedatives, you'll need to check your specific drugs with your pharmacist before starting—these are the highest-risk combinations.

Talk with your doctor or pharmacist about whether this product fits your needs and whether it's safe alongside anything else you're taking.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about SereniSelect, straight from the product label.

Brand Moss Nutrition
Barcode (UPC) M128
Net contents 120 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD May 22, 2021
DSLD ID 247677
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for SereniSelect by Moss Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
M128
IngredientAmount% DV
L-Theanine200 mg--
GABA550 mg--
Holy Basil leaf extract100 mg--

Other ingredients: Cellulose, Microcrystalline Cellulose, Silicon Dioxide, Vegetable Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: 2 capsules between meals, 1 or 2 times per day or as directed by your healthcare professional.

Precautions

Warning: If you are taking medication, have a medical condition or an upcoming medical procedure, or are pregnant or nursing, consult a physician before using.

If adverse reactions occur, discontinue use & consult your healthcare practitioner.

Keep out of reach of children.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

M Professional Supplements Est. 1991

Formula

Suntheanine

Formulation

Natural Support for Calmness & Relaxation

Does not contain gluten.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Suntheanine is a registered trademark of Taiyo International.

Storage

Store sealed in a cool, dry place.

See for yourself

SereniSelect by Moss Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in SereniSelect by Moss Nutrition

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Theanine

Interacts with
565 drugs
200 mg per serving

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong dro...

L-Theanine monograph & interactions

GABA

Interacts with
419 drugs
550 mg per serving

GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety, and sleep...

GABA monograph & interactions

Holy Basil leaf extract

Interacts with
212 drugs
100 mg per serving Form: Ursolic Acid

Holy basil (tulsi) is a traditional Ayurvedic herb most often used today for stress and general wellness, but the human evidence is mostly small and p...

Holy Basil leaf extract monograph & interactions

Other (inactive) ingredients: Cellulose, Microcrystalline Cellulose, Silicon Dioxide, Vegetable Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

SereniSelect by Moss Nutrition Drug Interactions

Want to check YOUR meds against SereniSelect?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
747Drugs
379 Moderate 368 Minor

Ingredients driving the most interactions

GABA 419

Each ingredient & the kinds of drugs it affects

For each ingredient in SereniSelect with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Theanine3 drug types · 565 drugs

Antihypertensive Drugs

Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.
Animal research shows that theanine can lower blood pressure in spontaneously hypertensive animals. Theoretically, concomitant use of theanine and antihypertensive drugs might potentiate the antihypertensive activity.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Theoretically, theanine may compete with glutamate and/or increase plasma gamma-aminobutyric acid (GABA) levels, which could cause CNS depression. In one clinical study, some subjects taking oral theanine reported drowsiness.

Likelihood Unlikely Evidence D
Serotonergic Drugs

Clinical studies regarding the effects of L-theanine on serotonin levels are conflicting. Some studies suggest it can increase serotonin levels in the brain while others report that it may decrease them. Nevertheless, there have been no reports of l-theanine being a causative agent in serotonergic-related side effects or serotonin syndrome.

Likelihood Unlikely Evidence C

GABA2 drug types · 419 drugs

Antihypertensive Drugs

Theoretically, taking GABA with antihypertensive drugs might increase the risk of hypotension.
Some clinical research shows that GABA can decrease blood pressure in patients with hypertension.

Likelihood Possible Evidence B
Cns Depressants

Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Endogenous GABA has well-established relaxant effects and GABA(A) receptors have an established physiological role in sleep. However, the effects of GABA supplements are unclear, as it is unknown whether exogenous GABA crosses the blood-brain barrier. Although there have been limited reports of drowsiness or tiredness with GABA supplements, these effects have not been widely reported in clinical studies. Additionally, intravenous GABA 0.1-1 mg/kg has been shown to induce anxiety in a dose-dependent manner.

Likelihood Unlikely Evidence D

Holy Basil leaf extract3 drug types · 212 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, holy basil seed oil might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Animal research shows that holy basil seed oil can prolong bleeding time, possibly due to inhibition of platelet aggregation. However, it is not known if this occurs in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, holy basil might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Small clinical studies show that taking holy basil can decrease fasting blood glucose and other measures of glycemic control in patients with type 2 diabetes.

Likelihood Possible Evidence B
Pentobarbital (Nembutal)

Theoretically, holy basil seed oil might increase the sedative effects of pentobarbital.
Animal research shows that holy basil seed oil increases pentobarbitone-induced sleeping time. However, it is not known if this occurs in humans or if this applies to other barbiturates or sedatives.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for SereniSelect, from the product label.

Moss Nutrition

See all Moss Nutrition products
Name
Moss Nutrition Products, Inc.
Street Address
380 Russell Street
City
Hadley
State
MA
ZipCode
01035
Phone Number
800-851-5444
Web Address
www.mossnutrition.com
Pharmacist Counseling Corner

SereniSelect by Moss Nutrition: Common Questions

Does SereniSelect by Moss Nutrition interact with any medications?
Yes. Based on its ingredients, SereniSelect has a known interaction with 747 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
SereniSelect contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take SereniSelect if I'm pregnant or breastfeeding?
For pregnancy: L-theanine and GABA don't have enough safety data—we can't say yes or no. Holy basil is rated possibly unsafe in pregnancy based on animal findings. For breastfeeding: all three ingredients lack sufficient information. Talk with your doctor or pharmacist before using this product in either situation.
What side effects might I notice?
L-theanine may cause headaches, drowsiness, or more vivid dreams. GABA commonly causes drowsiness, nausea, stomach upset, or muscle weakness. Holy basil may cause loose stools or nausea—though only a small number of trial participants reported these. Stop and talk to your pharmacist if anything concerns you.
Is this safe to take long-term?
Long-term safety hasn't been well studied for any of the three active ingredients. The data we have are mainly from short-term use. If you're thinking about taking SereniSelect regularly, discuss that with your doctor or pharmacist.
Does SereniSelect have fillers?
Yes, it has inactive ingredients: cellulose, microcrystalline cellulose, silicon dioxide, and vegetable stearate. These are standard binders and flow agents to make the capsule work.
Will this help my anxiety?
The evidence doesn't support that claim. All three ingredients—L-theanine, GABA, and holy basil—have insufficient reliable evidence for anxiety support. If you're dealing with anxiety, your doctor can discuss what's actually proven to help.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if SereniSelect is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

SereniSelect label
Sources

Sources & How We Checked

SereniSelect's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 26 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Theanine 6 references
  1. Yokogoshi H, Kobayashi M. Hypotensive effect of gamma-glutamylethylamide in spontaneously hypertensive rats. Life Sci 1998;62:1065-8.
  2. Haskell, C. F., Kennedy, D. O., Milne, A. L., Wesnes, K. A., and Scholey, A. B. The effects of L-theanine, caffeine and their combination on cognition and mood. Biol.Psychol. 2008;77(2):113-122. PubMed
  3. Yokogoshi, H., Kato, Y., Sagesaka, Y. M., Takihara-Matsuura, T., Kakuda, T., and Takeuchi, N. Reduction effect of theanine on blood pressure and brain 5-hydroxyindoles in spontaneously hypertensive rats. Biosci.Biotechnol.Biochem. 1995;59(4):615-618. PubMed
  4. Lyon MR, Kapoor MP, Juneja LR. The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial. Altern Med Rev. 2011;16(4):348-
  5. Hidese S, Ota M, Wakabayashi C, et al. Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study. Acta Neuropsychiatr 2017;29(2):72-9.
  6. Tsuchiya T, Honda H, Oikawa M, et al. Oral administration of the amino acids cystine and theanine attenuates the adverse events of S-1 adjuvant chemotherapy in gastrointestinal cancer patients. Int J Clin Oncol 2016;21(6):1085-90. PubMed

See these in context on the Theanine monograph →

Gamma-aminobutyric Acid (gaba) 12 references
  1. Cavagnini F, Invitti C, Pinto M, et al. Effect of acute and repeated administration of gamma aminobutyric acid (GABA) on growth hormone and prolactin secretion in man. Acta Endocrinol (Copenh) 1980;93:149-54.
  2. Nurnberger JI Jr, Berrettini WH, Simmons-Alling S, et al. Intravenous GABA administration is anxiogenic in man. Psychiatry Res 1986;19:113-7. PubMed
  3. Gershman RN, Vasilenko MA, Iliushina GG, et al. [Gammalon in the rehabilitation in infantile cerebral palsy]. Pediatr.Akus.Ginekol. 1977;(6):26-7.
  4. Loeb C, Benassi E, Bo, GP, et al. Preliminary evaluation of the effect of GABA and phosphatidylserine in epileptic patients. Epilepsy Res. 1987;1:209-12 . PubMed
  5. Inoue K, Shirai T, Ochiai H, et al. Blood-pressure-lowering effect of a novel fermented milk containing gamma-aminobutyric acid (GABA) in mild hypertensives. Eur J Clin Nutr 2003;57:490-95.
  6. ELLIOTT, K. A. and JASPER, H. H. Gammaaminobutyric acid. Physiol Rev. 1959;39(2):383-406.
  7. Winsky-Sommerer, R. Role of GABAA receptors in the physiology and pharmacology of sleep. Eur.J.Neurosci. 2009;29(9):1779-1794.
  8. Meldrum, B. S. GABAergic mechanisms in the pathogenesis and treatment of epilepsy. Br.J.Clin.Pharmacol. 1989;27 Suppl 1:3S-11S. PubMed
  9. Loeb, C., Marinari, U. M., Benassi, E., Besio, G., Cottalasso, D., Cupello, A., Maffini, M., Mainardi, P., Pronzato, M. A., and Scotto, P. A. Phosphatidylserine increases in vivo the synaptosomal uptake of exogenous GABA in rats. Exp.Neurol. 1988;99(2):4 PubMed
  10. Melis, G. B., Paoletti, A. M., Mais, V., and Fioretti, P. Interference of dopamine infusion on gamma-amino butyric acid (GABA)-stimulated prolactin increase. J.Endocrinol.Invest 1980;3(4):445-448.
  11. Boonstra E, de Kleijn R, Colzato LS, Alkemade A, Forstmann BU, Nieuwenhuis S. Neurotransmitters as food supplements: the effects of GABA on brain and behavior. Front Psychol. 2015 Oct 6;6:1520. doi: 10.3389/fpsyg.2015.01520. eCollection 2015. PubMed
  12. de Bie TH, Witkamp RF, Balvers MG, Jongsma MA. Effects of ?-aminobutyric acid supplementation on glucose control in adults with prediabetes: A double-blind, randomized, placebo-controlled trial. Am J Clin Nutr 2023;118(3):708-719. PubMed

See these in context on the Gamma-aminobutyric Acid (gaba) monograph →

Holy Basil 8 references
  1. Agrawal P, Rai V, Singh RB. Randomized placebo-controlled, single blind trial of holy basil leaves in patients with noninsulin-dependent diabetes mellitus. Int J Clin Pharmacol Ther 1996;34:406-9.
  2. Sakina MR, Dandiya PC, Hamdard ME, Hameed A. Preliminary psychopharmacological evaluation of Ocimum sanctum leaf extract. J Ethnopharmacol 1990;28:143-50. PubMed
  3. Singh S, Rehan HM, Majumdar DK. Effect of Ocimum sanctum fixed oil on blood pressure, blood clotting time and pentobarbitone-induced sleeping time. J Ethnopharmacol 2001;78:139-43. PubMed
  4. Mondal, S., Varma, S., Bamola, V. D., Naik, S. N., Mirdha, B. R., Padhi, M. M., Mehta, N., and Mahapatra, S. C. Double-blinded randomized controlled trial for immunomodulatory effects of Tulsi (Ocimum sanctum Linn.) leaf extract on healthy volunteers. J PubMed
  5. Agarwal, P. and Nagesh, L. Comparative evaluation of efficacy of 0.2% Chlorhexidine, Listerine and Tulsi extract mouth rinses on salivary Streptococcus mutans count of high school children--RCT. Contemp.Clin Trials 2011;32(6):802-808. PubMed
  6. Vohora, S. B., Garg, S. K., and Chaudhury, R. R. Antifertility screening of plants. 3. Effect of six indigenous plants on early pregnancy in albino rats. Indian J Med Res 1969;57(5):893-899.
  7. Khanna S, Gupta SR, Grover JK. Effect of long term feeding of tulsi (Ocimum sanctum Linn) on reproductive performance of adult albino rats. Indian J Exp Biol 1986;24(5):302-4.
  8. Somasundaram G, Manimekalai K, Salwe KJ, Pandiamunian J. Evaluation of the antidiabetic effect of Ocimum sanctum in type 2 diabetes patients. Int J Life Sci Pharma Res 2012;2(3):75-81.

See these in context on the Holy Basil monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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