Interactions on record — worth a quick check against your medications. Based on 3 of 5 ingredients. Check your meds →
Dietary supplement

SinuComp Ingredients & Drug Interactions

by Integrative Therapeutics

SinuComp label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking SinuComp against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

SinuComp is a dietary supplement by Integrative Therapeutics with 5 active ingredients. Its ingredients are commonly taken for loss of appetite, indigestion and bloating, digestive bitter tonic.Based on those ingredients, 333 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gentian, Sorrel. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against SinuComp by Integrative Therapeutics

Ask about any prescription or over-the-counter medication and we check it for interactions with SinuComp by Integrative Therapeutics — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of SinuComp by Integrative Therapeutics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

SinuComp has 5 active ingredients: gentian, cowslip, European Elder, European Vervain, and sorrel—all traditional herbs used for sinus and respiratory support. The tablet also contains several inactive ingredients (cellulose, gums, stearic acid, magnesium stearate, silica, glycerin, and wax) to hold it together and make it easier to swallow.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports sinus cavities and mucous membranes.
  • We looked for evidence on: Rhinosinusitis, Sinusitis, nasal congestion, sinus inflammation.
  • The strongest evidence on file: Cowslip is rated "Possibly Effective" for Sinusitis (Natural Medicines).
  • Also on file: Gentian is rated "Insufficient Reliable Evidence To Rate" for Rhinosinusitis.
  • Also on file: Sorrel is rated "Insufficient Reliable Evidence To Rate" for Rhinosinusitis.

The evidence for SinuComp's ingredients is limited. Cowslip is possibly effective for sinusitis based on available data.

For gentian, the effectiveness for wound healing, obesity, rhinosinusitis, and gastritis is rated insufficient—the research just isn't there yet. Sorrel shows the same picture: insufficient evidence for bronchitis, breast cancer, and rhinosinusitis.

We don't have effectiveness ratings on file for European Elder or European Vervain.

The evidence, ingredient by ingredient Gentian Cowslip Sorrel

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Gentian is generally tolerated in small amounts but can upset your stomach, especially at higher doses. In one trial combining gentian with turmeric and ginger, some people experienced nausea, vomiting, diarrhea, or bloating.

Cowslip is traditionally used in teas, though human safety data are limited and allergic reactions are possible. Sorrel contains high levels of oxalates—in large or concentrated doses, these can cause kidney issues.

One case of kidney inflammation was reported in a child who ate wild sorrel; another allergic reaction risk is through pollen exposure in hypersensitive people. Gentian and cowslip are best avoided during pregnancy; cowslip should also be avoided while breastfeeding.

Sorrel is rated possibly safe in pregnancy, but medicinal amounts haven't been proven safe, so talk with your doctor.

Side effects, ingredient by ingredient Gentian Cowslip Sorrel

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Gentian, Sorrel.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 333 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking SinuComp, check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (sorrel may strengthen their effect), blood pressure medications (gentian may lower pressure further), or fexofenadine (Allegra)—sorrel may reduce how well it works. OATP substrate drugs may also be affected by sorrel.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

SinuComp may be worth considering if you're looking for traditional sinus support, though the evidence for its herbs is limited. If you take blood thinners, blood pressure medications, or fexofenadine (Allegra), this product isn't a good fit without checking first.

Anyone with kidney concerns, or anyone pregnant or breastfeeding, should discuss it with their doctor or pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about SinuComp, straight from the product label.

Brand Integrative Therapeutics
Barcode (UPC) 871791001954
Net contents 90 Tablet(s)
Market status On market
Date entered into DSLD Aug 23, 2013
DSLD ID 24347
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for SinuComp by Integrative Therapeutics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
871791001954
IngredientAmount% DV
Gentian12 mg--
Cowslip36 mg--
European Elder36 mg--
European Vervain36 mg--
Sorrel36 mg--

Other ingredients: Cellulose, modified Cellulose Gum, Stearic Acid, Magnesium Stearate, Silicon Dioxide, Modified Cellulose, Vegetable Glycerin, Carnauba Wax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

If pregnant, nursing, or taking prescription drugs, consult your healthcare practitioner prior to use.

Seals/Symbols

VEGETARIAN

FDA Disclaimer Statement

THIS STATEMENT HAS NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT ANY DISEASE.

General Statements

EVIDENCE-BASED

Supports the sinus cavities, especially the mucous membranes

The ingredients in this formula comply with the safety and efficacy standards set forth by the German Commission E, which is the worldwide recognized authority for effective herbal remedies.

This product contains natural ingredients; color variations are normal.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommendations: Take 1 tablet three times daily.

Brand IP Statement(s)

SinuComp(R) is an all-herbal formula popular in Europe for supporting the sinus cavities, especially the mucous membranes.

Formula

SinuComp contains gentian root, cowslip flowers, sorrel, European elder flowers, and European vervain--natural ingredients that have stood the test of time for supporting health.

Formulation

Contains no sugar, salt, yeast, wheat, gluten, corn, soy, dairy products, artificial coloring, artificial flavoring, preservatives, or ingredients of animal origin.

General

LI78919.B02

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

SinuComp by Integrative Therapeutics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

SinuComp label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in SinuComp by Integrative Therapeutics

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Gentian

Interacts with
172 drugs
12 mg per serving

Gentian is a very bitter root traditionally used to stimulate appetite and ease mild digestive complaints, often as part of "bitters" before meals. Th...

Gentian monograph & interactions

Cowslip

No known
interactions
36 mg per serving

Cowslip is a traditional European herb whose flowers and roots have long been used as a tea or syrup, mainly for coughs and congestion. Solid human st...

Cowslip monograph & interactions

European Elder

36 mg per serving

European Vervain

36 mg per serving

Sorrel

Interacts with
169 drugs
36 mg per serving

Sorrel is a tangy, leafy herb used in cooking and traditional medicine, often for congestion, digestion, and inflammation. Solid human evidence for an...

Sorrel monograph & interactions

Other (inactive) ingredients: Cellulose, Modified Cellulose Gum, Stearic Acid, Magnesium Stearate, Silicon Dioxide, Modified Cellulose, Vegetable Glycerin, Carnauba Wax. These complete the product’s ingredient list but are not active constituents.

Interaction report

SinuComp by Integrative Therapeutics Drug Interactions

Want to check YOUR meds against SinuComp?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
333Drugs
333 Moderate

Ingredients driving the most interactions

Gentian 172
Sorrel 169

Individual Drug Interactions

The ingredients in SinuComp interact with 333 drugs. Click any drug to see the details.

2 of the 5 ingredients in SinuComp interact with drugs. Each result below shows which ingredient is responsible. Gentian Sorrel

Each ingredient & the kinds of drugs it affects

For each ingredient in SinuComp with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Gentian1 drug type · 172 drugs

Antihypertensive Drugs

Theoretically, taking gentian with antihypertensive drugs might increase the risk of hypotension.
In vitro research shows that gentian can cause vasodilation and lower blood pressure.

Likelihood Possible Evidence D
Gentian full monograph & interactions

Sorrel3 drug types · 169 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, sorrel might cause additive effects and side effects when used with anticoagulant or antiplatelet drugs.
In vitro, sorrel has been shown to inhibit platelet aggregation. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Fexofenadine (Allegra)

Sorrel might reduce the effectiveness of fexofenadine by reducing its absorption from the gut.
In vitro research shows that an ethanol extract of sorrel inhibits organic anion-transporting polypeptide 1A2 (OATP1A2), which transports fexofenadine from the intestine into cells. In rats, concomitant administration of sorrel extract with fexofenadine reduces oral absorption of fexofenadine and the area under the plasma concentration-time curve (AUC).

Likelihood Likely Evidence D
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Sorrel might reduce the effectiveness of OATP substrates by reducing their absorption from the gut.
In vitro research shows that sorrel inhibits OATP1A2. Theoretically it may inhibit other OATPs. The OATPs are expressed in the small intestine and liver and transport drugs into cells. Inhibition of OATP may reduce the bioavailability of oral drugs that are substrates of OATP.

Likelihood Possible Evidence D
Sorrel full monograph & interactions
The maker

Brand information

Manufacturer and brand details for SinuComp, from the product label.

Integrative Therapeutics

See all Integrative Therapeutics products
Name
Integrative Therapeutics, Inc.
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1.800.931.1709
Web Address
www.integrativeinc.com
Pharmacist Counseling Corner

SinuComp by Integrative Therapeutics: Common Questions

Does SinuComp by Integrative Therapeutics interact with any medications?
Yes. Based on its ingredients, SinuComp has a known interaction with 333 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
SinuComp contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Gentian and cowslip are best avoided in pregnancy due to limited safety data. Cowslip should also be avoided while breastfeeding. Sorrel is rated possibly safe in pregnancy, but medicinal amounts haven't been proven safe—talk with your doctor or pharmacist for personalized advice, since this is an individual decision.
Does this actually work for sinusitis?
Cowslip is possibly effective for sinusitis based on available data. The other ingredients haven't been studied enough to say. Overall, the evidence for this product is limited.
What are the side effects?
Gentian can upset your stomach—in one trial, participants experienced nausea, vomiting, diarrhea, and bloating when combined with other herbs. Sorrel can cause allergic reactions in sensitive people, and its high oxalate content may cause kidney issues at high doses. Cowslip is generally used in teas, though allergic reactions are possible.
Is this safe for long-term use?
Gentian is generally tolerated in small amounts by healthy adults but isn't well studied at high doses. Sorrel's oxalate content is a concern with large or concentrated doses. Overall, long-term safety data are limited for these ingredients.
What exactly is in this product?
It contains five herbal actives: gentian, cowslip, European Elder, European Vervain, and sorrel. These are mixed with inactive ingredients like cellulose and wax to form the tablet.
Can I take this with my allergy medicine?
If you take fexofenadine (Allegra), sorrel in this product may reduce how well it works by interfering with absorption. Check with your pharmacist before combining them.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

SinuComp label
Go deeper

The Full Monographs Behind SinuComp’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Gentian

Interacts with 172 drugs

Gentian is a very bitter root traditionally used to stimulate appetite and ease mild digestive complaints, often as part of "bitters" before meals. The evidence is mostly traditional and pre...

Read the full Gentian monograph → Herb & supplement monograph

Cowslip

Cowslip is a traditional European herb whose flowers and roots have long been used as a tea or syrup, mainly for coughs and congestion. Solid human studies are very limited, so its benefits...

Read the full Cowslip monograph → Herb & supplement monograph

Sorrel

Interacts with 169 drugs

Sorrel is a tangy, leafy herb used in cooking and traditional medicine, often for congestion, digestion, and inflammation. Solid human evidence for any health benefit is limited, and its hig...

Read the full Sorrel monograph →
Sources

Sources & How We Checked

SinuComp's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Gentian 5 references
  1. Neubauer N, Marz RW. Placebo-controlled, randomized, double-blind, clincal trial with Sinupret sugar coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomedicine 1994;1:177-81.
  2. Marz RW, Ismail C, Popp MA. Action profile and efficacy of a herbal combination preparation for the treatment of sinusitis. Wien Med Wochenschr 1999;149:202-8.
  3. Uncini Manganelli RE, Chericoni S, Baragatti B. Ethnopharmacobotany in Tuscany: plants used as antihypertensives. Fitoterapia 2000;71:S95-100. PubMed
  4. Baragatti B, Calderone V, Testai L, et al. Vasodilator activity of crude methanolic extract of Gentiana kokiana Perr. et Song. (Gentianaceae). J Ethnopharmacol 2002;79:369-72. PubMed
  5. Sanatani M, Younus J, Stitt L, et al. Tolerability of the combination of ginger (Zingiber officinalis), gentian (Gentiana lutea) and turmeric (Curcuma longa) in patients with cancer-associated anorexia. J Complement Integr Med. 2015;12(1):57-60.

See these in context on the Gentian monograph →

Cowslip 3 references
  1. Neubauer N, Marz RW. Placebo-controlled, randomized, double-blind, clincal trial with Sinupret sugar coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomedicine 1994;1:177-81.
  2. Marz RW, Ismail C, Popp MA. Action profile and efficacy of a herbal combination preparation for the treatment of sinusitis. Wien Med Wochenschr 1999;149:202-8.
  3. Peric A, Kovacevic SV, Gacesa D, Peric AV. Efficacy and safety of combined treatment of acute rhinosinusitis by herbal medicinal product Sinupret and mometasone furoate nasal spray. ENT Updates 2017;7(2):68-74. DOI

See these in context on the Cowslip monograph →

Sorrel 8 references
  1. Neubauer N, Marz RW. Placebo-controlled, randomized, double-blind, clincal trial with Sinupret sugar coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomedicine 1994;1:177-81.
  2. Marz RW, Ismail C, Popp MA. Action profile and efficacy of a herbal combination preparation for the treatment of sinusitis. Wien Med Wochenschr 1999;149:202-8.
  3. Zick, S. M., Sen, A., Feng, Y., Green, J., Olatunde, S., and Boon, H. Trial of Essiac to ascertain its effect in women with breast cancer (TEA-BC). J Altern Complement Med 2006;12(10):971-980. PubMed
  4. Sanz, P. and Reig, R. Clinical and pathological findings in fatal plant oxalosis. A review. Am J Forensic Med Pathol. 1992;13(4):342-345. PubMed
  5. Gniazdowska, B., Doroszewska, G., and Doroszewski, W. [Hypersensitivity to weed pollen allergens in the region of Bygdoszcz]. Pneumonol.Alergol.Pol. 1993;61(7-8):367-372.
  6. Selçuk SN, Gülhan B, Düzova A, Teksam Ö. Acute tubulointerstitial nephritis due to large amount of sorrel (Rumex acetosa) intake. Clin Toxicol (Phila) 2015;53(5):497. PubMed
  7. Ahn JH, Kim J, Rehman NU, Kim HJ, Ahn MJ, Chung HJ. Effect of Rumex Acetosa Extract, a Herbal Drug, on the Absorption of Fexofenadine. Pharmaceutics. 2020;12(6):E547. PubMed
  8. Jeong D, Irfan M, Lee DH, Hong SB, Oh JW, Rhee MH. Rumex acetosa modulates platelet function and inhibits thrombus formation in rats. BMC Complement Med Ther. 2020;20(1):98. PubMed

See these in context on the Sorrel monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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