Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Sleep Honey Lavender Flavored Ingredients & Drug Interactions

by Kion

Sleep Honey Lavender Flavored label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Sleep Honey Lavender Flavored against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Sleep Honey Lavender Flavored is a dietary supplement by Kion with 3 active ingredients. Its ingredients are commonly taken for sleep problems, low mood and depression, anxiety.Based on those ingredients, 565 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are L-Theanine, PharmaGABA, L-Tryptophan. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Sleep Honey Lavender Flavored by Kion

Ask about any prescription or over-the-counter medication and we check it for interactions with Sleep Honey Lavender Flavored by Kion — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Sleep Honey Lavender Flavored by Kion

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This powder contains 3 active ingredients. L-tryptophan is an amino acid your body uses to make serotonin, a chemical that affects mood and sleep.

L-theanine is an amino acid from tea that may promote calm without heavy sedation. PharmaGABA is a branded form of gamma-aminobutyric acid (GABA), a natural brain chemical involved in relaxation and sleep.

The product also contains inactive ingredients — bamboo shoot extract, natural flavors, stevia leaf extract, citric acid, and malic acid — which are fillers and flavor components.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Fall asleep fast, stay asleep, improve sleep quality.
  • We looked for evidence on: Insomnia, Sleep apnea, Anxiety, Generalized anxiety disorder (GAD), Stress, Depression — and 3 related terms.
  • The closest evidence on file: L-tryptophan is rated "Possibly Ineffective" for Depression (Natural Medicines).
  • Also on file: L-tryptophan is rated "Insufficient Reliable Evidence To Rate" for Anxiety, Sleep apnea.
  • Also on file: Gamma-aminobutyric Acid (gaba) is rated "Insufficient Reliable Evidence To Rate" for Anxiety, Depression, Insomnia, Post-traumatic stress disorder (PTSD).

Evidence for L-tryptophan as a sleep aid or for depression is limited; the data rates it possibly ineffective for depression and insufficient evidence exists for anxiety, athletic performance, bruxism (teeth grinding), or premenstrual dysphoric disorder. L-theanine shows possibly effective evidence for cognitive function, but insufficient evidence exists for age-related cognitive decline, Alzheimer disease, anxiety, OCD, or cancer.

PharmaGABA has insufficient reliable evidence for chronic bronchitis, anxiety, athletic performance, ADHD, cerebral palsy, or other conditions listed in the data we hold. In short, the effectiveness of this sleep product for its intended purpose is not established in our data.

The evidence, ingredient by ingredient L-tryptophan Theanine Gamma-aminobutyric Acid (gaba)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-tryptophan is generally well tolerated but has a significant past safety concern: in 1989, over 1,500 cases of eosinophilia-myalgia syndrome (EMS)—a serious neurological disorder causing skin changes, hair loss, and rash—were linked to contaminated L-tryptophan from a single Japanese manufacturer. About 95% of cases traced to that source, and the FDA restricted L-tryptophan imports in 1990.

Common mild side effects from L-tryptophan include belching, diarrhea, drowsiness, dry mouth, flatulence, headache, heartburn, lightheadedness, nausea, stomach pain, visual blurring, and vomiting. L-theanine is generally well tolerated short-term but long-term safety is not well studied; reported side effects include headache, drowsiness, increased sleep duration, and increased dream activity.

PharmaGABA is often well tolerated short-term, with reported side effects of drowsiness, gastric upset, minor throat burning, muscle weakness, and nausea, but long-term safety is unclear. None of these ingredients have adequate safety data for pregnancy or breastfeeding — the facts advise against use in both situations.

Side effects, ingredient by ingredient L-tryptophan Theanine Gamma-aminobutyric Acid (gaba)

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — L-tryptophan, Gamma-aminobutyric Acid (gaba), Theanine.
  • The most serious interaction on file is rated Major.
  • For scale: 565 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take CNS depressants (sleep aids, sedatives, anti-anxiety medications, or opioids) — L-tryptophan poses a Major risk of excessive sedation. Also double-check if you take serotonergic drugs such as antidepressants or migraine medications (Moderate risk of serotonin syndrome).

If you take blood pressure medications, confirm first — theanine and GABA may lower blood pressure further.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

Kion Sleep Honey Lavender may appeal to someone seeking a natural sleep aid without prescription medication, but the evidence it works is not established in our data. If you take any medication for sleep, mood, blood pressure, or seizures, or if you drink alcohol regularly, check with your doctor or pharmacist before starting — the interactions are real and could be serious.

This product also carries historical safety concerns about contamination; discuss those with your healthcare provider if you have questions.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sleep Honey Lavender Flavored, straight from the product label.

Brand Kion
Barcode (UPC) 850002207835
Net contents 2.22 Ounce(s); 63 Gram(s)
Market status On market
Date entered into DSLD Mar 22, 2024
DSLD ID 307267
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sleep Honey Lavender Flavored by Kion, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2.1 Gram(s)
Maximum serving Sizes:
2.1 Gram(s)
Servings per container
30
UPC/BARCODE
850002207835
IngredientAmount% DV
L-Tryptophan1000 mg--
L-Theanine200 mg--
PharmaGABA100 mg--

Other ingredients: Bamboo Shoot Extract, Natural Flavors, Stevia Leaf Extract, Citric Acid, Malic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Vegan

Non-GMO Gluten-free

Fall asleep fast Stay asleep Improve sleep quality

Formula

Sleep Honey lavender flavored

PharmaGABA

FDA Statement of Identity

Dietary Supplement

General Statements

Packaged by weight, not volume.

Suggested/Recommended/Usage/Directions

Suggested use Take one scoop in water or other beverage 30 minutes before bed.

Precautions

Caution Keep out of the reach of children.

Do not use if clear neck seal is broken or missing. Consult your healthcare practitioner before using this product.

Storage

Store at room temperature.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Sleep Honey Lavender Flavored by Kion label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Sleep Honey Lavender Flavored label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Sleep Honey Lavender Flavored by Kion

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2.1 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Tryptophan

Interacts with
394 drugs
1000 mg per serving

L-tryptophan is an essential amino acid the body uses to make serotonin and melatonin, and people take it to support sleep and mood. The evidence for...

L-Tryptophan monograph & interactions

L-Theanine

Interacts with
565 drugs
200 mg per serving

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong dro...

L-Theanine monograph & interactions

PharmaGABA

Interacts with
419 drugs
100 mg per serving

GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety, and sleep...

PharmaGABA monograph & interactions

Other (inactive) ingredients: Bamboo Shoot Extract, Natural Flavors, Stevia Leaf Extract, Citric Acid, Malic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sleep Honey Lavender Flavored by Kion Drug Interactions

Want to check YOUR meds against Sleep Honey Lavender Flavored?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
565Drugs
248 Major 317 Moderate

Ingredients driving the most interactions

L-Theanine 565
PharmaGABA 419
L-Tryptophan 394

Individual Drug Interactions

The ingredients in Sleep Honey Lavender Flavored interact with 565 drugs. Click any drug to see the details.

3 of the 3 ingredients in Sleep Honey Lavender Flavored interact with drugs. Each result below shows which ingredient is responsible. L-Theanine PharmaGABA L-Tryptophan

Each ingredient & the kinds of drugs it affects

For each ingredient in Sleep Honey Lavender Flavored with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Theanine3 drug types · 565 drugs

Antihypertensive Drugs

Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.
Animal research shows that theanine can lower blood pressure in spontaneously hypertensive animals. Theoretically, concomitant use of theanine and antihypertensive drugs might potentiate the antihypertensive activity.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Theoretically, theanine may compete with glutamate and/or increase plasma gamma-aminobutyric acid (GABA) levels, which could cause CNS depression. In one clinical study, some subjects taking oral theanine reported drowsiness.

Likelihood Unlikely Evidence D
Serotonergic Drugs

Clinical studies regarding the effects of L-theanine on serotonin levels are conflicting. Some studies suggest it can increase serotonin levels in the brain while others report that it may decrease them. Nevertheless, there have been no reports of l-theanine being a causative agent in serotonergic-related side effects or serotonin syndrome.

Likelihood Unlikely Evidence C
L-Theanine full monograph & interactions

PharmaGABA2 drug types · 419 drugs

Antihypertensive Drugs

Theoretically, taking GABA with antihypertensive drugs might increase the risk of hypotension.
Some clinical research shows that GABA can decrease blood pressure in patients with hypertension.

Likelihood Possible Evidence B
Cns Depressants

Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Endogenous GABA has well-established relaxant effects and GABA(A) receptors have an established physiological role in sleep. However, the effects of GABA supplements are unclear, as it is unknown whether exogenous GABA crosses the blood-brain barrier. Although there have been limited reports of drowsiness or tiredness with GABA supplements, these effects have not been widely reported in clinical studies. Additionally, intravenous GABA 0.1-1 mg/kg has been shown to induce anxiety in a dose-dependent manner.

Likelihood Unlikely Evidence D
PharmaGABA full monograph & interactions

L-Tryptophan2 drug types · 394 drugs

Cns Depressants

Theoretically, concomitant use of L-tryptophan with CNS depressants might cause additive sedative effects.
Clinical research shows that L-tryptophan can cause fatigue and drowsiness.

Likelihood Probable Evidence B
Serotonergic Drugs

Theoretically, combining L-tryptophan with serotonergic drugs might cause additive serotonergic effects.
L-tryptophan is a precursor to serotonin. Theoretically, combining serotonergic drugs with L-tryptophan might increase the risk of serotonergic side effects, including serotonin syndrome and cerebral vasoconstrictive disorders.

Likelihood Possible Evidence D
L-Tryptophan full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Sleep Honey Lavender Flavored, from the product label.

Kion

See all Kion products
Name
Kion LLC
City
Boulder
State
CO
ZipCode
80304
Phone Number
(855) 387-5466
Web Address
GetKion.com
Pharmacist Counseling Corner

Sleep Honey Lavender Flavored by Kion: Common Questions

Does Sleep Honey Lavender Flavored by Kion interact with any medications?
Yes. Based on its ingredients, Sleep Honey Lavender Flavored has a known interaction with 565 medications, including 248 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sleep Honey Lavender Flavored contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
The facts do not provide enough safety data to recommend this product during pregnancy or breastfeeding. The ingredient L-tryptophan carries conflicting ratings (one source says likely safe, another says possibly unsafe), and L-theanine and PharmaGABA both lack adequate pregnancy and lactation data. Talk with your doctor or pharmacist about whether it's right for you in these situations.
What side effects might I notice?
L-tryptophan commonly causes belching, diarrhea, drowsiness, dry mouth, flatulence, headache, heartburn, lightheadedness, nausea, stomach pain, visual blurring, and vomiting. L-theanine may cause headache, drowsiness, or increased dream activity. PharmaGABA may cause drowsiness, upset stomach, throat burning, muscle weakness, or nausea. Most are mild, but stop and contact your doctor if anything concerns you.
Is this safe given L-tryptophan's past safety issues?
In 1989, L-tryptophan from one contaminated Japanese manufacturer caused over 1,500 cases of eosinophilia-myalgia syndrome (EMS), a serious neurological disorder. The FDA restricted imports in 1990. Modern L-tryptophan products are subject to stricter controls, but the history is real — discuss your individual risk with your doctor or pharmacist.
Will this actually help me sleep?
The evidence in our data does not establish that this product works for sleep. L-tryptophan is rated possibly ineffective for depression and has insufficient evidence for sleep-related conditions. L-theanine and PharmaGABA also lack sufficient evidence for their roles here. Talk with your doctor about whether it's worth trying.
What is PharmaGABA and why is it in a sleep product?
PharmaGABA is a branded form of GABA (gamma-aminobutyric acid), a natural brain chemical that promotes relaxation and is involved in sleep. However, the evidence that GABA supplements actually work is not established in our data — it's unclear whether oral GABA reaches the brain effectively.
Can I take this with my blood pressure medication?
Both L-theanine and PharmaGABA may lower blood pressure, and combining them with antihypertensive drugs could strengthen that effect — rated Moderate concern. Check with your doctor or pharmacist first to make sure it's safe and to see if your blood pressure needs monitoring.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Sleep Honey Lavender Flavored is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sleep Honey Lavender Flavored label
Go deeper

The Full Monographs Behind Sleep Honey Lavender Flavored’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

L-tryptophan

Interacts with 394 drugs

L-tryptophan is an essential amino acid the body uses to make serotonin and melatonin, and people take it to support sleep and mood. The evidence for supplement use is limited and mixed, and...

Read the full L-tryptophan monograph → Herb & supplement monograph

Theanine

Interacts with 565 drugs

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong drowsiness. Early research suggests it may...

Read the full Theanine monograph → Herb & supplement monograph

Gamma-aminobutyric Acid (gaba)

Interacts with 419 drugs

GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety, and sleep. The science behind oral GABA supplemen...

Read the full Gamma-aminobutyric Acid (gaba) monograph →
Sources

Sources & How We Checked

Sleep Honey Lavender Flavored's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 36 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

L-tryptophan 18 references
  1. Messiha FS. Fluoxetine: adverse effects and drug-drug interactions. J Toxicol Clin Toxicol 1993;31:603-30. PubMed
  2. Devoe LD, Castillo RA, Searle NS. Maternal dietary substrates and human fetal biophysical activity. The effects of tryptophan and glucose on fetal breathing movements. Am J Obstet Gynecol 1986;155:135-9. DOI
  3. Lieberman HR, Corkin S, Spring BJ. The effects of dietary neurotransmitter precursors on human behavior. Am J Clin Nutr 1985;42:366-70. PubMed
  4. U. S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Nutritional Products, Labeling, and Dietary Supplements. Information Paper on L-Tryptophan and 5-hydroxy-L-tryptophan, February 2001.
  5. Sullivan EA, Kamb ML, Jones JL, et al. The natural history of eosinophilia-myalgia syndrome in a tryptophan-exposed cohort in South Carolina. Arch Intern Med 1996;156:973-9. DOI
  6. Philen RM, Hill RH, Flanders WD, et al. Tryptophan contaminants associated with eosinophilia-myalgia syndrome. Am J Epidemiol 1993;138:154-9. PubMed
  7. Bohme A, Wolter M, Hoelzer D. L-tryptophan-related eosinophilia-myalgia syndrome possibly associated with a chronic B-lymphocytic leukemia. Ann Hematol 1998;77:235-8. PubMed
  8. Singhal AB, Caviness VS, Begleiter AF, et al. Cerebral vasoconstriction and stroke after use of serotonergic drugs. Neurology 2002;58:130-3. PubMed
  9. Priori R, Conti F, Luan FL, et al. Chronic fatigue: a peculiar evolution of eosinophilia myalgia syndrome following treatment with L-tryptophan in four Italian adolescents. Eur J Pediatr 1994;153:344-6..
  10. Klein R, Berg PA. A comparative study on antibodies to nucleoli and 5-hydroxytryptamine in patients with fibromyalgia syndrome and tryptophan-induced eosinophilia-myalgia syndrome. Clin Investig 1994;72:541-9.. PubMed
  11. Simat TJ, Kleeberg KK, Muller B, Sierts A. Synthesis, formation, and occurrence of contaminants in biotechnologically manufactured L-tryptophan. Adv Exp Med Biol 1999;467:469-80.. PubMed
  12. Shaw K, Turner J, Del Mar C. Tryptophan and 5-hydroxytryptophan for depression. Cochrane Database Syst Rev 2002;(1):CD003198. PubMed
  13. Kilbourne EM, Philen RM, Kamb ML, Falk H. Tryptophan produced by Showa Denko and epidemic eosinophilia-myalgia syndrome. J Rheumatol Suppl 1996;46:81-8.
  14. Horwitz RI, Daniels SR. Bias or biology: evaluating the epidemiologic studies of L-tryptophan and the eosinophilia-myalgia syndrome. J Rheumatol Suppl 1996;46:60-72.
  15. Shapiro S. Epidemiologic studies of the association of L-tryptophan with the eosinophilia-myalgia syndrome: a critique. J Rheumatol Suppl 1996;46:44-58.
  16. Mayeno AN, Gleich GJ. The eosinophilia-myalgia syndrome: lessons from Germany. Mayo Clin Proc 1994;69:702-4. PubMed
  17. Carr L, Ruther E, Berg PA, Lehnert H. Eosinophilia-myalgia syndrome in Germany: an epidemiologic review. Mayo Clin Proc 1994;69:620-5. PubMed
  18. Ullrich SS, Fitzgerald PCE, Giesbertz P, Steinert RE, Horowitz M, Feinle-Bisset C. Effects of intragastric administration of tryptophan on the blood glucose response to a nutrient drink and energy intake, in lean and obese men. Nutrients 2018;10(4). pii: PubMed

See these in context on the L-tryptophan monograph →

Theanine 6 references
  1. Yokogoshi H, Kobayashi M. Hypotensive effect of gamma-glutamylethylamide in spontaneously hypertensive rats. Life Sci 1998;62:1065-8.
  2. Haskell, C. F., Kennedy, D. O., Milne, A. L., Wesnes, K. A., and Scholey, A. B. The effects of L-theanine, caffeine and their combination on cognition and mood. Biol.Psychol. 2008;77(2):113-122. PubMed
  3. Yokogoshi, H., Kato, Y., Sagesaka, Y. M., Takihara-Matsuura, T., Kakuda, T., and Takeuchi, N. Reduction effect of theanine on blood pressure and brain 5-hydroxyindoles in spontaneously hypertensive rats. Biosci.Biotechnol.Biochem. 1995;59(4):615-618. PubMed
  4. Lyon MR, Kapoor MP, Juneja LR. The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial. Altern Med Rev. 2011;16(4):348-
  5. Hidese S, Ota M, Wakabayashi C, et al. Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study. Acta Neuropsychiatr 2017;29(2):72-9.
  6. Tsuchiya T, Honda H, Oikawa M, et al. Oral administration of the amino acids cystine and theanine attenuates the adverse events of S-1 adjuvant chemotherapy in gastrointestinal cancer patients. Int J Clin Oncol 2016;21(6):1085-90. PubMed

See these in context on the Theanine monograph →

Gamma-aminobutyric Acid (gaba) 12 references
  1. Cavagnini F, Invitti C, Pinto M, et al. Effect of acute and repeated administration of gamma aminobutyric acid (GABA) on growth hormone and prolactin secretion in man. Acta Endocrinol (Copenh) 1980;93:149-54.
  2. Nurnberger JI Jr, Berrettini WH, Simmons-Alling S, et al. Intravenous GABA administration is anxiogenic in man. Psychiatry Res 1986;19:113-7. PubMed
  3. Gershman RN, Vasilenko MA, Iliushina GG, et al. [Gammalon in the rehabilitation in infantile cerebral palsy]. Pediatr.Akus.Ginekol. 1977;(6):26-7.
  4. Loeb C, Benassi E, Bo, GP, et al. Preliminary evaluation of the effect of GABA and phosphatidylserine in epileptic patients. Epilepsy Res. 1987;1:209-12 . PubMed
  5. Inoue K, Shirai T, Ochiai H, et al. Blood-pressure-lowering effect of a novel fermented milk containing gamma-aminobutyric acid (GABA) in mild hypertensives. Eur J Clin Nutr 2003;57:490-95.
  6. ELLIOTT, K. A. and JASPER, H. H. Gammaaminobutyric acid. Physiol Rev. 1959;39(2):383-406.
  7. Winsky-Sommerer, R. Role of GABAA receptors in the physiology and pharmacology of sleep. Eur.J.Neurosci. 2009;29(9):1779-1794.
  8. Meldrum, B. S. GABAergic mechanisms in the pathogenesis and treatment of epilepsy. Br.J.Clin.Pharmacol. 1989;27 Suppl 1:3S-11S. PubMed
  9. Loeb, C., Marinari, U. M., Benassi, E., Besio, G., Cottalasso, D., Cupello, A., Maffini, M., Mainardi, P., Pronzato, M. A., and Scotto, P. A. Phosphatidylserine increases in vivo the synaptosomal uptake of exogenous GABA in rats. Exp.Neurol. 1988;99(2):4 PubMed
  10. Melis, G. B., Paoletti, A. M., Mais, V., and Fioretti, P. Interference of dopamine infusion on gamma-amino butyric acid (GABA)-stimulated prolactin increase. J.Endocrinol.Invest 1980;3(4):445-448.
  11. Boonstra E, de Kleijn R, Colzato LS, Alkemade A, Forstmann BU, Nieuwenhuis S. Neurotransmitters as food supplements: the effects of GABA on brain and behavior. Front Psychol. 2015 Oct 6;6:1520. doi: 10.3389/fpsyg.2015.01520. eCollection 2015. PubMed
  12. de Bie TH, Witkamp RF, Balvers MG, Jongsma MA. Effects of ?-aminobutyric acid supplementation on glucose control in adults with prediabetes: A double-blind, randomized, placebo-controlled trial. Am J Clin Nutr 2023;118(3):708-719. PubMed

See these in context on the Gamma-aminobutyric Acid (gaba) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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