Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Slim PM Ingredients & Drug Interactions

by BodyDynamix

Slim PM label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Slim PM against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Slim PM is a dietary supplement by BodyDynamix with 6 active ingredients. Its ingredients are commonly taken for trouble falling asleep (insomnia), jet lag, delayed sleep phase syndrome.Based on those ingredients, 1,513 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Melatonin, L-Theanine, Lemon Balm Leaf Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Slim PM by BodyDynamix

Ask about any prescription or over-the-counter medication and we check it for interactions with Slim PM by BodyDynamix — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Slim PM by BodyDynamix

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Slim PM contains six active ingredients. Melatonin is a hormone that helps regulate sleep-wake cycles.

L-Theanine is an amino acid that may support relaxation. Lemon Balm Leaf Extract comes from an herb traditionally used for stress and mood.

Apple Cider Vinegar Powder is a fermented vinegar product. Grains of Paradise Seed Extract is derived from an African spice.

L-Carnitine is a compound involved in energy metabolism. The product also contains several inactive ingredients — maltodextrin, hydroxypropyl methylcellulose, microcrystalline cellulose, croscarmellose sodium, magnesium stearate, and silicon dioxide — which serve as fillers and binders in the capsule.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: weight management and metabolism support with nighttime relaxation.
  • We looked for evidence on: Athletic performance, Cachexia, Cancer-related fatigue, Chronic fatigue syndrome (CFS), Cognitive function, Exercise-induced muscle damage — and 4 related terms.
  • The strongest evidence on file: Theanine is rated "Possibly Effective" for Cognitive function (Natural Medicines).
  • Also on file: Melatonin is rated "Possibly Ineffective" for Athletic performance, Cachexia, Cancer-related fatigue.
  • Also on file: Lemon Balm is rated "Insufficient Reliable Evidence To Rate" for Cognitive function.

The evidence for Slim PM's ingredients is mixed. Melatonin is likely effective for two sleep disorders: non-24-hour sleep-wake disorder and delayed sleep phase syndrome.

It's possibly effective for pre-procedural anxiety, sunburn, and high blood pressure, though the strength of evidence is weaker. L-Theanine is possibly effective for cognitive function, but evidence is insufficient for age-related cognitive decline, Alzheimer disease, and anxiety disorders.

Lemon Balm Leaf Extract is possibly effective for cold sores, stress, and depression. Apple Cider Vinegar Powder has insufficient evidence for acne, athletic performance, cognitive function, dental plaque, depression, and eczema — meaning we don't have enough data to say whether it works.

L-Carnitine is effective for L-carnitine deficiency and possibly effective for high cholesterol, heart failure, and angina. Grains of Paradise Seed Extract has no effectiveness data on file.

The evidence, ingredient by ingredient Melatonin Theanine Lemon Balm Apple Cider Vinegar Grains Of Paradise L-carnitine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these ingredients are generally well tolerated in the short term, but long-term safety isn't well established. Melatonin's most common side effects are dizziness, drowsiness, headache, and nausea.

Rarely, it may increase seizure risk or cause mood changes including depression, delusions, or hallucinations. L-Theanine may cause headache, drowsiness, or increased dream activity.

Lemon Balm Leaf Extract can cause dizziness and sedation at rates no higher than placebo. Apple Cider Vinegar Powder in food amounts is well tolerated, but large doses long-term may cause dangerously low potassium levels, elevated kidney markers, and bone loss — one documented case involved daily use of 250 mL for six years.

L-Carnitine may cause stomach upset, diarrhea, nausea, and a fish-like body odor; seizures are rare. Grains of Paradise Seed Extract has not been well studied for safety.

Side effects, ingredient by ingredient Melatonin Theanine Lemon Balm Apple Cider Vinegar Grains Of Paradise L-carnitine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 6 matched ingredients can interact with medications — Lemon Balm, Apple Cider Vinegar, Melatonin, L-carnitine, Theanine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications.
  • For scale: 1,514 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications if you take blood thinners like warfarin or acenocoumarol (moderate risk with melatonin and L-carnitine), blood pressure medications (melatonin and L-theanine can lower BP further), insulin or diabetes drugs (apple cider vinegar and melatonin may increase low blood sugar risk), thyroid replacement hormones (lemon balm and L-carnitine may reduce effectiveness), seizure medications (melatonin may reduce their effect), digoxin or other heart medications (apple cider vinegar and nifedipine can interact with melatonin), diuretic water pills (apple cider vinegar may worsen potassium loss), immune-suppressing drugs (melatonin may interfere), or CNS depressants like sleep aids or anxiety medications (L-theanine and lemon balm add sedation). The medication checker on this page will search your exact drugs against the data we hold.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Slim PM is designed as a sleep support product, and melatonin is its only ingredient with strong evidence for that purpose — for specific sleep disorders, not just general sleep. If you take any blood thinners, blood pressure medications, diabetes medications, thyroid replacement, seizure medications, or digoxin, talk with your pharmacist before starting this product.

Long-term use of any of these ingredients hasn't been well studied, so this is best as a short-term tool.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Slim PM, straight from the product label.

Brand BodyDynamix
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Nov 22, 2024
DSLD ID 319510
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Slim PM by BodyDynamix, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
IngredientAmount% DV
Melatonin3 mg--
L-Theanine200 mg--
Lemon Balm Leaf Extract100 mg--
Apple Cider Vinegar, Powder100 mg--
Grains of Paradise Seed Extract500 mg--
L-Carnitine200 mg--

Other ingredients: Maltodextrin, Hydroxypropyl Methylcellulose, Microcrystalline Cellulose, Croscarmellose Sodium, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Get dynamic about your transformation BodyDynamix is the weight loss innovation house featuring blends by the experts at GNC. We find the fantastic in Mother Nature, optimize clinically studied ingredients and always listen to what the newest science has to say. Season after season, we obsess over helping you get dynamic about your weight loss goals. Transform dynamically

Advanced metabolism & sleep support formula BodyDynamix Slim PM helps you relax, recharge and fuel metabolism. Use in conjunction with the BodyDynamix meal and exercise plans. Designed by our scientists, this non-stimulant, nighttime formula features cutting-edge ingredients targeting metabolism and enhanced sleep support.

Formula transparency Gluten free No milk No artificial colors No artificial flavors No proprietary blends

Vegetarian

Metabolism support Nighttime formula Relaxation, sleep & metabolism

Stimulant free

Vegetarian

No artificial colors, no artificial flavors, gluten free, no milk. GF Gluten free

General Statements

Discover more proven weight management solutions at bodydynamix.gnc.com.

New

30-day supply

For more information: 1-888-462-2548

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one serving 30-60 minutes prior to bedtime.

Precautions

Warning: For adult use only at bedtime. Keep out of reach of children.

This product is not to be taken by pregnant or lactating women. If you are taking medication or have a medical condition, consult a physician before using this product.

Do not use in conjunction with alcoholic beverages, when driving a vehicle or while operating machinery. Discontinue use two weeks prior to surgery.

Storage

Store in a cool, dry place.

Brand IP Statement(s)

AfperFIT is a registered trademark of Vidya Herbs, Inc. and used with permission.

Suntheanine is a registered trademark of Taiyo International Inc.

Formula

Ingredient innovation for your nightstand Curated by the nutrition experts at GNC, Slim PM offers science-backed support to help you: Relax: 100 mg of lemon balm and 200 mg of clinically studied Suntheanine provide everyday stress and relaxation support Recharge: 3 mg of melatonin for a more restful night's sleep Fuel metabolism: 200 mg of L-carnitine to fuel fat metabolism and 500 mg of AfperFIT, a clinically studied grains of paradise extract designed to support metabolism.

Metabolism support and sleep aid with melatonin and clinically studied AfperFIT and Suntheanine

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Slim PM by BodyDynamix label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Slim PM label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Slim PM by BodyDynamix

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Melatonin

Interacts with
1,461 drugs
3 mg per serving

Melatonin is a hormone your body makes naturally to help control your sleep-wake cycle, and the supplement form is widely used to help with sleep timi...

Melatonin monograph & interactions

L-Theanine

Interacts with
565 drugs
200 mg per serving

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong dro...

L-Theanine monograph & interactions

Lemon Balm Leaf Extract

Interacts with
264 drugs
100 mg per serving

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold so...

Lemon Balm Leaf Extract monograph & interactions

Apple Cider Vinegar, Powder

Interacts with
162 drugs
100 mg per serving

Apple cider vinegar is a fermented apple product that many people use hoping to help with blood sugar, weight, or digestion. The evidence for most of...

Apple Cider Vinegar, Powder monograph & interactions

Grains of Paradise Seed Extract

No known
interactions
500 mg per serving Form: Aframomum melegueta Seed Extract

Grains of paradise is a West African spice in the ginger family that people use for digestion, as a spice, and more recently in supplements aimed at m...

Grains of Paradise Seed Extract monograph & interactions

L-Carnitine

Interacts with
19 drugs
200 mg per serving Form: L-Carnitine L-Tartrate

L-carnitine is a compound your body makes naturally and also gets from foods like meat. It helps cells turn fat into energy, and supplements are most...

L-Carnitine monograph & interactions

Other (inactive) ingredients: Maltodextrin, Hydroxypropyl Methylcellulose, Microcrystalline Cellulose, Croscarmellose Sodium, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Slim PM by BodyDynamix Drug Interactions

Want to check YOUR meds against Slim PM?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,513Drugs
1,137 Moderate 376 Minor

Ingredients driving the most interactions

Melatonin 1,461
L-Theanine 565
Lemon Balm Leaf Extract 264
Apple Cider Vinegar, Powder 162
L-Carnitine 19

Individual Drug Interactions

The ingredients in Slim PM interact with 1,513 drugs. Click any drug to see the details.

5 of the 6 ingredients in Slim PM interact with drugs. Each result below shows which ingredient is responsible. Melatonin L-Theanine Lemon Balm Leaf Extract Apple Cider Vinegar, Powder L-Carnitine

Each ingredient & the kinds of drugs it affects

For each ingredient in Slim PM with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Melatonin18 drug types · 1,461 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, melatonin may have anticoagulant effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There are isolated case reports of minor bleeding and decreased prothrombin activity in people taking melatonin with warfarin (Coumadin). The mechanism, if any, of this interaction is unknown. Taking melatonin orally seems to decrease coagulation activity within one hour of dosing in healthy men.

Likelihood Possible Evidence B
Anticonvulsants

Theoretically, melatonin may reduce the effects of anticonvulsants. Some clinical research suggests that melatonin may increase the frequency of seizures in certain patients, particularly children with neurological impairment.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, taking melatonin with antidiabetes drugs might increase the risk of hypoglycemia.
Some clinical research shows that melatonin reduces levels of fasting blood glucose and improves glycemic control. However, other research suggests that melatonin might impair glucose utilization and increase insulin resistance, while other research has found no effect on glucose levels. Until more is known, use melatonin cautiously in combination with antidiabetes drugs.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking melatonin with antihypertensive drugs might increase the risk of hypotension or hypertension.
Some clinical research suggests that taking melatonin decreases blood pressure in healthy adults. Also, melatonin seems to lower systolic and diastolic blood pressure in individuals with high blood pressure at nighttime or untreated essential hypertension. However, melatonin seems to worsen blood pressure in patients who are taking antihypertensive medications. Immediate-release melatonin 5 mg at night in combination with nifedipine GITS (Procardia XL) increases systolic blood pressure an average of 6.5 mmHg, diastolic blood pressure by an average of 4.9 mmHg, and heart rate by 3.9 bpm. Also, results from animal research suggest that melatonin reduces the effectiveness of certain antihypertensive drugs, including methoxamine and clonidine.

Likelihood Possible Evidence A
Caffeine

Theoretically, taking caffeine with melatonin might increase levels of melatonin.
Some evidence suggests that caffeine consumption can decrease endogenous melatonin levels, while other evidence suggests that caffeine increases endogenous melatonin levels. When administered in combination with melatonin supplements, caffeine seems to increase melatonin effects and levels. The reason for this discrepancy is not completely clear. Part of the discrepancy may result from the fact that caffeine can inhibit melatonin synthesis as well as inhibit melatonin metabolism. By functioning as an adenosine receptor antagonist, caffeine may indirectly inhibit the synthesis of melatonin. Conversely, because melatonin and caffeine are both metabolized by cytochrome P450 1A2 (CYP1A2) enzyme, concomitant use of melatonin and caffeine may reduce the metabolism of melatonin, resulting in higher serum levels.

Likelihood Probable Evidence B
Cns Depressants

Theoretically, taking melatonin might increase the sedative effects of CNS depressants.
Melatonin has sedative effects. Theoretically, concomitant use of melatonin with alcohol, benzodiazepines, or other sedative drugs might cause additive sedation.

Likelihood Possible Evidence D
Contraceptive Drugs

Theoretically, taking contraceptive drugs with melatonin might increase the effects and adverse effects of melatonin.
Contraceptive drugs can increase the levels of endogenous melatonin. Theoretically, these drugs may increase the effects and adverse effects of oral melatonin.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, melatonin might increase levels of drugs metabolized by CYP1A2. Also, other CYP1A2 substrates might decrease the metabolism of melatonin, increasing melatonin levels.
Melatonin is metabolized in the liver primarily by the CYP2C19 and CYP1A2 enzymes. Theoretically, combined administration of melatonin with drugs metabolized by the CYP1A2 enzyme might reduce the metabolism of these drugs, resulting in increased serum levels. Conversely, some drugs metabolized by CYP1A2 may inhibit the metabolism of melatonin, resulting in increased serum levels of melatonin. Until more is known, use melatonin cautiously in patients taking drugs metabolized by these enzymes.

Likelihood Probable Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, melatonin might increase levels of drugs metabolized by CYP2C19. Also, other CYP2C19 substrates might decrease the metabolism of melatonin, increasing melatonin levels.
Melatonin is metabolized in the liver primarily by the CYP2C19 and CYP1A2 enzymes. Theoretically, combined administration of melatonin with certain drugs metabolized by the CYP2C19 enzyme may reduce the metabolism of these drugs, resulting in increased serum levels. Conversely, some drugs metabolized by CYP2C19 may inhibit the metabolism of melatonin, resulting in increased serum levels of melatonin. Until more is known, use melatonin cautiously in patients taking drugs metabolized by these enzymes.

Likelihood Probable Evidence D
Fluvoxamine (Luvox)

Theoretically, taking fluvoxamine with melatonin might increase levels of melatonin.
Fluvoxamine can significantly increase melatonin levels. In some cases, fluvoxamine might increase bioavailability of exogenously administered melatonin by up to 20 times. Some researchers think this might be a beneficial interaction and be potentially useful for cases of refractory insomnia. However, this interaction might also cause unwanted excessive drowsiness and possibly other adverse effects. Fluvoxamine is known to increase endogenous melatonin secretion. It seems to increase serum levels of exogenously administered melatonin possibly by decreasing melatonin metabolism by inhibiting cytochrome P450 (CYP450) 1A2 and 2C19 or by inhibiting melatonin elimination. This effect has been found in healthy people taking fluvoxamine 50-75 mg and melatonin 5 mg.

Likelihood Probable Evidence B
Immunosuppressants

Theoretically, melatonin might interfere with immunosuppressive therapy.
Melatonin can stimulate immune function. Theoretically, melatonin might interfere with immunosuppressive therapy.

Likelihood Possible Evidence B
Methamphetamine (Desoxyn)

Theoretically, taking melatonin with methamphetamine may increase the adverse effects of methamphetamine.
Animal research suggests that melatonin exacerbates the adverse effects of methamphetamine, resulting in greater depression of tryptophan hydroxylase (TPH) and tyrosine hydroxylase (TH) activity, as well as a significant reduction in dopamine levels. This has not been shown in humans.

Likelihood Possible Evidence D
Nifedipine Gits (Procardia Xl)

Theoretically, taking melatonin with extended release nifedipine reduces the effects of nifedipine.
Melatonin can decrease the effectiveness of extended release nifedipine (GITS). Immediate-release melatonin 5 mg at night in combination with nifedipine GITS 30-60 mg daily increases systolic and blood pressure by an average of 6.5 mmHg and 4.9 mmHg, respectively. Concomitant use with melatonin also increases heart rate by 3.9 bpm. The mechanism of this interaction is not known.

Likelihood Probable Evidence B
Seizure Threshold Lowering Drugs

Theoretically, taking melatonin with drugs that lower the seizure threshold might increase the risk of seizure activity.
Some clinical evidence suggests that melatonin may increase the frequency of seizures in certain patients, particularly children with neurological disabilities.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, melatonin may have antiplatelet effects and may increase the risk of bleeding with warfarin.
Three cases of increased prothrombin time have been reported for patients aged 48-72 years who took melatonin orally in combination with warfarin. However, three cases of decreased prothrombin time have also been reported for patients aged 51-84 years who took melatonin orally in combination with warfarin. Until more is known, use melatonin cautiously in patients taking warfarin.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, melatonin might increase levels of drugs metabolized by CYP2D6.
Laboratory research suggests that certain lots of melatonin inhibit CYP2D6. Theoretically, combined administration of melatonin with certain drugs metabolized by the CYP2D6 enzyme may reduce the metabolism of these drugs, resulting in increased serum levels. Until more is known, use melatonin cautiously in patients taking drugs metabolized by these enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, melatonin might increase levels of drugs metabolized by CYP3A4.
Laboratory research shows that certain lots of melatonin inhibit CYP3A4. Theoretically, combined administration of melatonin with certain drugs metabolized by CYP3A4 may reduce the metabolism of these drugs, resulting in increased serum levels. Until more is known, use melatonin cautiously in patients taking drugs metabolized by these enzymes.

Likelihood Possible Evidence D
Flumazenil (Romazicon)

Theoretically, taking flumazenil with melatonin might reduce the effects of melatonin.
Animal research shows that flumazenil may inhibit the effect of melatonin.

Likelihood Possible Evidence D
Melatonin full monograph & interactions

L-Theanine3 drug types · 565 drugs

Antihypertensive Drugs

Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.
Animal research shows that theanine can lower blood pressure in spontaneously hypertensive animals. Theoretically, concomitant use of theanine and antihypertensive drugs might potentiate the antihypertensive activity.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Theoretically, theanine may compete with glutamate and/or increase plasma gamma-aminobutyric acid (GABA) levels, which could cause CNS depression. In one clinical study, some subjects taking oral theanine reported drowsiness.

Likelihood Unlikely Evidence D
Serotonergic Drugs

Clinical studies regarding the effects of L-theanine on serotonin levels are conflicting. Some studies suggest it can increase serotonin levels in the brain while others report that it may decrease them. Nevertheless, there have been no reports of l-theanine being a causative agent in serotonergic-related side effects or serotonin syndrome.

Likelihood Unlikely Evidence C
L-Theanine full monograph & interactions

Lemon Balm Leaf Extract2 drug types · 264 drugs

Cns Depressants

Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Lemon balm seems to have CNS depressant activity in animals and in humans.

Likelihood Possible Evidence B
Thyroid Hormone

Theoretically, lemon balm might interfere with thyroid hormone replacement therapy.
In vitro, constituents of lemon balm extract bind to thyroid stimulating hormone (TSH), preventing TSH receptor-binding and leading to the inhibition of TSH-stimulated adenylate cyclase activity. In animals, lemon balm extract has been shown to decrease levels of circulating TSH and inhibit thyroid secretion.

Likelihood Possible Evidence D
Lemon Balm Leaf Extract full monograph & interactions

Apple Cider Vinegar, Powder4 drug types · 162 drugs

Digoxin (Lanoxin)

Theoretically, concomitant use of apple cider vinegar with digoxin might increase the risk of cardiac toxicity.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. Theoretically, overuse of apple cider vinegar could decrease potassium levels, increasing the risk of toxicity with digoxin.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, concomitant use of apple cider vinegar with diuretic drugs might increase the risk of hypokalemia.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. There is some concern that people taking apple cider vinegar along with potassium depleting diuretics might have an increased risk for hypokalemia.

Likelihood Possible Evidence D
Insulin

Theoretically, concomitant use of apple cider vinegar with insulin might increase the risk of hypokalemia.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. Theoretically, overuse of apple cider vinegar concomitantly with insulin might increase the risk of hypokalemia.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking apple cider vinegar with antidiabetes drugs might increase the risk of hypoglycemia.
Apple cider vinegar might reduce fasting and postprandial blood glucose levels and decrease gastric emptying in people with diabetes. However, not all research agrees. Theoretically, it might have additive effects on glucose levels when used with antidiabetes drugs.

Likelihood Possible Evidence B
Apple Cider Vinegar, Powder full monograph & interactions

L-Carnitine3 drug types · 19 drugs

Acenocoumarol (Sintrom)

Theoretically, L-carnitine might increase the anticoagulant effects of acenocoumarol.
L-carnitine might enhance the anticoagulant effects of acenocoumarol, an oral anticoagulant similar to warfarin, but shorter-acting. There are at least two case reports of INR elevation with concomitant use. In one case, a 33-year-old male with a previously stable INR had an elevated INR of 4.65 after L-carnitine was started and continued for 10 weeks. INR normalized after discontinuation of the L-carnitine-containing product.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, L-carnitine might decrease the effectiveness of thyroid hormone replacement.
L-carnitine appears to act as a peripheral thyroid hormone antagonist by inhibiting entry of thyroid hormone into the nucleus of cells. Taking L-carnitine also seems to diminish some of the symptoms of hyperthyroidism.

Likelihood Probable Evidence B
Warfarin (Coumadin)

Theoretically, L-carnitine might increase the anticoagulant effects of warfarin.
L-carnitine might increase the anticoagulant effects of acenocoumarol, a shorter-acting oral anticoagulant similar to warfarin. There is not enough information to know whether this interaction occurs with L-carnitine and warfarin.

Likelihood Possible Evidence D
L-Carnitine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Slim PM, from the product label.

BodyDynamix

See all BodyDynamix products
Name
GNC Holdings, LLC
City
Pittsburgh
State
PA
ZipCode
15222
Phone Number
1-888-462-2548
Web Address
bodydynamix.gnc.com
Pharmacist Counseling Corner

Slim PM by BodyDynamix: Common Questions

Does Slim PM by BodyDynamix interact with any medications?
Yes. Based on its ingredients, Slim PM has a known interaction with 1,513 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Slim PM contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is it safe to take Slim PM while pregnant?
The safety data advises against melatonin and L-theanine during pregnancy due to insufficient information. Lemon balm, apple cider vinegar, and L-carnitine also lack enough safety data in pregnancy. Grains of Paradise has no pregnancy data on file. Talk with your doctor or pharmacist before using this product if you're pregnant — it's not a decision to make on your own.
Is it safe while breastfeeding?
Safety while breastfeeding has not been established for melatonin, L-theanine, apple cider vinegar, and grains of paradise. Lemon balm has limited safety data and requires caution. L-carnitine safety while breastfeeding is not well studied. Check with your doctor or pharmacist before using this product if you're nursing.
What are the most common side effects?
Melatonin most often causes dizziness, drowsiness, headache, and nausea. L-Theanine may cause headache, drowsiness, or vivid dreams. Lemon balm can cause dizziness and sedation, though not more often than placebo. Apple cider vinegar and L-carnitine may cause stomach upset, nausea, and diarrhea. Most side effects are mild, but stop taking it and talk with your pharmacist if anything concerns you.
Will this help me sleep better?
Melatonin, the main sleep-supporting ingredient, is likely effective for two specific sleep disorders — non-24-hour sleep-wake disorder and delayed sleep phase syndrome. For general sleep trouble, the evidence is weaker. L-Theanine and lemon balm are possibly effective for relaxation, which may support sleep indirectly. Results vary person to person, so it may work for you or it may not.
Can I take this long-term?
Long-term safety of these ingredients isn't well established. Melatonin is generally well tolerated short-term, but long-term use safety is less certain and product quality varies. The same goes for L-theanine and lemon balm. Apple cider vinegar in large doses over years has caused serious side effects like dangerously low potassium and bone loss. Use short-term unless your doctor advises otherwise.
What is L-Carnitine for?
L-Carnitine is involved in how your body produces and uses energy. It's effective for people with a true L-carnitine deficiency and possibly effective for high cholesterol, heart failure, and angina. In this sleep product, its role is unclear — the evidence doesn't show it supports sleep.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

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Go deeper

The Full Monographs Behind Slim PM’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Melatonin

Interacts with 1,461 drugs

Melatonin is a hormone your body makes naturally to help control your sleep-wake cycle, and the supplement form is widely used to help with sleep timing problems and jet lag. The evidence is...

Read the full Melatonin monograph → Herb & supplement monograph

Theanine

Interacts with 565 drugs

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong drowsiness. Early research suggests it may...

Read the full Theanine monograph → Herb & supplement monograph

Lemon Balm

Interacts with 264 drugs

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold sores. Early studies are promising but gen...

Read the full Lemon Balm monograph → Herb & supplement monograph

Apple Cider Vinegar

Interacts with 162 drugs

Apple cider vinegar is a fermented apple product that many people use hoping to help with blood sugar, weight, or digestion. The evidence for most of these uses is limited and mixed, and the...

Read the full Apple Cider Vinegar monograph → Herb & supplement monograph

Grains Of Paradise

Grains of paradise is a West African spice in the ginger family that people use for digestion, as a spice, and more recently in supplements aimed at metabolism. Early human research suggests...

Read the full Grains Of Paradise monograph → Herb & supplement monograph

L-carnitine

Interacts with 19 drugs

L-carnitine is a compound your body makes naturally and also gets from foods like meat. It helps cells turn fat into energy, and supplements are most clearly useful for people with a true ca...

Read the full L-carnitine monograph →
Sources

Sources & How We Checked

Slim PM's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 190 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Melatonin 118 references
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Theanine 6 references
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Lemon Balm 12 references
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Apple Cider Vinegar 11 references
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Grains Of Paradise 2 references
  1. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
  2. Using Dietary Supplements Wisely — NIH NCCIH Source

See these in context on the Grains Of Paradise monograph →

L-carnitine 41 references
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