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Dietary supplement

Smart PS Phosphatidylserine Ingredients & Drug Interactions

by Vinco

Smart PS Phosphatidylserine label
See full label image
Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Smart PS Phosphatidylserine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Smart PS Phosphatidylserine is a dietary supplement by Vinco with 3 active ingredients. Its ingredients are commonly taken for liver health, memory and brain support, ulcerative colitis.Based on those ingredients, 219 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Phosphatidylserine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Smart PS Phosphatidylserine by Vinco

Ask about any prescription or over-the-counter medication and we check it for interactions with Smart PS Phosphatidylserine by Vinco — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Smart PS Phosphatidylserine by Vinco

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Smart PS Phosphatidylserine contains 3 active ingredients: phosphatidylserine, phosphatidylcholine, and phosphatidylethanolamine. Phosphatidylserine and phosphatidylcholine are phospholipids—fatty compounds found naturally in cell membranes—and are included here to support brain health and cognitive function.

The product also contains inactive ingredients (gelatin, glycerin, polyglycitol syrup, and purified water) that form the softgel capsule and help deliver the active ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: brain function, cognition, memory, and mental alertness.
  • We looked for evidence on: Age-related cognitive decline, Alzheimer disease, Attention deficit-hyperactivity disorder (ADHD), Cognitive function, Dementia, Memory — and 3 related terms.
  • The strongest evidence on file: Phosphatidylserine is rated "Possibly Effective" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Phosphatidylserine is rated "Possibly Effective" for Alzheimer disease.
  • Also on file: Phosphatidylcholine is rated "Insufficient Reliable Evidence To Rate" for Alzheimer disease, Memory, Dementia.

Phosphatidylserine has possibly effective evidence for age-related cognitive decline and Alzheimer disease. For athletic performance, ADHD, general cognitive function, and dementia, the evidence isn't established in the data we hold.

Phosphatidylcholine shows possibly effective evidence for ulcerative colitis; for nonalcoholic fatty liver disease and alcohol-related liver disease, evidence is insufficient. We have no effectiveness data on file for phosphatidylethanolamine.

The evidence, ingredient by ingredient Phosphatidylcholine Phosphatidylserine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Phosphatidylserine is generally well tolerated in studies, but long-term safety isn't fully established. The most common side effects taken orally are flatulence, gastrointestinal upset, headache, insomnia (especially at higher doses around 600 mg), and nausea.

Phosphatidylcholine is also generally well tolerated, though high doses (around 30 grams per day) can cause gastrointestinal upset and diarrhea; even smaller doses may trigger bloating, diarrhea, altered taste, nausea, or vomiting in some people. Safety data for phosphatidylethanolamine isn't on file.

For pregnancy, the safety data advises against phosphatidylserine use. For phosphatidylcholine, choline is needed in pregnancy, but supplement safety beyond food sources isn't well studied—talk with your doctor about this product if you're pregnant.

While breastfeeding, safety data for both phosphatidylserine and phosphatidylcholine is insufficient or unknown; speak with your healthcare provider first.

Side effects, ingredient by ingredient Phosphatidylcholine Phosphatidylserine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Phosphatidylserine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 219 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this supplement, double-check with your doctor or pharmacist if you take anticholinergic drugs or cholinergic drugs. Both are Moderate-severity concerns with phosphatidylserine, which may reduce how anticholinergic medications work or add to the effects of cholinergic ones.

Use the medication checker below to verify your exact prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Smart PS Phosphatidylserine is an option if you're looking to support cognitive health, especially if you're dealing with age-related memory changes or early Alzheimer disease. If you take anticholinergic or cholinergic medications, or any other prescriptions, check them against this product with your doctor or pharmacist before starting—the interactions are theoretical but documented.

Pregnant or breastfeeding? Talk it over with your healthcare provider, as the safety data for both ingredients is limited or advises against use.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 24, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Smart PS Phosphatidylserine, straight from the product label.

Brand Vinco
Barcode (UPC) 739930275423
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Sep 24, 2019
DSLD ID 206604
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Smart PS Phosphatidylserine by Vinco, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
60
UPC/BARCODE
739930275423
IngredientAmount% DV
Phosphatidylcholine25 mg--
Phosphatidylserine100 mg--
Phosphatidylethanolamine2.5 mg--

Other ingredients: Gelatin, Glycerin, Polyglycitol Syrup, purified Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions for use: As a dietary supplement for adults and children twelve or more years of age, take one or two softgels per day, or as directed by a qualified healthcare professional.

General Statements

Vinco's Smart PS (PS) provides nutritional support for brain functions. PS is essential for healthy brain cells. PS has been shown to benefit cognition, memory recall, and nerve transmission and function.

Promotes mental alertness

Professional formulation

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Gluten free

No wheat, no gluten, no corn, no dairy, yeast free

FDA Statement of Identity

Dietary Supplement

Formula

This product contains Soy.

Precautions

This product contains Soy.

Keep out of reach of children

Tamper resistant. Do not purchase if seal is broken.

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Smart PS Phosphatidylserine by Vinco label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Smart PS Phosphatidylserine label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Smart PS Phosphatidylserine by Vinco

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Phosphatidylcholine

No known
interactions
25 mg per serving Form: Soy

Phosphatidylcholine is a phospholipid that is part of every cell membrane and a source of choline. People take it for liver, brain, and gut health, bu...

Phosphatidylcholine monograph & interactions

Phosphatidylserine

Interacts with
219 drugs
100 mg per serving Form: Soy

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinki...

Phosphatidylserine monograph & interactions

Phosphatidylethanolamine

2.5 mg per serving Form: Soy

Other (inactive) ingredients: Gelatin, Glycerin, Polyglycitol Syrup, Purified Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Smart PS Phosphatidylserine by Vinco Drug Interactions

Want to check YOUR meds against Smart PS Phosphatidylserine?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
219Drugs
219 Moderate

Ingredients driving the most interactions

Phosphatidylserine 219

Individual Drug Interactions

The ingredients in Smart PS Phosphatidylserine interact with 219 drugs. Click any drug to see the details.

1 of the 3 ingredients in Smart PS Phosphatidylserine interact with drugs. Each result below shows which ingredient is responsible. Phosphatidylserine

Each ingredient & the kinds of drugs it affects

For each ingredient in Smart PS Phosphatidylserine with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Phosphatidylserine2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically interfere with the activity of anticholinergic agents.

Likelihood Possible Evidence B
Cholinergic Drugs

Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence B
Phosphatidylserine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Smart PS Phosphatidylserine, from the product label.

Vinco

See all Vinco products
Name
Vinco Inc.
City
Evans City
State
PA
ZipCode
16033
Phone Number
1-800-245-1939
Web Address
www.vincoinc.com
Pharmacist Counseling Corner

Smart PS Phosphatidylserine by Vinco: Common Questions

Does Smart PS Phosphatidylserine by Vinco interact with any medications?
Yes. Based on its ingredients, Smart PS Phosphatidylserine has a known interaction with 219 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Smart PS Phosphatidylserine contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's the difference between phosphatidylserine and phosphatidylcholine?
Both are phospholipids—fatty compounds in cell membranes—but they have different roles. Phosphatidylserine is included here mainly for brain health and cognitive support; phosphatidylcholine supports liver and digestive health. This product combines them to work together.
Can phosphatidylserine really help with memory loss?
Phosphatidylserine has possibly effective evidence for age-related cognitive decline and Alzheimer disease. That means there's some promising research, but it's not conclusive. For other cognitive concerns like ADHD or general brain fog, the evidence isn't established yet in the data we hold.
What are the most common side effects?
With phosphatidylserine, the most common are gastrointestinal upset (bloating, flatulence, nausea), headache, and insomnia—particularly at higher doses. Phosphatidylcholine can cause similar digestive issues, especially altered taste, bloating, and diarrhea. Most people tolerate it well at typical doses.
Is it safe to take if I'm pregnant or breastfeeding?
For phosphatidylserine, the safety data advises against use in pregnancy. For phosphatidylcholine, while choline itself is needed in pregnancy, supplement safety beyond food sources isn't well studied. Either way, talk with your doctor before taking this product if you're pregnant or breastfeeding.
Will this interact with my blood pressure or dementia medications?
Phosphatidylserine has Moderate interactions documented with anticholinergic and cholinergic drugs—medication types used for various conditions. Rather than guess which of your medications might be affected, run them through the checker on this page, or ask your pharmacist before you start.
How do I know if the dose in this product is effective?
That depends on which condition you're taking it for and which ingredient you're relying on. Phosphatidylserine studies have shown benefit at various doses; insomnia risk is higher around 600 mg. If you're unsure whether the dose here matches what's been studied, check with your doctor or pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Smart PS Phosphatidylserine label
Go deeper

The Full Monographs Behind Smart PS Phosphatidylserine’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Phosphatidylcholine

Phosphatidylcholine is a phospholipid that is part of every cell membrane and a source of choline. People take it for liver, brain, and gut health, but solid human evidence is limited for mo...

Read the full Phosphatidylcholine monograph → Herb & supplement monograph

Phosphatidylserine

Interacts with 219 drugs

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinking. Some research suggests possible bene...

Read the full Phosphatidylserine monograph →
Sources

Sources & How We Checked

Smart PS Phosphatidylserine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 24 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phosphatidylcholine 15 references
  1. Domino EF, May WW, Demetriou S, et al. Lack of clinically significant improvement of patients with tardive dyskinesia following phosphatidylcholine therapy. Biol Psychiatry 1985;20:1189-96. PubMed
  2. Aronson PJ, Lorincz AL. Promotion of palmar sweating with oral phosphatidylcholine. Acta Derm Venereol 1985;65:19-24. DOI
  3. Hexsel DM, Serra M, de Oliveira Dal'Forno T, et al. Cosmetic uses of injectable phosphatidylcholine on the face. Otolaryngol Clin North Am 2005;38:1119-29. PubMed
  4. Kopera D, Binder B, Toplak H, et al. Histopathologic changes after intralesional application of phosphatidylcholine for lipoma reduction: report of a case. Am J Dermatopathol 2006;28:331-3. PubMed
  5. Rittes PG. The use of phosphatidylcholine for correction of lower lid bulging due to prominent fat pads. Dermatol Surg 2001;27:391-2. PubMed
  6. Rotunda AM, Kolodney MS. Mesotherapy and phosphatidylcholine injections: historical clarification and review. Dermatol Surg 2006;32:465-80. PubMed
  7. Hexsel D, Serra M, Mazzuco R, et al. Phosphatidylcholine in the treatment of localized fat. J Drugs Dermatol 2003;2:511-8.
  8. Hasengschwandtner F. Phosphatidylcholine treatment to induce lipolysis. Cosmet Dermatol 2005;4:308-13. PubMed
  9. Rittes PG. The use of phosphatidylcholine for correction of localized fat deposits. Aesthetic Plast Surg 2003;27:315-8. PubMed
  10. Ablon G, Rotunda AM. Treatment of lower eyelid fat pads using phosphatidylcholine: clinical trial and review. Dermatol Surg 2004;30:422-7. PubMed
  11. Loguercio C, Andreone P, Brisc C, et al. Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: a randomized controlled trial. Free Radic Biol Med 2012;52(9):1658-65. PubMed
  12. Panos, J. M., Palson, R., Johnson, R., Portmann, B., and Williams, R. Polyunsaturated phosphatidylcholine for acute alcoholic hepatitis: a double blind randomized placebo controlled trial. Eur.J.Gastroenterol 1990;2:351-355.
  13. Stremmel W, Braun A, Hanemann A, Ehehalt R, Autschbach F, Karner M. Delayed release phosphatidylcholine in chronic-active ulcerative colitis: a randomized, double-blinded, dose finding study. J Clin Gastroenterol 2010;44(5):e101-7. PubMed
  14. Stremmel W, Ehehalt R, Autschbach F, Karner M. Phosphatidylcholine for steroid-refractory chronic ulcerative colitis: a randomized trial. Ann Intern Med. 2007;147(9):603-10. PubMed
  15. Stremmel W, Vural H, Evliyaoglu O, Weiskirchen R. Delayed Release Phosphatidylcholine is Effective for Treatment of Ulcerative Colitis: A Meta-Analysis. Dig Dis 2021;39(5):508-515. PubMed

See these in context on the Phosphatidylcholine monograph →

Phosphatidylserine 9 references
  1. Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28:61-6.
  2. Pepping J. Phosphatidylserine. Am J Health-Syst Pharm 1999;56:2038,2043-4.
  3. Kidd PM. Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Altern Med Rev 1996;1:70-84.
  4. Kim HY, Akbar M, Lau A, et al. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. J Biol Chem 2000;275:35215-23.. PubMed
  5. Zanotti A, Valzelli L, Toffano G. Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology (Berl) 1989;99:316-21.. PubMed
  6. Schreiber S, Kampf-Sherf O, Gorfine M, et al. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci 2000;37:302-7.
  7. Pepping, J. Phosphatidylserine. Am J Health Syst.Pharm. 10-15-1999;56(20):2038, 2043-2038, 2044.
  8. Monteverde, A., Gnemmi, P., Rossi, F., Monteverde, A., and Finali, G. C. Selegiline in the treatment of mild to moderate Alzheimer-type dementia. Clin.Ther 1990;12(4):315-322.
  9. Vakhapova V, Cohen T, Richter Y, Herzog Y, Kam Y, Korczyn AD. Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study. Dement Geri PubMed

See these in context on the Phosphatidylserine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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