Stabilized Oxygen Ingredients & Drug Interactions
by World Nutrition Incorporated
What is this page for?
First and foremost: checking Stabilized Oxygen against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Stabilized Oxygen is a dietary supplement by World Nutrition Incorporated with 4 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 205 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sodium Chlorite. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Stabilized Oxygen by World Nutrition Incorporated
Ask about any prescription or over-the-counter medication and we check it for interactions with Stabilized Oxygen by World Nutrition Incorporated — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Stabilized Oxygen by World Nutrition Incorporated
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This liquid supplement has 4 ingredients. The active component is sodium chlorite, which is a source of supplemental sodium.
The other ingredients are deionized water, carbonates, and bicarbonates — these are inactive excipients that make up the formulation.
Does it work?
Strong evidence
The data we hold shows sodium chlorite is likely effective for cystic fibrosis and possibly effective for amphotericin B nephrotoxicity (kidney damage from an antifungal drug). For bipolar disorder and congestive heart failure, there isn't enough reliable evidence to establish how well it works.
How safe is it?
Well-documented data
Sodium is essential in small amounts, but too much is linked to high blood pressure and heart strain. The facts show that at moderate intakes — up to the recommended Chronic Disease Risk Reduction level of 2.3 grams daily — sodium is well tolerated.
But serious complications are rare and include worsened cardiovascular disease, high blood pressure, and kidney disease. There's also observational evidence linking high sodium intake to an increased risk of gastric cancer.
For pregnancy and lactation, the safety rating is mixed — it's rated likely safe but also possibly unsafe, so talk with your doctor or pharmacist about whether it's right for you if you're pregnant or breastfeeding.
Meds to double-check
Moderate interaction found
Check with your pharmacist before taking this if you're on blood pressure drugs (antihypertensives), lithium, corticosteroids, HIV medications like didanosine, or any sodium-containing drugs or supplements — sodium chlorite can alter how these medications work or raise your sodium to unsafe levels.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
This product is a sodium supplement, so it's most relevant if you have cystic fibrosis or specific kidney concerns related to amphotericin B. If you take any blood pressure medication, lithium, corticosteroids, or HIV drugs, you need to check with your pharmacist first — sodium can interfere with how these work.
Anyone with heart disease, high blood pressure, or kidney problems should not take this without medical guidance.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2013.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Stabilized Oxygen, straight from the product label.
| Brand | World Nutrition Incorporated |
|---|---|
| Barcode (UPC) | 805034657776 |
| Net contents | 70 mL; 2.33 fl. Oz. |
| Market status | On market |
| Date entered into DSLD | Mar 25, 2013 |
| DSLD ID | 19735 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Stabilized Oxygen by World Nutrition Incorporated, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| deionized Water | 0 NP | -- |
| Sodium Chlorite | 0 NP | -- |
| Carbonates | 0 NP | -- |
| Bicarbonates | 0 NP | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
RECOMMENDED: As a dietary supplement, add six to eight drops per eight oz. glass of water two to three times daily. Best when taken on an empty stomach.
Precautions
KEEP AWAY FROM HEAT.
KEEP OUT OF REACH OF CHILDREN.
Warning: Stabilized Oxygen is a concentrate. If consumed in its concentrate form, it may cause irritation and nausea. If consumed undiluted, drink milk followed by yogurt or other sources of friendly bacteria.
Seals/Symbols
Suitable for Vegetarians
FDA Disclaimer Statement
These statements made herein have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
General Statements
Made in the USA
Full Internal Release
Helps Enhance: Energy + Alertness + Quicker Muscle Recovery + pH Balance
Storage
World Nutrition INCORPORATED
General
REV. 1/12
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Stabilized Oxygen by World Nutrition Incorporated label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Stabilized Oxygen by World Nutrition Incorporated
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size6 Drop(s) Dosage formLiquid Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Deionized Water
Sodium Chlorite
Interacts with205 drugs
Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...
Sodium Chlorite monograph & interactionsCarbonates
Bicarbonates
Stabilized Oxygen by World Nutrition Incorporated Drug Interactions
HelloPharmacist Interaction Report
Stabilized Oxygen by World Nutrition Incorporated contains sodium chlorite, which interacts with a number of medications.
The most serious concern is with blood pressure drugs (antihypertensives) — high sodium intake can reduce how well they work and may require dose adjustments to keep your blood pressure controlled.
Read the full breakdown — every affected drug type, severity by severity
You'll also want to flag this product if you take lithium for mood disorders, because sodium can shift how much lithium stays in your bloodstream and raise the risk of toxicity. The same sodium-related concern applies to corticosteroids (like prednisone), didanosine (an HIV medication), sodium phosphate bowel-prep solutions, tolvaptan (for low sodium levels), and any other sodium-containing drugs — all carry a moderate risk of dangerously high sodium levels if combined with this supplement.
We could not check deionized water, carbonates, or bicarbonates for interactions — we hold no data for them. Altogether, these interactions span 203 individual medications.
Run your exact medications through the search tool on this page before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Stabilized Oxygen?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Stabilized Oxygen interact with 205 drugs. Click any drug to see the details.
1 of the 4 ingredients in Stabilized Oxygen interact with drugs. Each result below shows which ingredient is responsible. Sodium Chlorite
Betamethasone DipropionateSernivo
How Betamethasone Dipropionate interacts with Stabilized Oxygen — through 1 ingredient. Tap an ingredient for the detail:
Sodium ChloriteCorticosteroids Moderate
Interaction Summary
Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Read the full Sodium Chlorite + Betamethasone Dipropionate interactionBetamethasone Dipropionate, CalcipotrieneEnstilar, Wynzora
How Betamethasone Dipropionate, Calcipotriene interacts with Stabilized Oxygen — through 1 ingredient. Tap an ingredient for the detail:
Sodium ChloriteCorticosteroids Moderate
Interaction Summary
Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Read the full Sodium Chlorite + Betamethasone Dipropionate, Calcipotriene interactionBetamethasone ValerateLuxiq
How Betamethasone Valerate interacts with Stabilized Oxygen — through 1 ingredient. Tap an ingredient for the detail:
Sodium ChloriteCorticosteroids Moderate
Interaction Summary
Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Read the full Sodium Chlorite + Betamethasone Valerate interactionBetaxololBetoptic, Kerlone
How Betaxolol interacts with Stabilized Oxygen — through 1 ingredient. Tap an ingredient for the detail:
Sodium ChloriteAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium Chlorite + Betaxolol interactionBisoprololZebeta
How Bisoprolol interacts with Stabilized Oxygen — through 1 ingredient. Tap an ingredient for the detail:
Sodium ChloriteAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium Chlorite + Bisoprolol interactionBisoprolol, HydrochlorothiazideZiac
How Bisoprolol, Hydrochlorothiazide interacts with Stabilized Oxygen — through 1 ingredient. Tap an ingredient for the detail:
Sodium ChloriteAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium Chlorite + Bisoprolol, Hydrochlorothiazide interactionBosentanTracleer
How Bosentan interacts with Stabilized Oxygen — through 1 ingredient. Tap an ingredient for the detail:
Sodium ChloriteAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium Chlorite + Bosentan interactionBudesonideEntocort EC, Eohilia, Pulmicort, Tarpeyo, Uceris
How Budesonide interacts with Stabilized Oxygen — through 1 ingredient. Tap an ingredient for the detail:
Sodium ChloriteCorticosteroids Moderate
Interaction Summary
Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Read the full Sodium Chlorite + Budesonide interactionBumetanideBurinex
How Bumetanide interacts with Stabilized Oxygen — through 1 ingredient. Tap an ingredient for the detail:
Sodium ChloriteAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium Chlorite + Bumetanide interactionBumetanide (iv)Bumex
How Bumetanide (iv) interacts with Stabilized Oxygen — through 1 ingredient. Tap an ingredient for the detail:
Sodium ChloriteAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium Chlorite + Bumetanide (iv) interactionBumetanide (oral)Bumex
How Bumetanide (oral) interacts with Stabilized Oxygen — through 1 ingredient. Tap an ingredient for the detail:
Sodium ChloriteAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium Chlorite + Bumetanide (oral) interactionCandesartan CilexetilAmias, Atacand
How Candesartan Cilexetil interacts with Stabilized Oxygen — through 1 ingredient. Tap an ingredient for the detail:
Sodium ChloriteAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium Chlorite + Candesartan Cilexetil interactionCandesartan Cilexetil, HydrochlorothiazideAtacand HCT
How Candesartan Cilexetil, Hydrochlorothiazide interacts with Stabilized Oxygen — through 1 ingredient. Tap an ingredient for the detail:
Sodium ChloriteAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium Chlorite + Candesartan Cilexetil, Hydrochlorothiazide interactionCaptoprilAcepril, Capoten
How Captopril interacts with Stabilized Oxygen — through 1 ingredient. Tap an ingredient for the detail:
Sodium ChloriteAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium Chlorite + Captopril interactionCaptopril, HydrochlorothiazideAcezide, Capozide
How Captopril, Hydrochlorothiazide interacts with Stabilized Oxygen — through 1 ingredient. Tap an ingredient for the detail:
Sodium ChloriteAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium Chlorite + Captopril, Hydrochlorothiazide interactionCarteololCartrol, Ocupress
How Carteolol interacts with Stabilized Oxygen — through 1 ingredient. Tap an ingredient for the detail:
Sodium ChloriteAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium Chlorite + Carteolol interactionCarvedilolCoreg, Coreg CR
How Carvedilol interacts with Stabilized Oxygen — through 1 ingredient. Tap an ingredient for the detail:
Sodium ChloriteAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium Chlorite + Carvedilol interactionCeliprololCelicard
How Celiprolol interacts with Stabilized Oxygen — through 1 ingredient. Tap an ingredient for the detail:
Sodium ChloriteAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium Chlorite + Celiprolol interactionChlorothiazideDiuril
How Chlorothiazide interacts with Stabilized Oxygen — through 1 ingredient. Tap an ingredient for the detail:
Sodium ChloriteAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium Chlorite + Chlorothiazide interactionChlorothiazide, MethyldopaAldochlor, Aldoclor 150, Aldoclor 250
How Chlorothiazide, Methyldopa interacts with Stabilized Oxygen — through 1 ingredient. Tap an ingredient for the detail:
Sodium ChloriteAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium Chlorite + Chlorothiazide, Methyldopa interactionChlorothiazide, ReserpineDiupres
How Chlorothiazide, Reserpine interacts with Stabilized Oxygen — through 1 ingredient. Tap an ingredient for the detail:
Sodium ChloriteAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium Chlorite + Chlorothiazide, Reserpine interactionChlorthalidoneHygroton, Thalitone
How Chlorthalidone interacts with Stabilized Oxygen — through 1 ingredient. Tap an ingredient for the detail:
Sodium ChloriteAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium Chlorite + Chlorthalidone interactionChlorthalidone, ClonidineClorpres, Combipres
How Chlorthalidone, Clonidine interacts with Stabilized Oxygen — through 1 ingredient. Tap an ingredient for the detail:
Sodium ChloriteAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium Chlorite + Chlorthalidone, Clonidine interactionCilazaprilInhibace
How Cilazapril interacts with Stabilized Oxygen — through 1 ingredient. Tap an ingredient for the detail:
Sodium ChloriteAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium Chlorite + Cilazapril interactionClevidipineCleviprex
How Clevidipine interacts with Stabilized Oxygen — through 1 ingredient. Tap an ingredient for the detail:
Sodium ChloriteAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium Chlorite + Clevidipine interactionClobetasolClobex, Temovate
How Clobetasol interacts with Stabilized Oxygen — through 1 ingredient. Tap an ingredient for the detail:
Sodium ChloriteCorticosteroids Moderate
Interaction Summary
Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Read the full Sodium Chlorite + Clobetasol interactionClonidineCatapres
How Clonidine interacts with Stabilized Oxygen — through 1 ingredient. Tap an ingredient for the detail:
Sodium ChloriteAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium Chlorite + Clonidine interactionCortisone AcetateCortisone Tablets, Cortone
How Cortisone Acetate interacts with Stabilized Oxygen — through 1 ingredient. Tap an ingredient for the detail:
Sodium ChloriteCorticosteroids Moderate
Interaction Summary
Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Read the full Sodium Chlorite + Cortisone Acetate interactionCryptenamine, MethyclothiazideDiutensen
How Cryptenamine, Methyclothiazide interacts with Stabilized Oxygen — through 1 ingredient. Tap an ingredient for the detail:
Sodium ChloriteAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium Chlorite + Cryptenamine, Methyclothiazide interactionCyclothiazideAnhydron, Fluidil
How Cyclothiazide interacts with Stabilized Oxygen — through 1 ingredient. Tap an ingredient for the detail:
Sodium ChloriteAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
Read the full Sodium Chlorite + Cyclothiazide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Stabilized Oxygen with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Sodium Chlorite
Antihypertensive Drugs
Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.
Corticosteroids
Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.
Didanosine (Videx)
Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.
Lithium
Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.
Sodium Phosphates
Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.
Sodium-Containing Drugs
Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.
Tolvaptan (Samsca)
Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.
Brand information
Manufacturer and brand details for Stabilized Oxygen, from the product label.
World Nutrition Incorporated
See all World Nutrition Incorporated products- Name
- World Nutrition, Inc.
- Street Address
- 7001 N. Scottsdale Road
- City
- Scottsdale
- State
- AZ
- ZipCode
- 85253
- Web Address
- www.worldnutrition.info
Stabilized Oxygen by World Nutrition Incorporated: Common Questions
Does Stabilized Oxygen by World Nutrition Incorporated interact with any medications?
How can one product interact with so many drugs?
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Can I take this if I have high blood pressure?
What are the side effects?
Why do I need to be careful about sodium if I take lithium?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Stabilized Oxygen is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Stabilized Oxygen’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Stabilized Oxygen's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 38 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Sodium 38 references
- Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
- Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
- Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
- Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
- Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
- Alam S, Johnson AG. A meta-analysis of randomised controlled trials (RCT) among healthy normotensive and essential hypertensive elderly patients to determine the effect of high salt (NaCl) diet of blood pressure. J Hum Hypertens 1999;13(6):367-74.
- Boudville N, Ward S, Benaroia M, House AA. Increased sodium intake correlates with greater use of antihypertensive agents by subjects with chronic kidney disease. Am J Hypertens 2005;18(10):1300-5. PubMed
- Bennett WM. Drug interactions and consequences of sodium restriction. Am J Clin Nutr 1997;65(2 Suppl):678S-681S. PubMed
- Okusa MD, Crystal LJ. Clinical manifestations and management of acute lithium intoxication. Am J Med 1994;97(4):383-9. PubMed
- Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/openbook.php?record_id=10925. DOI
- D'Elia L, Rossi G, Ippolito R, Cappuccio FP, Strazzullo P. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr 2012;31(4):489-98. PubMed
- Goldsmith SR. Hyponatremia in heart failure: time for a trial. J Card Fail 2013;19(6):398-400. PubMed
- Willocks L, Brettle R, Keen J, Valentine C, Pinching AJ. Formulations of didanosine (ddI) and salt overload. Lancet 1992;339(8786):190.
- Chen L, Zhang Z, Chen W, Whelton PK, Appel LJ. Lower Sodium Intake and Risk of Headaches: Results From the Trial of Nonpharmacologic Interventions in the Elderly. Am J Public Health. 2016;106(7):1270-5. PubMed
- Cook NR, Appel LJ, Whelton PK. Lower levels of sodium intake and reduced cardiovascular risk. Circulation. 2014;129(9):981-9. PubMed
- Cook NR, Appel LJ, Whelton PK. Sodium Intake and All-Cause Mortality Over 20 Years in the Trials of Hypertension Prevention. J Am Coll Cardiol. 2016;68(15):1609-1617. PubMed
- Mente A, O'Donnell M, Rangarajan S, et al. Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies. Lancet. 2016;388(10043):465-75. PubMed
- Moosavian SP, Haghighatdoost F, Surkan PJ, Azadbakht L. Salt and obesity: a systematic review and meta-analysis of observational studies. Int J Food Sci Nutr. 2017;68(3):265-277. PubMed
- O'Donnell M, Mente A, Rangarajan S, et al. Urinary sodium and potassium excretion, mortality, and cardiovascular events. N Engl J Med. 2014;371(7):612-23. DOI
- Poggio R, Gutierrez L, Matta MG, Elorriaga N, Irazola V, Rubinstein A. Daily sodium consumption and CVD mortality in the general population: systematic review and meta-analysis of prospective studies. Public Health Nutr. 2015;18(4):695-704. PubMed
- Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad
- Mahtani KR, Heneghan C, Onakpoya I, et al. Reduced Salt Intake for Heart Failure: A Systematic Review. JAMA Intern Med. 2018 Dec 1;178(12):1693-1700. PubMed
- Yancy CW. Sodium Restriction in Heart Failure: Too Much Uncertainty-Do the Trials. JAMA Intern Med. 2018 Dec 1;178(12):1700-1701. PubMed
- He FJ, Campbell NRC, Ma Y, MacGregor GA, Cogswell ME, Cook NR. Errors in estimating usual sodium intake by the Kawasaki formula alter its relationship with mortality: implications for public health. Int J Epidemiol. 2018;47(6):1784-1795. PubMed
- Murthy K, Ondrey GJ, Malkani N, et al. THE EFFECTS OF HYPONATREMIA ON BONE DENSITY AND FRACTURES: A SYSTEMATIC REVIEW AND META-ANALYSIS. Endocr Pract. 2019;25(4):366-378. PubMed
- Messerli FH, Hofstetter L, Syrogiannouli L, et al. Sodium intake, life expectancy, and all-cause mortality. Eur Heart J 2021;42(21):2103-2112. PubMed
- Graudal NA, Hubeck-Graudal T, Jurgens G. Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride. Cochrane Database Syst Rev 2020;12(12):CD004022. PubMed
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