Major interaction on record — check this product against your medications before combining. Based on 3 of 9 ingredients. Check your meds →
Dietary supplement

Stone-K Formula Ingredients & Drug Interactions

by Plum Flower Modern Masters

Stone-K Formula label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Stone-K Formula against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Stone-K Formula is a dietary supplement by Plum Flower Modern Masters with 9 active ingredients. Its ingredients are commonly taken for fluid retention and swelling, digestive complaints, sleep and calming support.Based on those ingredients, 1,147 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Citrus aurantium extract, Poria cocos sclerotium extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Stone-K Formula by Plum Flower Modern Masters

Ask about any prescription or over-the-counter medication and we check it for interactions with Stone-K Formula by Plum Flower Modern Masters — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Stone-K Formula by Plum Flower Modern Masters

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 9 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (4 Gram(s)) without saying how much of each component you get.

Stone-K Formula contains nine active ingredients, most of them plant extracts. The two with known interactions are Poria cocos sclerotium extract (a mushroom used in traditional medicine) and Citrus aurantium extract (bitter orange).

We also hold data for Luffa cylindrica extract. The other active ingredients — Achyranthes bidentata, Desmodium styracifolium, Plantago asiatica, Abutilon Theophrastii, Lygodium japonicum, and Clematis armandii extracts — are in a proprietary blend, so their individual amounts aren't disclosed.

The formula also contains inactive ingredients: microcrystalline cellulose, China wax, and activated carbon, which serve as fillers and binders.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

The label doesn't state a purpose we can grade — see each ingredient's own graded uses on its monograph instead.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for Stone-K Formula's active ingredients is not established in the data we hold. For Poria mushroom extract, we have insufficient reliable evidence to rate its use for cancer, chronic fatigue, dementia, diabetes, diabetic kidney disease, or diarrhea.

Luffa extract similarly shows insufficient evidence for hay fever or sinus inflammation. Bitter orange has insufficient evidence for hay fever, hair loss, sexual function, anxiety, or athletic performance.

No effectiveness ratings are on file for the other ingredients.

The evidence, ingredient by ingredient Poria Mushroom Bitter Orange Luffa

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Poria mushroom extract is generally well tolerated in traditional use, though human safety data are limited. Rarely, allergic reactions have been reported, including allergic rhinitis and allergic asthma.

Bitter orange in supplement amounts is potentially unsafe when taken orally — it can raise blood pressure and heart rate, especially with caffeine, and rare serious effects including heart attack, stroke, and dangerous heart rhythms have been noted. Luffa extract taken internally is not well studied; external sponge use is generally safe, but oral supplements may irritate the stomach.

The safety data for Achyranthes bidentata, Desmodium styracifolium, Plantago asiatica, Abutilon Theophrastii, Lygodium japonicum, and Clematis armandii are not on file.

Side effects, ingredient by ingredient Poria Mushroom Bitter Orange Luffa

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Poria Mushroom, Bitter Orange.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: diabetes medications; heart-rhythm medications.
  • For scale: 1,148 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Stone-K Formula, check your medications against this list. Most serious: monoamine oxidase inhibitors (MAOIs for depression or Parkinson's) and midazolam (a sedative).

Next: drugs your liver breaks down through the CYP3A4 pathway — a large group that includes many statins, blood thinners, and other common medications. Also check stimulant drugs, diabetes medications, caffeine, anticholinergic drugs (for overactive bladder), cholinergic drugs (for Alzheimer's or myasthenia gravis), QT-prolonging heart drugs, and dextromethorphan (cough suppressant).

Use the interaction checker on this page with your full medication list.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Stone-K Formula is a traditional herbal blend with two ingredients that interact with a significant number of medications, particularly those affecting the nervous system, heart rhythm, blood pressure, and blood sugar. If you take any prescription or over-the-counter drugs — especially antidepressants, sedatives, stimulants, diabetes medications, or heart medications — check them against this product before starting.

Talk with your pharmacist or doctor about whether it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 27, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Stone-K Formula, straight from the product label.

Brand Plum Flower Modern Masters
Net contents 1.98 Ounce(s); 56 Gram(s); 14 Packet(s)
Market status On market
Date entered into DSLD Jul 27, 2021
DSLD ID 252211
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Stone-K Formula by Plum Flower Modern Masters, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Packet(s)
Maximum serving Sizes:
1 Packet(s)
Servings per container
14
IngredientAmount% DV
Proprietary Blend4 Gram(s)--
Poria cocos sclerotium extract0 NP--
Achyranthes bidentata extract0 NP--
Citrus aurantium extract0 NP--
Desmodium styracifolium extract0 NP--
Plantago asiatica extract0 NP--
Luffa cylindrica extract0 NP--
Abutilon Theophrastii extract0 NP--
Lygodium japonicum extract0 NP--
Clematis armandii extract0 NP--

Other ingredients: Microcrystalline Cellulose, China Wax, Activated Carbon

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Take 1 packet, twice daily or as directed by your health care practitioner

Best used under the guidance of a qualified practitioner.

Precautions

Not for use during pregnancy or while nursing

Keep out of reach of children

General Statements

Our Modern Masters Series are specially designed herbal formulas guided by modern research and clinical testing.

Formulation

Stone-K was developed by a urologist surgeon based on his research into Traditional Chinese Medicine (TCM) and over 50 years of clinical experience. This unique combination is rooted in TCM concepts but formulated and evaluated from a western science and medicine perspective.

No pharmaceuticals

Microbial and heavy metal tested Produced at a Good Manufacturing Practices (GMP) certified factory Made in China at a cGMP certified facility cGMP Compliant Made at a cGMP Facility Plum Flower Guarantee Species Verified

FDA Statement of Identity

Herbal Supplement

Formula

Scientifically authenticated herbs

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Stone-K Formula by Plum Flower Modern Masters label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Stone-K Formula label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Stone-K Formula by Plum Flower Modern Masters

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Packet(s) Dosage formPowder Servings per container14 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

4 Gram(s) per serving

Other (inactive) ingredients: Microcrystalline Cellulose, China Wax, Activated Carbon. These complete the product’s ingredient list but are not active constituents.

Interaction report

Stone-K Formula by Plum Flower Modern Masters Drug Interactions

Want to check YOUR meds against Stone-K Formula?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,147Drugs
10 Major 1,104 Moderate 33 Minor

Ingredients driving the most interactions

Citrus aurantium extract 957
Poria cocos sclerotium extract 417

Individual Drug Interactions

The ingredients in Stone-K Formula interact with 1,147 drugs. Click any drug to see the details.

2 of the 9 ingredients in Stone-K Formula interact with drugs. Each result below shows which ingredient is responsible. Citrus aurantium extract Poria cocos sclerotium extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Stone-K Formula with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Citrus aurantium extract13 drug types · 957 drugs

Midazolam (Versed)

Bitter orange might increase blood levels of midazolam.
One small clinical study shows that bitter orange juice can increase midazolam levels, likely through inhibition of cytochrome P450 3A4 (CYP3A4). Theoretically, bitter orange might increase the risk of midazolam-related adverse effects.

Likelihood Probable Evidence B
Monoamine Oxidase Inhibitors (Maois)

Theoretically, taking MAOIs with synephrine-containing bitter orange preparations might increase the hypertensive effects of synephrine, potentially leading to hypertensive crisis.
Bitter orange contains tyramine, octopamine, and synephrine, which are MAO substrates.

Likelihood Probable Evidence D
Antidiabetes Drugs

Theoretically, bitter orange might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Some clinical research shows that drinking a tea containing bitter orange and Indian snakeroot reduces fasting and postprandial glucose levels in patients with type 2 diabetes who are using antidiabetes drugs. However, it is unclear if these effects are due to bitter orange, Indian snakeroot, or the combination. An animal study also shows that p-synephrine in combination with gliclazide , a sulfonylurea, causes an additional 20% to 44% decrease in glucose levels when compared with gliclazide alone.

Likelihood Possible Evidence B
Caffeine

Bitter orange might increase blood pressure and heart rate when taken with caffeine.
Small clinical studies show that taking bitter orange in combination with caffeine can increase blood pressure and heart rate in otherwise healthy normotensive adults. Theoretically, this might increase the risk of serious cardiovascular adverse effects.

Likelihood Possible Evidence B
Colchicine

Bitter orange might affect colchicine levels.
Colchicine is a substrate of P-glycoprotein and cytochrome P450 3A4 (CYP3A4). Bitter orange has been reported to inhibit CYP3A4 and increase levels of CYP3A4 substrates. However, one small clinical study in healthy adults shows that drinking bitter orange juice 240 mL twice daily for 4 days and taking a single dose of colchicine 0.6 mg on the 4th day decreases colchicine peak serum levels by 24%, time to peak serum level by 1 hour, and overall exposure to colchicine by 20%. The clinical significance of this finding is unclear.

Likelihood Possible Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Bitter orange might increase levels of drugs metabolized by CYP3A4.
Small clinical studies suggest that single or multiple doses of freshly squeezed bitter orange juice 200-240 mL can inhibit CYP3A4 metabolism of drugs, causing increased drug levels and potentially increasing the risk of adverse effects. However, the extent of the effect of bitter orange on CYP3A4-mediated drug interactions is unknown. Some evidence suggests that bitter orange selectively inhibits intestinal CYP3A4, but not hepatic CYP3A4. Its effect on P-glycoprotein, which strongly overlaps with CYP3A4 interactions, is unclear. One small clinical study shows that drinking 8 ounces of freshly squeezed bitter orange juice has no effect on cyclosporine, which seems to be more dependent on hepatic CYP3A4 and P-glycoprotein than intestinal CYP3A4.

Likelihood Possible Evidence B
Dextromethorphan (Robitussin Dm, Others)

Bitter orange might increase blood levels of dextromethorphan.
One small clinical study shows that bitter orange juice increases dextromethorphan levels, likely through cytochrome P450 3A4 (CYP3A4) inhibition. Theoretically, bitter orange might increase the risk for dextromethorphan-related adverse effects.

Likelihood Possible Evidence B
Felodipine (Plendil)

Bitter orange might increase blood levels of felodipine.
One small clinical study shows that bitter orange juice increases felodipine levels, likely through cytochrome P450 3A4 (CYP3A4) inhibition. Theoretically, bitter orange might increase the risk for felodipine-related adverse effects.

Likelihood Probable Evidence B
Indinavir (Crixivan)

Bitter orange might increase blood levels of indinavir.
One small clinical study shows that bitter orange juice slightly increases indinavir levels, but this effect is likely to be clinically insignificant. Bitter orange selectively inhibits intestinal cytochrome P450 3A4 (CYP3A4); however, the metabolism of indinavir seems to be more dependent on hepatic CYP3A4. The effect of bitter orange on other protease inhibitors has not been studied.

Likelihood Possible Evidence B
Qt Interval-Prolonging Drugs

Theoretically, bitter orange might have an additive effect when combined with drugs that prolong the QT interval, potentially increasing the risk of ventricular arrhythmias.
One case report suggests that taking bitter orange in combination with other stimulants such as caffeine might prolong the QT interval in some patients.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Bitter orange juice might increase blood levels of sildenafil.
A small clinical study in healthy adult males shows that drinking freshly squeezed bitter orange juice 250 mL daily for 3 days and taking a single dose of sildenafil 50 mg on the 3rd day increases the peak plasma concentration of sildenafil by 18% and the overall exposure to sildenafil by 44%. Theoretically, this may be due to inhibition of cytochrome P450 3A4 by bitter orange.

Likelihood Probable Evidence B
Stimulant Drugs

Theoretically, bitter orange might increase the risk of hypertension and adverse cardiovascular effects when taken with stimulant drugs.
Bitter orange appears to have stimulant effects.

Likelihood Possible Evidence B
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, bitter orange might increase levels of drug metabolized by CYP2D6.
In vitro research shows that octopamine, a constituent of bitter orange, weakly inhibits CYP2D6 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Citrus aurantium extract full monograph & interactions

Poria cocos sclerotium extract3 drug types · 417 drugs

Anticholinergic Drugs

Theoretically, poria mushroom might decrease the clinical effects of anticholinergic drugs.
In animal research, poria mushroom essential oil reduces acetylcholinesterase activity. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, poria mushroom might have additive effects when used with cholinergic drugs.
In animal research, poria mushroom essential oil reduces acetylcholinesterase activity. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Animal research shows that poria mushroom extract has sedative properties. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Poria cocos sclerotium extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Stone-K Formula, from the product label.

Plum Flower Modern Masters

See all Plum Flower Modern Masters products
Name
Mayway Herbs
City
Oakland
State
CA
ZipCode
94607
Web Address
www.plumflowerherbs.com
Pharmacist Counseling Corner

Stone-K Formula by Plum Flower Modern Masters: Common Questions

Does Stone-K Formula by Plum Flower Modern Masters interact with any medications?
Yes. Based on its ingredients, Stone-K Formula has a known interaction with 1,147 medications, including 10 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Stone-K Formula contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm pregnant?
The safety data advises against Poria mushroom extract and bitter orange during pregnancy. Luffa extract taken internally is best avoided in pregnancy as well because there isn't enough safety information. Talk with your doctor or pharmacist before starting — they can help you decide based on your individual situation.
Can I take this while breastfeeding?
Safety data for Poria mushroom extract and bitter orange during breastfeeding are not sufficient, so avoidance is recommended. Luffa extract taken internally is also best avoided while breastfeeding because safety is unknown. Check with your pharmacist or doctor before using this product.
What are the side effects I should watch for?
Bitter orange can raise blood pressure and heart rate, especially if you also consume caffeine or other stimulants. Rare serious effects include heart attack, stroke, and dangerous heart rhythms. Poria mushroom extract may rarely trigger allergic reactions like allergic rhinitis or asthma. Luffa taken internally may cause stomach irritation.
Does this actually work for anything?
We don't have reliable evidence in our data to say whether Stone-K Formula works for its intended purposes. The active ingredients show insufficient evidence for conditions like hay fever, diabetes, hair loss, and fatigue. Your pharmacist or doctor can discuss whether this formula makes sense for your needs.
Is this safe to take with caffeine or coffee?
No — bitter orange in this formula can raise your blood pressure and heart rate when combined with caffeine, and studies show this combination increases both systolic and diastolic blood pressure. If you're thinking about using this product, avoid caffeine while taking it and talk with your pharmacist first.
Why does this product interact with so many medications?
Bitter orange contains compounds that slow down how your liver breaks down many drugs through an enzyme called CYP3A4, causing those medications to build up in your system. It also acts as a stimulant and contains compounds related to adrenaline, affecting blood pressure and heart rate. These properties create a wide range of potential interactions.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Stone-K Formula is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Stone-K Formula label
Go deeper

The Full Monographs Behind Stone-K Formula’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Poria Mushroom

Interacts with 417 drugs

Poria mushroom (Fu Ling) is a fungus long used in Traditional Chinese Medicine, mainly as a mild diuretic and digestive and calming aid. Modern scientific evidence in humans is very limited,...

Read the full Poria Mushroom monograph → Herb & supplement monograph

Bitter Orange

Interacts with 957 drugs

Bitter orange is a citrus fruit whose extracts contain synephrine, a mild stimulant often added to weight-loss and energy supplements. Evidence that it works for weight loss or performance i...

Read the full Bitter Orange monograph → Herb & supplement monograph

Luffa

Luffa is a tropical gourd best known as the source of the natural loofah bath sponge, and its extracts appear in homeopathic and traditional remedies for congestion and allergies. Good-quali...

Read the full Luffa monograph →
Sources

Sources & How We Checked

Stone-K Formula's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 53 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Poria Mushroom 3 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Kim H, Park I, Park K, Park S, Kim YI, Park BG. The positive effects of Poria cocos extract on quality of sleep in insomnia rat models. Int J Environ Res Public Health 2022;19(11):6629. PubMed
  3. Lv Q, Di X, Bian B, Li K, Guo J. Neuroprotective effects of Poria cocos (Agaricomycetes) essential oil on Aß1-40-induced learning and memory deficit in rats. Int J Med Mushrooms 2022;24(10):73-82.

See these in context on the Poria Mushroom monograph →

Bitter Orange 47 references
  1. Penzak SR, Jann MW, Cold JA, et al. Seville (sour) orange juice: synephrine content and cardiovascular effects in normotensive adults. J Clin Pharmacol 2001;41:1059-63. PubMed
  2. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  3. Calapai G, Firenzuoli F, Saitta A, et al. Antiobesity and cardiovascular toxic effects of Citrus aurantium extracts in the rat: A preliminary report. Fitoterapia 1999;70:586-92. DOI
  4. Keogh AM, Baron DW. Sympathomimetic abuse and coronary artery spasm. Br Med J 1985;291:940.
  5. Malhotra S, Bailey DG, Paine MF, Watkins PB. Seville orange juice-felodipine interaction: comparison with dilute grapefruit juice and involvement of furocoumarins. Clin Pharmacol Ther 2001;69:14-23. PubMed
  6. Pellati F, Benvenuti S, Melegari M, Firenzuoli F. Determination of adrenergic agonists from extracts and herbal products of Citrus aurantium L. var. amara by LC. J Pharm Biomed Anal 2002;29:1113-9. . PubMed
  7. Colker CM, Kalman DS, Torina GC, et al. Effects of Citrus aurantium extract, caffeine, and St. John's wort on body fat loss, lipid levels, and mood states in overweight healthy adults. Curr Ther Res 1999;60:145-153. DOI
  8. Penzak SR, Acosta EP, Turner M, et al. Effect of Seville orange juice and grapefruit juice on indinavir pharmacokinetics. J Clin Pharmacol 2002;42:1165-70. PubMed
  9. Edwards DJ, Fitzsimmons ME, Schuetz EG, et al. 6',7'-Dihydroxybergamottin in grapefruit juice and Seville orange juice: effects on cyclosporine disposition, enterocyte CYP3A4, and P-glycoprotein. Clin Pharmacol Ther 1999;65:237-44. PubMed
  10. Di Marco MP, Edwards DJ, Wainer IW, Ducharme MP. The effect of grapefruit juice and seville orange juice on the pharmacokinetics of dextromethorphan: the role of gut CYP3A and P-glycoprotein. Life Sci 2002;71:1149-60. PubMed
  11. Visentin V, Morin N, Fontana E, et al. Dual action of octopamine on glucose transport into adipocytes: inhibition via beta3-adrenoceptor activation and stimulation via oxidation by amine oxidases. J Pharmacol Exp Ther 2001;299:96-104.
  12. Nykamp DL, Fackih MN, Compton AL. Possible association of acute lateral-wall myocardial infarction and bitter orange supplement. Ann Pharmacother 2004;38:812-6. PubMed
  13. Fugh-Berman A, Myers A. Citrus aurantium, an ingredient of dietary supplements marketed for weight loss: Current status of clinical and basic Research. Exp Biol Med 2004;229:698-704.
  14. Suzuki O, Matsumoto T, Oya M, Katsumata Y. Oxidation of synephrine by type A and type B monoamine oxidase. Experientia 1979;35:1283-4. PubMed
  15. Nasir JM, Durning SJ, Ferguson M, et al. Exercise-induced syncope associated with QT prolongation and ephedra-free Xenadrine. Mayo Clin Proc 2004;79:1059-62.. PubMed
  16. Firenzuoli F, Gori L, Galapai C. Adverse reaction to an adrenergic herbal extract (Citrus aurantium). Phytomedicine 2005;12:247-8. PubMed
  17. Bouchard NC, Howland MA, Greller HA, et al. Ischemic stroke associated with use of an ephedra-free dietary supplement containing synephrine. Mayo Clin Proc 2005;80:541-5. PubMed
  18. Haller CA, Benowitz NL, Jacob P 3rd. Hemodynamic effects of ephedra-free weight-loss supplements in humans. Am J Med 2005;118:998-1003.. PubMed
  19. Bui LT, Nguyen DT, Ambrose PJ. Blood pressure and heart rate effects following a single dose of bitter orange. Ann Pharmacother 2006;40:53-7. PubMed
  20. Min B, Cios D, Kluger J, White CM. Absence of QTc-interval-prolonging or hemodynamic effects of a single dose of bitter-orange extract in healthy subjects. Pharmacotherapy 2005;25:1719-24. PubMed
  21. Gange CA, Madias C, Felix-Getzik EM, et al. Variant angina associated with bitter orange in a dietary supplement. Mayo Clin Proc 2006;81:545-8. PubMed
  22. Jordan S, Murty M, Pilon K. Products containing bitter orange or synephrine: suspected cardiovascular adverse reactions. Canadian Adverse Reaction Newsletter 2004;14:3-4.
  23. Burke J, Seda G, Allen D, Knee TS. A case of severe exercise-induced rhabdomyolysis associated with a weight loss dietary supplement. Mil Med 2007;172:656-8. PubMed
  24. Gray, S. and Woolf, A. D. Citrus aurantium used for weight loss by an adolescent with anorexia nervosa. J Adolesc.Health 2005;37(5):414-415. PubMed
  25. Haller, C. A., Duan, M., Jacob, P., III, and Benowitz, N. Human pharmacology of a performance-enhancing dietary supplement under resting and exercise conditions. Br J Clin Pharmacol 2008;65(6):833-840. PubMed
  26. Thomas, J. E., Munir, J. A., McIntyre, P. Z., and Ferguson, M. A. STEMI in a 24-year-old man after use of a synephrine-containing dietary supplement: a case report and review of the literature. Tex.Heart Inst.J 2009;36(6):586-590.
  27. Campbell-Tofte, J. I., Molgaard, P., Josefsen, K., Abdallah, Z., Hansen, S. H., Cornett, C., Mu, H., Richter, E. A., Petersen, H. W., Norregaard, J. C., and Winther, K. Randomized and double-blinded pilot clinical study of the safety and anti-diabetic ef
  28. Seifert, J. G., Nelson, A., Devonish, J., Burke, E. R., and Stohs, S. J. Effect of acute administration of an herbal preparation on blood pressure and heart rate in humans. Int J Med Sci 2011;8(3):192-197. PubMed
  29. Stohs, S. J., Preuss, H. G., Keith, S. C., Keith, P. L., Miller, H., and Kaats, G. R. Effects of p-synephrine alone and in combination with selected bioflavonoids on resting metabolism, blood pressure, heart rate and self-reported mood changes. Int J Med
  30. Wason, S., DiGiacinto, J. L., and Davis, M. W. Effects of grapefruit and Seville orange juices on the pharmacokinetic properties of colchicine in healthy subjects. Clin Ther 2012;34(10):2161-2173. PubMed
  31. Kaats, G. R., Miller, H., Preuss, H. G., and Stohs, S. J. A 60day double-blind, placebo-controlled safety study involving Citrus aurantium (bitter orange) extract. Food Chem Toxicol. 2013;55:358-362.
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See these in context on the Bitter Orange monograph →

Luffa 3 references
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  3. Adler, M. Efficacy and safety of a fixed-combination homeopathic therapy for sinusitis. Adv Ther 1999;16(2):103-111.

See these in context on the Luffa monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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