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Dietary supplement

Strontium (Citrate) Ingredients & Drug Interactions

by Pure Encapsulations

Strontium (Citrate) label
See full label image
Capsule Category: Mineral
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Strontium (Citrate) against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Strontium (Citrate) is a dietary supplement by Pure Encapsulations with 1 active ingredient. Its ingredients are commonly taken for bone health and osteoporosis, reducing fracture risk, tooth sensitivity (in some toothpastes).Based on those ingredients, 101 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Strontium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Strontium (Citrate) by Pure Encapsulations

Ask about any prescription or over-the-counter medication and we check it for interactions with Strontium (Citrate) by Pure Encapsulations — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Strontium (Citrate) by Pure Encapsulations

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: strontium in citrate form. Strontium is a mineral that's been studied for bone and tooth health.

The capsule itself is made from vegetarian material, and the product also includes hypoallergenic plant fiber and ascorbyl palmitate (a form of vitamin C) as inactive ingredients.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: bone health and osteoporosis support.
  • We looked for evidence on: Osteoporosis, Fractures, Bone density, Bone strength.
  • The strongest evidence on file: Strontium is rated "Likely Effective" for Osteoporosis (Natural Medicines).
  • Also on file: Strontium is rated "Insufficient Reliable Evidence To Rate" for Fractures.

Strontium is rated effective for dental hypersensitivity and painful bony metastases (bone tumors or secondary cancer in bone). It's likely effective for osteoporosis — it appears to help slow bone loss and support bone density.

The evidence is possibly effective for osteoarthritis and prostate cancer, meaning some studies suggest a benefit, but more research is needed to be certain.

The evidence, ingredient by ingredient Strontium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Strontium ranelate has been linked to serious heart and clotting risks, especially with long-term use — clinical research shows it increases the relative risk of blood clots (venous thromboembolism) by about 50% and the risk of heart attack by about 1.6-fold in people with osteoporosis. Common side effects include dermatitis, eczema, diarrhea, headache, and nausea.

Safety data advises against use during pregnancy. There isn't enough safety information to recommend it while breastfeeding — talk with your pharmacist or doctor for personalized guidance.

Side effects, ingredient by ingredient Strontium

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Strontium.
  • The most serious interaction on file is rated Moderate.
  • For scale: 101 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications if you take estrogens or androgens (male hormones), antacids, quinolone antibiotics, or tetracycline antibiotics — all are rated moderate interactions requiring timing adjustments or monitoring. Discuss this product with your pharmacist before starting, particularly if you have a history of heart attack or blood clots.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Strontium may help with bone health, dental sensitivity, and certain types of bone pain. If you take estrogens, androgens, antacids, or quinolone or tetracycline antibiotics, you'll need to space your doses carefully — or strontium may not work well, or your antibiotics may not absorb properly.

Given the serious heart and clotting risks documented in long-term studies, talk with your pharmacist or doctor before starting, especially if you have heart or clotting concerns.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 7, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Strontium (Citrate), straight from the product label.

Brand Pure Encapsulations
Barcode (UPC) 766298008301
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Jan 7, 2019
DSLD ID 185255
Product type Mineral
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Strontium (Citrate) by Pure Encapsulations, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
UPC/BARCODE
766298008301
IngredientAmount% DV
Strontium227 mg--

Other ingredients: Vegetarian Capsule, hypoallergenic Plant Fiber, Ascorbyl Palmitate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

Store in a cool, dry place.

Suggested/Recommended/Usage/Directions

Recommendations: As a dietary supplement, take 1 capsule, 1-3 times daily, with or between meals, away from calcium containing foods or supplements.

Precautions

Warning: If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.

Keep out of the reach of children.

Use only if safety seal is intact.

General Statements

Scan to learn about our hypoallergenic supplements

Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity.

Supports bone health

Formulation

Certified Gluten-free by the Gluten-free Certification Organization, www.gluten.org

Gluten-free, Non-GMO & Hypoallergenic

Gluten-free, Non-GMO & Hypoallergenic

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

GF

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General

v4 code: STC9

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Strontium (Citrate) by Pure Encapsulations label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Strontium (Citrate) label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Strontium (Citrate) by Pure Encapsulations

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Strontium

Interacts with
101 drugs
227 mg per serving Form: Strontium Citrate

Strontium is a mineral that has been studied mainly for bone health and osteoporosis. The prescription form (strontium ranelate) showed benefit for fr...

Strontium monograph & interactions

Other (inactive) ingredients: Vegetarian Capsule, Hypoallergenic Plant Fiber, Ascorbyl Palmitate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Strontium (Citrate) by Pure Encapsulations Drug Interactions

Want to check YOUR meds against Strontium (Citrate)?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
101Drugs
101 Moderate

Ingredients driving the most interactions

Strontium 101

Individual Drug Interactions

The ingredients in Strontium (Citrate) interact with 101 drugs. Click any drug to see the details.

1 of the 1 ingredient in Strontium (Citrate) interact with drugs. Each result below shows which ingredient is responsible. Strontium

Each ingredient & the kinds of drugs it affects

For each ingredient in Strontium (Citrate) with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Strontium5 drug types · 101 drugs

Androgens

Theoretically, androgens might reduce the excretion of strontium, potentially increasing its effects and adverse effects.
A small clinical study suggests that treatment with androgens such as testosterone, nandrolone, oxandrolone, and oxymetholone for 5-6 weeks might decrease urinary strontium excretion. The clinical significance of this interaction is unknown.

Likelihood Possible Evidence D
Antacids

Antacids can reduce the absorption of strontium, potentially decreasing its effectiveness.
Aluminum hydroxide and magnesium hydroxide can reduce absorption of strontium ranelate by 20% to 25%. Calcium can reduce its absorption to 60% to 70%. Avoid taking antacids within 2 hours of a dose of strontium ranelate. This interaction has also been reported with orally-administered radioactive strontium-85. It will likely also occur with other forms of strontium.

Likelihood Probable Evidence C
Estrogens

Theoretically, estrogens might reduce the excretion of strontium, potentially increasing its effects and adverse effects.
A small clinical study suggests that treatment with estrogens for 5-6 weeks might decrease urinary strontium excretion. The clinical significance of this interaction is unknown.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, strontium might decrease the absorption of quinolone antibiotics.
Strontium is a divalent cation with similar properties to calcium. It is likely to form complexes with quinolones in the gastrointestinal (GI) tract, preventing absorption of the antibiotic. Recommend taking strontium supplements at least 2 hours before or after quinolones to avoid an interaction.

Likelihood Probable Evidence D
Tetracycline Antibiotics

Theoretically, strontium might decrease the absorption of tetracycline antibiotics.
Strontium is a divalent cation with similar properties to calcium. It is likely to form complexes with tetracyclines in the gastrointestinal (GI) tract, preventing absorption of the antibiotic. Recommend taking strontium supplements at least 2 hours before or after tetracyclines to avoid an interaction.

Likelihood Probable Evidence D
Strontium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Strontium (Citrate), from the product label.

Pure Encapsulations

See all Pure Encapsulations products
Name
Pure Encapsulations
Street Address
490 Boston Post Road
City
Sudbury
State
MA
Phone Number
1-800-753-2277
Web Address
www.PureEncapsulations.com
Pharmacist Counseling Corner

Strontium (Citrate) by Pure Encapsulations: Common Questions

Does Strontium (Citrate) by Pure Encapsulations interact with any medications?
Yes. Based on its ingredients, Strontium (Citrate) has a known interaction with 101 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Strontium (Citrate) contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is strontium safe to take during pregnancy or breastfeeding?
Safety hasn't been established during pregnancy, so the data advises against use. While breastfeeding, there isn't enough safety information either — talk with your pharmacist or doctor about whether it's right for you in either situation.
What are the most common side effects of strontium?
The most common side effects are dermatitis, eczema, diarrhea, headache, and nausea. Serious side effects are rare but can include heart attack and blood clots — which is why it's important to discuss this product with your healthcare provider before you start.
Can I take strontium with my antacid?
You'll need to space them out. Antacids can reduce how much strontium your body absorbs — by 20% to 70%, depending on the type. Wait at least 2 hours between your strontium dose and your antacid.
Does strontium actually work for bone health?
It's rated likely effective for osteoporosis, meaning research suggests it does help slow bone loss and support bone density. It's also effective for dental hypersensitivity and painful bony metastases.
What is strontium and why would I take it?
Strontium is a mineral that your body uses for bone and tooth structure. People take it to support bone density, reduce dental sensitivity, and manage certain types of bone pain.
I take a tetracycline antibiotic — can I use this product?
Yes, but you'll need to space them carefully. Strontium can prevent your antibiotic from being absorbed properly. Take your strontium at least 2 hours before or after your tetracycline dose.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Strontium (Citrate) label
Go deeper

The Full Monographs Behind Strontium (Citrate)’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Strontium

Interacts with 101 drugs

Strontium is a mineral that has been studied mainly for bone health and osteoporosis. The prescription form (strontium ranelate) showed benefit for fracture risk but carries serious heart-re...

Read the full Strontium monograph →
Sources

Sources & How We Checked

Strontium (Citrate)'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 22 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Strontium 22 references
  1. Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
  2. Meunier PJ, Roux C, Seeman E, et al. The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. N Engl J Med 2004;350:459-68.. PubMed
  3. El-Hajj Fuleihan G. Strontium ranelate--a novel therapy for osteoporosis or a permutation of the same? N Engl J Med 2004;350:504-6. PubMed
  4. Verberckmoes SC, De Broe ME, D'Haese PC. Dose-dependent effects of strontium on osteoblast function and mineralization. Kidney Int 2003;64:534-43. . PubMed
  5. Meunier PJ, Slosman DO, Delmas PD, et al. Strontium ranelate: dose-dependent effects in established postmenopausal vertebral osteoporosis--a 2-year randomized placebo controlled trial. J Clin Endocrinol Metab 2002;87:2060-6.. DOI
  6. Brandi ML. New treatment strategies: ipriflavone, strontium, vitamin D metabolites and analogs. Am J Med 1993;95:69S-74S. . PubMed
  7. Eisenberg E. Effects of androgens, estrogens and corticoids on strontium kinetics in man. J Clin Endocrinol Metab 1966;26:566-72.
  8. Metastron prescribing information. Medi-Physics, Inc., Amersham Healthcare, Arlington Heights, IL, 1998. http://www.cancerpaintherapy.com/METATECHPAGE.htm. (Accessed 13 March 2004).
  9. Protelos European Summary of Product Characteristics. Les Laboratoires Servier, 2006. Available at: www.servier.com/pro/osteoporose/protelos/protelos_spc.asp. (Accessed 01 August 2006).
  10. US Department of Health and Human Services, Public Health Service. Agency for Toxic Substances and Disease Registry. Toxicological profile for strontium. April 2004. Available at: www.atsdr.cdc.gov/toxprofiles/tp159.pdf. (Accessed 8 August 2006).
  11. Apostolidis N, Paradellis T, Karydas A, et al. Calcium and strontium metabolic studies in patients on CAPD. Perit Dial Int 1998;18:410-4. DOI
  12. Ozgur S, Sumer H, Kocoglu G. Rickets and soil strontium. Arch Dis Child 1996;75:524-6. PubMed
  13. Schrooten I, Elseviers MM, Lamberts LV, et al. Increased serum strontium levels in dialysis patients: an epidemiological survey. Kidney Int 1999;56:1886-92. PubMed
  14. D'Haese PC, Couttenye MM, Lamberts LV, et al. Aluminum, iron, lead, cadmium, copper, zinc, chromium, magnesium, strontium, and calcium content in bone of end-stage renal failure patients. Clin Chem 1999;45:1548-56. DOI
  15. Pennington JA, Jones JW. Molybdenum, nickel, cobalt, vanadium, and strontium in total diets. J Am Diet Assoc 1987;87:1644-50. DOI
  16. O'Donnell S, Cranney A, Wells GA, et al. Strontium ranelate for preventing and treating postmenopausal osteoporosis. Cochrane Musculoskeletal Group. Cochrane Database Syst Rev 2006;(4):CD005326. PubMed
  17. Protelos European Public Assessment Report, Scientific Discussion. European Medicines Agency, 2005. Available at: www.emea.eu.int/humandocs/Humans/EPAR/protelos/protelos.htm. (Accessed 10 October 2006).
  18. Rousselet F, El Solh N, Maurat JP, et al. Strontium and calcium metabolism. Interaction of strontium and vitamin D. C R Seances Soc Biol Fil 1975;169:322-9.
  19. O'Donnell, S., Cranney, A., Wells, G. A., Adachi, J. D., and Reginster, J. Y. Strontium ranelate for preventing and treating postmenopausal osteoporosis. Cochrane.Database.Syst.Rev. 2006;3:CD005326. PubMed
  20. Rizzoli R, Chapurlat RD, Laroche JM, et al. Effects of strontium ranelate and alendronate on bone microstructure in women with osteoporosis. Results of a 2-year study. Osteoporosis Int. 2012. 23(1):305-315. doi: 10.1007/s00198-011-1758-z. PubMed
  21. Reginster JY, Kaufman JM, Goemaere S, et al. Maintenance of antifracture efficacy over 10 years with strontium ranelate in postmenopausal osteoporosis. Osteoporos Int. 2012;23(3):1115-1122. doi: 10.1007/s00198-011-1847-z. PubMed
  22. Protos [Product Information]. Available at: http://www.guildlink.com.au/gc/ws/servier/pi.cfm?product=sepproto. Accessed May 1, 2018.

See these in context on the Strontium monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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