Sweet Wormwood 300 mg Ingredients & Drug Interactions
by Solaray
What is this page for?
First and foremost: checking Sweet Wormwood 300 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Sweet Wormwood 300 mg is a dietary supplement by Solaray with 1 active ingredient. Its ingredients are commonly taken for malaria (traditional), fever, inflammation.Based on those ingredients, 889 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sweet Wormwood. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Sweet Wormwood 300 mg by Solaray
Ask about any prescription or over-the-counter medication and we check it for interactions with Sweet Wormwood 300 mg by Solaray — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Sweet Wormwood 300 mg by Solaray
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: Sweet Wormwood (Sweet Annie), 300 mg per capsule. Sweet Wormwood is a plant used traditionally to support various aspects of health.
The capsule itself is made from cellulose (a plant fiber), rice extract blend, and silica (an inactive ingredient that helps with capsule stability).
Does it work?
Moderate evidence
The data we have shows Sweet Wormwood is possibly effective for allergic rhinitis (hay fever). For nonalcoholic fatty liver disease, malaria, and osteoarthritis, the evidence isn't established—we don't have reliable data to rate whether it works.
If you're considering this supplement for a specific reason, ask your pharmacist whether the evidence supports that use.
How safe is it?
Well-documented data
Sweet Wormwood is generally well tolerated when taken by mouth. The most common side effects are nausea and vomiting.
Rarely, it may cause liver damage (hepatotoxicity)—there's one case report of a person who developed hepatitis after taking high doses of artemisinin (a Sweet Wormwood component) for 10 days. A mild allergic reaction (rash and cough) has also been reported once.
Additionally, if you're allergic to Sweet Annie, taking it under the tongue can cause numbness and throat itching. The safety data advises against using this supplement during pregnancy because of possible harm to the developing baby.
There isn't enough safety information to know whether it's okay while breastfeeding, so talk with your doctor or pharmacist before using it. Because quality and dose vary widely, this supplement shouldn't replace proven treatments—it's generally used short-term.
Meds to double-check
Moderate interaction found
Before taking this product, double-check with your pharmacist if you take medications that stress the liver (hepatotoxic drugs), or any drugs broken down by the liver enzymes CYP3A4 or CYP2B6. These include many heart, blood pressure, immune, hormonal, and psychiatric medications.
Both the severity and the direction of the effect are uncertain, which makes the check even more important.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
Sweet Wormwood may be worth considering if you have hay fever and want to explore possibly effective options. However, because it interacts with hundreds of medications and may strain the liver, it's not a casual add-on.
Check your medications with the tool on this page, and talk with your pharmacist before starting—especially if you take anything that affects your liver or involves the enzymes this supplement alters.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Sweet Wormwood 300 mg, straight from the product label.
| Brand | Solaray |
|---|---|
| Barcode (UPC) | 076280658095 |
| Net contents | 100 VegCap(s) |
| Market status | On market |
| Date entered into DSLD | Aug 22, 2025 |
| DSLD ID | 338826 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Sweet Wormwood 300 mg by Solaray, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Sweet Wormwood | 300 mg | -- |
Other ingredients: Cellulose, Rice extract Blend, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
Solaray Est. 1973 A Brighter Way 1973
General Statements
True Herbs
Since 1973, we've scoured the globe for the highest quality ingredients, connecting you with the most efficacious supplements that help you live brighter & embrace the moments that matter most.
100% PCR Bottles
Formulation
Herbal support
Vegan
Discussion: Sweet wormwood contains a compound known as artemisinin, which is believed to provide support for healthy intestinal balance as well as digestive and immune system health.
FDA Statement of Identity
Dietary Supplement
Seals/Symbols
Lab Verified Vegan
Precautions
Warning: Do not use if safety seal is broken or missing. Keep your licensed health care practitioner informed when using this product.
Keep out of reach of children.
Do not use if you are pregnant.
California Residents Only Warning: Reproductive harm - www.P65Warnings.ca.gov
Suggested/Recommended/Usage/Directions
Directions: Use only as directed. Take 1 VegCap three times daily with a meal or glass of water.
Storage
Store in a cool, dry place.
FDA Disclaimer Statement
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Sweet Wormwood 300 mg by Solaray label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Sweet Wormwood 300 mg by Solaray
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 VegCap(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.
Sweet Wormwood
Interacts with889 drugs
Sweet Annie (Artemisia annua) is the source of artemisinin, a compound used in prescription antimalarial drugs. While the purified drug is well studie...
Sweet Wormwood monograph & interactionsOther (inactive) ingredients: Cellulose, Rice extract Blend, Silica. These complete the product’s ingredient list but are not active constituents.
Sweet Wormwood 300 mg by Solaray Drug Interactions
HelloPharmacist Interaction Report
Solaray's Sweet Wormwood 300 mg contains one active ingredient—Sweet Wormwood (also called Sweet Annie)—that interacts with medications.
The most serious concern is with drugs that stress the liver (hepatotoxic drugs); using this supplement alongside them could theoretically add to that liver strain, which is a moderate-level risk. The ingredient may also alter how your body processes certain medications.
Sweet Wormwood can induce or inhibit CYP3A4 and CYP2B6, two liver enzymes that break down many common drugs. This means the supplement could raise or lower levels of medications metabolized by these pathways, potentially changing how well they work or increasing side effects—again, moderate severity.
Read the full breakdown — every affected drug type, severity by severity
The catch is that Sweet Wormwood's effect on these enzymes is mixed: one of its components (artemisinin) appears to speed up the enzymes in lab studies, while the whole extract seems to slow them down. That unpredictability makes it harder to predict what'll happen with your specific medications.
Altogether, these interactions span 870 individual medications.
Before you start this product, run your exact medications through the interaction checker on this page. If you take anything for your liver, heart, blood pressure, immune function, hormonal health, or mental health, that's especially important—many of those drugs depend on the enzymes Sweet Wormwood affects.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Sweet Wormwood 300 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Sweet Wormwood 300 mg interact with 889 drugs. Click any drug to see the details.
1 of the 1 ingredient in Sweet Wormwood 300 mg interact with drugs. Each result below shows which ingredient is responsible. Sweet Wormwood
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Sweet Wormwood 300 mg — through 1 ingredient. Tap an ingredient for the detail:
Sweet WormwoodHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Sweet Wormwood + 6-mercaptopurine interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Sweet Wormwood 300 mg — through 1 ingredient. Tap an ingredient for the detail:
Sweet WormwoodCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Sweet Wormwood + Ado-trastuzumab Emtansine interactionAbacavir Sulfate, Dolutegravir, LamivudineTriumeq
How Abacavir Sulfate, Dolutegravir, Lamivudine interacts with Sweet Wormwood 300 mg — through 1 ingredient. Tap an ingredient for the detail:
Sweet WormwoodHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Sweet Wormwood + Abacavir Sulfate, Dolutegravir, Lamivudine interactionAbacavir, LamivudineEpzicom
How Abacavir, Lamivudine interacts with Sweet Wormwood 300 mg — through 1 ingredient. Tap an ingredient for the detail:
Sweet WormwoodHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Sweet Wormwood + Abacavir, Lamivudine interactionAbemaciclibVerzenio
How Abemaciclib interacts with Sweet Wormwood 300 mg — through 1 ingredient. Tap an ingredient for the detail:
Sweet WormwoodCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Sweet Wormwood + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Sweet Wormwood 300 mg — through 1 ingredient. Tap an ingredient for the detail:
Sweet WormwoodHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Sweet Wormwood + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Sweet Wormwood 300 mg — through 1 ingredient. Tap an ingredient for the detail:
Sweet WormwoodHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Sweet Wormwood + Abiraterone Acetate interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Sweet Wormwood 300 mg — through 1 ingredient. Tap an ingredient for the detail:
Sweet WormwoodCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Sweet Wormwood + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Sweet Wormwood 300 mg — through 1 ingredient. Tap an ingredient for the detail:
Sweet WormwoodHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Sweet Wormwood + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Sweet Wormwood 300 mg — through 1 ingredient. Tap an ingredient for the detail:
Sweet WormwoodHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Sweet Wormwood + Acebutolol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Sweet Wormwood 300 mg — through 1 ingredient. Tap an ingredient for the detail:
Sweet WormwoodHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Sweet Wormwood + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Sweet Wormwood 300 mg — through 1 ingredient. Tap an ingredient for the detail:
Sweet WormwoodHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Sweet Wormwood + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Sweet Wormwood 300 mg — through 1 ingredient. Tap an ingredient for the detail:
Sweet WormwoodHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Sweet Wormwood + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Sweet Wormwood 300 mg — through 1 ingredient. Tap an ingredient for the detail:
Sweet WormwoodHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Sweet Wormwood + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Sweet Wormwood 300 mg — through 1 ingredient. Tap an ingredient for the detail:
Sweet WormwoodHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Sweet Wormwood + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Sweet Wormwood 300 mg — through 1 ingredient. Tap an ingredient for the detail:
Sweet WormwoodHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Sweet Wormwood + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Sweet Wormwood 300 mg — through 1 ingredient. Tap an ingredient for the detail:
Sweet WormwoodCytochrome P450 3a4 (cyp3a4) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Sweet Wormwood + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Sweet Wormwood 300 mg — through 1 ingredient. Tap an ingredient for the detail:
Sweet WormwoodHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Sweet Wormwood + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Sweet Wormwood 300 mg — through 1 ingredient. Tap an ingredient for the detail:
Sweet WormwoodHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Sweet Wormwood + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Sweet Wormwood 300 mg — through 1 ingredient. Tap an ingredient for the detail:
Sweet WormwoodHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Sweet Wormwood + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Sweet Wormwood 300 mg — through 1 ingredient. Tap an ingredient for the detail:
Sweet WormwoodCytochrome P450 3a4 (cyp3a4) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Sweet Wormwood + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Sweet Wormwood 300 mg — through 1 ingredient. Tap an ingredient for the detail:
Sweet WormwoodHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Sweet Wormwood + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Sweet Wormwood 300 mg — through 1 ingredient. Tap an ingredient for the detail:
Sweet WormwoodCytochrome P450 3a4 (cyp3a4) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Sweet Wormwood + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Sweet Wormwood 300 mg — through 1 ingredient. Tap an ingredient for the detail:
Sweet WormwoodHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Sweet Wormwood + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Sweet Wormwood 300 mg — through 1 ingredient. Tap an ingredient for the detail:
Sweet WormwoodCytochrome P450 3a4 (cyp3a4) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Sweet Wormwood + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Sweet Wormwood 300 mg — through 1 ingredient. Tap an ingredient for the detail:
Sweet WormwoodHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Sweet Wormwood + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Sweet Wormwood 300 mg — through 1 ingredient. Tap an ingredient for the detail:
Sweet WormwoodHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Sweet Wormwood + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Sweet Wormwood 300 mg — through 1 ingredient. Tap an ingredient for the detail:
Sweet WormwoodCytochrome P450 3a4 (cyp3a4) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Sweet Wormwood + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Sweet Wormwood 300 mg — through 1 ingredient. Tap an ingredient for the detail:
Sweet WormwoodHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
Read the full Sweet Wormwood + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Sweet Wormwood 300 mg — through 1 ingredient. Tap an ingredient for the detail:
Sweet WormwoodCytochrome P450 3a4 (cyp3a4) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Sweet Wormwood + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Sweet Wormwood 300 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Sweet Wormwood
Cytochrome P450 2B6 (Cyp2B6) Substrates
Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP2B6.
In vitro research shows that the Sweet Annie constituent artemisinin induces CYP2B6, possibly increasing CYP2B6 activity by 1.6-fold. However, Sweet Annie extract seems to inhibit the activity of CYP2B6 in vitro, suggesting that other constituents of Sweet Annie play a role in its effects on the overall activity of this enzyme. More information is needed to determine whether taking Sweet Annie extract affects the metabolism of CYP2B6 substrates.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Sweet Annie may alter plasma levels and clinical effects of drugs metabolized by CYP3A4.
In vitro research shows that the Sweet Annie constituent artemisinin induces CYP3A4, possibly increasing CYP3A4 activity by 1.9-fold. However, Sweet Annie extract seems to inhibit the activity of CYP3A4 in vitro, suggesting that other constituents of Sweet Annie play a role in its effects on the overall activity of this enzyme. More information is needed to determine whether taking Sweet Annie extract affects the metabolism of CYP3A4 substrates.
Hepatotoxic Drugs
Theoretically, concomitant use might have additive adverse hepatotoxic effects.
There is some concern that Sweet Annie can adversely affect the liver.
Brand information
Manufacturer and brand details for Sweet Wormwood 300 mg, from the product label.
Sweet Wormwood 300 mg by Solaray: Common Questions
Does Sweet Wormwood 300 mg by Solaray interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this while I'm pregnant?
Is it safe to breastfeed while taking this?
What's the most common side effect?
Can this supplement actually damage my liver?
Does this work for hay fever?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Sweet Wormwood 300 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Sweet Wormwood 300 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Sweet Wormwood 300 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 11 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Sweet Annie 11 references
- Mueller MS, Karhagomba IB, Hirt HM, Wemakor E. The potential of Artemisia annua L. as a locally produced remedy for malaria in the tropics: agricultural, chemical and clinical aspects. J Ethnopharmacol 2000;73:487-93. PubMed
- Rath K, Taxis K, Walz G, et al. Pharmacokinetic study of artemisinin after oral intake of a traditional preparation of Artemisia annua L. (annual wormwood). Am J Trop Med Hyg 2004;70:128-32. DOI
- Centers for Disease Control and Prevention (CDC). Hepatitis temporally associated with an herbal supplement containing artemisinin-Washington, 2008. MMWR Morb Mortal Wkly Rep 2009;58:854-8.
- Xing J, Kirby BJ, Whittington D, et al. Evaluation of P450 inhibition and induction by artemisinin antimalarials in human liver microsomes and primary human hepatocytes. Drug Metabl Dispos 2012;40(9):1757-64. PubMed
- Savage RL, Hill GR, Barnes J, Kenyon SH, Tatley MV. Suspected hepatotoxicity with a supercritical carbon dioxide extract of Artemisia annua in grapeseed oil used in New Zealand. Front Pharmacol. 2019;10:1448. PubMed
- Ruperti-Repilado FJ, Haefliger S, Rehm S, et al. Danger of herbal tea: a case of acute cholestatic hepatitis due to Artemisia annua tea. Front Med (Lausanne). 2019;6:221. PubMed
- Yang J, Shen Z, Liu L, et al. Clinical efficacy and safety of Artesimia annua-Sublingual immunotherapy in seasonal allergic rhinitis patients based on different intervention time. Int Arch Allergy Immunol 2022;183(8):852-859.
- Kane NF, Kiani BH, Desrosiers MR, Towler MJ, Weathers PJ. Artemisia extracts differ from artemisinin effects on human hepatic CYP450s 2B6 and 3A4 in vitro. J Ethnopharmacol 2022. DOI
- Feng Y, Cao Y, Liu Y, et al. Clinical efficacy and safety of coseasonal initiation of Artemisia annua sublingual immunotherapy on patients with Artemisia-induced rhinoconjunctivitis. Am J Otolaryngol 2023;44(5):103942. PubMed
- Yang J, Wang W, Shen Z, et al. Efficacy and safety of Artemisia annua sublingual immunotherapy in patients with seasonal allergic rhinoconjunctivitis over two pollen seasons. Eur Arch Otorhinolaryngol. 2023;280(11):4939-4947. PubMed
- Shen Z, Zhang P, Kang W, et al. Clinical efficacy in one-year treatment with Artemisia annua-SLIT drops in monosensitized and polysensitized individuals. Am J Otolaryngol 2023;44(6):104002. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC