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Dietary supplement

Thyroid Calming Ingredients & Drug Interactions

by Herb Pharm Professional

Thyroid Calming label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Thyroid Calming against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Thyroid Calming is a dietary supplement by Herb Pharm Professional with 4 active ingredients. Its ingredients are commonly taken for anxiety and stress, sleep problems, digestive upset.Based on those ingredients, 273 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lemon Balm extract, Motherwort extract, Bugleweed extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Thyroid Calming by Herb Pharm Professional

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HelloPharmacist Scorecard of Thyroid Calming by Herb Pharm Professional

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 4 active ingredients.
  • “Proprietary Extract Blend” is a proprietary blend — the label gives one combined amount (654 mg) without saying how much of each component you get.

Thyroid Calming contains four active ingredients: lemon balm extract, motherwort extract, cactus grandiflorus extract, and bugleweed extract. The product also includes three inactive ingredients—certified organic cane alcohol, distilled water, and certified organic vegetable glycerin—which serve as the liquid base and preservative.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support healthy thyroid function and calm.
  • We looked for evidence on: Anxiety, Hyperthyroidism, Insomnia, Stress, Thyroid overactivity, Heart palpitations — and 1 related terms.
  • The strongest evidence on file: Lemon Balm is rated "Possibly Effective" for Stress (Natural Medicines).
  • Also on file: Motherwort is rated "Insufficient Reliable Evidence To Rate" for Anxiety, Hyperthyroidism, Insomnia.
  • Also on file: Bugleweed is rated "Insufficient Reliable Evidence To Rate" for Hyperthyroidism, Insomnia.

The effectiveness data on file shows lemon balm is possibly effective for cold sores, stress, and depression. Motherwort is possibly effective for bleeding; however, evidence is insufficient to rate it for anxiety, alcohol use disorder, or asthma.

For cactus grandiflorus and bugleweed, no effectiveness ratings are on file in our data. The product is marketed for thyroid support, but the evidence we hold doesn't establish effectiveness for that use.

The evidence, ingredient by ingredient Lemon Balm Motherwort Cereus Bugleweed

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lemon balm is generally well tolerated for short-term use in healthy adults, though dizziness and sedation have been reported — though they don't occur more often than with placebo. A single case of heart rhythm changes (complete atrioventricular block and QT prolongation) was reported in a young woman using a different product containing lemon balm and other ingredients; it resolved when she stopped.

Motherwort is generally well tolerated orally but may cause diarrhea and stomach irritation. High doses (more than 3 grams) can trigger uterine bleeding.

Cactus grandiflorus may cause mouth burning, nausea, vomiting, and diarrhea. Bugleweed carries no reported adverse effects in our data.

During pregnancy: lemon balm should be avoided unless your doctor advises otherwise; motherwort and bugleweed are likely unsafe; cactus grandiflorus is best avoided. While breastfeeding: lemon balm requires caution and a conversation with your doctor; bugleweed should be avoided because it may reduce milk production; cactus grandiflorus is best avoided.

Side effects, ingredient by ingredient Lemon Balm Motherwort Cereus Bugleweed

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Motherwort, Bugleweed, Lemon Balm, Cereus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: heart-rhythm medications.
  • For scale: 273 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start Thyroid Calming, check with your pharmacist if you take thyroid hormone replacement therapy (both lemon balm and bugleweed may interfere), any CNS depressants like sedatives or some antidepressants (lemon balm and motherwort may add to their effect), digoxin or other cardiac glycosides (cactus grandiflorus may enhance them), or monoamine oxidase inhibitors or MAOIs (cactus grandiflorus may theoretically interact).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product combines herbs traditionally used for thyroid and nervous-system support, but every ingredient in it has documented interactions with medications — most seriously with thyroid hormones and CNS depressants. If you take thyroid medication, heart drugs, or any psychiatric medication, talk to your pharmacist before using Thyroid Calming.

Pregnant women and those breastfeeding should avoid it unless guided by their doctor.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Thyroid Calming, straight from the product label.

Brand Herb Pharm Professional
Barcode (UPC) 090700029869
Net contents 2 fl. Oz.; 60 mL
Market status On market
Date entered into DSLD Nov 21, 2019
DSLD ID 201008
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Thyroid Calming by Herb Pharm Professional, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.7 mL
Maximum serving Sizes:
0.7 mL
Servings per container
84
UPC/BARCODE
090700029869
IngredientAmount% DV
Lemon Balm extract0 NP--
Motherwort extract0 NP--
Cactus Grandiflorus extract0 NP--
Proprietary Extract Blend654 mg--
Bugleweed extract0 NP--

Other ingredients: certified organic Cane Alcohol, distilled Water, certified organic Vegetable Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use Shake well before using Add 1 full squeeze of the dropper bulb to 2 oz. of water or juice, 2 to 4 times per day. Best take between meals. Practitioner may increase dosage if desired.

Precautions

Caution: Seek expert medical advice before taking during pregnancy or nursing.

Not for use in hypothyroidism or thyroid enlargement.

Use with caution in persons taking thyroid and heart medications.

Keep out of the reach of children

Storage

Store away from heat & light

General

003

Formula

Lycopus Leonurus

FDA Statement of Identity

Herbal Supplement

Formulation

Gluten-Free

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Thyroid Calming by Herb Pharm Professional label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Thyroid Calming label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Thyroid Calming by Herb Pharm Professional

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.7 mL Dosage formLiquid Servings per container84 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Extract Blend

654 mg per serving

Other (inactive) ingredients: Certified organic Cane Alcohol, Distilled Water, Certified organic Vegetable Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Thyroid Calming by Herb Pharm Professional Drug Interactions

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273Drugs
273 Moderate

Ingredients driving the most interactions

Lemon Balm extract 264
Motherwort extract 248
Bugleweed extract 16
Cactus Grandiflorus extract 10

Individual Drug Interactions

The ingredients in Thyroid Calming interact with 273 drugs. Click any drug to see the details.

4 of the 4 ingredients in Thyroid Calming interact with drugs. Each result below shows which ingredient is responsible. Lemon Balm extract Motherwort extract Bugleweed extract Cactus Grandiflorus extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Thyroid Calming with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Lemon Balm extract2 drug types · 264 drugs

Cns Depressants

Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Lemon balm seems to have CNS depressant activity in animals and in humans.

Likelihood Possible Evidence B
Thyroid Hormone

Theoretically, lemon balm might interfere with thyroid hormone replacement therapy.
In vitro, constituents of lemon balm extract bind to thyroid stimulating hormone (TSH), preventing TSH receptor-binding and leading to the inhibition of TSH-stimulated adenylate cyclase activity. In animals, lemon balm extract has been shown to decrease levels of circulating TSH and inhibit thyroid secretion.

Likelihood Possible Evidence D
Lemon Balm extract full monograph & interactions

Motherwort extract1 drug type · 248 drugs

Cns Depressants

Theoretically, taking motherwort concomitantly with other CNS depressants may increase the risk of sedation.
Motherwort has been reported to cause CNS depression and sedation.

Likelihood Possible Evidence D
Motherwort extract full monograph & interactions

Bugleweed extract1 drug type · 16 drugs

Thyroid Hormone

Theoretically, bugleweed may alter thyroid function.
Concomitant use of bugleweed may reduce the effects of thyroid hormones by blocking peripheral conversion of thyroxine (T4) to triiodothyronine (T3).

Likelihood Probable Evidence D
Bugleweed extract full monograph & interactions

Cactus Grandiflorus extract2 drug types · 10 drugs

Digoxin (Lanoxin)

Cereus may potentiate the actions of cardiac glycosides and may enhance the effect of other cardiac drugs.

Likelihood Possible Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, excessive doses of cereus may interact with MAOIs, because of the tyramine content.

Likelihood Possible Evidence D
Cactus Grandiflorus extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Thyroid Calming, from the product label.

Herb Pharm Professional

See all Herb Pharm Professional products
Name
Herb Pharm
City
Williams
State
OR
ZipCode
97544
Phone Number
800-348-4372
Web Address
www.herb-pharm.com
Pharmacist Counseling Corner

Thyroid Calming by Herb Pharm Professional: Common Questions

Does Thyroid Calming by Herb Pharm Professional interact with any medications?
Yes. Based on its ingredients, Thyroid Calming has a known interaction with 273 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Thyroid Calming contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Thyroid Calming if I'm on thyroid medication?
No — not without talking to your pharmacist or doctor first. Lemon balm and bugleweed, two of the four active ingredients, can interfere with how thyroid hormones work. Your medication may become less effective if you add this product.
Is Thyroid Calming safe during pregnancy?
No. Motherwort and bugleweed are likely unsafe in pregnancy; lemon balm should be avoided unless your doctor advises otherwise; and cactus grandiflorus is best avoided. Talk to your doctor before using this product if you're pregnant or planning to become pregnant.
Will it make me drowsy?
Dizziness and sedation have been reported with lemon balm, one of the main ingredients. However, in clinical trials these didn't happen more often than with placebo. If you take sedatives or sleep aids, this product could add to that drowsy effect.
What is lemon balm supposed to do?
Lemon balm is possibly effective for cold sores, stress, and depression. It appears to have a calming effect on the central nervous system.
Can I breastfeed while taking Thyroid Calming?
Probably not. Bugleweed may reduce milk production and is possibly unsafe while breastfeeding. Lemon balm requires caution, and cactus grandiflorus is best avoided. Check with your doctor before using it.
What's in the bottle besides the active ingredients?
The product is a liquid base made with certified organic cane alcohol, distilled water, and certified organic vegetable glycerin. These serve as the base and preservative.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Thyroid Calming label
Go deeper

The Full Monographs Behind Thyroid Calming’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lemon Balm

Interacts with 264 drugs

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold sores. Early studies are promising but gen...

Read the full Lemon Balm monograph → Herb & supplement monograph

Motherwort

Interacts with 248 drugs

Motherwort is a traditional herb in the mint family long used for anxiety, heart palpitations, and women's reproductive complaints, but solid human evidence is very limited. It should be avo...

Read the full Motherwort monograph → Herb & supplement monograph

Cereus

Interacts with 10 drugs

Cereus (often called night-blooming cereus) is a cactus traditionally used in folk and homeopathic medicine for heart-related complaints like palpitations. High-quality human evidence suppor...

Read the full Cereus monograph → Herb & supplement monograph

Bugleweed

Interacts with 16 drugs

Bugleweed is a traditional herb most often used for mild overactive thyroid symptoms and the rapid heartbeat that can come with it, but high-quality human evidence is very limited. Because i...

Read the full Bugleweed monograph →
Sources

Sources & How We Checked

Thyroid Calming's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 25 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lemon Balm 12 references
  1. Wolbling RH, Leonhardt K. Local therapy of herpes simplex with dried extract from Melissa officinalis. Phytomedicine 1994;1:25-31.
  2. Akhondzadeh S, Noroozian M, Mohammadi M, et al. Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomised, placebo controlled trial. J Neurol Neurosurg Psychiatry 2003;74:863-6. PubMed
  3. Kennedy DO, Scholey AB, Tildesley NT, et al. Modulation of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm). Pharmacol Biochem Behav 2002;72:953-64. PubMed
  4. Albrecht M, Berger W, Laux P, Schmidt U, et al. Psychopharmaka und Verkehrssicherheit. Der Einfluß von Euvegal® - Dragees forte auf die Fahrtüchtigkeit und Kombinationswirkungen mit Alkohol Z Allg Med 1995;71:1215-25.
  5. Herberg, KW. Nebenwirkungen pflanzlicher Beruhigungsmittel/ Leistung und Befinden nach Einnahme einer Baldrian-Hopfen-Kombination. Z.Allg Med 1996;72:234-240.
  6. Soulimani R, Fleurentin J, Mortier F, et al. Neurotropic action of the hydroalcoholic extract of Melissa officinalis in the mouse. Planta Med. 1991 Apr;57:105-9.
  7. Sourgens H, Winterhoff H, Gumbinger HG, et al. Antihormonal effects of plant extracts. TSH- and prolactin-suppressing properties of Lithospermum officinale and other plants. Planta Med. 1982 Jun;45:78-86. DOI
  8. Auf'mkolk M, Ingbar JC, Amir SM, et al. Inhibition by certain plant extracts of the binding and adenylate cyclase stimulatory effect of bovine thyrotropin in human thyroid membranes. Endocrinology. 1984 Aug;115:527-34. PubMed
  9. Santini F, Vitti P, Ceccarini G, et al. In vitro assay of thyroid disruptors affecting TSH-stimulated adenylate cyclase activity. J Endocrinol Invest. 2003 Oct;26:950-5. PubMed
  10. Alijaniha F, et al. Heart palpitation relief with Melissa officinalis leaf extract: double blind, randomized, placebo controlled trial of efficacy and safety. J Ethnopharmacol. 2015;164:378-384. doi: 10.1016/j.jep.2015.02.007. Epub 2015 Feb 11. PubMed
  11. Araj-Khodaei M, Noorbala AA, Yarani R, et al. A double-blind, randomized pilot study for comparison of Melissa officinalis L. and Lavandula angustifolia Mill. with Fluoxetine for the treatment of depression. BMC Complement Med Ther. 2020;20(1):207. PubMed
  12. Kucuk U, Pham M, Raza Raja MH, Saad Shaukat MH, Clark R. Transient complete atrioventricular block associated with herbal supplement use. S D Med 2023;76(7):311-313.

See these in context on the Lemon Balm monograph →

Motherwort 6 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Wojtyniak K, Szymanski M, Matlawska I. Leonurus cardiaca L. (motherwort): a review of its phytochemistry and pharmacology. Phytother Res 2013;27(8):1115-20.
  5. Xia WT, Zhou H, Wang Y, et al. Motherwort injection in preventing post-abortion hemorrhage after induced abortion: A multi-center, prospective, randomized controlled trial. Explore (NY). 2019. pii: S1550-8307(19)30447-1. PubMed
  6. Cao Shan DOSOGC, Zhang W, Zhao Z, et al. Post-marketing safety surveillance and reevaluation of Motherwort injection: A clinical study of 10 094 cases. J Tradit Chin Med. 2018 Aug;38(4):625-635. DOI

See these in context on the Motherwort monograph →

Cereus 3 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Fetrow CW, Avila JR. Professional's Handbook of Complementary & Alternative Medicines. 1st ed. Springhouse, PA: Springhouse Corp., 1999.

See these in context on the Cereus monograph →

Bugleweed 4 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  4. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

See these in context on the Bugleweed monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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