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Dietary supplement

ThyroSoothe Ingredients & Drug Interactions

by Native Remedies

ThyroSoothe label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking ThyroSoothe against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

ThyroSoothe is a dietary supplement by Native Remedies with 3 active ingredients. Its ingredients are commonly taken for anxiety and stress, heart palpitations, menstrual discomfort.Based on those ingredients, 264 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lemon Balm, Motherwort, Bugleweed, Fresh. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against ThyroSoothe by Native Remedies

Ask about any prescription or over-the-counter medication and we check it for interactions with ThyroSoothe by Native Remedies — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of ThyroSoothe by Native Remedies

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Proprietary Formula” is a proprietary blend — the label gives one combined amount (0.50 mL) without saying how much of each component you get.

ThyroSoothe contains three active ingredients: motherwort, lemon balm, and bugleweed fresh. The product is delivered as a liquid and also contains glycerin and deionized water as inactive ingredients.

These herbs have traditionally been used to support thyroid and nervous system function, though the evidence for each varies — some have limited scientific backing in our data.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports the thyroid gland and promotes health.
  • We looked for evidence on: Anxiety, Arrhythmia, Hyperthyroidism, Insomnia, Menopausal symptoms, Premenstrual syndrome (PMS) — and 4 related terms.
  • The strongest evidence on file: Lemon Balm is rated "Possibly Effective" for Stress (Natural Medicines).
  • Also on file: Motherwort is rated "Insufficient Reliable Evidence To Rate" for Anxiety, Arrhythmia, Hyperthyroidism, Insomnia, and more.
  • Also on file: Bugleweed is rated "Insufficient Reliable Evidence To Rate" for Hyperthyroidism.

The evidence for ThyroSoothe's ingredients is mixed. Lemon balm is possibly effective for stress and depression, and possibly effective for cold sores.

Motherwort is possibly effective for bleeding, but for anxiety, amenorrhea, asthma, and alcohol use disorder the evidence is insufficient to rate. Bugleweed's effectiveness for hyperthyroidism, insomnia, and premenstrual syndrome is also insufficient to rate in our data.

Because the product is marketed for thyroid support and none of its ingredients have established effectiveness for that purpose, we don't have solid evidence it works for what this product appears intended to do.

The evidence, ingredient by ingredient Motherwort Lemon Balm Bugleweed

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Motherwort is generally well tolerated when taken by mouth in the short term, though human safety data are limited. The most common side effects are diarrhea and stomach irritation.

It should be avoided in pregnancy because it's traditionally thought to stimulate the uterus, and safety information during breastfeeding isn't available. Lemon balm is generally well tolerated for short-term use in healthy adults, but long-term safety hasn't been well studied.

It should be avoided in pregnancy unless your doctor advises otherwise, and you should talk to your doctor before using it while breastfeeding. Bugleweed may affect thyroid function and is considered likely unsafe in pregnancy and possibly unsafe while breastfeeding because it may reduce milk production.

Side effects, ingredient by ingredient Motherwort Lemon Balm Bugleweed

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Motherwort, Bugleweed, Lemon Balm.
  • The most serious interaction on file is rated Moderate.
  • For scale: 264 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before taking ThyroSoothe if you take thyroid hormone replacement therapy (levothyroxine, liothyronine, desiccated thyroid, and similar medications) or CNS depressants such as sedatives, sleep aids, anti-anxiety medications, and opioids. These are the medication types most likely to be affected.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

ThyroSoothe isn't right for you if you take thyroid hormone medication or CNS depressants like sleep aids or anti-anxiety drugs without checking first. Pregnancy and breastfeeding are concerns — motherwort and bugleweed both carry cautions.

Talk to your pharmacist before you start, especially if you're on any regular medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 21, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about ThyroSoothe, straight from the product label.

Brand Native Remedies
Barcode (UPC) 810845013789
Net contents 2 Fluid Ounce(s); 59 mL
Market status On market
Date entered into DSLD May 21, 2025
DSLD ID 331841
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Adult (18 - 50 Years), Kosher
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for ThyroSoothe by Native Remedies, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.5 mL
Maximum serving Sizes:
0.5 mL
Servings per container
118
UPC/BARCODE
810845013789
IngredientAmount% DV
Proprietary Formula0.5 mL--
Motherwort0 NP--
Lemon Balm0 NP--
Bugleweed, Fresh0 NP--

Other ingredients: Glycerin, Water, Deionized

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Tamper resistant for your protection. Use only if safety seal is intact.

Caution: Do not use for hypothyroid conditions or with prescription thyroid medication unless under a doctor's supervision. Safety during pregnancy and breastfeeding has not yet been established. Not recommended for women trying to conceive.

Formulation

Contains no artificial flavors or colorants. No gluten added.

All Native Remedies health products are especially formulated by experts in the field of natural health and are manufactured according to the highest pharmaceutical standards for maximum safety and effectiveness.

All-Natural Supports the thyroid gland & promotes health Liquid Drops

Suggested/Recommended/Usage/Directions

Suggested Use: Dilute drops in a small amount of water or juice, or drop directly into mouth, 3 times daily. Adults & Children 12+: 0.50 mL. Children 6-11: 1 drop per year of age.

Seals/Symbols

K Parve (Kosher) K-1604

Formula

K Parve (Kosher) K-1604

FDA Statement of Identity

Herbal Supplement

General Statements

Int'l.: +1-920-232-3275

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

ThyroSoothe by Native Remedies label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

ThyroSoothe label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in ThyroSoothe by Native Remedies

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.5 mL Dosage formLiquid Servings per container118 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Formula

0.5 mL per serving

Other (inactive) ingredients: Glycerin, Water, Deionized. These complete the product’s ingredient list but are not active constituents.

Interaction report

ThyroSoothe by Native Remedies Drug Interactions

Want to check YOUR meds against ThyroSoothe?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
264Drugs
264 Moderate

Ingredients driving the most interactions

Lemon Balm 264
Motherwort 248
Bugleweed, Fresh 16

Individual Drug Interactions

The ingredients in ThyroSoothe interact with 264 drugs. Click any drug to see the details.

3 of the 3 ingredients in ThyroSoothe interact with drugs. Each result below shows which ingredient is responsible. Lemon Balm Motherwort Bugleweed, Fresh

Each ingredient & the kinds of drugs it affects

For each ingredient in ThyroSoothe with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Lemon Balm2 drug types · 264 drugs

Cns Depressants

Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Lemon balm seems to have CNS depressant activity in animals and in humans.

Likelihood Possible Evidence B
Thyroid Hormone

Theoretically, lemon balm might interfere with thyroid hormone replacement therapy.
In vitro, constituents of lemon balm extract bind to thyroid stimulating hormone (TSH), preventing TSH receptor-binding and leading to the inhibition of TSH-stimulated adenylate cyclase activity. In animals, lemon balm extract has been shown to decrease levels of circulating TSH and inhibit thyroid secretion.

Likelihood Possible Evidence D
Lemon Balm full monograph & interactions

Motherwort1 drug type · 248 drugs

Cns Depressants

Theoretically, taking motherwort concomitantly with other CNS depressants may increase the risk of sedation.
Motherwort has been reported to cause CNS depression and sedation.

Likelihood Possible Evidence D
Motherwort full monograph & interactions

Bugleweed, Fresh1 drug type · 16 drugs

Thyroid Hormone

Theoretically, bugleweed may alter thyroid function.
Concomitant use of bugleweed may reduce the effects of thyroid hormones by blocking peripheral conversion of thyroxine (T4) to triiodothyronine (T3).

Likelihood Probable Evidence D
Bugleweed, Fresh full monograph & interactions
The maker

Brand information

Manufacturer and brand details for ThyroSoothe, from the product label.

Native Remedies

See all Native Remedies products
Name
Silver Star Brands
City
Oshkosh
State
WI
ZipCode
54906
Phone Number
1-877-289-1235
Web Address
www.nativeremedies.com
Pharmacist Counseling Corner

ThyroSoothe by Native Remedies: Common Questions

Does ThyroSoothe by Native Remedies interact with any medications?
Yes. Based on its ingredients, ThyroSoothe has a known interaction with 264 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
ThyroSoothe contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take ThyroSoothe if I'm pregnant?
No. Motherwort is likely unsafe in pregnancy because it's traditionally thought to stimulate the uterus, and bugleweed is also likely unsafe. Lemon balm should be avoided unless your doctor advises otherwise. Talk to your doctor before taking any of these herbs while pregnant.
Can I take ThyroSoothe while breastfeeding?
Bugleweed should not be used while breastfeeding because it may reduce prolactin and milk production. Lemon balm has limited safety information, so talk to your doctor first. We don't have safety data on file for motherwort during breastfeeding.
What does each ingredient in ThyroSoothe do?
Motherwort has been used traditionally to support bleeding and nervous system function. Lemon balm is possibly effective for stress, depression, and cold sores. Bugleweed has traditionally been used for thyroid concerns, though evidence is insufficient in our data. All three have sedating properties that may add together.
What are the most common side effects of motherwort?
When taken by mouth, the most common side effects are diarrhea and stomach irritation. Amounts greater than 3 grams can cause uterine bleeding. Safety data in humans are limited.
Does lemon balm cause drowsiness?
Lemon balm has caused dizziness and sedation in some reports, but studies show it doesn't occur more often than placebo. It also doesn't seem to affect reaction time or cognitive performance when used with alcohol.
Are there any fillers or other ingredients in ThyroSoothe besides the three active herbs?
The product contains glycerin and deionized water as inactive ingredients to create the liquid form.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if ThyroSoothe is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

ThyroSoothe label
Go deeper

The Full Monographs Behind ThyroSoothe’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Motherwort

Interacts with 248 drugs

Motherwort is a traditional herb in the mint family long used for anxiety, heart palpitations, and women's reproductive complaints, but solid human evidence is very limited. It should be avo...

Read the full Motherwort monograph → Herb & supplement monograph

Lemon Balm

Interacts with 264 drugs

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold sores. Early studies are promising but gen...

Read the full Lemon Balm monograph → Herb & supplement monograph

Bugleweed

Interacts with 16 drugs

Bugleweed is a traditional herb most often used for mild overactive thyroid symptoms and the rapid heartbeat that can come with it, but high-quality human evidence is very limited. Because i...

Read the full Bugleweed monograph →
Sources

Sources & How We Checked

ThyroSoothe's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 22 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Motherwort 6 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Wojtyniak K, Szymanski M, Matlawska I. Leonurus cardiaca L. (motherwort): a review of its phytochemistry and pharmacology. Phytother Res 2013;27(8):1115-20.
  5. Xia WT, Zhou H, Wang Y, et al. Motherwort injection in preventing post-abortion hemorrhage after induced abortion: A multi-center, prospective, randomized controlled trial. Explore (NY). 2019. pii: S1550-8307(19)30447-1. PubMed
  6. Cao Shan DOSOGC, Zhang W, Zhao Z, et al. Post-marketing safety surveillance and reevaluation of Motherwort injection: A clinical study of 10 094 cases. J Tradit Chin Med. 2018 Aug;38(4):625-635. DOI

See these in context on the Motherwort monograph →

Lemon Balm 12 references
  1. Wolbling RH, Leonhardt K. Local therapy of herpes simplex with dried extract from Melissa officinalis. Phytomedicine 1994;1:25-31.
  2. Akhondzadeh S, Noroozian M, Mohammadi M, et al. Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomised, placebo controlled trial. J Neurol Neurosurg Psychiatry 2003;74:863-6. PubMed
  3. Kennedy DO, Scholey AB, Tildesley NT, et al. Modulation of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm). Pharmacol Biochem Behav 2002;72:953-64. PubMed
  4. Albrecht M, Berger W, Laux P, Schmidt U, et al. Psychopharmaka und Verkehrssicherheit. Der Einfluß von Euvegal® - Dragees forte auf die Fahrtüchtigkeit und Kombinationswirkungen mit Alkohol Z Allg Med 1995;71:1215-25.
  5. Herberg, KW. Nebenwirkungen pflanzlicher Beruhigungsmittel/ Leistung und Befinden nach Einnahme einer Baldrian-Hopfen-Kombination. Z.Allg Med 1996;72:234-240.
  6. Soulimani R, Fleurentin J, Mortier F, et al. Neurotropic action of the hydroalcoholic extract of Melissa officinalis in the mouse. Planta Med. 1991 Apr;57:105-9.
  7. Sourgens H, Winterhoff H, Gumbinger HG, et al. Antihormonal effects of plant extracts. TSH- and prolactin-suppressing properties of Lithospermum officinale and other plants. Planta Med. 1982 Jun;45:78-86. DOI
  8. Auf'mkolk M, Ingbar JC, Amir SM, et al. Inhibition by certain plant extracts of the binding and adenylate cyclase stimulatory effect of bovine thyrotropin in human thyroid membranes. Endocrinology. 1984 Aug;115:527-34. PubMed
  9. Santini F, Vitti P, Ceccarini G, et al. In vitro assay of thyroid disruptors affecting TSH-stimulated adenylate cyclase activity. J Endocrinol Invest. 2003 Oct;26:950-5. PubMed
  10. Alijaniha F, et al. Heart palpitation relief with Melissa officinalis leaf extract: double blind, randomized, placebo controlled trial of efficacy and safety. J Ethnopharmacol. 2015;164:378-384. doi: 10.1016/j.jep.2015.02.007. Epub 2015 Feb 11. PubMed
  11. Araj-Khodaei M, Noorbala AA, Yarani R, et al. A double-blind, randomized pilot study for comparison of Melissa officinalis L. and Lavandula angustifolia Mill. with Fluoxetine for the treatment of depression. BMC Complement Med Ther. 2020;20(1):207. PubMed
  12. Kucuk U, Pham M, Raza Raja MH, Saad Shaukat MH, Clark R. Transient complete atrioventricular block associated with herbal supplement use. S D Med 2023;76(7):311-313.

See these in context on the Lemon Balm monograph →

Bugleweed 4 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
  3. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  4. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

See these in context on the Bugleweed monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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