Tian Ma Gou Teng Teapills Ingredients & Drug Interactions
by Plum Flower
What is this page for?
First and foremost: checking Tian Ma Gou Teng Teapills against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Tian Ma Gou Teng Teapills is a dietary supplement by Plum Flower with 11 active ingredients. Its ingredients are commonly taken for anti-aging and longevity, hair graying and hair loss, general tonic for vitality.Based on those ingredients, 1,529 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Polygonum multiflorum extract, Scutellaria baicalensis extract, Poria cocos extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Tian Ma Gou Teng Teapills by Plum Flower
Ask about any prescription or over-the-counter medication and we check it for interactions with Tian Ma Gou Teng Teapills by Plum Flower — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Tian Ma Gou Teng Teapills by Plum Flower
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Tian Ma Gou Teng Teapills contains 11 ingredients in a proprietary extract blend. The active ingredients include Polygonum multiflorum (fo-ti), Eucommia ulmoides, Poria cocos (poria mushroom), Scutellaria baicalensis (Baikal skullcap), Leonurus japonicus (motherwort), Gastrodia elata, Gardenia jasminoides, Haliotis diversicolor, Taxillus chinensis, and Cyathula officinalis.
The inactive ingredients are maltose, microcrystalline cellulose, hydrated magnesium silicate, activated charcoal, and china wax.
Does it work?
Moderate evidence
The evidence supporting these ingredients is limited. For Polygonum multiflorum and Poria cocos, the data we hold rates effectiveness as insufficient to establish whether they work for age-related cognitive decline, hair loss, Alzheimer's disease, osteoporosis, or heart disease.
Scutellaria baicalensis shows insufficient evidence for hay fever, anxiety, atherosclerosis, ADHD, prostate cancer, and headache. Leonurus japonicus is rated possibly effective for bleeding, but insufficient evidence exists for the other conditions listed.
Gardenia jasminoides also carries insufficient evidence ratings for anxiety, dementia, depression, diabetes, high blood pressure, and flu. We have no effectiveness data on file for Eucommia ulmoides, Gastrodia elata, Haliotis diversicolor, Taxillus chinensis, or Cyathula officinalis.
How safe is it?
Well-documented data
Fo-ti is linked to liver damage — the facts note around 450 documented cases of hepatitis in the medical literature, affecting patients ages 5 to 78 at varying doses and durations. Liver injury can range from full recovery to cirrhosis and death.
The most common side effects from unprocessed fo-ti are abdominal pain, diarrhea, nausea, and vomiting. Motherwort is traditionally thought to stimulate the uterus and should be avoided in pregnancy.
Baikal skullcap is generally well tolerated orally but may cause abdominal pain, constipation, diarrhea, nausea, and vomiting; rare serious effects include liver damage and hypersensitivity pneumonitis with certain combination products. Poria mushroom is well tolerated in traditional use but carries limited human safety data and rare allergic reactions.
Gardenia has limited safety data; topical exposure can cause allergic contact dermatitis. None of these ingredients have sufficient safety data during pregnancy or breastfeeding — the product should be avoided.
Meds to double-check
Moderate interaction found
Before taking this product, check with us if you're on blood thinners (anticoagulants) or warfarin, any drug metabolized by your liver's CYP enzymes, blood pressure medications, diabetes drugs, lithium, thyroid drugs, stimulant laxatives, diuretics, sedatives, or anticholinergic/cholinergic drugs. No interactions are documented for the ingredients we could not check in our data.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
This product is not a good fit if you take blood thinners, heart medications, diabetes drugs, blood pressure drugs, or anything metabolized by your liver. Fo-ti's link to liver injury is a real concern, especially with long-term use.
Talk to your pharmacist or doctor before starting, particularly if you're pregnant, breastfeeding, or on any regular medication.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 5 of 11 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Tian Ma Gou Teng Teapills, straight from the product label.
| Brand | Plum Flower |
|---|---|
| Barcode (UPC) | 739934833360 |
| Net contents | 1000 Pill(s) |
| Market status | On market |
| Date entered into DSLD | Nov 22, 2024 |
| DSLD ID | 310592 |
| Product type | Other Combinations |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Tian Ma Gou Teng Teapills by Plum Flower, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Extract Blend | 1360 mg | -- |
| Polygonum multiflorum extract | 0 NP | -- |
| Eucommia ulmoides extract | 0 NP | -- |
| Poria cocos extract | 0 NP | -- |
| Scutellaria baicalensis extract | 0 NP | -- |
| Leonurus japonicus extract | 0 NP | -- |
| Gastrodia elata extract | 0 NP | -- |
| Gardenia jasminoides extract | 0 NP | -- |
| Haliotis diversicolor extract | 0 NP | -- |
| Taxillus chinensis extract | 0 NP | -- |
| Cyathula officinalis extract | 0 NP | -- |
| Uncaria rhynchophylla extract | 0 NP | -- |
Other ingredients: Maltose, Microcrystalline Cellulose, hydrated Magnesium Silicate, activated Carbon, China Wax
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Economy size
Foci Pharmaceutical 1929
FDA Statement of Identity
Herbal Supplement
Suggested/Recommended/Usage/Directions
Take 8 pills 3 times daily or as directed by your health care practitioner
Precautions
Not for use during pregnancy
Keep out of reach of children
Formulation
Plum Flower Guarantee US owned & operated since 1969. Made in China in partnership with the award-winning Lanzhou Foci Pharmaceutical Co. Ltd.
Formula
Tian Ma Gou Teng Wan
Seals/Symbols
Sourced sustainably FDA Registered cGMP Compliant Made in a cGMP certified facility Lab Tested Quality Verified Species Verified
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Tian Ma Gou Teng Teapills by Plum Flower label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Tian Ma Gou Teng Teapills by Plum Flower
These are the 11 active ingredients this product is made of. Select any to open its full monograph.
Serving size8 Pill(s) Dosage formTablet Or Pill Servings per container125 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Extract Blend
- › Polygonum multiflorum extract
- › Eucommia ulmoides extract
- › Poria cocos extract
- › Scutellaria baicalensis extract
- › Leonurus japonicus extract
- › Gastrodia elata extract
- › Gardenia jasminoides extract
- › Haliotis diversicolor extract
- › Taxillus chinensis extract
- › Cyathula officinalis extract
- › Uncaria rhynchophylla extract
Other (inactive) ingredients: Maltose, Microcrystalline Cellulose, Hydrated Magnesium Silicate, Activated Carbon, China Wax. These complete the product’s ingredient list but are not active constituents.
Tian Ma Gou Teng Teapills by Plum Flower Drug Interactions
HelloPharmacist Interaction Report
Tian Ma Gou Teng Teapills by Plum Flower contains several ingredients with documented interactions with medications.
The most serious concern is Polygonum multiflorum (fo-ti), which has been linked to liver injury that can affect blood clotting — in one documented case, a patient stable on warfarin developed acute hepatitis with a dangerously elevated INR after 90 days of fo-ti use. Altogether, these interactions span 1,506 individual medications.
Read the full breakdown — every affected drug type, severity by severity
Fo-ti carries moderate-severity interactions with blood thinners (anticoagulants) and warfarin specifically, as well as with drugs metabolized by your liver's CYP2B6 and CYP2C8 enzymes — sulindac, digoxin, and several enzyme-substrate drugs. It also interacts with diuretic drugs and stimulant laxatives, raising the risk of low potassium (hypokalemia).
Scutellaria baicalensis (Baikal skullcap) has moderate interactions with blood pressure medications, blood thinners, diabetes drugs, lithium, thyroid medications, and several drug-metabolizing enzymes (CYP1A2 and CYP2C19 substrates). Poria cocos (poria mushroom) may enhance sedatives and interact with anticholinergic and cholinergic drugs.
Leonurus japonicus (motherwort) carries a moderate interaction with sedatives and CNS depressants. Gardenia jasminoides interacts with stimulant laxatives.
We could not check interactions for Eucommia ulmoides, Gastrodia elata, Haliotis diversicolor, Taxillus chinensis, and Cyathula officinalis — interaction data are not on file for these ingredients. Use the medication checker on this page to verify your exact drugs before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Tian Ma Gou Teng Teapills?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Tian Ma Gou Teng Teapills interact with 1,529 drugs. Click any drug to see the details.
5 of the 11 ingredients in Tian Ma Gou Teng Teapills interact with drugs. Each result below shows which ingredient is responsible. Polygonum multiflorum extract Scutellaria baicalensis extract Poria cocos extract Leonurus japonicus extract Gardenia jasminoides extract
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Tian Ma Gou Teng Teapills — through 1 ingredient. Tap an ingredient for the detail:
Polygonum Multiflorum ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, fo-ti might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Polygonum Multiflorum Extract + 6-mercaptopurine interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Tian Ma Gou Teng Teapills — through 1 ingredient. Tap an ingredient for the detail:
Polygonum Multiflorum ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fo-ti might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Polygonum Multiflorum Extract + Ado-trastuzumab Emtansine interactionAbacavir Sulfate, Dolutegravir, LamivudineTriumeq
How Abacavir Sulfate, Dolutegravir, Lamivudine interacts with Tian Ma Gou Teng Teapills — through 1 ingredient. Tap an ingredient for the detail:
Polygonum Multiflorum ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, fo-ti might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Polygonum Multiflorum Extract + Abacavir Sulfate, Dolutegravir, Lamivudine interactionAbacavir, LamivudineEpzicom
How Abacavir, Lamivudine interacts with Tian Ma Gou Teng Teapills — through 1 ingredient. Tap an ingredient for the detail:
Polygonum Multiflorum ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, fo-ti might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Polygonum Multiflorum Extract + Abacavir, Lamivudine interactionAbciximabReoPro
How Abciximab interacts with Tian Ma Gou Teng Teapills — through 2 ingredients. Tap an ingredient for the detail:
Polygonum Multiflorum ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Fo-ti has been linked to cases of acute liver failure which can decrease clotting factor production and increase the effects of anticoagulants.
Read the full Polygonum Multiflorum Extract + Abciximab interactionScutellaria Baicalensis ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, Baikal skullcap might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full Scutellaria Baicalensis Extract + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Tian Ma Gou Teng Teapills — through 1 ingredient. Tap an ingredient for the detail:
Polygonum Multiflorum ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fo-ti might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Polygonum Multiflorum Extract + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Tian Ma Gou Teng Teapills — through 1 ingredient. Tap an ingredient for the detail:
Polygonum Multiflorum ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, fo-ti might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Polygonum Multiflorum Extract + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Tian Ma Gou Teng Teapills — through 1 ingredient. Tap an ingredient for the detail:
Polygonum Multiflorum ExtractHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fo-ti might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Polygonum Multiflorum Extract + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Tian Ma Gou Teng Teapills — through 2 ingredients. Tap an ingredient for the detail:
Polygonum Multiflorum ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 2c9 (cyp2c9) Substrates +1 Moderate
Interaction Summary
Fo-ti has been linked to cases of acute liver failure which can decrease clotting factor production and increase the effects of anticoagulants.
Read the full Polygonum Multiflorum Extract + Abrocitinib interactionScutellaria Baicalensis ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 2c19 (cyp2c19) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full Scutellaria Baicalensis Extract + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Tian Ma Gou Teng Teapills — through 2 ingredients. Tap an ingredient for the detail:
Polygonum Multiflorum ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, fo-ti might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Polygonum Multiflorum Extract + Acalabrutinib interactionScutellaria Baicalensis ExtractP-glycoprotein Substrates Minor
Interaction Summary
Theoretically, Baikal skullcap might increase levels of drugs transported by P-glycoprotein.
Read the full Scutellaria Baicalensis Extract + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Tian Ma Gou Teng Teapills — through 2 ingredients. Tap an ingredient for the detail:
Polygonum Multiflorum ExtractAntidiabetes Drugs, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, fo-ti might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Polygonum Multiflorum Extract + Acarbose interactionScutellaria Baicalensis ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of Baikal skullcap with antidiabetes drugs might enhance blood glucose lowering effects.
Read the full Scutellaria Baicalensis Extract + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Tian Ma Gou Teng Teapills — through 2 ingredients. Tap an ingredient for the detail:
Polygonum Multiflorum ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, fo-ti might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Polygonum Multiflorum Extract + Acebutolol interactionScutellaria Baicalensis ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of Baikal skullcap with antihypertensive drugs might have additive effects and increase the risk of hypotension.
Read the full Scutellaria Baicalensis Extract + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Tian Ma Gou Teng Teapills — through 2 ingredients. Tap an ingredient for the detail:
Polygonum Multiflorum ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Fo-ti has been linked to cases of acute liver failure which can decrease clotting factor production and increase the effects of anticoagulants.
Read the full Polygonum Multiflorum Extract + Acenocoumarol interactionScutellaria Baicalensis ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, Baikal skullcap might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full Scutellaria Baicalensis Extract + Acenocoumarol interactionAcepromazineAtravet
How Acepromazine interacts with Tian Ma Gou Teng Teapills — through 3 ingredients. Tap an ingredient for the detail:
Poria Cocos ExtractAnticholinergic Drugs, Cns Depressants Moderate
Interaction Summary
Theoretically, poria mushroom might decrease the clinical effects of anticholinergic drugs.
Read the full Poria Cocos Extract + Acepromazine interactionLeonurus Japonicus ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking motherwort concomitantly with other CNS depressants may increase the risk of sedation.
Read the full Leonurus Japonicus Extract + Acepromazine interactionScutellaria Baicalensis ExtractCns Depressants Minor
Interaction Summary
Theoretically, Baikal skullcap might cause additive therapeutic and adverse effects when used concomitantly with drugs with sedative properties.
Read the full Scutellaria Baicalensis Extract + Acepromazine interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Tian Ma Gou Teng Teapills — through 2 ingredients. Tap an ingredient for the detail:
Scutellaria Baicalensis ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Scutellaria Baicalensis Extract + Acetaminophen interactionPolygonum Multiflorum ExtractHepatotoxic Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, fo-ti might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Polygonum Multiflorum Extract + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Tian Ma Gou Teng Teapills — through 2 ingredients. Tap an ingredient for the detail:
Polygonum Multiflorum ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Hepatotoxic Drugs +1 Moderate
Interaction Summary
Theoretically, fo-ti might increase or decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Polygonum Multiflorum Extract + Acetaminophen, Aspirin interactionScutellaria Baicalensis ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Scutellaria Baicalensis Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Tian Ma Gou Teng Teapills — through 2 ingredients. Tap an ingredient for the detail:
Scutellaria Baicalensis ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Read the full Scutellaria Baicalensis Extract + Acetaminophen, Aspirin, Caffeine interactionPolygonum Multiflorum ExtractHepatotoxic Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, fo-ti might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Polygonum Multiflorum Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Tian Ma Gou Teng Teapills — through 2 ingredients. Tap an ingredient for the detail:
Scutellaria Baicalensis ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Scutellaria Baicalensis Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionPolygonum Multiflorum ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, fo-ti might increase or decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Polygonum Multiflorum Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Tian Ma Gou Teng Teapills — through 2 ingredients. Tap an ingredient for the detail:
Polygonum Multiflorum ExtractHepatotoxic Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, fo-ti might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Polygonum Multiflorum Extract + Acetaminophen, Butalbital interactionScutellaria Baicalensis ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Scutellaria Baicalensis Extract + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Tian Ma Gou Teng Teapills — through 2 ingredients. Tap an ingredient for the detail:
Scutellaria Baicalensis ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Scutellaria Baicalensis Extract + Acetaminophen, Butalbital, Caffeine interactionPolygonum Multiflorum ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, fo-ti might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Polygonum Multiflorum Extract + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Tian Ma Gou Teng Teapills — through 4 ingredients. Tap an ingredient for the detail:
Polygonum Multiflorum ExtractHepatotoxic Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, fo-ti might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Polygonum Multiflorum Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionPoria Cocos ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Read the full Poria Cocos Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionLeonurus Japonicus ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking motherwort concomitantly with other CNS depressants may increase the risk of sedation.
Read the full Leonurus Japonicus Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionScutellaria Baicalensis ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Scutellaria Baicalensis Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Tian Ma Gou Teng Teapills — through 4 ingredients. Tap an ingredient for the detail:
Scutellaria Baicalensis ExtractCns Depressants, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap might cause additive therapeutic and adverse effects when used concomitantly with drugs with sedative properties.
Read the full Scutellaria Baicalensis Extract + Acetaminophen, Butalbital, Codeine interactionPolygonum Multiflorum ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, fo-ti may increase the levels and clinical effects of drugs metabolized by CYP2D6.
Read the full Polygonum Multiflorum Extract + Acetaminophen, Butalbital, Codeine interactionLeonurus Japonicus ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking motherwort concomitantly with other CNS depressants may increase the risk of sedation.
Read the full Leonurus Japonicus Extract + Acetaminophen, Butalbital, Codeine interactionPoria Cocos ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Read the full Poria Cocos Extract + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Tian Ma Gou Teng Teapills — through 4 ingredients. Tap an ingredient for the detail:
Scutellaria Baicalensis ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Scutellaria Baicalensis Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionPoria Cocos ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Read the full Poria Cocos Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionPolygonum Multiflorum ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, fo-ti might increase or decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Polygonum Multiflorum Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionLeonurus Japonicus ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking motherwort concomitantly with other CNS depressants may increase the risk of sedation.
Read the full Leonurus Japonicus Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Tian Ma Gou Teng Teapills — through 4 ingredients. Tap an ingredient for the detail:
Polygonum Multiflorum ExtractHepatotoxic Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, fo-ti might increase the risk of liver damage when taken with hepatotoxic drugs.
Read the full Polygonum Multiflorum Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionPoria Cocos ExtractAnticholinergic Drugs, Cns Depressants Moderate
Interaction Summary
Theoretically, poria mushroom might decrease the clinical effects of anticholinergic drugs.
Read the full Poria Cocos Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionLeonurus Japonicus ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking motherwort concomitantly with other CNS depressants may increase the risk of sedation.
Read the full Leonurus Japonicus Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionScutellaria Baicalensis ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Scutellaria Baicalensis Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Tian Ma Gou Teng Teapills — through 4 ingredients. Tap an ingredient for the detail:
Polygonum Multiflorum ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Theoretically, fo-ti might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Polygonum Multiflorum Extract + Acetaminophen, Caffeine, Codeine interactionScutellaria Baicalensis ExtractCns Depressants, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap might cause additive therapeutic and adverse effects when used concomitantly with drugs with sedative properties.
Read the full Scutellaria Baicalensis Extract + Acetaminophen, Caffeine, Codeine interactionLeonurus Japonicus ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking motherwort concomitantly with other CNS depressants may increase the risk of sedation.
Read the full Leonurus Japonicus Extract + Acetaminophen, Caffeine, Codeine interactionPoria Cocos ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Read the full Poria Cocos Extract + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Tian Ma Gou Teng Teapills — through 4 ingredients. Tap an ingredient for the detail:
Scutellaria Baicalensis ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Scutellaria Baicalensis Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionPolygonum Multiflorum ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Hepatotoxic Drugs +2 Moderate
Interaction Summary
Theoretically, fo-ti might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Polygonum Multiflorum Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionPoria Cocos ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Read the full Poria Cocos Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionLeonurus Japonicus ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking motherwort concomitantly with other CNS depressants may increase the risk of sedation.
Read the full Leonurus Japonicus Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Tian Ma Gou Teng Teapills — through 4 ingredients. Tap an ingredient for the detail:
Polygonum Multiflorum ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Hepatotoxic Drugs +2 Moderate
Interaction Summary
Theoretically, fo-ti might increase or decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Polygonum Multiflorum Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionPoria Cocos ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Read the full Poria Cocos Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionLeonurus Japonicus ExtractCns Depressants Moderate
Interaction Summary
Theoretically, taking motherwort concomitantly with other CNS depressants may increase the risk of sedation.
Read the full Leonurus Japonicus Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionScutellaria Baicalensis ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cns Depressants Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Scutellaria Baicalensis Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Tian Ma Gou Teng Teapills — through 2 ingredients. Tap an ingredient for the detail:
Polygonum Multiflorum ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Hepatotoxic Drugs +1 Moderate
Interaction Summary
Theoretically, fo-ti might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Polygonum Multiflorum Extract + Acetaminophen, Caffeine, Isometheptene interactionScutellaria Baicalensis ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Scutellaria Baicalensis Extract + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Tian Ma Gou Teng Teapills — through 3 ingredients. Tap an ingredient for the detail:
Scutellaria Baicalensis ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Scutellaria Baicalensis Extract + Acetaminophen, Caffeine, Pyrilamine interactionPolygonum Multiflorum ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Diuretic Drugs +2 Moderate
Interaction Summary
Theoretically, fo-ti might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Polygonum Multiflorum Extract + Acetaminophen, Caffeine, Pyrilamine interactionPoria Cocos ExtractAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, poria mushroom might decrease the clinical effects of anticholinergic drugs.
Read the full Poria Cocos Extract + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Tian Ma Gou Teng Teapills — through 3 ingredients. Tap an ingredient for the detail:
Poria Cocos ExtractAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, poria mushroom might decrease the clinical effects of anticholinergic drugs.
Read the full Poria Cocos Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionPolygonum Multiflorum ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Theoretically, fo-ti might increase or decrease the levels and clinical effects of drugs metabolized by CYP1A2.
Read the full Polygonum Multiflorum Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionScutellaria Baicalensis ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
Read the full Scutellaria Baicalensis Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Tian Ma Gou Teng Teapills with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Polygonum multiflorum extract
Anticoagulant/Antiplatelet Drugs
Fo-ti has been linked to cases of acute liver failure which can decrease clotting factor production and increase the effects of anticoagulants. In one case, a patient who had been stable on warfarin presented with acute hepatitis and an INR elevated to 14.98. The patient had been taking fo-ti for 90 days prior to admission. Discontinuation of warfarin and fo-ti lead to a decrease in the INR and full recovery. Theoretically, concomitant use of fo-ti with anticoagulant or antiplatelet drugs may increase the risk of bleeding in some patients. Until more is known, monitor patients taking fo-ti and drugs that affect bleeding.
Some of these drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), dipyridamole (Persantine), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.
Antidiabetes Drugs
Theoretically, fo-ti might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Fo-ti reportedly has hypoglycemic effects.
Contraceptive Drugs
Theoretically, taking large amounts of fo-ti might interfere with contraceptive drugs due to competition for estrogen receptors.
In vitro research suggests that fo-ti extract has estrogenic activity.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, fo-ti might increase or decrease the levels and clinical effects of drugs metabolized by CYP1A2.
In vitro research suggests that fo-ti might inhibit CYP1A2. Additionally, in vitro research suggests that the degree of CYP1A2 inhibition depends on the type of fo-ti extract (i.e., the raw plant leads to greater inhibition than extensively processed extracts). However, in an animal study, an aqueous extract of fo-ti inhibited CYP1A2 while an alcoholic extract of fo-ti induced CYP1A2. Induction or inhibition of CYP1A2 by fo-ti has not been reported in humans.
Cytochrome P450 2B6 (Cyp2B6) Substrates
Theoretically, fo-ti might increase the levels and clinical effects of drugs metabolized by CYP2B6.
Animal research suggests that fo-ti might inhibit CYP2B6. One in vitro study suggests that the degree of CYP2B6 inhibition may depend on the type of fo-ti extract (i.e., the raw plant leads to greater inhibition than extensively processed extracts). However, this interaction has not been reported in humans.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, fo-ti may increase the levels and clinical effects of drugs metabolized by CYP2C19.
Animal and in vitro research suggests that fo-ti may inhibit CYP2C19. An in vitro study suggests that the degree of CYP2C19 inhibition may depend on the type of fo-ti extract (i.e., the raw plant leads to greater inhibition than extensively processed extracts). However, this interaction has not been reported in humans.
Cytochrome P450 2C8 (Cyp2C8) Substrates
Theoretically, fo-ti might increase the levels and clinical effects of drugs metabolized by CYP2C8.
In vitro research suggests that fo-ti might inhibit CYP2C8. However, this interaction has not been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, fo-ti may increase the levels and clinical effects of drugs metabolized by CYP2C9.
Animal and in vitro research suggests that fo-ti may inhibit CYP2C9. However, this interaction has not been reported in humans.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, fo-ti may increase the levels and clinical effects of drugs metabolized by CYP2D6.
Animal research suggests that fo-ti might inhibit CYP2D6. Additionally, an in vitro study suggests that the degree of CYP2D6 inhibition may depend on the type of fo-ti extract (i.e., the raw plant leads to greater inhibition than extensively processed extracts). However, this interaction has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, fo-ti might increase the levels and clinical effects of drugs metabolized by CYP3A4.
In vitro research suggests that fo-ti might inhibit CYP3A4. One in vitro study suggests that the degree of CYP3A4 inhibition may depend on the type of fo-ti extract (i.e., the raw plant leads to greater inhibition than extensively processed extracts). However, this evidence conflicts with animal research suggesting that fo-ti does not inhibit CYP3A4. This interaction has not been reported in humans.
Digoxin (Lanoxin)
Theoretically, fo-ti, particularly raw fo-ti root, might increase the risk of hypokalemia and cardiotoxicity when taken with digoxin.
Raw fo-ti root contains anthraquinone derivatives, which might have stimulant laxative effects. In vitro research shows that fermented and processed fo-ti root have reduced laxative effects compared with raw fo-ti root.
Diuretic Drugs
Theoretically, fo-ti, particularly raw fo-ti root, might increase the risk of hypokalemia when taken with diuretic drugs.
Raw fo-ti root contains anthraquinone derivatives, which might have stimulant laxative effects and compound diuretic-induced potassium loss. In vitro research shows that fermented and processed fo-ti root have reduced laxative effects compared with raw fo-ti root.
Estrogens
Theoretically, taking large amounts of fo-ti might interfere with hormone replacement therapy through competition for estrogen receptors.
In vitro research suggests that fo-ti extract has estrogenic activity.
Hepatotoxic Drugs
Theoretically, fo-ti might increase the risk of liver damage when taken with hepatotoxic drugs.
Fo-ti has been linked to liver damage in many reports.
Stimulant Laxatives
Theoretically, fo-ti, particularly raw fo-ti root, might increase the risk of fluid and electrolyte depletion when taken with stimulant laxatives.
Raw fo-ti root contains anthraquinone derivatives, which might have stimulant laxative effects. However, in vitro research shows that fermented and processed fo-ti root have reduced laxative effects compared with raw fo-ti root.
Sulindac (Clinoril)
Theoretically, fo-ti might increase or decrease the levels and clinical effects of sulindac.
Animal research suggests that the type of fo-ti extract might affect the levels of sulindac differently; the raw plant may increase levels, but processed parts may decrease levels. Induction or inhibition of CYP1A2 by fo-ti has not been reported in humans.
Warfarin (Coumadin)
Theoretically, fo-ti might increase the effects and adverse effects of warfarin.
Fo-ti may have stimulant laxative effects and cause diarrhea, especially when the raw or unprocessed fo-ti root is used. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. Also, fo-ti has been linked to cases of acute liver failure which can decrease clotting factor production and increase the effects of warfarin. In one case, a patient who had been stable on warfarin presented with acute hepatitis and an INR elevated to 14.98. The patient had been taking fo-ti for 90 days prior to admission. Discontinuation of warfarin and fo-ti lead to a decrease in the INR and full recovery.
Scutellaria baicalensis extract
Anticoagulant/Antiplatelet Drugs
Theoretically, Baikal skullcap might increase the risk of bleeding when used concomitantly with anticoagulant and antiplatelet drugs.
Preliminary clinical research suggests that taking capsules containing a combination of astragalus, goldthread, and Baikal skullcap daily for 4 weeks inhibits platelet aggregation; the effect seems to be similar to that of aspirin 50 mg daily. It is unclear if this effect is due to Baikal skullcap, other ingredients, or the combination.
Antidiabetes Drugs
Theoretically, concomitant use of Baikal skullcap with antidiabetes drugs might enhance blood glucose lowering effects.
Baicalein, a constituent of Baikal skullcap, has alpha-glucosidase inhibitory activity in vitro. Animal research also suggests that Baikal skullcap enhances the antidiabetic effects of metformin. However, in a small human study, taking Baikal skullcap extract did not enhance the antidiabetic effects of metformin, although it did modestly lower glucose levels during an oral glucose tolerance test (OGTT). Until more is known, use cautiously.
Antihypertensive Drugs
Theoretically, concomitant use of Baikal skullcap with antihypertensive drugs might have additive effects and increase the risk of hypotension.
Animal research suggests that baicalein, a constituent of Baikal skullcap, might lower blood pressure.
Antithyroid Drugs
Theoretically, concomitant use of Baikal skullcap and antithyroid drugs may result in additive activity and increase the risk of hypothyroidism.
In an animal hyperthyroid model, Baikal skullcap improved levels of triiodothyronine (T3), thyroxine (T4), and thyroid stimulating hormone (TSH). The clinical significance of this effect is unclear.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, Baikal skullcap may increase levels of drugs metabolized by CYP1A2 enzymes.
In vitro evidence suggests that constituents of Baikal skullcap inhibit the activity of CYP1A2. This effect has not been reported in humans.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, Baikal skullcap might increase levels of drugs metabolized by CYP2C19 enzymes.
In vitro evidence suggest that wogonin, a constituent of Baikal skullcap, modestly inhibits the activity of CYP2C19 enzymes. This effect has not been reported in humans.
Estrogens
Theoretically, concomitant use of large amounts of Baikal skullcap might interfere with hormone replacement therapy, due to competition for estrogen receptors.
In vitro evidence suggests that Baikal skullcap has estrogenic activity.
Lithium
Theoretically, Baikal skullcap might reduce lithium excretion and increase serum levels of lithium.
Baikal skullcap is thought to have diuretic properties, which may reduce lithium excretion. The dose of lithium might need to be decreased.
Alcohol (Ethanol)
Theoretically, Baikal skullcap might potentiate the sedative effects of alcohol.
In vitro and animal research suggests that Baikal skullcap binds to GABA-A receptors and causes sedation. Theoretically, Baikal skullcap might potentiate the sedative effects of alcohol. Preliminary clinical research has not identified clinically relevant sedation after use of Baikal skullcap; however, a thorough evaluation of safety outcomes has not been conducted.
Cns Depressants
Theoretically, Baikal skullcap might cause additive therapeutic and adverse effects when used concomitantly with drugs with sedative properties.
In vitro and animal research suggests that Baikal skullcap binds to GABA-A receptors and causes sedation. Theoretically, Baikal skullcap might cause additive therapeutic and adverse effects when used concomitantly with drugs with sedative properties. Preliminary clinical research has not identified clinically relevant sedation after use of Baikal skullcap; however, a thorough evaluation of safety outcomes has not been conducted.
Organic Anion-Transporting Polypeptide Substrates (Oatp)
Theoretically, Baikal skullcap might alter the levels and clinical effects of OATP substrates.
Some pharmacokinetic research shows that baicalin, a constituent of Baikal skullcap, can decrease plasma levels of rosuvastatin. The mechanism is thought to involve stimulation of the activity of the organic anion-transporting polypeptide 1B1 (OATP1B1), which transports rosuvastatin into the liver. This decreases plasma levels of the drug, but increases levels at the site of action in the liver. The degree to which rosuvastatin levels are affected depends on the OATP1B1 haplotype of the individual. Baikal skullcap might also affect other OATP1B1 substrates.
P-Glycoprotein Substrates
Theoretically, Baikal skullcap might increase levels of drugs transported by P-glycoprotein.
In vitro and animal research suggests that baicalein, oroxylin A, and wogonin, constituents of Baikal skullcap, can inhibit P-glycoprotein. This effect has not been reported in humans.
Poria cocos extract
Anticholinergic Drugs
Theoretically, poria mushroom might decrease the clinical effects of anticholinergic drugs.
In animal research, poria mushroom essential oil reduces acetylcholinesterase activity. This interaction has not been shown in humans.
Cholinergic Drugs
Theoretically, poria mushroom might have additive effects when used with cholinergic drugs.
In animal research, poria mushroom essential oil reduces acetylcholinesterase activity. This interaction has not been shown in humans.
Cns Depressants
Theoretically, taking poria mushroom extract may enhance the therapeutic and adverse effects of sedatives.
Animal research shows that poria mushroom extract has sedative properties. This interaction has not been shown in humans.
Leonurus japonicus extract
Cns Depressants
Theoretically, taking motherwort concomitantly with other CNS depressants may increase the risk of sedation.
Motherwort has been reported to cause CNS depression and sedation.
Gardenia jasminoides extract
Stimulant Laxatives
Theoretically, gardenia might increase the effects and adverse effects of stimulant laxatives.
Animal research shows that geniposide, a glucoside found in gardenia fruit, may function as a laxative and cause diarrhea when taken orally.
Brand information
Manufacturer and brand details for Tian Ma Gou Teng Teapills, from the product label.
Plum Flower
- Name
- Mayway Herbs
- City
- Oakland
- State
- CA
- Web Address
- plumflowerherbs.com
Tian Ma Gou Teng Teapills by Plum Flower: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Tian Ma Gou Teng Teapills’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Fo-ti
Interacts with 1,257 drugsFo-ti (He Shou Wu) is a root used in traditional Chinese medicine, often promoted for healthy aging and hair. High-quality human evidence for these benefits is limited, and processed Fo-ti h...
Read the full Fo-ti monograph → Herb & supplement monographPoria Mushroom
Interacts with 417 drugsPoria mushroom (Fu Ling) is a fungus long used in Traditional Chinese Medicine, mainly as a mild diuretic and digestive and calming aid. Modern scientific evidence in humans is very limited,...
Read the full Poria Mushroom monograph → Herb & supplement monographBaikal Skullcap
Interacts with 946 drugsBaikal skullcap is a traditional Chinese herb (Huang Qin) used for inflammation, allergies, and infections, with active compounds like baicalin and baicalein studied mostly in the lab. Human...
Read the full Baikal Skullcap monograph → Herb & supplement monographMotherwort
Interacts with 248 drugsMotherwort is a traditional herb in the mint family long used for anxiety, heart palpitations, and women's reproductive complaints, but solid human evidence is very limited. It should be avo...
Read the full Motherwort monograph → Herb & supplement monographGardenia
Interacts with 21 drugsGardenia fruit has a long history in traditional Chinese medicine and is also used as a natural food coloring. While early lab and animal studies are interesting, strong human evidence for i...
Read the full Gardenia monograph →Sources & How We Checked
Tian Ma Gou Teng Teapills's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 76 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Fo-ti 28 references
- Foster S, Tyler VE. Tyler's Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies. 3rd ed., Binghamton, NY: Haworth Herbal Press, 1993.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
- Park GJ, Mann SP, Ngu MC. Acute hepatitis induced by Shou-Wu-Pian, a herbal product derived from Polygonum multiflorum. J Gastroenterol Hepatol 2001;16:115-7.
- But PP, Tomlinson B, Lee KL. Hepatitis related to the Chinese medicine Shou-wu-pian manufactured from Polygonum multiflorum. Vet Hum Toxicol 1996;38:280-2.
- Oerter Klein KO, Janfaza M, Wong JA, Chang RJ. Estrogen bioactivity in Fo-Ti and other herbs used for their estrogen-like effects as determined by a recombinant cell bioassay. J Clin Endocrinol Metab 2003;88:4077-9.. PubMed
- Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed
- UK Medicines and Healthcare Products Regulatory Agency. Polygonum multiflorum and liver reactions. April 2006. Available at: www.mhra.gov.uk/home/idcplg?IdcService= SS_GET_PAGE&useSecondary=true&ssDocName= CON2023590&ssTargetNodeId= 833 (Accessed 10 May 2
- Panis B, Wong DR, Hooymans PM, De Smet PA, Rosias PP. Recurrent toxic hepatitis in a Caucasian girl related to the use of Shou-Wu-Pian, a Chinese herbal preparation. J Pediatr Gastroenterol Nutr 2005;41:256-8. PubMed
- Mazzanti G, Battinelli L, Daniele C, et al. New case of acute hepatitis following the consumption of Shou Wu Pian, a Chinese herbal product derived from Polygonum multiflorum. Ann Intern Med 2004;140:E589-90.
- Cardenas A, Restrepo JC, Sierra F, Correa G. Acute hepatitis due to shen-min: a herbal product derived from Polygonum multiflorum. J Clin Gastroenterol 2006;40:629-32. PubMed
- Zhang CZ, Wang SX, Zhang Y, et al. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. J Ethnopharmacol 2005;98:295-300. PubMed
- Laird AR, Ramchandani N, deGoma EM, et al. Acute hepatitis associated with the use of an herbal supplement (Polygonum multiflorum) mimicking iron-overload syndrome. J Clin Gastroenterol 2008;42:861-2. PubMed
- Jung KA, Min HJ, Yoo SS, et al. Drug-Induced Liver Injury: Twenty Five Cases of Acute Hepatitis Following Ingestion of Polygonum multiflorum Thunb. Gut Liver 2011;5(4):493-9. PubMed
- Kang, S. C., Lee, C. M., Choi, H., Lee, J. H., Oh, J. S., Kwak, J. H., and Zee, O. P. Evaluation of oriental medicinal herbs for estrogenic and antiproliferative activities. Phytother Res 2006;20(11):1017-1019. PubMed
- Yuen, M. F., Tam, S., Fung, J., Wong, D. K., Wong, B. C., and Lai, C. L. Traditional Chinese medicine causing hepatotoxicity in patients with chronic hepatitis B infection: a 1-year prospective study. Aliment.Pharmacol.Ther 10-15-2006;24(8):1179-1186. PubMed
- Zhang, L., Yang, X., Sun, Z., and Qu, Y. [Retrospective study of adverse events of Polygonum multiflorum and risk control]. Zhongguo Zhong.Yao Za Zhi. 2009;34(13):1724-1729.
- Bae, S. H., Kim, D. H., Bae, Y. S., Lee, K. J., Kim, D. W., Yoon, J. B., Hong, J. H., and Kim, S. H. [Toxic hepatitis associated with Polygoni multiflori]. Korean J.Hepatol. 2010;16(2):182-186. PubMed
- Furukawa, M., Kasajima, S., Nakamura, Y., Shouzushima, M., Nagatani, N., Takinishi, A., Taguchi, A., Fujita, M., Niimi, A., Misaka, R., and Nagahara, H. Toxic hepatitis induced by show-wu-pian, a Chinese herbal preparation. Intern.Med. 2010;49(15):1537-1 PubMed
- McGuffin, M., Hobbs, C., Upton, R., and Goldberg, A. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC;1997.
- Dong H, Slain D, Cheng J, Ma W, Liang W. Eighteen cases of liver injury following ingestion of Polygonum multiflorum. Complement Ther Med 2014;22(1):70-4. PubMed
- Lei X, Chen J, Ren J, et al. Liver damage associated with Polygonum multiflorum Thunb.: a systematic review of case reports and case series. Evid Based Complement Alternat Med 2015;2015:459749.
- Ma KF, Zhang XG, Jia HY. CYP1A2 polymorphism in Chinese patients with acute liver injury induced by Polygonum multiflorum. Genet Mol Res 2014;13(3):5637-43. PubMed
- Zhang Y, Ding T, Diao T, Deng M, Chen S. Effects of Polygonum multiflorum on the activity of cytochrome P450 isoforms in rats. Pharmazie 2015;70(1):47-54. DOI
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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