Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Toco-9 Ingredients & Drug Interactions

by Iconic Formulations

Toco-9 label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Toco-9 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Toco-9 is a dietary supplement by Iconic Formulations with 4 active ingredients. Its ingredients are commonly taken for eye and vision health, skin health and acne, immune support.Based on those ingredients, 1,247 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Vitamin E, Sesame seed (Sesamum indicum L.) hydroalcoholic extract, Vitamin A. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Toco-9 by Iconic Formulations

Ask about any prescription or over-the-counter medication and we check it for interactions with Toco-9 by Iconic Formulations — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Toco-9 by Iconic Formulations

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 5 of its 6 active ingredients.
  • “Red Palm oil (Elaeis guineensis) vacuum distillation extract” is listed as a grouped ingredient — the label gives one combined amount (970 mg) without saying how much of each component you get.

Toco-9 contains 6 active ingredients. Coenzyme Q10, vitamin A, vitamin E, and tocochromanols (a form of vitamin E related to tocotrienols) are antioxidants that support cellular health.

Red palm oil and sesame seed extract contribute additional plant-based compounds, including carotenoids (which we could not fully assess). The product also contains hypromellose, an inactive ingredient that forms the capsule shell.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Vitamin A deficiency — rated "Effective" (Vitamin A) (Natural Medicines).
  • On file: Vitamin E deficiency — rated "Effective" (Vitamin E) (Natural Medicines).
  • On file: Ataxia with vitamin E deficiency (AVED) — rated "Effective" (Vitamin E) (Natural Medicines).
  • On file: Coenzyme Q10 deficiency — rated "Likely Effective" (Coenzyme Q10) (Natural Medicines).
  • On file: Aging skin — rated "Possibly Effective" (Vitamin A) (Natural Medicines).

Evidence for these ingredients comes in mixed strengths. Coenzyme Q10 is likely effective for CoQ10 deficiency and possibly effective for fibromyalgia, migraines, heart failure, and diabetic nerve pain.

Vitamin A is effective for vitamin A deficiency and possibly effective for aging skin, measles, and certain inflammatory conditions. Vitamin E is effective for vitamin E deficiency and possibly effective for Alzheimer disease and certain blood disorders.

Tocochromanols are possibly effective for diabetes but possibly ineffective for high cholesterol; evidence is insufficient for breast cancer and hair loss. Sesame seed is possibly effective for high blood pressure but possibly ineffective for cough.

We hold no effectiveness data for red palm oil or carotenoids in this product.

The evidence, ingredient by ingredient Vitamin A Vitamin E Palm Oil Coenzyme Q10 Tocotrienols Sesame

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Coenzyme Q10 is generally well tolerated; rare side effects include gastrointestinal upset (less than 1% of users), headache, dizziness, insomnia, and rarely skin itching or rash. Vitamin A is safe at recommended amounts but can build up in your body and cause toxicity at high doses—avoid high-dose supplements during pregnancy because they can cause birth defects.

Vitamin E is well tolerated at usual amounts, though high doses increase bleeding risk and may raise the chance of stroke; amounts from food and prenatal vitamins are fine, but avoid high-dose supplements while pregnant or breastfeeding without doctor approval. Tocochromanols appear well tolerated orally with no reported adverse effects in trials, but should be avoided during pregnancy due to insufficient safety data; safety while breastfeeding is unknown.

Sesame is a major allergen—allergic reactions (skin reactions, breathing problems, anaphylaxis) have been reported, and the product contains sesame seed extract. Normal dietary sesame amounts are generally safe, but concentrated supplements are less studied.

Side effects, ingredient by ingredient Vitamin A Vitamin E Palm Oil Coenzyme Q10 Tocotrienols Sesame

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Coenzyme Q10, Vitamin E, Vitamin A, Sesame, Tocotrienols.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; cancer treatments; diabetes medications.
  • For scale: 1,248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before using Toco-9 if you take retinoid drugs (Major interaction with vitamin A), blood thinners or antiplatelet agents (Moderate with vitamin A, E, and tocochromanols), chemotherapy drugs that generate free radicals like cyclophosphamide (Moderate with vitamin A and E), tetracycline antibiotics (Moderate with vitamin A), blood-pressure medications (Moderate with sesame, minor with CoQ10), diabetes drugs (Moderate with sesame), liver-toxic drugs (Moderate with vitamin A), certain heart or transplant drugs like cyclosporine (Moderate with vitamin E), CYP3A4-metabolized drugs (Moderate with vitamin E), or CYP2C9-metabolized drugs (Moderate with sesame). No interactions are documented for the carotenoids in this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with strong clinical evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.

Toco-9 is an antioxidant supplement that may suit people with specific nutrient deficiencies or those interested in general cellular support—but it's not for everyone. If you take a blood thinner, retinoid acne medication, chemotherapy, diabetes or blood-pressure medication, or any drug your liver processes heavily, talk to your pharmacist before starting.

If you have a sesame allergy, skip this product entirely.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Toco-9, straight from the product label.

Brand Iconic Formulations
Barcode (UPC) 604776380535
Net contents 60 Vegetarian Liquid Capsule(s)
Market status On market
Date entered into DSLD Jul 23, 2020
DSLD ID 229371
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Toco-9 by Iconic Formulations, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
604776380535
IngredientAmount% DV
Calories5 Calorie(s)--
Total Fat0.5 Gram(s)1%
Coenzyme Q100 NP--
Vitamin A3960 mcg440%
Vitamin E30 mg200%
Red Palm oil (Elaeis guineensis) vacuum distillation extract970 mg--
Tocochromanols160 mg--
Carotenoids30 mg--
Sesame seed (Sesamum indicum L.) hydroalcoholic extract100 mg--

Other ingredients: Hypromellose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Tamper-evident safety seal For your safety, look for this logo on the shrink band.

Do not exceed the recommended dose.

Formula

Wildlife friendly Malaysian Palm

Palm extract from ExcelVite.

Palm Fruit Phytonutrient Complex

Suggested/Recommended/Usage/Directions

As a food supplement, take 1-2 capsules daily with food.

Formulation

Pesticide free Non GMO natural product

Vegan

Clinically effective antioxidant support Clinically effective dose

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Protect product form light. Store below 26 degrees Celsius (78 degrees Fahrenheit).

General Statements

Oxygen absorber Maximum freshness

FDA Statement of Identity

Phytonutrient Supplement

Seals/Symbols

Tamper-evident safety seal

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Toco-9 by Iconic Formulations label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Toco-9 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Toco-9 by Iconic Formulations

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin A

Interacts with
387 drugs
3960 mcg per serving Form: Red Palm Oil extract

Vitamin A is an essential nutrient important for vision, skin, immune function, and growth. Most people get enough from a balanced diet, and supplemen...

Vitamin A monograph & interactions

Vitamin E

Interacts with
764 drugs
30 mg per serving Form: Red Palm Oil extract

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correc...

Vitamin E monograph & interactions

Red Palm oil (Elaeis guineensis) vacuum distillation extract

Interacts with
122 drugs
970 mg per serving Form: Palm Oil

Palm oil is a widely used edible oil pressed from the fruit of the oil palm tree, and red palm oil is a notable source of vitamin A and vitamin E comp...

Red Palm oil (Elaeis guineensis) vacuum distillation extract monograph & interactions

Sesame seed (Sesamum indicum L.) hydroalcoholic extract

Interacts with
528 drugs
100 mg per serving Form: Sesamin

Sesame is a nutritious seed and oil widely used in cooking and traditional medicine, and it provides healthy fats, fiber, and antioxidant compounds ca...

Sesame seed (Sesamum indicum L.) hydroalcoholic extract monograph & interactions

Other (inactive) ingredients: Hypromellose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Toco-9 by Iconic Formulations Drug Interactions

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Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,247Drugs
9 Major 1,193 Moderate 45 Minor

Ingredients driving the most interactions

Vitamin E 764
Sesame seed (Sesamum indicum L.) hydroalcoholic extract 528
Vitamin A 387
Red Palm oil (Elaeis guineensis) vacuum distillation extract 122

Individual Drug Interactions

The ingredients in Toco-9 interact with 1,247 drugs. Click any drug to see the details.

4 of the 4 ingredients in Toco-9 interact with drugs. Each result below shows which ingredient is responsible. Vitamin E Sesame seed (Sesamum indicum L.) hydroalcoholic extract Vitamin A Red Palm oil (Elaeis guineensis) vacuum distillation extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Toco-9 with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin E8 drug types · 764 drugs

Alkylating Agents

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of alkylating agents.
There's concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Concomitant use of vitamin E and anticoagulant or antiplatelet agents might increase the risk of bleeding.
Vitamin E seems to inhibit of platelet aggregation and antagonize the effects of vitamin K-dependent clotting factors. These effects appear to be dose-dependent, and are probably only likely to be clinically significant with doses of at least 800 units daily. Mixed tocopherols, such as those found in food, might have a greater antiplatelet effect than alpha-tocopherol. RRR alpha-tocopherol (natural vitamin E) 1000 IU daily antagonizes vitamin K-dependent clotting factors. Advise patients to avoid high doses of vitamin E, especially in people with low vitamin K intake or other risk factors for bleeding.

Likelihood Possible Evidence B
Antitumor Antibiotics

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of antitumor antibiotics.
There's concern that antioxidants could reduce the activity of antitumor antibiotic drugs such as doxorubicin, which generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

A specific form of vitamin E might increase absorption and levels of cyclosporine.
There is some evidence that one specific formulation of vitamin E (D-alpha-tocopheryl-polyethylene glycol-1000 succinate, TPGS, tocophersolan, Liqui-E) might increase absorption of cyclosporine. This vitamin E formulation forms micelles which seems to increase absorption of cyclosporine by 40% to 72% in some patients. However, this interaction is unlikely to occur with the usual forms of vitamin E.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Vitamin E appears to bind with the nuclear receptor, pregnane X receptor (PXR), which results in increased expression of CYP3A4. Although the clinical significance of this is not known, use caution when considering concomitant use of vitamin E and other drugs affected by these enzymes.

Likelihood Possible Evidence D
Selumetinib (Koselugo)

Taking selumetinib with vitamin E can result in a total daily dose of vitamin E that exceeds safe limits and therefore might increase the risk of bleeding.
Selumetinib contains 48-54 IU vitamin E per capsule. The increased risk of bleeding with vitamin E appears to be dose-dependent. Be cautious when using selumetinib in combination with supplemental vitamin E, especially in patients at higher risk of bleed, such as those with chronic conditions and those taking antiplatelet drugs.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Using vitamin E with warfarin might increase the risk of bleeding.
Due to interference with production of vitamin K-dependent clotting factors, use of more than 400 IU of vitamin E daily with warfarin might increase prothrombin time (PT), INR, and the risk of bleeding,. At a dose of 1000 IU per day, vitamin E can antagonize vitamin K-dependent clotting factors even in people not taking warfarin. Limited clinical evidence suggests that doses up to 1200 IU daily may be used safely by patients taking warfarin, but this may not be applicable in all patient populations.

Likelihood Possible Evidence B
Niacin

Vitamin E might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises high-density lipoprotein (HDL) cholesterol levels in people with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50%. Vitamin E alone combined with a statin does not seem to decrease HDL levels. It is not known whether the adverse effect on HDL is due to one of the other antioxidants or to the combination. It also is not known whether it will occur in other patient populations.

Likelihood Possible Evidence A
Vitamin E full monograph & interactions

Sesame seed (Sesamum indicum L.) hydroalcoholic extract5 drug types · 528 drugs

Antidiabetes Drugs

Taking sesame oil with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical studies show that sesame oil can decrease plasma glucose and glycated hemoglobin (HbA1c) levels. Some clinical research in patients taking glibenclamide shows that using sesame oil or a blend of sesame oil and rice bran oil in place of other oil for cooking reduces plasma glucose more than glibenclamide alone. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D
Antihypertensive Drugs

Taking sesame oil with antihypertensive drugs might increase the risk of hypotension.
Clinical research shows that replacing other cooking oil with sesame oil can lower systolic blood pressure (SBP) and diastolic blood pressure (DBP) in patients with or without hypertension. There is also some evidence that sesame oil has additive effects in patients also taking atenolol, nifedipine, and/or hydrochlorothiazide. In patients using nifedipine, using a blend of sesame oil and rice bran oil for cooking reduces both SBP and DBP more than nifedipine alone.

Likelihood Probable Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, sesame might increase the levels and clinical effects of CYP2C9 substrates.
In vitro, sesame inhibits CYP2C9. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, sesame might interfere with tamoxifen.
In animal research, sesame seed reduces the tumor-inhibitory effect of tamoxifen by reducing apoptosis and increasing proliferation. This interaction has not been reported in humans.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, sesame might alter the transport of P-glycoprotein substrates.
In vitro research suggests that sesamin, a constituent of sesame, can inhibit the multi-drug transporter protein, P-glycoprotein. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Sesame seed (Sesamum indicum L.) hydroalcoholic extract full monograph & interactions

Vitamin A4 drug types · 387 drugs

Retinoids

Concomitant use of retinoids with vitamin A supplements might produce supratherapeutic vitamin A levels.
Retinoids, which are vitamin A derivatives, could have additive toxic effects when taken with vitamin A supplements.

Likelihood Probable Evidence D
Hepatotoxic Drugs

Theoretically, taking high doses of vitamin A in combination with other potentially hepatotoxic drugs might increase the risk of liver disease.
The tolerable upper intake level (UL) is the highest level of intake that is likely to pose no risk of adverse effects. Doses of vitamin A above the UL can cause hepatotoxicity, ranging from elevated liver enzymes to liver failure.

Likelihood Possible Evidence C
Tetracycline Antibiotics

Theoretically, taking tetracycline antibiotics with high doses of vitamin A can increase the risk of pseudotumor cerebri.
Benign intracranial hypertension (pseudotumor cerebri) can occur with tetracyclines and with acute or chronic vitamin A toxicity. Case reports suggest that taking tetracyclines and vitamin A concurrently can increase the risk of this condition. Avoid high doses of vitamin A in people taking tetracyclines chronically.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, high doses of vitamin A could increase the risk of bleeding with warfarin.
Vitamin A toxicity is associated with hemorrhage and hypoprothrombinemia, possibly due to vitamin K antagonism. Advise patients taking warfarin to avoid doses of vitamin A above the tolerable upper intake level of 10,000 IU/day for adults.

Likelihood Possible Evidence D
Vitamin A full monograph & interactions

Red Palm oil (Elaeis guineensis) vacuum distillation extract1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, palm oil might decrease the effectiveness of antiplatelet or anticoagulant drugs.
The palm olein constituent in palm oil seems to increase platelet aggregation.

Likelihood Possible Evidence B
Red Palm oil (Elaeis guineensis) vacuum distillation extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Toco-9, from the product label.

Iconic Formulations

See all Iconic Formulations products
Name
Iconic Formulations
City
San Diego
State
CA
ZipCode
92121
Phone Number
1-858-205-1315
Pharmacist Counseling Corner

Toco-9 by Iconic Formulations: Common Questions

Does Toco-9 by Iconic Formulations interact with any medications?
Yes. Based on its ingredients, Toco-9 has a known interaction with 1,247 medications, including 9 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Toco-9 contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is Toco-9 safe to take if I'm pregnant?
Vitamin A at high doses can cause birth defects, so avoid high-dose supplements unless your doctor advises otherwise. Tocochromanols should be avoided during pregnancy due to insufficient safety data. Normal dietary amounts of sesame and vitamin E from food or prenatal vitamins are appropriate. Talk with your doctor or pharmacist for personalized advice, since this is an individual medical decision.
Can I take Toco-9 while breastfeeding?
There isn't enough data on breastfeeding safety for coenzyme Q10, vitamin E at high doses, tocochromanols, or sesame supplements—check with your doctor before using. Normal dietary amounts of these nutrients from food are generally fine.
What does coenzyme Q10 do in this product?
CoQ10 is likely effective if you have a CoQ10 deficiency and possibly effective for fibromyalgia, migraines, heart failure, and diabetic nerve pain. It's an antioxidant that supports cellular energy production.
I have a sesame allergy—is this product safe for me?
No. Toco-9 contains sesame seed extract, and sesame is a major allergen. Allergic reactions can range from skin rashes to breathing problems and anaphylaxis. Do not take this product.
What are the most common side effects?
Coenzyme Q10 may cause mild gastrointestinal upset like nausea, diarrhea, or heartburn in less than 1% of people. Vitamin A at high doses can cause dry skin, headache, or liver problems. Vitamin E is generally well tolerated but can increase bleeding risk at high doses. Most people tolerate the ingredients without problems.
Does this product really work for anti-aging?
Vitamin A is possibly effective for aging skin based on the data we hold. The other antioxidants are studied mainly for specific deficiencies and health conditions, not cosmetic aging. Results vary by person and ingredient.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Toco-9 label
Go deeper

The Full Monographs Behind Toco-9’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin A

Interacts with 387 drugs

Vitamin A is an essential nutrient important for vision, skin, immune function, and growth. Most people get enough from a balanced diet, and supplements are mainly useful for correcting a tr...

Read the full Vitamin A monograph → Herb & supplement monograph

Vitamin E

Interacts with 764 drugs

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correct a true deficiency, but high-dose vitam...

Read the full Vitamin E monograph → Herb & supplement monograph

Palm Oil

Interacts with 122 drugs

Palm oil is a widely used edible oil pressed from the fruit of the oil palm tree, and red palm oil is a notable source of vitamin A and vitamin E compounds called tocotrienols. As a food it...

Read the full Palm Oil monograph → Herb & supplement monograph

Coenzyme Q10

Interacts with 198 drugs

CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated and is most studied for heart condition...

Read the full Coenzyme Q10 monograph → Herb & supplement monograph

Tocotrienols

Interacts with 122 drugs

Tocotrienols are a less common form of vitamin E with strong antioxidant activity studied mostly for cholesterol, liver, and heart health. Early research is interesting but far from conclusi...

Read the full Tocotrienols monograph → Herb & supplement monograph

Sesame

Interacts with 528 drugs

Sesame is a nutritious seed and oil widely used in cooking and traditional medicine, and it provides healthy fats, fiber, and antioxidant compounds called lignans. Some early research sugges...

Read the full Sesame monograph →
Sources

Sources & How We Checked

Toco-9's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 204 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Coenzyme Q10 40 references
  1. Kamikawa T, Kobayashi A, Yamashita T, et al. Effects of coenzyme Q10 on exercise tolerance in chronic stable angina pectoris. Am J Cardiol 1985;56:247-51. PubMed
  2. Langsjoen P, Willis R, Folkers K. Treatment of essential hypertension with coenzyme Q10. Mol Aspects Med 1994;S265-72. PubMed
  3. Spigset O. Reduced effect of warfarin caused by ubidecarenone. Lancet 1994;334:1372-3. PubMed
  4. Singh RB, Niaz MA, Rastogi SS, et al. Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease. J Hum Hypertens 1999;13:203-8. PubMed
  5. Portakal O, Ozkaya O, Erden Inal M, et al. Coenzyme Q10 concentrations and antioxidant status in tissues of breast cancer patients. Clin Biochem 2000;33:279-84. PubMed
  6. Lund EL, Quistorff B, Spang-Thomsen M, Kristjansen PE. Effect of radiation therapy on small-cell lung cancer is reduced by ubiquinone intake. Folia Microbiol (Praha) 1998;43:505-6. PubMed
  7. Langsjoen PH, Langsjoen PH, Folkers K. Long-term efficacy and safety of coenzyme Q10 therapy for idiopathic dilated cardiomyopathy. Am J Cardiol 1990;65:521-3. PubMed
  8. Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm 2000;57:1221-7. DOI
  9. Landbo C, Almdal TP. [Interaction between warfarin and coenzyme Q10]. Ugeskr Laeger 1998;160:3226-7.
  10. Baggio E, Gandini R, Plauncher AC, et al. Italian multicenter study on the safety and efficacy of coenzyme Q10 as adjunctive therapy in heart failure. CoQ10 Drug Surveillance Investigators. Mol Aspects Med 1994;15 Suppl:S287-94. PubMed
  11. Burke BE, Neuenschwander R, Olson RD. Randomized, double-blind, placebo-controlled trial of coenzyme Q10 in isolated systolic hypertension. South Med J 2001;94:1112-7. PubMed
  12. The Huntington Study Group. A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease. Neurology 2001;57:397-404.
  13. Hodgson JM, Watts GF, Playford DA, et al. Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes. Eur J Clin Nutr 2002;56:1137-42. PubMed
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Palm Oil 12 references
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Tocotrienols 4 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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