Total Human B Complex Ingredients & Drug Interactions
by Onnit
What is this page for?
First and foremost: checking Total Human B Complex against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Total Human B Complex is a dietary supplement by Onnit with 6 active ingredients. Its ingredients are commonly taken for hair growth and thinning hair, brittle nails, skin health.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Total Human B Complex by Onnit
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Total Human B Complex contains 6 active ingredients: biotin, vitamin B1, vitamin B2, vitamin B5, and folate — all B vitamins that support energy, nerve function, and cell health. The product is rounded out with inactive ingredients (vegetarian capsule, microcrystalline cellulose, magnesium oxide, and silica) that act as binders and fillers.
Does it work?
Strong evidence
Biotin is rated likely effective for biotin deficiency, meaning the evidence backs it for treating a genuine shortage of this vitamin. For multiple sclerosis and seborrheic dermatitis, biotin is rated possibly ineffective — the evidence doesn't show it works for those conditions.
For hair loss (alopecia areata), there isn't enough reliable evidence to say one way or the other. We don't hold effectiveness data on the other B vitamins in this product.
How safe is it?
Well-documented data
Biotin is generally well tolerated, even at higher doses, because your body removes excess amounts in urine. In trials, a small number of people taking high-dose biotin reported mild diarrhea.
One case report described a patient taking biotin along with pantothenic acid who developed a rare inflammation (eosinophilic pleuropericarditis), but whether biotin caused it — or whether other factors played a role — remains unclear, and no similar cases have been reported since. For pregnancy and lactation, biotin is rated likely safe.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients we could check. That said, we hold no interaction information for vitamin B1, vitamin B2, vitamin B5, or folate, so check your specific medications using the search tool on this page before you start.
The bottom line
Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. No medication interactions are currently documented, and safety information is well characterized.
This is a straightforward B-complex supplement useful if you're deficient in biotin or just want a daily B-vitamin top-up. It's generally well tolerated at standard doses.
If you're pregnant, planning to become pregnant, breastfeeding, or take any regular medications, talk with your doctor or pharmacist before starting — especially if you're on high-dose biotin elsewhere.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Total Human B Complex, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Total Human B Complex by Onnit, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Biotin | 300 mcg | 1000% |
| Vitamin B1 | 1.5 mg | 130% |
| Vitamin B1 | 150 mg | -- |
| Vitamin B2 | 1.7 mg | 130% |
| Vitamin B5 | 10 mg | 200% |
| Folate | 400 mcg DFE | 100% |
Other ingredients: Vegetarian Capsule, Microcrystalline Cellulose, Nu-Mag, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Complete Supplement Packs
General Statements
Go beyond a multivitamin Day support Contains 1 Day Pack Not labeled for individual sale ONN
Suggested/Recommended/Usage/Directions
Suggested Use: Adults, as a dietary supplement, take one day packet in the morning or early afternoon, preferably with a light meal.
Precautions
Consult a medical doctor before taking this or any other nutritional supplement if you have or suspect a medical condition, or are taking any medications. Do not use if you are pregnant or nursing.
Keep out of reach of children.
Storage
Store in a cool, dry place.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Total Human B Complex by Onnit label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Total Human B Complex by Onnit
These are the 6 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container7 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Biotin
No knowninteractions
Biotin (vitamin B7) is a water-soluble vitamin your body needs to turn food into energy and to support healthy hair, skin, and nails. Most people get...
Biotin monograph & interactionsVitamin B1
Vitamin B1
Vitamin B2
Vitamin B5
Folate
Other (inactive) ingredients: Vegetarian Capsule, Microcrystalline Cellulose, Nu-Mag, Silica. These complete the product’s ingredient list but are not active constituents.
Total Human B Complex by Onnit Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Total Human B Complex. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Total Human B Complex, from the product label.
Total Human B Complex by Onnit: Common Questions
Does Total Human B Complex by Onnit interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is biotin safe during pregnancy and while breastfeeding?
Will biotin help my hair loss?
Can high-dose biotin cause side effects?
What does biotin actually do?
Does this product have any fillers or artificial ingredients?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Total Human B Complex is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Total Human B Complex’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Total Human B Complex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 4 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Biotin 4 references
- Debourdeau PM, Djezzar S, Estival JL, et al. Life-threatening eosinophilic pleuropericardial effusion related to vitamins B5 and H. Ann Pharmacother 2001;35:424-6. DOI
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
- Mock DM, Quirk JG, Mock NI. Marginal biotin deficiency during normal pregnancy. Am J Clin Nutr 2002;75:295-9. PubMed
- Sedel F, Papeix C, Bellanger A, Touitou V, Lebrun-Frenay C, Galanaud D, et al. High doses of biotin in chronic progressive multiple sclerosis: a pilot study.Mult Scler Relat Disord. 2015;4(2):159-69. doi: 10.1016/j.msard.2015.01.005. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC