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Dietary supplement

Trib-650 Ingredients & Drug Interactions

by Dymatize Nutrition

Trib-650 label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Trib-650 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Trib-650 is a dietary supplement by Dymatize Nutrition with 1 active ingredient. Its ingredients are commonly taken for low libido and sexual function, athletic performance and muscle building, testosterone support.Based on those ingredients, 259 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Tribulus terrestris. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Trib-650 by Dymatize Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Trib-650 by Dymatize Nutrition — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Trib-650 by Dymatize Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Trib-650 contains one active ingredient: tribulus terrestris, a plant traditionally used to support sexual function and athletic performance. The capsule itself is made from gelatin and vegetable cellulose, with silicon dioxide, titanium dioxide, and magnesium stearate as inactive processing aids.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: Athletic performance and muscle building.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Strength and endurance, Muscle recovery, Sports performance.
  • The closest evidence on file: Tribulus is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).
  • Also on file: Tribulus is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle damage.

The evidence for tribulus in sexual dysfunction is possibly effective — meaning some clinical evidence supports it, but more research is needed to be certain. For athletic performance, the evidence is actually possibly ineffective; the data we hold doesn't support that use.

For benign prostatic hyperplasia (enlarged prostate), there isn't enough reliable evidence to rate whether it works.

The evidence, ingredient by ingredient Tribulus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Tribulus is often well tolerated over the short term in healthy adults, but long-term safety data are limited and the quality of research varies. Serious side effects are rare but have been reported, including liver or kidney injury and seizures.

More commonly, some people report stomach upset — nausea, diarrhea, cramping, or constipation — though in one study these complaints were about as common in the placebo group. Do not use this product if you're pregnant; tribulus may affect hormones and safety hasn't been established.

The same goes for breastfeeding — there isn't enough reliable safety information. If you're in either situation, talk with your doctor or pharmacist before taking it.

Side effects, ingredient by ingredient Tribulus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Tribulus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 259 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before using this product if you take blood pressure medications, diabetes medications, or lithium. These are the medication types with documented moderate-severity interactions with tribulus.

If you're on any of these, we need to make sure it's safe for you.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Trib-650 may help with sexual function, though the evidence is moderate. If you take blood pressure meds, diabetes medications, or lithium, you'll need to check with your pharmacist or doctor first — tribulus can interact with all three.

Avoid it in pregnancy and while breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 24, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Trib-650, straight from the product label.

Brand Dymatize Nutrition
Barcode (UPC) 705016140909
Net contents 100 Capsule(s)
Market status On market
Date entered into DSLD Nov 24, 2015
DSLD ID 53273
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Trib-650 by Dymatize Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
UPC/BARCODE
705016140909
IngredientAmount% DV
Tribulus terrestris650 mg--

Other ingredients: Gelatin, Vegetable Cellulose, Silicon Dioxide, Titanium Dioxide, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General

8056

Suggested/Recommended/Usage/Directions

Suggested Use: As an adult dietary supplement, take 1-2 capsules daily daily with a meal.

Precautions

Warning: This product is not intended for use by those with a serious medical condition or pregnant or lactating women.

Consult with your physician before use.

Keep out of reach of children.

Storage

Storage conditions: Store at room temperature 59(0)F - 86(0)F (15(0)C - 30(0)C).

Brand IP Statement(s)

Your Ambition. Our Nutrition.

Formulation

This product does not contain corn, yeast, wheat, soy, dairy, artificial flavors, artificial colors or preservatives.

Formula

650 mg Tribulus Terrestris Extract

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Trib-650 by Dymatize Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Trib-650 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Trib-650 by Dymatize Nutrition

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Tribulus terrestris

Interacts with
259 drugs
650 mg per serving Form: Steroidal Saponins

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims...

Tribulus terrestris monograph & interactions

Other (inactive) ingredients: Gelatin, Vegetable Cellulose, Silicon Dioxide, Titanium Dioxide, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Trib-650 by Dymatize Nutrition Drug Interactions

Want to check YOUR meds against Trib-650?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
259Drugs
259 Moderate

Ingredients driving the most interactions

Tribulus terrestris 259

Individual Drug Interactions

The ingredients in Trib-650 interact with 259 drugs. Click any drug to see the details.

1 of the 1 ingredient in Trib-650 interact with drugs. Each result below shows which ingredient is responsible. Tribulus terrestris

Each ingredient & the kinds of drugs it affects

For each ingredient in Trib-650 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Tribulus terrestris3 drug types · 259 drugs

Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that Tribulus can lower blood glucose levels in adults with type 2 diabetes who are taking antidiabetes medications.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that tribulus can lower blood pressure by inhibiting angiotensin-converting enzyme (ACE). Tribulus has also demonstrated hypotensive effects in pre-hypertensive adults.

Likelihood Possible Evidence D
Lithium

Theoretically, tribulus might increase the levels and clinical effects of lithium.
Tribulus is thought to have diuretic properties. Due to these potential diuretic effects, tribulus might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Tribulus terrestris full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Trib-650, from the product label.

Dymatize Nutrition

See all Dymatize Nutrition products
Name
Dymatize Enterprises, LLC
City
Dallas
State
TX
ZipCode
75234
Phone Number
(888) 334-5326/ (214) 445-4864
Web Address
Dymatize.com
Pharmacist Counseling Corner

Trib-650 by Dymatize Nutrition: Common Questions

Does Trib-650 by Dymatize Nutrition interact with any medications?
Yes. Based on its ingredients, Trib-650 has a known interaction with 259 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Trib-650 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No — tribulus may affect your hormones and safety hasn't been proven in pregnancy, so it's best to avoid it. The same applies to breastfeeding, where there isn't enough reliable safety data. Talk with your doctor or pharmacist if you have questions.
What does tribulus actually do?
Tribulus is used mainly to support sexual function; some clinical evidence suggests it may help. It's also promoted for athletic performance, but the research we have doesn't support that use. It's not proven to help with prostate problems, though some people use it for that.
Does this have any side effects?
Most people tolerate it fine, but stomach upset — nausea, diarrhea, cramping — can happen. Serious side effects like liver or kidney problems and seizures have been reported, though they're rare. Long-term safety data are still limited.
Why does this interact with blood pressure and diabetes medications?
Tribulus can lower blood pressure and blood sugar on its own. If you're already on meds that do the same thing, you risk dropping your pressure or blood sugar too low, which can be dangerous.
How many active ingredients are in this product?
Just one: tribulus terrestris. The rest of what's in the capsule is gelatin, cellulose, and processing aids — not active ingredients.
Is this safe to take long-term?
Short-term use in healthy adults seems generally well tolerated, but we don't have strong long-term safety data. If you're thinking of taking it regularly, talk with your pharmacist to make sure it fits your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Trib-650 label
Go deeper

The Full Monographs Behind Trib-650’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tribulus

Interacts with 259 drugs

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims is weak and inconsistent. It is general...

Read the full Tribulus monograph →
Sources

Sources & How We Checked

Trib-650's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tribulus 10 references
  1. Sharifi AM, Darabi R, Akbarloo N. Study of antihypertensive mechanism of Tribulus terrestris in 2K1C hypertensive rats: role of tissue ACE activity. Life Sci 2003;73:2963-71. PubMed
  2. Walker D, Bird A, Flora T, O'Sullivan B. Some effects of feeding Tribulus terrestris, Ipomoea lonchophylla and the seed of Abelmoschus ficulneus on fetal development and the outcome of pregnancy in sheep. Reprod Fertil Dev 1992;4:135-44. PubMed
  3. Al-Ali M, Wahbi S, Twaij H, Al-Badr A. Tribulus terrestris: preliminary study of its diuretic and contractile effects and comparison with Zea mays. J Ethnopharmacol 2003;85:257-60. PubMed
  4. Tabakova, P., Dimitrov, M., Ognyanov, K., and et al. Clinical study of Tribestan in females with endocrine sterility. Documentation for Registration (unpublished) 1999.
  5. Akhtari E, Raisi F, Keshavarz M, et al. Tribulus terrestris for treatment of sexual dysfunction in women: randomized double-blind placebo-controlled study. Daru 2014;22:40. PubMed
  6. Ryan M, Lazar I, Nadasdy GM, et al. Acute kidney injury and hyperbilirubinemia in a young male after ingestion of Tribulus terrestris. Clin Nephrol 2015;83(3):177-83. PubMed
  7. Postigo S, Lima SM, Yamada SS, et al. Assessment of the effects of Tribulus terrestris on sexual function of menopausal women. Rev Bras Ginecol Obstet 2016;38(3):140-6. PubMed
  8. Talasaz AH, Abbasi MR, Abkhiz S, Dashti-Khavidaki S. Tribulus terrestris-induced severe nephrotoxicity in a young healthy male. Nephrol Dial Tranplant 2010;25(11):3792-3. PubMed
  9. Samani NB, Jokar A, Soveid M, Heydari M, Mosavat SH. Efficacy of the hydroalcoholic extract of Tribulus terrestris on the serum glucose and lipid profile of women with diabetes mellitus: a double-blind randomized placebo-controlled clinical trial. J Evid
  10. Siddiqui MA, Itrat M, Mobeen A, Khan MI. Efficacy of khar-i-khasak (Tribulus terrestris Linn.) in prehypertension: a randomized, double-blind, placebo-controlled trial. J Complement Integr Med. 2021.

See these in context on the Tribulus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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