Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Tribulus Terrestris 625 mg Ingredients & Drug Interactions

by Pure Advantage

Tribulus Terrestris 625 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Tribulus Terrestris 625 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Tribulus Terrestris 625 mg is a dietary supplement by Pure Advantage with 1 active ingredient. Its ingredients are commonly taken for low libido and sexual function, athletic performance and muscle building, testosterone support.Based on those ingredients, 259 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Tribulus terrestris. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Tribulus Terrestris 625 mg by Pure Advantage

Ask about any prescription or over-the-counter medication and we check it for interactions with Tribulus Terrestris 625 mg by Pure Advantage — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Tribulus Terrestris 625 mg by Pure Advantage

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains a single active ingredient: tribulus terrestris at 625 mg per capsule. The capsule also holds inactive ingredients — microcrystalline cellulose, magnesium stearate, rice flour, and a gelatin capsule shell — which are fillers and binders that give the supplement its form.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: testosterone support and sexual function.
  • We looked for evidence on: Erectile dysfunction (ED), Male infertility, Premature ejaculation, Sexual dysfunction, Menopausal symptoms, Libido — and 2 related terms.
  • The strongest evidence on file: Tribulus is rated "Possibly Effective" for Sexual dysfunction (Natural Medicines).
  • Also on file: Tribulus is rated "Insufficient Reliable Evidence To Rate" for Erectile dysfunction (ED), Menopausal symptoms, Premature ejaculation, Male infertility.

Tribulus terrestris is rated possibly effective for sexual dysfunction in adults — the evidence shows promise but isn't conclusive. For athletic performance, the data suggests it's possibly ineffective.

We don't have enough reliable evidence to rate whether it helps benign prostatic hyperplasia (enlarged prostate).

The evidence, ingredient by ingredient Tribulus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Tribulus is generally well tolerated in the short term for healthy adults, though long-term safety data are limited. Most people don't report side effects, though some experience mild gastrointestinal complaints like stomach pain, nausea, cramping, or changes in bowel habits — though studies show these occur at rates similar to placebo.

Serious side effects are rare but have been reported: liver and kidney injury, seizures, and in one case a patient drinking large amounts of tribulus water developed severe weakness, seizures, kidney injury, and liver inflammation. Avoid this product during pregnancy because it may affect hormones and safety is not established.

Don't take it while breastfeeding due to lack of reliable safety information.

Side effects, ingredient by ingredient Tribulus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Tribulus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 259 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check your blood pressure medications, antidiabetes drugs, and lithium with your pharmacist or using the medication checker on this page. All three drug types carry Moderate-severity interaction risks with tribulus.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Tribulus terrestris may be worth considering if you're interested in sexual function support and don't take blood pressure or diabetes medications or lithium. If you take any of those drugs, or have kidney or liver concerns, talk with your pharmacist before starting.

Long-term safety data are thin, so this is best used short-term and under professional guidance.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 26, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Tribulus Terrestris 625 mg, straight from the product label.

Brand Pure Advantage
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Aug 26, 2014
DSLD ID 36880
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Tribulus Terrestris 625 mg by Pure Advantage, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
IngredientAmount% DV
Tribulus terrestris625 mg--

Other ingredients: Micro Crystalline Cellulose, Magnesium Stearate, Rice Flour, Gelatin capsules

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Take the Pure Advantage(TM)

General Statements

Tribulus Terrestris is NOT a hormone and works completely different from pro-hormones. Tribulus may increases testosterone through increasing luteinizing hormone (LH) in your body. LH tells your body to produce testosterone. Tribulus merely works within the body's natural limits, helping you achieve muscle and strength.

Formulation

Does not contain any dairy, egg, sugar, corn, yeast, wheat, soy, gluten, artificial colors, flavors or preservatives.

Precautions

KEEP OUT OF REACH OF CHILDREN.

Storage

STORE IN A COOL, DRY PLACE.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

NUTRITIONAL BRANDS(TM)

FDA Statement of Identity

A Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 2 capsules daily or as directed by a health professional.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Tribulus Terrestris 625 mg by Pure Advantage label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Tribulus Terrestris 625 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Tribulus Terrestris 625 mg by Pure Advantage

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Tribulus terrestris

Interacts with
259 drugs
625 mg per serving

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims...

Tribulus terrestris monograph & interactions

Other (inactive) ingredients: Micro Crystalline Cellulose, Magnesium Stearate, Rice Flour, Gelatin capsules. These complete the product’s ingredient list but are not active constituents.

Interaction report

Tribulus Terrestris 625 mg by Pure Advantage Drug Interactions

Want to check YOUR meds against Tribulus Terrestris 625 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
259Drugs
259 Moderate

Ingredients driving the most interactions

Tribulus terrestris 259

Individual Drug Interactions

The ingredients in Tribulus Terrestris 625 mg interact with 259 drugs. Click any drug to see the details.

1 of the 1 ingredient in Tribulus Terrestris 625 mg interact with drugs. Each result below shows which ingredient is responsible. Tribulus terrestris

Each ingredient & the kinds of drugs it affects

For each ingredient in Tribulus Terrestris 625 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Tribulus terrestris3 drug types · 259 drugs

Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that Tribulus can lower blood glucose levels in adults with type 2 diabetes who are taking antidiabetes medications.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that tribulus can lower blood pressure by inhibiting angiotensin-converting enzyme (ACE). Tribulus has also demonstrated hypotensive effects in pre-hypertensive adults.

Likelihood Possible Evidence D
Lithium

Theoretically, tribulus might increase the levels and clinical effects of lithium.
Tribulus is thought to have diuretic properties. Due to these potential diuretic effects, tribulus might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Tribulus terrestris full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Tribulus Terrestris 625 mg, from the product label.

Pure Advantage

See all Pure Advantage products
Name
Pure Advantage
City
Phoenix
Phone Number
1-800-798-0707
Web Address
www.pure-advantage.net
Pharmacist Counseling Corner

Tribulus Terrestris 625 mg by Pure Advantage: Common Questions

Does Tribulus Terrestris 625 mg by Pure Advantage interact with any medications?
Yes. Based on its ingredients, Tribulus Terrestris 625 mg has a known interaction with 259 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Tribulus Terrestris 625 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or nursing?
No. Tribulus may affect hormones during pregnancy and safety isn't established, so avoid it if you're pregnant. There isn't enough reliable safety data for breastfeeding either, so skip it while nursing. Talk with your doctor or pharmacist about what's right for you.
Does tribulus actually help with sexual function?
The evidence says possibly — it's been studied and shows promise, but the data aren't definitive. Results vary from person to person.
Will this help me build muscle or improve athletic performance?
No — the evidence suggests tribulus is likely ineffective for athletic performance.
What side effects should I watch for?
Most people tolerate it well. Mild stomach upset — pain, nausea, cramping, or diarrhea — can happen, though studies show it occurs at rates similar to placebo. Serious effects like liver or kidney injury are rare but have been reported, especially with very high doses or long-term use.
How safe is tribulus long-term?
Short-term use in healthy adults is generally well tolerated, but we don't have strong long-term safety data. If you're thinking of taking it regularly, check in with your pharmacist first.
Will this help my enlarged prostate?
We don't have enough reliable evidence to say whether tribulus helps benign prostatic hyperplasia. If that's a concern, talk with your doctor about treatments with stronger evidence.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Tribulus Terrestris 625 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Tribulus Terrestris 625 mg label
Go deeper

The Full Monographs Behind Tribulus Terrestris 625 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tribulus

Interacts with 259 drugs

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims is weak and inconsistent. It is general...

Read the full Tribulus monograph →
Sources

Sources & How We Checked

Tribulus Terrestris 625 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tribulus 10 references
  1. Sharifi AM, Darabi R, Akbarloo N. Study of antihypertensive mechanism of Tribulus terrestris in 2K1C hypertensive rats: role of tissue ACE activity. Life Sci 2003;73:2963-71. PubMed
  2. Walker D, Bird A, Flora T, O'Sullivan B. Some effects of feeding Tribulus terrestris, Ipomoea lonchophylla and the seed of Abelmoschus ficulneus on fetal development and the outcome of pregnancy in sheep. Reprod Fertil Dev 1992;4:135-44. PubMed
  3. Al-Ali M, Wahbi S, Twaij H, Al-Badr A. Tribulus terrestris: preliminary study of its diuretic and contractile effects and comparison with Zea mays. J Ethnopharmacol 2003;85:257-60. PubMed
  4. Tabakova, P., Dimitrov, M., Ognyanov, K., and et al. Clinical study of Tribestan in females with endocrine sterility. Documentation for Registration (unpublished) 1999.
  5. Akhtari E, Raisi F, Keshavarz M, et al. Tribulus terrestris for treatment of sexual dysfunction in women: randomized double-blind placebo-controlled study. Daru 2014;22:40. PubMed
  6. Ryan M, Lazar I, Nadasdy GM, et al. Acute kidney injury and hyperbilirubinemia in a young male after ingestion of Tribulus terrestris. Clin Nephrol 2015;83(3):177-83. PubMed
  7. Postigo S, Lima SM, Yamada SS, et al. Assessment of the effects of Tribulus terrestris on sexual function of menopausal women. Rev Bras Ginecol Obstet 2016;38(3):140-6. PubMed
  8. Talasaz AH, Abbasi MR, Abkhiz S, Dashti-Khavidaki S. Tribulus terrestris-induced severe nephrotoxicity in a young healthy male. Nephrol Dial Tranplant 2010;25(11):3792-3. PubMed
  9. Samani NB, Jokar A, Soveid M, Heydari M, Mosavat SH. Efficacy of the hydroalcoholic extract of Tribulus terrestris on the serum glucose and lipid profile of women with diabetes mellitus: a double-blind randomized placebo-controlled clinical trial. J Evid
  10. Siddiqui MA, Itrat M, Mobeen A, Khan MI. Efficacy of khar-i-khasak (Tribulus terrestris Linn.) in prehypertension: a randomized, double-blind, placebo-controlled trial. J Complement Integr Med. 2021.

See these in context on the Tribulus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team