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Dietary supplement

Tribulus terrestris Extract Powder 1500 mg Ingredients & Drug Interactions

by BulkSupplements.com

Tribulus terrestris Extract Powder 1500 mg label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Tribulus terrestris Extract Powder 1500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Tribulus terrestris Extract Powder 1500 mg is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for low libido and sexual function, athletic performance and muscle building, testosterone support.Based on those ingredients, 259 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Tribulus terrestris Fruit, Whole Herbs Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Tribulus terrestris Extract Powder 1500 mg by BulkSupplements.com

Ask about any prescription or over-the-counter medication and we check it for interactions with Tribulus terrestris Extract Powder 1500 mg by BulkSupplements.com — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Tribulus terrestris Extract Powder 1500 mg by BulkSupplements.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Tribulus terrestris Fruit, Whole Herbs Extract at 1500 mg per serving. Tribulus is a plant extract traditionally used to support sexual function and athletic performance.

The powder also contains dextrin as an inactive ingredient (a filler that helps with consistency and flow).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Tribulus's overall clinical evidence instead.

Moderate

Some clinical evidence supports Tribulus for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Sexual dysfunction — rated "Possibly Effective" (Natural Medicines).

Tribulus appears possibly effective for sexual dysfunction — multiple studies support some benefit here. For athletic performance, the evidence leans toward possibly ineffective, so don't count on it to boost your workouts.

Benign prostatic hyperplasia (enlarged prostate) — we simply don't have enough reliable evidence to know whether it helps.

The evidence, ingredient by ingredient Tribulus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Tribulus is generally well tolerated in short-term use by healthy adults, but long-term safety data are limited and quality varies across products. Serious side effects are rare but have been reported, including liver and kidney injury, seizures, and in one case, a person who drank 2 liters of tribulus water daily for two days developed seizures, kidney damage, and liver inflammation.

More common mild effects include abdominal pain, cramping, nausea, vomiting, diarrhea, and constipation — though in some studies these occurred at similar rates in people taking placebo. Avoid this supplement during pregnancy because it may affect hormones and safety is not established.

Also avoid while breastfeeding due to lack of reliable safety information.

Side effects, ingredient by ingredient Tribulus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Tribulus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 259 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this, double-check with your pharmacist if you're on blood pressure medications (antihypertensives) — tribulus may lower your pressure too much. Also flag it if you take diabetes medications (risk of low blood sugar) or lithium (may raise your lithium levels).

Use the search tool below to verify your exact prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Tribulus may help with sexual dysfunction if you're looking for that effect, but it's not proven for athletic performance. Because it can lower blood pressure and blood sugar and may raise lithium levels, check your medications before starting — especially if you take blood pressure pills, diabetes medications, or lithium.

Talk to your pharmacist about whether it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Tribulus terrestris Extract Powder 1500 mg, straight from the product label.

Brand BulkSupplements.com
Barcode (UPC) X000IOCCGJ
Net contents 100 Gram(s); 3.5 Ounce(s)
Market status On market
Date entered into DSLD Apr 24, 2025
DSLD ID 330894
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Tribulus terrestris Extract Powder 1500 mg by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1500 Milligram(s)
Maximum serving Sizes:
1500 Milligram(s)
Servings per container
66
UPC/BARCODE
X000IOCCGJ
IngredientAmount% DV
Tribulus terrestris Fruit, Whole Herbs Extract1500 mg--

Other ingredients: Dextrin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

BulkSupplements.com Clean & Pure Bulk Supplements

Formula

Tribulus terrestris Extract Powder 1500 mg per serving

Formulation

Color may vary

Free of: Added sugar, soy, dairy, yeast, gluten

FDA Disclaimer Statement

Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Always consult a physician before taking any dietary supplement.

Keep out of reach of children.

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 1500mg (about 3/5 tsp) one to three times daily, or as directed by a physician.

General Statements

Use an accurate milligram scale. New

Storage

Contents are sold by weight, not volume. Settling may occur. Store in a dry, cool place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Tribulus terrestris Extract Powder 1500 mg by BulkSupplements.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Tribulus terrestris Extract Powder 1500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Tribulus terrestris Extract Powder 1500 mg by BulkSupplements.com

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1500 Milligram(s) Dosage formPowder Servings per container66 Amounts shown are per serving.

Tribulus terrestris Fruit, Whole Herbs Extract

Interacts with
259 drugs
1500 mg per serving Form: Tribulus terrestris Fruit Extract, Tribulus terrestris Whole Herb Extract

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims...

Tribulus terrestris Fruit, Whole Herbs Extract monograph & interactions

Other (inactive) ingredients: Dextrin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Tribulus terrestris Extract Powder 1500 mg by BulkSupplements.com Drug Interactions

Want to check YOUR meds against Tribulus terrestris Extract Powder 1500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
259Drugs
259 Moderate

Ingredients driving the most interactions

Tribulus terrestris Fruit, Whole Herbs Extract 259

Individual Drug Interactions

The ingredients in Tribulus terrestris Extract Powder 1500 mg interact with 259 drugs. Click any drug to see the details.

1 of the 1 ingredient in Tribulus terrestris Extract Powder 1500 mg interact with drugs. Each result below shows which ingredient is responsible. Tribulus terrestris Fruit, Whole Herbs Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Tribulus terrestris Extract Powder 1500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Tribulus terrestris Fruit, Whole Herbs Extract3 drug types · 259 drugs

Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that Tribulus can lower blood glucose levels in adults with type 2 diabetes who are taking antidiabetes medications.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that tribulus can lower blood pressure by inhibiting angiotensin-converting enzyme (ACE). Tribulus has also demonstrated hypotensive effects in pre-hypertensive adults.

Likelihood Possible Evidence D
Lithium

Theoretically, tribulus might increase the levels and clinical effects of lithium.
Tribulus is thought to have diuretic properties. Due to these potential diuretic effects, tribulus might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Tribulus terrestris Fruit, Whole Herbs Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Tribulus terrestris Extract Powder 1500 mg, from the product label.

BulkSupplements.com

See all BulkSupplements.com products
Name
BulkSupplements.com
Street Address
7511 Eastgate Rd
City
Henderson
State
NV
ZipCode
89011
Web Address
BulkSupplements.com
Pharmacist Counseling Corner

Tribulus terrestris Extract Powder 1500 mg by BulkSupplements.com: Common Questions

Does Tribulus terrestris Extract Powder 1500 mg by BulkSupplements.com interact with any medications?
Yes. Based on its ingredients, Tribulus terrestris Extract Powder 1500 mg has a known interaction with 259 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Tribulus terrestris Extract Powder 1500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No — avoid it during pregnancy because tribulus may affect hormones and safety hasn't been established. Also avoid while breastfeeding because we don't have reliable safety data. Talk to your doctor or midwife if you're thinking about any supplement during pregnancy or lactation.
What are the most common side effects?
Mild gastrointestinal complaints like abdominal pain, nausea, diarrhea, and cramping have been reported, though in some studies these happened at similar rates in people taking placebo. Serious effects are rare but have included liver and kidney injury and seizures.
Does tribulus actually work for sexual function?
The evidence suggests possibly — multiple studies point to some benefit for sexual dysfunction, so it's worth trying if that's what you're after. Results vary person to person, though.
Will this help my athletic performance?
The research leans toward no — the evidence we have rates it possibly ineffective for athletic performance, so you shouldn't count on it for a workout boost.
How long can I safely take this?
Tribulus is generally well tolerated short-term in healthy adults, but long-term safety data are limited. We don't have solid information on how long you can take it, so check with your pharmacist about your specific situation.
What's in this besides the tribulus extract?
Just dextrin, which is an inactive filler ingredient to help the powder flow and mix well.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Tribulus terrestris Extract Powder 1500 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Tribulus terrestris Extract Powder 1500 mg label
Go deeper

The Full Monographs Behind Tribulus terrestris Extract Powder 1500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tribulus

Interacts with 259 drugs

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims is weak and inconsistent. It is general...

Read the full Tribulus monograph →
Sources

Sources & How We Checked

Tribulus terrestris Extract Powder 1500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tribulus 10 references
  1. Sharifi AM, Darabi R, Akbarloo N. Study of antihypertensive mechanism of Tribulus terrestris in 2K1C hypertensive rats: role of tissue ACE activity. Life Sci 2003;73:2963-71. PubMed
  2. Walker D, Bird A, Flora T, O'Sullivan B. Some effects of feeding Tribulus terrestris, Ipomoea lonchophylla and the seed of Abelmoschus ficulneus on fetal development and the outcome of pregnancy in sheep. Reprod Fertil Dev 1992;4:135-44. PubMed
  3. Al-Ali M, Wahbi S, Twaij H, Al-Badr A. Tribulus terrestris: preliminary study of its diuretic and contractile effects and comparison with Zea mays. J Ethnopharmacol 2003;85:257-60. PubMed
  4. Tabakova, P., Dimitrov, M., Ognyanov, K., and et al. Clinical study of Tribestan in females with endocrine sterility. Documentation for Registration (unpublished) 1999.
  5. Akhtari E, Raisi F, Keshavarz M, et al. Tribulus terrestris for treatment of sexual dysfunction in women: randomized double-blind placebo-controlled study. Daru 2014;22:40. PubMed
  6. Ryan M, Lazar I, Nadasdy GM, et al. Acute kidney injury and hyperbilirubinemia in a young male after ingestion of Tribulus terrestris. Clin Nephrol 2015;83(3):177-83. PubMed
  7. Postigo S, Lima SM, Yamada SS, et al. Assessment of the effects of Tribulus terrestris on sexual function of menopausal women. Rev Bras Ginecol Obstet 2016;38(3):140-6. PubMed
  8. Talasaz AH, Abbasi MR, Abkhiz S, Dashti-Khavidaki S. Tribulus terrestris-induced severe nephrotoxicity in a young healthy male. Nephrol Dial Tranplant 2010;25(11):3792-3. PubMed
  9. Samani NB, Jokar A, Soveid M, Heydari M, Mosavat SH. Efficacy of the hydroalcoholic extract of Tribulus terrestris on the serum glucose and lipid profile of women with diabetes mellitus: a double-blind randomized placebo-controlled clinical trial. J Evid
  10. Siddiqui MA, Itrat M, Mobeen A, Khan MI. Efficacy of khar-i-khasak (Tribulus terrestris Linn.) in prehypertension: a randomized, double-blind, placebo-controlled trial. J Complement Integr Med. 2021.

See these in context on the Tribulus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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