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Dietary supplement

Tru Niagen Unflavored Ingredients & Drug Interactions

by ChromaDex

Tru Niagen Unflavored label
See full label image
Powder Category: Vitamin
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Tru Niagen Unflavored against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Tru Niagen Unflavored is a dietary supplement by ChromaDex with 2 active ingredients. Its ingredients are commonly taken for healthy aging, boosting cellular energy, supporting metabolism.Based on those ingredients, 2,030 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dietary Fiber, Niagen. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Tru Niagen Unflavored by ChromaDex

Ask about any prescription or over-the-counter medication and we check it for interactions with Tru Niagen Unflavored by ChromaDex — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Tru Niagen Unflavored by ChromaDex

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • “Total Carb.” is listed as a grouped ingredient — the label gives one combined amount (4 Gram(s)) without saying how much of each component you get.

Tru Niagen Unflavored is a powder containing 2 active ingredients: nicotinamide riboside (Niagen) and total carbohydrates. Nicotinamide riboside is a form of vitamin B3 that your body converts into NAD+, a molecule involved in cellular energy and metabolism.

The product also contains inulin as an inactive ingredient (a type of fiber used as a filler or binder).

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Unlock cellular energy and support NAD+ levels.
  • We looked for evidence on: Athletic performance, Physical performance, Cellular energy metabolism, Mitochondrial function, Age-related energy decline.
  • The closest evidence on file: Nicotinamide Riboside is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Nicotinamide Riboside is rated "Insufficient Reliable Evidence To Rate" for Physical performance.

The evidence for nicotinamide riboside isn't established yet for the conditions we have on file. We hold insufficient reliable evidence to rate it for age-related macular degeneration, Alzheimer disease, athletic performance, nonalcoholic fatty liver disease (NAFLD), and heart failure.

If you're considering this product for a specific health goal, talk with your pharmacist or doctor about what the current research actually shows.

The evidence, ingredient by ingredient Nicotinamide Riboside Black Psyllium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Nicotinamide riboside appears generally well tolerated in short-term studies, though long-term safety isn't fully known. The most common side effects reported in trials include bloating, muscle pain, nausea, itching, sweating, and changes in bowel movements.

One person in a trial reported leg cramps, and some experienced mild muscle soreness. Because there isn't enough safety data, the evidence advises against use during pregnancy and while breastfeeding.

Side effects, ingredient by ingredient Nicotinamide Riboside Black Psyllium

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Black Psyllium, Nicotinamide Riboside.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: heart-rhythm medications; lithium.
  • For scale: 2,031 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antihypertensive drugs (blood pressure medications), double-check them against the medication search tool below before starting Tru Niagen. Nicotinamide riboside may add to their blood pressure-lowering effect.

We could not check the total carbohydrates ingredient for interactions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Tru Niagen is designed for people interested in NAD+ support and cellular health, though the evidence for specific health claims remains limited. If you take blood pressure medications, check with your pharmacist before starting this product.

Pregnant women and those breastfeeding should avoid it. Talk to your pharmacist about whether this product makes sense for your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Tru Niagen Unflavored, straight from the product label.

Brand ChromaDex
Barcode (UPC) 856029008226
Net contents 120 Gram(s); 4.2 Ounce(s); 30 Packet(s)
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 266756
Product type Vitamin
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Halal
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Tru Niagen Unflavored by ChromaDex, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Gram(s)
Maximum serving Sizes:
4 Gram(s)
Servings per container
30
UPC/BARCODE
856029008226
IngredientAmount% DV
Dietary Fiber3 Gram(s)10%
Calories15 Calorie(s)--
Niagen300 mg--
Total Carb.4 Gram(s)1%

Other ingredients: Inulin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Tru Niagen Unlock your cellular energy

Formulation

Tru Niagen increases your NAD+, a vital coenzyme used to fuel your body’s energy engines (mitochondria). Your body utilizes NAD+ every day for daily activity. NAD+ levels decline with age and under metabolic stress. Use Tru Niagen to increase your cellular energy production and promote cellular repair.

Age better Increases NAD+ Increase cellular energy Support cellular metabolism Promote cellular repair Unflavored

Vegetarian

Suggested/Recommended/Usage/Directions

Take your Tru Niagen on the go with these convenient single-serving packets that easily mix into your favorite cold or room-temperature beverage.

Suggested Use: Adults use 1 packet daily or as recommended by your healthcare professional. Directions: Daily-Add contents of 1 packet to 16 fl oz of cold or room-temperature liquid while stirring, mix thoroughly until dissolved.

Seals/Symbols

NSF Certified sport Crescent M (Halal)

Formula

Star-K (Kosher)

Crescent M (Halal)

Storage

Storage Information: Store in a cool, dry place.

Precautions

Caution: if you are pregnant, nursing, or taking any medications, please seek the advice of a healthcare professional prior to use.

Not intended for use by children under 18.

Do not use if sealed packet is ripped or torn.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Tru Niagen Unflavored by ChromaDex label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Tru Niagen Unflavored label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Tru Niagen Unflavored by ChromaDex

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size4 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Niagen

Interacts with
172 drugs
300 mg per serving Form: Nicotinamide Riboside Chloride

Nicotinamide riboside (NR) is a form of vitamin B3 that the body converts into NAD+, a molecule involved in cellular energy and repair. Early human st...

Niagen monograph & interactions

Total Carb.

4 Gram(s) per serving

Other (inactive) ingredients: Inulin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Tru Niagen Unflavored by ChromaDex Drug Interactions

Want to check YOUR meds against Tru Niagen Unflavored?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,030Drugs
23 Moderate 2,007 Minor

Ingredients driving the most interactions

Dietary Fiber 2,025
Niagen 172

Individual Drug Interactions

The ingredients in Tru Niagen Unflavored interact with 2,030 drugs. Click any drug to see the details.

2 of the 2 ingredients in Tru Niagen Unflavored interact with drugs. Each result below shows which ingredient is responsible. Dietary Fiber Niagen

Each ingredient & the kinds of drugs it affects

For each ingredient in Tru Niagen Unflavored with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Dietary Fiber7 drug types · 2,025 drugs

Carbamazepine (Tegretol)

Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Lithium

Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Metformin (Glucophage)

Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.

Likelihood Possible Evidence D
Olanzapine (Zyprexa)

Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.

Likelihood Unlikely Evidence B
Ethinyl Estradiol

Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.

Likelihood Unlikely Evidence D
Oral Drugs

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.

Likelihood Possible Evidence B
Dietary Fiber full monograph & interactions

Niagen1 drug type · 172 drugs

Antihypertensive Drugs

Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
One small clinical study suggests that nicotinamide riboside can modestly reduce blood pressure in hypertensive patients. However, other clinical research did not find a reduction in blood pressure when compared with control.

Likelihood Possible Evidence D
Niagen full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Tru Niagen Unflavored, from the product label.

ChromaDex

See all ChromaDex products
Name
ChromaDex, Inc
Street Address
10900 Wilshire Blvd Suite 600
City
Los Angeles
State
CA
ZipCode
90024
Phone Number
888-642-4361
Web Address
TruNiagen.com
Pharmacist Counseling Corner

Tru Niagen Unflavored by ChromaDex: Common Questions

Does Tru Niagen Unflavored by ChromaDex interact with any medications?
Yes. Based on its ingredients, Tru Niagen Unflavored has a known interaction with 2,030 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Tru Niagen Unflavored contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
No. There isn't enough safety data on nicotinamide riboside during pregnancy or while breastfeeding, so the evidence advises against it. Talk with your doctor or pharmacist for personalized guidance.
What are the most common side effects?
Nicotinamide riboside appears well tolerated overall. The side effects reported in trials include bloating, nausea, muscle pain, itching, sweating, and changes in bowel movements. One person reported leg cramps. Most of these are mild.
Is this proven to work for anti-aging or energy?
The evidence for nicotinamide riboside isn't established yet for the conditions on file—including age-related macular degeneration, Alzheimer disease, athletic performance, nonalcoholic fatty liver disease, and heart failure. We can't say it works for anti-aging or energy based on what we hold.
What does nicotinamide riboside do in the body?
Nicotinamide riboside is a form of vitamin B3 that your body converts into NAD+, a molecule your cells use for energy and metabolism. That's the main proposed mechanism, but the practical health benefits haven't been firmly established in research yet.
Is this a filler-free product?
The product contains inulin as an inactive ingredient—a type of fiber used as a filler or binder. So it does have an inactive ingredient, though only one.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Tru Niagen Unflavored is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Tru Niagen Unflavored label
Go deeper

The Full Monographs Behind Tru Niagen Unflavored’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Nicotinamide Riboside

Interacts with 172 drugs

Nicotinamide riboside (NR) is a form of vitamin B3 that the body converts into NAD+, a molecule involved in cellular energy and repair. Early human studies show it can reliably raise NAD+ le...

Read the full Nicotinamide Riboside monograph → Herb & supplement monograph

Black Psyllium

Interacts with 2,025 drugs

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. It is best known and most studied for rel...

Read the full Black Psyllium monograph →
Sources

Sources & How We Checked

Tru Niagen Unflavored's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 25 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Black Psyllium 18 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  4. Etman M. Effect of a bulk forming laxative on the bioavailablility of carbamazepine in man. Drug Dev Ind Pharm 1995;21:1901-6.
  5. Perlman BB. Interaction between lithium salts and ispaghula husk. Lancet 1990;335:416.
  6. Vaswani SK, Hamilton RG, Valentine MD, Adkinson NF. Psyllium laxative-induced anaphylaxis, asthma, and rhinitis. Allergy 1996;51:266-8. PubMed
  7. Lantner RR, Espiritu BR, Zumerchik P, Tobin MC. Anaphylaxis following ingestion of a psyllium-containing cereal. JAMA 1990;264:2534-6. DOI
  8. Kaplan MJ. Anaphylactic reaction to "Heartwise." N Engl J Med 1990;323:1072-3. DOI
  9. Nordstrom M, Melander A, Robertsson E, Steen B. Influence of wheat bran and of a bulk-forming ispaghula cathartic on the bioavailability of digoxin in geriatric in-patients. Drug Nutr Interact 1987;5:67-9..
  10. Robinson DS, Benjamin DM, McCormack JJ. Interaction of warfarin and nonsystemic gastrointestinal drugs. Clin Pharmacol Ther 1971;12:491-5. PubMed
  11. Garcia JJ, Fernandez N, Diez MJ, et al. Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol. Contraception 2000;62:253-7. PubMed
  12. Fernandez N, Lopez C, Díez R, et al. Drug interactions with the dietary fiber Plantago ovata husk. Expert Opin Drug Metab Toxicol 2012;8(11):1377-86.
  13. Semen plantaginis in: WHO Monographs on Selected Medicinal Plants, volume 1. World Health Organization, Geneva, 1999. Available at http://apps.who.int/medicinedocs/en/d/Js2200e/. Accessed November 26, 1026.
  14. Code of Federal Regulations, Title 21 (21CFR 101.17). Food labeling warning, notice, and safe handling statements. Available at www.ecfr.gov/cgi-bin/text-idx?SID=20f647d3b74161501f46564b915b4048&mc=true&node=se21.2.101_117&rgn=div8. Accessed December 3, 2
  15. Code of Federal Regulations, Title 21 (21CFR 201.319). Specific labeling requirements - water-soluble gums, hydrophilic gums, and hydrophilic mucilloids. Available at www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=201.319. Accessed Dece
  16. Diez R, Garcia JJ, Diez MJ, Sierra M, Sahagun AM, Fernandez N. Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits. BMC Complement Altern Med. 2017 Jun 7;17(1):298. PubMed
  17. Chiu AC, Sherman SI. Effects of pharmacological fiber supplements on levothyroxine absorption. Thyroid. 1998;8(8):667-71. PubMed
  18. Merrick C, Madden CA, Capurso NA. A Case of Blunted Orally Disintegrating Olanzapine Effect Due to Coadministered Psyllium. J Clin Psychiatry 2021;82(2):20cr13633. PubMed

See these in context on the Black Psyllium monograph →

Nicotinamide Riboside 7 references
  1. Martens CR, Denman BA, Mazzo MR, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun 2018;9(1):1286. PubMed
  2. Dollerup OL, Christensen B, Svart M, et al. A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects. Am J Clin Nutr 2018;108(2):343-53. PubMed
  3. Dellinger RW, Santos SR, Morris M, et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safety and sustainably: a randomized, double-blind, placebo-controlled study. NPJ J Aging Mech Dis 2017;3:17.
  4. Conze D, Brenner C, Kruger CL. Safety and metabolism of long-term administration of NIAGEN (nicotinamide riboside chloride) in a randomized, double-blind, placebo-controlled clinical trial of healthy overweight adults. Sci Rep 2019;9(1):9772. PubMed
  5. Remie CME, Roumans KHM, Moonen MPB, et al. Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans. Am J Clin Nutr. 2020;112(2):413-426. PubMed
  6. Turck D, Castenmiller J, de Henauw S, et al. Safety of nicotinamide riboside chloride as a novel food pursuant to Regulation (EU) 2015/2283 and bioavailability of nicotinamide from this source, in the context of Directive 2002/46/EC. EFSA J. 2019;17(8):e0
  7. EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, et al. Extension of use of nicotinamide riboside chloride as a novel food pursuant to Regulation (EU) 2015/2283. EFSA J 2021;19(11):e06843.

See these in context on the Nicotinamide Riboside monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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