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Dietary supplement

Tru Niagen Pro 500 Ingredients & Drug Interactions

by ChromaDex

Tru Niagen Pro 500 label
See full label image
Capsule Category: Vitamin
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Tru Niagen Pro 500 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Tru Niagen Pro 500 is a dietary supplement by ChromaDex with 1 active ingredient. Its ingredients are commonly taken for healthy aging, boosting cellular energy, supporting metabolism.Based on those ingredients, 172 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Niagen. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Tru Niagen Pro 500 by ChromaDex

Ask about any prescription or over-the-counter medication and we check it for interactions with Tru Niagen Pro 500 by ChromaDex — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Tru Niagen Pro 500 by ChromaDex

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: nicotinamide riboside (also sold as Niagen), which is a form of vitamin B3 (niacin). It's designed to support cellular energy and metabolism.

The capsule also contains inactive ingredients — microcrystalline cellulose (a binder), hypromellose (a capsule material), and magnesium stearate (a lubricant) — that help deliver the active ingredient.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Nicotinamide Riboside's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: increases NAD+ and supports mitochondrial health.
  • We looked for evidence on: Athletic performance, Physical performance, Heart failure, Diabetes, Nonalcoholic fatty liver disease (NAFLD), Cellular energy metabolism — and 2 related terms.
  • The closest evidence on file: Nicotinamide Riboside is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Nicotinamide Riboside is rated "Insufficient Reliable Evidence To Rate" for Nonalcoholic fatty liver disease (NAFLD), Heart failure, Diabetes, Physical performance.

The evidence for nicotinamide riboside isn't yet established for the conditions listed on the product label. The data we hold shows insufficient reliable evidence to rate its use for age-related macular degeneration (AMD), Alzheimer disease, athletic performance, nonalcoholic fatty liver disease (NAFLD), and heart failure.

That doesn't mean it doesn't work — it means the research so far isn't robust enough to draw firm conclusions.

The evidence, ingredient by ingredient Nicotinamide Riboside

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Nicotinamide riboside appears generally well tolerated in short-term studies, but long-term safety isn't fully known. The most common side effects reported in trials are bloating, muscle pain, nausea, itching, sweating, and changes in stool consistency.

Mild nausea and transient digestive changes have also been documented. One person in a trial reported leg cramps.

Because there isn't enough safety data, it's best to avoid this product during pregnancy and while breastfeeding — talk with your doctor or pharmacist for personalized guidance.

Side effects, ingredient by ingredient Nicotinamide Riboside

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Nicotinamide Riboside.
  • The most serious interaction on file is rated Minor.
  • For scale: 172 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take any blood pressure–lowering medication (antihypertensive drugs), check your exact prescriptions with the search tool below before you begin this product. A pharmacist can advise whether you need monitoring or any adjustment.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

This product is for people curious about nicotinamide riboside as a cellular energy supplement and who don't take blood pressure medication — or who want to check their exact blood pressure drugs first. If you're pregnant, breastfeeding, or on any prescriptions, talk with your pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 21, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Tru Niagen Pro 500, straight from the product label.

Brand ChromaDex
Barcode (UPC) 856029008707
Net contents 30 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Dec 21, 2024
DSLD ID 323174
Product type Vitamin
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Halal
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Tru Niagen Pro 500 by ChromaDex, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
Servings per container
30
UPC/BARCODE
856029008707
IngredientAmount% DV
Niagen500 mg--

Other ingredients: Microcrystalline Cellulose, Hypromellose, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Significantly increases NAD+ Supports ongoing mitochondrial health Increases cellular energy production

Cellular energy & repair

Suggested/Recommended/Usage/Directions

Suggested use: Adults take one capsule daily or as recommended by your healthcare professional.

Storage

Store in original container in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

Patents: See NRPatents.com. Niagen and TRU Niagen are trademarks of ChromaDex, Inc.

General Statements

Only to be distributed by Health Care Professionals.

Practitioner exclusive Customer Service Center: 1-888-642-4361

Seals/Symbols

NSF Certified Sport Crescent M (Halal) Star-K (Kosher)

Formula

Crescent M (Halal)

Star-K (Kosher)

FDA Statement of Identity

Dietary Supplement

Precautions

Caution: If you are pregnant, nursing, or taking any medications, please seek the advice of a healthcare professional prior to use.

Not intended for use by children under 18.

Tamper resistant: Do not use if seal under cap is broken or missing.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Tru Niagen Pro 500 by ChromaDex label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Tru Niagen Pro 500 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Tru Niagen Pro 500 by ChromaDex

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Niagen

Interacts with
172 drugs
500 mg per serving Form: Nicotinamide Riboside Chloride

Nicotinamide riboside (NR) is a form of vitamin B3 that the body converts into NAD+, a molecule involved in cellular energy and repair. Early human st...

Niagen monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Hypromellose, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Tru Niagen Pro 500 by ChromaDex Drug Interactions

Want to check YOUR meds against Tru Niagen Pro 500?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
172Drugs
172 Minor

Ingredients driving the most interactions

Niagen 172

Individual Drug Interactions

The ingredients in Tru Niagen Pro 500 interact with 172 drugs. Click any drug to see the details.

1 of the 1 ingredient in Tru Niagen Pro 500 interact with drugs. Each result below shows which ingredient is responsible. Niagen

Each ingredient & the kinds of drugs it affects

For each ingredient in Tru Niagen Pro 500 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Niagen1 drug type · 172 drugs

Antihypertensive Drugs

Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
One small clinical study suggests that nicotinamide riboside can modestly reduce blood pressure in hypertensive patients. However, other clinical research did not find a reduction in blood pressure when compared with control.

Likelihood Possible Evidence D
Niagen full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Tru Niagen Pro 500, from the product label.

ChromaDex

See all ChromaDex products
Name
ChromaDex, Inc.
Street Address
10900 Wilshire Blvd., Ste 600
City
Los Angeles
State
CA
ZipCode
90024
Phone Number
1-888-642-4361
Web Address
Pro.Truniagen.com
Pharmacist Counseling Corner

Tru Niagen Pro 500 by ChromaDex: Common Questions

Does Tru Niagen Pro 500 by ChromaDex interact with any medications?
Yes. Based on its ingredients, Tru Niagen Pro 500 has a known interaction with 172 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Tru Niagen Pro 500 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is Niagen?
Niagen is nicotinamide riboside, a form of vitamin B3. It's meant to support your cells' energy production and metabolism.
What side effects might I notice?
The most common ones in trials were bloating, muscle pain, nausea, itching, and changes in stool. These are usually mild and temporary. A small number of people have reported leg cramps or muscle soreness.
Can I take this if I'm pregnant or breastfeeding?
There isn't enough safety data, so it's best to avoid it in both cases. Talk with your doctor or pharmacist before starting if you're pregnant, planning to become pregnant, or breastfeeding.
Does it actually work for what the label says?
The evidence for conditions like macular degeneration, Alzheimer disease, athletic performance, fatty liver disease, and heart failure is insufficient — we don't yet have solid research to say whether it does or doesn't help.
How long has this been studied?
Short-term studies show it's well tolerated, but long-term safety data isn't fully available. If you're thinking of taking it long-term, that's worth discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Tru Niagen Pro 500 is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Tru Niagen Pro 500 label
Go deeper

The Full Monographs Behind Tru Niagen Pro 500’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Nicotinamide Riboside

Interacts with 172 drugs

Nicotinamide riboside (NR) is a form of vitamin B3 that the body converts into NAD+, a molecule involved in cellular energy and repair. Early human studies show it can reliably raise NAD+ le...

Read the full Nicotinamide Riboside monograph →
Sources

Sources & How We Checked

Tru Niagen Pro 500's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Nicotinamide Riboside 7 references
  1. Martens CR, Denman BA, Mazzo MR, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun 2018;9(1):1286. PubMed
  2. Dollerup OL, Christensen B, Svart M, et al. A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects. Am J Clin Nutr 2018;108(2):343-53. PubMed
  3. Dellinger RW, Santos SR, Morris M, et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safety and sustainably: a randomized, double-blind, placebo-controlled study. NPJ J Aging Mech Dis 2017;3:17.
  4. Conze D, Brenner C, Kruger CL. Safety and metabolism of long-term administration of NIAGEN (nicotinamide riboside chloride) in a randomized, double-blind, placebo-controlled clinical trial of healthy overweight adults. Sci Rep 2019;9(1):9772. PubMed
  5. Remie CME, Roumans KHM, Moonen MPB, et al. Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans. Am J Clin Nutr. 2020;112(2):413-426. PubMed
  6. Turck D, Castenmiller J, de Henauw S, et al. Safety of nicotinamide riboside chloride as a novel food pursuant to Regulation (EU) 2015/2283 and bioavailability of nicotinamide from this source, in the context of Directive 2002/46/EC. EFSA J. 2019;17(8):e0
  7. EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, et al. Extension of use of nicotinamide riboside chloride as a novel food pursuant to Regulation (EU) 2015/2283. EFSA J 2021;19(11):e06843.

See these in context on the Nicotinamide Riboside monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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