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Dietary supplement

Tru Niagen 300 mg Ingredients & Drug Interactions

by ChromaDex

Capsule Category: Vitamin
Most serious interaction: Minor
The interaction bottom line Most serious interaction: Minor

Tru Niagen 300 mg is a dietary supplement by ChromaDex with 1 active ingredient. Its ingredients are commonly taken for healthy aging, boosting cellular energy, supporting metabolism.Based on those ingredients, 172 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Niagen. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Tru Niagen 300 mg by ChromaDex

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Tru Niagen contains one active ingredient: nicotinamide riboside (branded as Niagen by ChromaDex). Each capsule delivers 300 mg.

The product also includes inactive ingredients — microcrystalline cellulose, hypromellose, and magnesium stearate — which are common binders and capsule materials.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Nicotinamide Riboside's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Healthy aging and cellular energy support.
  • We looked for evidence on: Athletic performance, Physical performance, Metabolic health, Cellular vitality, General wellness.
  • The closest evidence on file: Nicotinamide Riboside is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Nicotinamide Riboside is rated "Insufficient Reliable Evidence To Rate" for Physical performance.

The evidence we hold on nicotinamide riboside doesn't yet support a clear-cut claim for any specific condition. For age-related macular degeneration, Alzheimer disease, athletic performance, nonalcoholic fatty liver disease, and heart failure, the reliable evidence is insufficient to rate whether it works.

You'd want to talk with your healthcare provider about whether this supplement makes sense for your particular situation.

The evidence, ingredient by ingredient Nicotinamide Riboside

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Nicotinamide riboside appears generally well tolerated in short-term studies, though long-term safety isn't fully known. The most common side effects reported in trials are bloating, muscle pain, nausea, itching, sweating, and temporary changes in stools.

One person reported leg cramps, and mild cases of nausea and bloating have been noted in some patients. Because there isn't enough safety data, the facts advise against use during pregnancy and while breastfeeding — talk with your doctor or pharmacist for personalized guidance if either applies to you.

Side effects, ingredient by ingredient Nicotinamide Riboside

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Nicotinamide Riboside.
  • The most serious interaction on file is rated Minor.
  • For scale: 172 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take blood pressure medications (antihypertensives), double-check your specific drugs before starting Tru Niagen — nicotinamide riboside may have an additive effect and increase the risk of low blood pressure (hypotension). No other medication interactions are documented in our data for this ingredient.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

Tru Niagen is a single-ingredient supplement of nicotinamide riboside that's generally tolerated in the short term. If you take blood pressure medication, check your specific drugs before starting.

Pregnant or breastfeeding? You'll want to discuss this with your pharmacist or doctor first.

The evidence for most health claims isn't established yet, so clarity on your goals matters.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Tru Niagen 300 mg, straight from the product label.

Brand ChromaDex
Barcode (UPC) 850015311116
Net contents 30 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Apr 24, 2025
DSLD ID 323170
Product type Vitamin
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Halal
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Tru Niagen 300 mg by ChromaDex, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
Servings per container
30
UPC/BARCODE
850015311116
IngredientAmount% DV
Niagen300 mg--

Other ingredients: Microcrystalline Cellulose, Hypromellose, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Adults take one capsule 1-3 times daily as needed or as recommended by your healthcare professional.

Storage

Store in original container in a cool, dry place.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Crescent M (Halal) Star-K (Kosher) Alkemist Assured

Formula

Crescent M (Halal)

Star-K (Kosher)

Brand IP Statement(s)

Patents: See NRPatents.com. Niagen and TRU Niagen are trademarks of ChromaDex, Inc. ChromaDex Age better

FDA Statement of Identity

Dietary Supplement

Precautions

Caution: If you are pregnant, nursing, or taking any medications, please seek the advice of a healthcare professional prior to use.

Not intended for use by children under 18.

Tamper resistant: Do not use if seal under cap is broken or missing.

See for yourself

Tru Niagen 300 mg by ChromaDex label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Tru Niagen 300 mg by ChromaDex

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Niagen

Interacts with
172 drugs
300 mg per serving Form: Nicotinamide Riboside Chloride

Nicotinamide riboside (NR) is a form of vitamin B3 that the body converts into NAD+, a molecule involved in cellular energy and repair. Early human st...

Niagen monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Hypromellose, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Tru Niagen 300 mg by ChromaDex Drug Interactions

Want to check YOUR meds against Tru Niagen 300 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
172Drugs
172 Minor

Ingredients driving the most interactions

Niagen 172

Each ingredient & the kinds of drugs it affects

For each ingredient in Tru Niagen 300 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Niagen1 drug type · 172 drugs

Antihypertensive Drugs

Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
One small clinical study suggests that nicotinamide riboside can modestly reduce blood pressure in hypertensive patients. However, other clinical research did not find a reduction in blood pressure when compared with control.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Tru Niagen 300 mg, from the product label.

ChromaDex

See all ChromaDex products
Name
ChromaDex, Inc
Street Address
10900 Wilshire Blvd., Suite 600
City
Los Angeles
State
CA
ZipCode
90024
Phone Number
+1 (888) 642-4361
Web Address
TruNiagen.com
Pharmacist Counseling Corner

Tru Niagen 300 mg by ChromaDex: Common Questions

Does Tru Niagen 300 mg by ChromaDex interact with any medications?
Yes. Based on its ingredients, Tru Niagen 300 mg has a known interaction with 172 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Tru Niagen 300 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's Niagen?
Niagen is ChromaDex's brand name for nicotinamide riboside, a compound related to B vitamins. Each Tru Niagen capsule contains 300 mg of it.
Can I take this if I'm pregnant or breastfeeding?
The safety data available isn't enough to know either way, so it's best to avoid it during pregnancy and breastfeeding. Talk with your doctor or pharmacist for personalized advice.
What side effects might I get?
In trials, people have reported bloating, muscle pain, nausea, itching, sweating, and temporary changes in stools. One person reported leg cramps. Most folks tolerate it well short-term, though long-term safety isn't fully known.
Does it actually work for anti-aging or brain health?
The reliable evidence we hold isn't enough to say whether it helps with age-related eye health, Alzheimer disease, athletic performance, liver health, or heart failure. You'd want to discuss your specific goals with your doctor.
Are there fillers in this?
Yes — the capsule contains microcrystalline cellulose, hypromellose, and magnesium stearate as inactive ingredients. These are common binders and capsule materials used across the industry.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Tru Niagen 300 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Tru Niagen 300 mg label
Sources

Sources & How We Checked

Tru Niagen 300 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Nicotinamide Riboside 7 references
  1. Martens CR, Denman BA, Mazzo MR, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun 2018;9(1):1286. PubMed
  2. Dollerup OL, Christensen B, Svart M, et al. A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects. Am J Clin Nutr 2018;108(2):343-53. PubMed
  3. Dellinger RW, Santos SR, Morris M, et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safety and sustainably: a randomized, double-blind, placebo-controlled study. NPJ J Aging Mech Dis 2017;3:17.
  4. Conze D, Brenner C, Kruger CL. Safety and metabolism of long-term administration of NIAGEN (nicotinamide riboside chloride) in a randomized, double-blind, placebo-controlled clinical trial of healthy overweight adults. Sci Rep 2019;9(1):9772. PubMed
  5. Remie CME, Roumans KHM, Moonen MPB, et al. Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans. Am J Clin Nutr. 2020;112(2):413-426. PubMed
  6. Turck D, Castenmiller J, de Henauw S, et al. Safety of nicotinamide riboside chloride as a novel food pursuant to Regulation (EU) 2015/2283 and bioavailability of nicotinamide from this source, in the context of Directive 2002/46/EC. EFSA J. 2019;17(8):e0
  7. EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, et al. Extension of use of nicotinamide riboside chloride as a novel food pursuant to Regulation (EU) 2015/2283. EFSA J 2021;19(11):e06843.

See these in context on the Nicotinamide Riboside monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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