Major interaction on record — check this product against your medications before combining. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

TrueOC Quick Melt Orange Flavor Ingredients & Drug Interactions

by NatureCity

TrueOC Quick Melt Orange Flavor label
See full label image
Lozenge Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking TrueOC Quick Melt Orange Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

TrueOC Quick Melt Orange Flavor is a dietary supplement by NatureCity with 3 active ingredients. Its ingredients are commonly taken for minor burns and skin irritation, wound healing, constipation.Based on those ingredients, 461 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are ACTIValoe. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against TrueOC Quick Melt Orange Flavor by NatureCity

Ask about any prescription or over-the-counter medication and we check it for interactions with TrueOC Quick Melt Orange Flavor by NatureCity — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of TrueOC Quick Melt Orange Flavor by NatureCity

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This lozenge has three active ingredients: two probiotic strains — Streptococcus salivarius BLIS K-12 and BLIS M18 — and aloe (marketed as ACTIValoe). The probiotics are meant to support oral health, while aloe is included for its potential effects on skin and digestive function.

The rest is inactive ingredients like mannitol, sorbitol, and natural flavors that make up the lozenge base.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: oral and throat health support.
  • We looked for evidence on: Dental plaque, Gingivitis, Periodontitis, Canker sores, Oral mucositis, Traumatic oral ulcers — and 4 related terms.
  • The strongest evidence on file: Aloe is rated "Possibly Effective" for Traumatic oral ulcers (Natural Medicines).
  • Also on file: Aloe is rated "Insufficient Reliable Evidence To Rate" for Common cold, Dental plaque, Dry mouth, Gingivitis, and more.

The aloe in this product is rated as possibly effective for acne, obesity, diabetes, psoriasis, burns, and constipation based on the data we hold. That means there's some preliminary evidence, but it's not definitive — more research would strengthen the case.

We don't have effectiveness ratings on file for the two probiotic strains, so we can't speak to how well they work for oral health.

The evidence, ingredient by ingredient Aloe

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Aloe gel is generally well tolerated when used in typical amounts. However, oral aloe latex — the inner leaf material — can cause serious side effects, especially at high doses or with long-term use.

Common effects are belly pain, cramping, and diarrhea. In rare cases, long-term use may lead to potassium loss, muscle weakness, heart rhythm problems, or pigment spots in the colon (harmless and usually reversible).

Avoid this product during pregnancy because aloe latex may stimulate the uterus and act as a strong laxative. Also avoid it while breastfeeding due to limited safety data and its laxative effects.

Side effects, ingredient by ingredient Aloe

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Aloe.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications.
  • For scale: 461 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with us before starting if you take digoxin (Lanoxin) — that's a Major interaction. Also double-check if you're on blood thinners like warfarin or aspirin, diabetes medications, water pills (diuretics), or stimulant laxatives — those are all Moderate.

And let us know if you take any drug your liver processes, since aloe may weaken it.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

If you take digoxin, blood thinners, diabetes medications, or diuretics, talk to your pharmacist before using this product — the aloe can cause real interactions. It's also not appropriate during pregnancy or while breastfeeding.

For others without those concerns, the aloe is generally well tolerated at normal doses, though some belly discomfort and diarrhea are possible.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about TrueOC Quick Melt Orange Flavor, straight from the product label.

Brand NatureCity
Barcode (UPC) 859003007154
Net contents 30 Lozenge(s)
Market status On market
Date entered into DSLD Feb 23, 2025
DSLD ID 320945
Product type Other Combinations
Supplement form Lozenge
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for TrueOC Quick Melt Orange Flavor by NatureCity, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Lozenge(s)
Maximum serving Sizes:
1 Lozenge(s)
Servings per container
30
UPC/BARCODE
859003007154
IngredientAmount% DV
Streptococcus salivarius BLIS K-1220 mg--
Streptococcus salivarius BLIS M1820 mg--
ACTIValoe50 mg--

Other ingredients: Mannitol, Crospovidone, Microcrystalline Cellulose, Sorbitol, Silica, Copovidone, Natural Flavors, Citric Acid, Stearic Acid, Rebaudioside A

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Take one (1) lozenge per day. Allow lozenge to dissolve completely by swirling around mouth before swallowing. For additional oral care support, a second lozenge can be taken, or as directed by your healthcare practitioner.

Formula

TrueOC contains dairy-free BLIS K12 and BLIS M18 which are two strains of the naturally occurring probiotic organism Streptococcus salivarius. Orange flavor. When taken regularly, these specific probiotic stains may help support several aspects of tooth and gum health and protect against the overgrowth of bacteria that causes bad breath. In addition, BLIS K12 and BLIS M18 help support upper respiratory, ear and throat health. ACTIValoe aloe vera provides additional support for tooth and gum health.

Oral care probiotics with aloe

Contains BLIS K12 Contains BLIS M18 ACTIValoe Qmatrix Proprietary Processing

Formulation

Promotes healthy gums and teeth Supports upper respiratory, ear and throat health Helps reduce bad breath

Dairy-Free

Vegan Friendly

Non GMO Dairy free Gluten free Sugar free

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

BLIS, BLIS K12 and BLIS M18 are trademarks of Blis Technologies Limited and the subject of USA patent nos 7226590, 7595041 and 8057790 for Halitosis. / ACTIValoe is a registered trademark of Aloecorp, Inc.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

TrueOC Quick Melt Orange Flavor by NatureCity label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

TrueOC Quick Melt Orange Flavor label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in TrueOC Quick Melt Orange Flavor by NatureCity

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Lozenge(s) Dosage formLozenge Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Streptococcus salivarius BLIS K-12

20 mg per serving

Streptococcus salivarius BLIS M18

20 mg per serving

ACTIValoe

Interacts with
461 drugs
50 mg per serving Form: Aloe vera Inner Leaf Gel

Aloe vera gel is widely used on the skin for minor burns and irritation, and some research suggests it may help. Aloe latex (the yellow part) is a str...

ACTIValoe monograph & interactions

Other (inactive) ingredients: Mannitol, Crospovidone, Microcrystalline Cellulose, Sorbitol, Silica, Copovidone, Natural Flavors, Citric Acid, Stearic Acid, Rebaudioside A. These complete the product’s ingredient list but are not active constituents.

Interaction report

TrueOC Quick Melt Orange Flavor by NatureCity Drug Interactions

Want to check YOUR meds against TrueOC Quick Melt Orange Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
461Drugs
1 Major 304 Moderate 156 Minor

Ingredients driving the most interactions

ACTIValoe 461

Individual Drug Interactions

The ingredients in TrueOC Quick Melt Orange Flavor interact with 461 drugs. Click any drug to see the details.

1 of the 3 ingredients in TrueOC Quick Melt Orange Flavor interact with drugs. Each result below shows which ingredient is responsible. ACTIValoe

Each ingredient & the kinds of drugs it affects

For each ingredient in TrueOC Quick Melt Orange Flavor with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

ACTIValoe7 drug types · 461 drugs

Digoxin (Lanoxin)

Theoretically, aloe latex might increase the risk of adverse effects when taken with cardiac glycosides.
Overuse of aloe latex can increase the risk of adverse effects from cardiac glycoside drugs, such as digoxin, due to potassium depletion. Overuse of aloe, along with cardiac glycoside drugs, can increase the risk of toxicity.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that aloe gel can inhibit platelet aggregation. This inhibition was greater than that seen with celecoxib, but less than that seen with aspirin.

Likelihood Possible Evidence D
Antidiabetes Drugs

Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Preliminary clinical research suggests aloe gel might lower blood glucose levels and have additive effects when used with antidiabetes drugs. Monitor blood glucose levels closely.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Overuse of aloe latex might compound diuretic-induced potassium loss, increasing the risk of hypokalemia.

Likelihood Possible Evidence D
Stimulant Laxatives

Theoretically, aloe latex might increase the risk for fluid and electrolyte loss when taken with stimulant laxatives.
Due to cathartic laxative effects of aloe latex, concomitant use with other stimulant laxatives might compound fluid and electrolyte loss.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, aloe latex might increase the risk of bleeding when taken with warfarin.
Aloe latex has stimulant laxative effects. In some people aloe latex can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. Advise patients who take warfarin not to take excessive amounts of aloe vera.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that aloe extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
ACTIValoe full monograph & interactions
The maker

Brand information

Manufacturer and brand details for TrueOC Quick Melt Orange Flavor, from the product label.

NatureCity

See all NatureCity products
Name
NatureCity
Street Address
990 S. Rogers Circle
City
Boca Raton
State
FL
ZipCode
33487
Phone Number
1-800-593-2563
Web Address
www.naturecity.com
Pharmacist Counseling Corner

TrueOC Quick Melt Orange Flavor by NatureCity: Common Questions

Does TrueOC Quick Melt Orange Flavor by NatureCity interact with any medications?
Yes. Based on its ingredients, TrueOC Quick Melt Orange Flavor has a known interaction with 461 medications, including 1 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
TrueOC Quick Melt Orange Flavor contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What are the probiotic strains in this, and what do they do?
The lozenges contain two strains: Streptococcus salivarius BLIS K-12 and BLIS M18. They're meant to support oral health, but we don't have effectiveness data on file for either strain to tell you how well they work.
Can I take this if I'm pregnant or breastfeeding?
No — the aloe in this product should be avoided during pregnancy because it may stimulate the uterus and act as a strong laxative. Also avoid it while breastfeeding because we don't have enough safety data and aloe has laxative effects.
What side effects might I get from the aloe?
At typical doses, aloe gel is generally well tolerated. But oral aloe can cause belly pain, cramping, and diarrhea. With long-term or heavy use, you might see potassium loss, muscle weakness, or heart rhythm issues — though those are rare.
Is aloe really in here, or just the name?
Yes — the ingredient is ACTIValoe, which is aloe. The product uses the actual herb, so you need to be aware of the interactions and safety cautions that come with oral aloe.
Does this lozenge have a lot of fillers or other stuff in it?
Besides the three active ingredients, there are inactive ingredients like mannitol, sorbitol, cellulose, and natural flavors that form the lozenge. That's typical for a tablet or lozenge formula.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if TrueOC Quick Melt Orange Flavor is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

TrueOC Quick Melt Orange Flavor label
Go deeper

The Full Monographs Behind TrueOC Quick Melt Orange Flavor’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Aloe

Interacts with 461 drugs

Aloe vera gel is widely used on the skin for minor burns and irritation, and some research suggests it may help. Aloe latex (the yellow part) is a strong laxative that can cause cramping and...

Read the full Aloe monograph →
Sources

Sources & How We Checked

TrueOC Quick Melt Orange Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 41 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Aloe 41 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Wichtl MW. Herbal Drugs and Phytopharmaceuticals. Ed. N.M. Bisset. Stuttgart: Medpharm GmbH Scientific Publishers, 1994.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Nusko G, Schneider B, Schneider I, et al. Anthranoid laxative use is not a risk factor for colorectal neoplasia: results of a prospective case control study. Gut 2000;46:651-5. PubMed
  5. Luyckx VA, Ballantine R, Claeys M, et al. Herbal remedy-associated acute renal failure secondary to Cape aloes. Am J Kidney Dis 2002;39:E13. PubMed
  6. Rajasekaran S, Sivagnanam K, Ravi K, Subramanian S. Hypoglycemic effect of Aloe vera gel on streptozotocin-induced diabetes in experimental rats. J Med Food 2004;7:61-6.
  7. Williams MS, Burk M, Loprinzi CL, et al. Phase III double-blind evaluation of an aloe vera gel as a prophylactic agent for radiation-induced skin toxicity. Int J Radiat Oncol Biol Phys 1996;36:345-9. PubMed
  8. Vogler BK, Ernst E. Aloe vera: a systematic review of its clinical effectiveness. Br J Gen Pract 1999;49:823-8.
  9. Bottenberg MM, Wall GC, Harvey RL, Habib S. Oral aloe vera-induced hepatitis. Ann Pharmacother 2007;41:1740-3. PubMed
  10. Rabe C, Musch A, Schirmacher P, et al. Acute hepatitis induced by an Aloe vera preparation: a case report. World J Gastroenterol 2005;11:303-4. PubMed
  11. Kanat O, Ozet A, Ataergin S. Aloe vera-induced acute toxic hepatitis in a healthy young man. Eur J Int Med 2006;17:589. PubMed
  12. Mueller SO, Stopper H. Characterization of the genotoxicity of anthraquinones in mammalian cells. Biochim Biophys Acta 1999;1428:406-14. PubMed
  13. Schorkhuber M, Richter M, Dutter A, et al. Effect of anthraquinone laxatives on the proliferation and urokinase secretion of normal, premalignant and malignant colonic epithelial cells. Eur J Cancer 1998;34:1091-8. PubMed
  14. Yang HN, Kim DJ, Kim YM, et al. Aloe-induced toxic hepatitis. J Korean Med Sci 2010;25:492-5. PubMed
  15. Choonhakarn C, Busaracome P, Sripanidkulchai B, et al. A prospective, randomized clinical trial comparing topical aloe vera with 0.1% triamcinolone acetonide in mild to moderate plaque psoriasis. J.Eur.Acad.Dermatol.Venereol. 2010;24:168-72. PubMed
  16. Ishii Y, Tanizawa H, Takino Y. Studies of aloe. IV. Mechanism of cathartic effect. (3). Biol Pharm Bull. 1994;17:495-7. PubMed
  17. Ishii Y, Tanizawa H, Takino Y. Studies of aloe. V. Mechanism of cathartic effect. (4). Biol Pharm Bull. 1994;17:651-3. PubMed
  18. Nelemans FA. Clinical and toxicological aspects of anthraquinone laxatives. Pharmacology. 1976;14 Suppl 1:73-7. PubMed
  19. Paulsen E, Korsholm L, Brandrup F. A double-blind, placebo-controlled study of a commercial Aloe vera gel in the treatment of slight to moderate psoriasis vulgaris. J Eur Acad Dermatol Venereol. 2005;19:326-31.
  20. Huseini HF, Kianbakht S, Hajiaghaee R, et al. Anti-hyperglycemic and anti-hypercholesterolemic effects of Aloe vera leaf gel in hyperlipidemic type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial. Planta Med. 2012;78:311-6
  21. Ferreira, M., Teixeira, M., Silva, E., and Selores, M. Allergic contact dermatitis to Aloe vera. Contact Dermatitis 2007;57(4):278-279.
  22. Choonhakarn, C., Busaracome, P., Sripanidkulchai, B., and Sarakarn, P. The efficacy of aloe vera gel in the treatment of oral lichen planus: a randomized controlled trial. Br J Dermatol 2008;158(3):573-577. PubMed
  23. Baretta, Z., Ghiotto, C., Marino, D., and Jirillo, A. Aloe-induced hypokalemia in a patient with breast cancer during chemotherapy. Ann.Oncol. 2009;20(8):1445-1446. PubMed
  24. Hunter, D. and Frumkin, A. Adverse reactions to vitamin E and aloe vera preparations after dermabrasion and chemical peel. Cutis 1991;47(3):193-196.
  25. Alvarez-Perea, A., Garcia, A. P., Hernandez, A. L., de, Barrio M., and Baeza, M. L. Urticaria due to aloe vera: a new sensitizer? Ann.Allergy Asthma Immunol. 2010;105(5):404-405. PubMed
  26. Hogan, D. J. Widespread dermatitis after topical treatment of chronic leg ulcers and stasis dermatitis. CMAJ. 2-15-1988;138(4):336-338.
  27. Savchak VI. Acute bullous allergic dermatitis due to local application of aloe leaves. Vestnik Dermatologii i Venerologii 1977;12:44-45.
  28. Nakamura, T. and Kotajima, S. Contact dermatitis from aloe arborescens. Contact Dermatitis 1984;11(1):51. PubMed
  29. Shoji, A. Contact dermatitis to Aloe arborescens. Contact Dermatitis 1982;8(3):164-167. PubMed
  30. Morrow, D. M., Rapaport, M. J., and Strick, R. A. Hypersensitivity to aloe. Arch Dermatol. 1980;116(9):1064-1065. DOI
  31. Cosmetic Ingredient Review Expert Panel. Final report on the safety assessment of AloeAndongensis Extract, Aloe Andongensis Leaf Juice,aloe Arborescens Leaf Extract, Aloe Arborescens Leaf Juice, Aloe Arborescens Leaf Protoplasts, Aloe Barbadensis Flower E
  32. Bhalang K, Thunyakitpisal P, Rungsirisatean N. Acemannan, a polysaccharide extracted from Aloe vera, is effective in the treatment of oral aphthous ulceration. J Altern Complement Med 2013;19(5):429-34.
  33. Hajheydari Z, Saeedi M, Morteza-Semnani K, Soltani A. Effect of Aloe vera topical gel combined with tretinoin in treatment of mild and moderate acne vulgaris: a randomized, double-blind, prospective trial. J Dermatolog Treat 2014;25(2):123-9.
  34. Jiménez-Encarnación E, Ríos G, Muñoz-Mirabal A, Vilá LM. Euforia-induced acute hepatitis in a patient with scleroderma. BMJ Case Rep 2012;2012. PubMed
  35. Lee J, Lee MS, Nam KW. Acute toxic hepatitis caused by an aloe vera preparation in a young patient: a case report with a literature review. Korean J Gastroenterol 2014;64(1):54-8. PubMed
  36. Guo X, Mei N. Aloe Vera - A Review of Toxicity and Adverse Clinical Effects. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2016;34(2):77-96.
  37. Hoogenboom TCH, Patel N, Cook NA, Williams R, Taylor-Robinson SD, Lim AKP. The effect of Aloe vera juice on liver enzymes and hepatic structure in a healthy population. Integr Med (Encinitas) 2020;19(3):30-4.
  38. Mushtaq S, Mushtaq Z, Sarfraz J, et al. Comparison of effect of aloe vera gel with aspirin and celecoxib on platelet aggregation. Professional Med J. 2020; 27(5):973-978. DOI
  39. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
  40. Sabbaghzadegan S, Soltani MH, Kamalinejad M, Bahrami M, Kabir A, Dadmehr M. The effect of a standardized capsule of Aloe vera gel on the quality of life in patients with systolic heart failure: A randomized double-blind placebo-controlled clinical trial.
  41. Lewis ED, Crowley DC, Guthrie N, Evans M. Healthy adults supplemented with a nutraceutical formulation containing Aloe vera gel, rosemary and Poria cocos enhances the effect of influenza vaccination in a randomized, triple-blind, placebo-controlled trial. PubMed

See these in context on the Aloe monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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