Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

TruePS Ingredients & Drug Interactions

by NatureCity

TruePS label
See full label image
Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking TruePS against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

TruePS is a dietary supplement by NatureCity with 2 active ingredients. Its ingredients are commonly taken for memory and cognitive support, age-related cognitive decline, attention and focus (adhd).Based on those ingredients, 219 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Phosphatidylserine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against TruePS by NatureCity

Ask about any prescription or over-the-counter medication and we check it for interactions with TruePS by NatureCity — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of TruePS by NatureCity

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

TruePS has 2 active ingredients — both are phosphatidylserine, a natural compound that's part of cell membranes. One is plain phosphatidylserine; the other is Sharp-PS Green, a specific extract form.

They're the same compound, just sourced differently. The softgel capsule also contains gelatin, glycerin, polyglycitol syrup, and purified water as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports brain health.
  • We looked for evidence on: Age-related cognitive decline, Cognitive function, Attention deficit-hyperactivity disorder (ADHD), Alzheimer disease, Dementia, memory — and 2 related terms.
  • The strongest evidence on file: Phosphatidylserine is rated "Possibly Effective" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Phosphatidylserine is rated "Possibly Effective" for Alzheimer disease.
  • Also on file: Phosphatidylserine is rated "Insufficient Reliable Evidence To Rate" for Attention deficit-hyperactivity disorder (ADHD), Cognitive function, Dementia.

Phosphatidylserine is rated possibly effective for age-related cognitive decline and Alzheimer disease based on available evidence. For other uses — including athletic performance, attention deficit-hyperactivity disorder (ADHD), general cognitive function, and dementia — the evidence isn't established well enough to rate it.

If you're considering this for a specific condition, talk it over with your doctor to see if the evidence matches your situation.

The evidence, ingredient by ingredient Phosphatidylserine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Phosphatidylserine is generally well tolerated in studies, though long-term safety isn't fully established. The most common side effects are flatulence, stomach upset, headache, insomnia, and nausea.

Insomnia is more likely at higher doses, particularly around 600 mg. Stomach upset can occur even at lower doses of 200–300 mg per day.

There's not enough safety information to recommend this supplement during pregnancy, so it's best to avoid it. Safety while breastfeeding is also unknown, so breastfeeding is not recommended while taking TruePS.

If you're pregnant, planning pregnancy, or breastfeeding, talk with your doctor or pharmacist before starting.

Side effects, ingredient by ingredient Phosphatidylserine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Phosphatidylserine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 219 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take TruePS, double-check with your doctor or pharmacist if you're on anticholinergic drugs (medications that block acetylcholine, commonly used for overactive bladder, muscle stiffness, or certain other conditions) or cholinergic drugs (medications that boost acetylcholine, used for conditions like myasthenia gravis or Parkinson disease). Phosphatidylserine could theoretically make anticholinergic drugs less effective or amplify cholinergic drug effects — both Moderate severity concerns.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

TruePS might be worth considering if you're interested in supporting age-related cognitive health, though the evidence is modest. If you take anticholinergic or cholinergic medications — especially for urinary issues, Parkinson disease, myasthenia gravis, or certain psychiatric conditions — check with your doctor or pharmacist first, since this supplement could theoretically interfere with how they work.

Pregnant and breastfeeding folks should skip it. Have a conversation with your own healthcare provider about whether it fits your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about TruePS, straight from the product label.

Brand NatureCity
Barcode (UPC) 859003007192
Net contents 30 Softgel(s)
Market status On market
Date entered into DSLD Mar 22, 2023
DSLD ID 283382
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for TruePS by NatureCity, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
3 Softgel(s)
Servings per container
30
UPC/BARCODE
859003007192
IngredientAmount% DV
Phosphatidylserine100 mg--
Sharp-PS Green556 mg--

Other ingredients: Gelatin, Glycerin, Polyglycitol Syrup, Water, Purified

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Take three (3) soft gels a day for the first 4 weeks. Thereafter, a maintenance serving of one (1) soft gel a day is typically recommended, or use as directed by your health care practitioner.

Formula

TruePS is a highly purified and stabilized phosphatidylserine (PS) from non-GMO sunflower lecithin that supports brain health.

Sharp - PS Green

Stabilized Phosphatidylserine

Precautions

Keep out of reach of children

Do not use if seal is broken or missing

Storage

Store in a cool dry place

General Statements

BPA free

Formulation

Soy free Non GMO Gluten free

Seals/Symbols

Blended & Packaged in the USA

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Sharp-PS Green is a registered trademark of Frutarom

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

TruePS by NatureCity label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

TruePS label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in TruePS by NatureCity

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Phosphatidylserine

Interacts with
219 drugs
100 mg per serving

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinki...

Phosphatidylserine monograph & interactions

Sharp-PS Green

Interacts with
219 drugs
556 mg per serving Form: Sunflower Lecithin

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinki...

Sharp-PS Green monograph & interactions

Other (inactive) ingredients: Gelatin, Glycerin, Polyglycitol Syrup, Water, Purified. These complete the product’s ingredient list but are not active constituents.

Interaction report

TruePS by NatureCity Drug Interactions

Want to check YOUR meds against TruePS?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
219Drugs
219 Moderate

Ingredients driving the most interactions

Phosphatidylserine 219

Individual Drug Interactions

The ingredients in TruePS interact with 219 drugs. Click any drug to see the details.

1 of the 2 ingredients in TruePS interact with drugs. Each result below shows which ingredient is responsible. Phosphatidylserine

Each ingredient & the kinds of drugs it affects

For each ingredient in TruePS with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Phosphatidylserine2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically interfere with the activity of anticholinergic agents.

Likelihood Possible Evidence B
Cholinergic Drugs

Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence B
Phosphatidylserine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for TruePS, from the product label.

NatureCity

See all NatureCity products
Name
NatureCity
Street Address
990 S. Rogers Circle
City
Boca Raton
State
FL
ZipCode
33487
Phone Number
1-800-593-2563
Web Address
www.naturecity.com
Pharmacist Counseling Corner

TruePS by NatureCity: Common Questions

Does TruePS by NatureCity interact with any medications?
Yes. Based on its ingredients, TruePS has a known interaction with 219 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
TruePS contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What exactly is phosphatidylserine, and why is it in this product?
Phosphatidylserine is a natural compound that's a structural part of cell membranes throughout your body. It's included because research suggests it may support cognitive function and brain health, particularly in age-related decline and Alzheimer disease.
What's the difference between the two phosphatidylserine ingredients in TruePS?
Both are phosphatidylserine — one is the standard form, and the other is Sharp-PS Green, a specific plant-derived extract. They're the same active ingredient from different sources and have identical interaction and safety profiles.
Can phosphatidylserine actually improve my memory or focus?
Phosphatidylserine is possibly effective for age-related cognitive decline and Alzheimer disease based on available studies. For general memory, focus, or ADHD, the evidence isn't strong enough to rate it either way. Your individual results may vary, so it's worth discussing with your doctor.
What side effects might I get from taking this?
The most common side effects are flatulence, stomach upset, headache, insomnia, and nausea. Insomnia is more likely if you take a higher dose (around 600 mg), and stomach upset can happen even at lower doses of 200–300 mg per day.
Is TruePS safe to take long-term?
Phosphatidylserine is generally well tolerated in studies, but long-term safety hasn't been fully established. If you're thinking about taking it regularly for weeks or months, check in with your doctor or pharmacist first.
Can I take TruePS while pregnant or breastfeeding?
No. There isn't enough safety information to recommend phosphatidylserine during pregnancy, so it's best to avoid it. Safety while breastfeeding is also unknown. Talk with your doctor or pharmacist if you're pregnant, planning pregnancy, or nursing before starting any new supplement.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

TruePS label
Go deeper

The Full Monographs Behind TruePS’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Phosphatidylserine

Interacts with 219 drugs

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinking. Some research suggests possible bene...

Read the full Phosphatidylserine monograph →
Sources

Sources & How We Checked

TruePS's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phosphatidylserine 9 references
  1. Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28:61-6.
  2. Pepping J. Phosphatidylserine. Am J Health-Syst Pharm 1999;56:2038,2043-4.
  3. Kidd PM. Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Altern Med Rev 1996;1:70-84.
  4. Kim HY, Akbar M, Lau A, et al. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. J Biol Chem 2000;275:35215-23.. PubMed
  5. Zanotti A, Valzelli L, Toffano G. Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology (Berl) 1989;99:316-21.. PubMed
  6. Schreiber S, Kampf-Sherf O, Gorfine M, et al. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci 2000;37:302-7.
  7. Pepping, J. Phosphatidylserine. Am J Health Syst.Pharm. 10-15-1999;56(20):2038, 2043-2038, 2044.
  8. Monteverde, A., Gnemmi, P., Rossi, F., Monteverde, A., and Finali, G. C. Selegiline in the treatment of mild to moderate Alzheimer-type dementia. Clin.Ther 1990;12(4):315-322.
  9. Vakhapova V, Cohen T, Richter Y, Herzog Y, Kam Y, Korczyn AD. Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study. Dement Geri PubMed

See these in context on the Phosphatidylserine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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