Interactions on record — worth a quick check against your medications. Based on 1 of 5 ingredients. Check your meds →
Dietary supplement

TruFloraPro Ingredients & Drug Interactions

by Master Supplements

TruFloraPro label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking TruFloraPro against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

TruFloraPro is a dietary supplement by Master Supplements with 5 active ingredients. Its ingredients are commonly taken for constipation, irritable bowel syndrome (ibs), diarrhea.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are ProDURA. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against TruFloraPro by Master Supplements

Ask about any prescription or over-the-counter medication and we check it for interactions with TruFloraPro by Master Supplements — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of TruFloraPro by Master Supplements

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 5 active ingredients.
  • “Proprietary Probiotic Blend” is a proprietary blend — the label gives one combined amount (96.75 mg) without saying how much of each component you get.

TruFloraPro contains five active ingredients: two Lactobacillus strains (salivarius LS-33 and plantarum Lp-115), Bacillus coagulans (trademarked as ProDURA), and two enzymes — Beta-Glucanase and Hemicellulase — plus a proprietary probiotic blend whose individual components are listed separately. The probiotics are live microorganisms meant to support digestive health; the enzymes assist in breaking down food.

The product also contains inactive ingredients like cellulose, maltodextrin, and magnesium stearate as binders and fillers.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive and immune health support.
  • We looked for evidence on: Antibiotic-associated diarrhea, Clostridioides difficile infection, Constipation, Diarrhea, Dyspepsia, Flatulence — and 4 related terms.
  • The strongest evidence on file: Bacillus Coagulans is rated "Possibly Effective" for Constipation (Natural Medicines).
  • Also on file: Bacillus Coagulans is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Bacillus Coagulans is rated "Insufficient Reliable Evidence To Rate" for Antibiotic-associated diarrhea, Inflammatory bowel disease (IBD), Diarrhea, Dyspepsia, and more.

Bacillus coagulans has been rated possibly effective for constipation and irritable bowel syndrome (IBS). The evidence for its use in antibiotic-associated diarrhea, athletic performance, cancer prevention, and nonalcoholic fatty liver disease is not yet established.

The effectiveness of the Lactobacillus strains and enzymes in this product is not on file in our data.

The evidence, ingredient by ingredient Bacillus Coagulans

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bacillus coagulans is generally well tolerated in healthy adults, though the safety evidence varies and product quality can differ. There isn't enough reliable safety data overall — talk to your doctor before using this product.

A rare concern: probiotic products containing live organisms have been linked to infection (bacteremia and sepsis) in patients with central lines, severe illness, or weakened immune systems, including very premature infants. Healthy people with intact immune systems are at much lower risk, but those categories should be cautious.

We don't have pregnancy or breastfeeding safety data on file for any of these ingredients; talk with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Bacillus Coagulans

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bacillus Coagulans.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotics, separate them from this product — the living organisms in Bacillus coagulans can be killed by antibiotics, which reduces effectiveness. No other medication interactions are documented for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with constipation or IBS symptoms. If you're on antibiotics, you'll need to time this supplement carefully — separate the two by a few hours.

If you're severely ill, immunocompromised, or have a central venous catheter, check with your doctor first. Run your medications through the checker below before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about TruFloraPro, straight from the product label.

Brand Master Supplements
Barcode (UPC) 850063164030
Net contents 62 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Aug 22, 2025
DSLD ID 336296
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for TruFloraPro by Master Supplements, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
62
UPC/BARCODE
850063164030
IngredientAmount% DV
Lactobacillus salivarius LS-330 NP--
Beta-Glucanase73.12 mg--
Proprietary Probiotic Blend96.75 mg--
Hemicellulase27 mg--
Lactobacillus plantarum Lp-1150 NP--
ProDURA0 NP--

Other ingredients: Cellulose, Water, Tapioca Dextrin, Microcrystalline Cellulose, Sodium Alginate, Magnesium Stearate, Trisodium Phosphate, Maltodextrin, Silicon Dioxide, Ascorbic Acid, LactoStim, Calcium Silicate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

TruFloraPRO is a high potency probiotic supplement containing 15 billion live CFU and 2 enzymes that work primarily in the small intestine to support digestive and immune health.

Bio-cleansing probiotic 15 billion CFU guaranteed through expiration Includes 3 probiotics + 2 enzymes

Formulation

Each batch is laboratory tested to meet strict quality control standards; guaranteed at time of expiration when kept refrigerated.

For gastrointestinal support

Contains No: Milk, Eggs, Wheat, Soy, Casein, Nuts, Seafood, or Beef products.

Storage

Each batch is laboratory tested to meet strict quality control standards; guaranteed at time of expiration when kept refrigerated.

Suggested/Recommended/Usage/Directions

Suggested use: Take 1 capsule daily. Take 2 capsules a day for additional digestive support. TruFloraPRO can be taken with antibiotics; separate by 2 hours.

Precautions

TruFloraPRO can be taken with antibiotics; separate by 2 hours. Warning: If you are pregnant, nursing, on medication or have any medical condition consult a health care professional before using this product.

Discontinue use and consult a doctor if any adverse reaction occurs.

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Available for healthcare professionals at usenzymes.com 800-926-2961

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

PRODURA is a trademark of Chr. Hansen A/S

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

TruFloraPro by Master Supplements label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

TruFloraPro label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in TruFloraPro by Master Supplements

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container62 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Beta-Glucanase

73.12 mg per serving

Proprietary Probiotic Blend

96.75 mg per serving
  • › Lactobacillus salivarius LS-33
  • › Lactobacillus plantarum Lp-115
  • › ProDURA

Hemicellulase

27 mg per serving

Other (inactive) ingredients: Cellulose, Water, Tapioca Dextrin, Microcrystalline Cellulose, Sodium Alginate, Magnesium Stearate, Trisodium Phosphate, Maltodextrin, Silicon Dioxide, Ascorbic Acid, LactoStim, Calcium Silicate. These complete the product’s ingredient list but are not active constituents.

Interaction report

TruFloraPro by Master Supplements Drug Interactions

Want to check YOUR meds against TruFloraPro?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

ProDURA 182

Individual Drug Interactions

The ingredients in TruFloraPro interact with 182 drugs. Click any drug to see the details.

1 of the 5 ingredients in TruFloraPro interact with drugs. Each result below shows which ingredient is responsible. ProDURA

Each ingredient & the kinds of drugs it affects

For each ingredient in TruFloraPro with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

ProDURA1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B. coagulans.
B. coagulans preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. coagulans preparations by at least two hours.

Likelihood Probable Evidence D
ProDURA full monograph & interactions
The maker

Brand information

Manufacturer and brand details for TruFloraPro, from the product label.

Master Supplements

See all Master Supplements products
Name
Master Supplements, Inc.
City
Victoria
State
MN
ZipCode
55386
Phone Number
800-926-2961
Web Address
usenzymes.com
Pharmacist Counseling Corner

TruFloraPro by Master Supplements: Common Questions

Does TruFloraPro by Master Supplements interact with any medications?
Yes. Based on its ingredients, TruFloraPro has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
TruFloraPro contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this with my antibiotic?
Not at the same time. Antibiotics will kill the living probiotic organisms, making this product less effective. Take them several hours apart — your pharmacist can help you schedule them. Finish your antibiotic course as directed by your doctor.
What does this do?
Bacillus coagulans in this product has been rated possibly effective for constipation and irritable bowel syndrome. The enzymes help break down certain carbohydrates during digestion. The other Lactobacillus strains are probiotics, but we don't have effectiveness data on them yet.
Is it safe if I'm pregnant or breastfeeding?
We don't have safety data on file for these ingredients during pregnancy or breastfeeding. Talk with your doctor or pharmacist — they can give you personalized advice based on your situation.
What are the side effects?
Bacillus coagulans is generally well tolerated. In rare cases, live probiotic organisms have caused infection in people with weakened immune systems, severe illness, or certain types of medical tubing. Healthy people are at very low risk.
Does it have fillers?
Yes. The product contains inactive ingredients like cellulose, maltodextrin, and magnesium stearate to form the capsule and stabilize the blend.
Can I take it if I'm on multiple medications?
Use the medication checker on this page with your exact drug names and dosages. Antibiotics are the main concern we've documented. For the other ingredients we couldn't check, ask your pharmacist to look them up in their system.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if TruFloraPro is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

TruFloraPro label
Go deeper

The Full Monographs Behind TruFloraPro’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bacillus Coagulans

Interacts with 182 drugs

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, and certain types of diarrhea. The eviden...

Read the full Bacillus Coagulans monograph →
Sources

Sources & How We Checked

TruFloraPro's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 20 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bacillus Coagulans 20 references
  1. Saxelin M, Chuang NH, Chassy B, et al. Lactobacilli and bacteremia in southern Finland 1989-1992. Clin Infect Dis 1996;22:564-6. PubMed
  2. Tynkkynen S, Singh KV, Varmanen P. Vancomycin resistance factor of Lactobacillus rhamnosus GG in relation to enterococcal vancomycin resistance (van) genes. Int J Food Microbiol 1998;41:195-204. PubMed
  3. Klein G, Zill E, Schindler R, et al. Peritonitis associated with vancomycin-resistant Lactobacillus rhamnosus in a continuous ambulatory peritoneal dialysis patient; organism identification, antibiotic therapy, and case report. J Clin Microbiol 1998;36:
  4. Kalima P, Masterton RG, Roddie PH, et al. Lactobacillus rhamnosus infection in a child following bone marrow transplant. J Infect 1996;32:165-7. PubMed
  5. Goldin BR. Health Benefits of probiotics. Br J Nutr 1998;80:S203-7. DOI
  6. Rautio M, Jousimies-Somer H, Kauma H, et al. Liver abscess due to Lactobacillus rhamnosus strain indistinguishable from L. rhamnosus strain GG. Clin Infect Dis 1999;28:1159-60.
  7. MacGregor G, Smith AJ, Thakker B, Kinsella J. Yoghurt biotherapy: contraindicated in immunosuppressed patients? Postgrad Med J 2002;78:366-7. PubMed
  8. Land MH, Rouster-Stevens K, Woods CR, et al. Lactobacillus sepsis associated with probiotic therapy. Pediatrics 2005;115:178-81.
  9. De Groote MA, Frank DN, Dowell E, et al. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatr Infect Dis J 2005;24:278-80. PubMed
  10. Vahabnezhad E, Mochon AB, Wozniak LJ, Ziring DA. Lactobacillus bacteremia associated with probiotic use in a pediatric patient with ulcerative colitis. J Clin Gastroenterol. 2013;47(5):437-9. PubMed
  11. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  12. Sendil S, Shrimanker I, Mansoora Q, Goldman J, Nookala VK. Lactobacillus rhamnosus bacteremia in an immunocompromised renal transplant patient. Cureus. 2020;12(2):e6887. PubMed
  13. Albarillo FS, Shah U, Joyce C, Slade D. Lactobacillus rhamnosus Infection: A single-center 4-year descriptive analysis. J Glob Infect Dis. 2020;12(3):119-123. PubMed
  14. Pasala S, Singer L, Arshad T, Roach K. Lactobacillus endocarditis in a healthy patient with probiotic use. IDCases. 2020;22:e00915. PubMed
  15. Agrawal S, Tuchman ES, Bruce MJ, Theodorou ME. Fatal Lactobacillus endocarditis in a patient with transcatheter aortic valve replacement. BMJ Case Rep. 2020;13(11):e236835.
  16. Antoun M, Hattab Y, Akhrass FA, Hamilton LD. Uncommon pathogen, Lactobacillus, causing infective endocarditis: Case report and review. Case Rep Infect Dis. 2020;2020:8833948. PubMed
  17. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  18. Franko B, Vaillant M, Recule C, Vautrin E, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics. Med Mal Infect. 2013;43(4):171-3. PubMed
  19. Campbell RE, Miller A, Afroze A. Native valve endocarditis secondary to Lactobacillus paracasei bacteremia. Consultant. 2020;60(9):27-8. DOI
  20. Kato K, Funabashi N, Takaoka H, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics with advanced and severe bicuspid aortic valve stenosis complicated with diffuse left ventricular mid-layer fibrosis. Int J Cardiol. 2016;224:157-161. PubMed

See these in context on the Bacillus Coagulans monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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