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Dietary supplement

Ultimate Flora Colon Care Probiotic 80 Billion Ingredients & Drug Interactions

by Renew Life

Ultimate Flora Colon Care Probiotic 80 Billion label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ultimate Flora Colon Care Probiotic 80 Billion against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Ultimate Flora Colon Care Probiotic 80 Billion is a dietary supplement by Renew Life with 2 active ingredients.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Ultimate Flora Colon Care Probiotic 80 Billion by Renew Life

Ask about any prescription or over-the-counter medication and we check it for interactions with Ultimate Flora Colon Care Probiotic 80 Billion by Renew Life — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Ultimate Flora Colon Care Probiotic 80 Billion by Renew Life

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 12 active ingredients.
  • “Colon Care Probiotic Culture Blend” is a proprietary blend — the label gives one combined amount (241 mg) without saying how much of each component you get.
  • “Bifido Probiotic blend” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Lacto Probiotic blend” is a proprietary blend — the label doesn't break down how much of each component you get.

This product has 12 active ingredients — all live probiotic bacteria in various strains. The two main types are Lactobacillus and Bifidobacterium, each with several different strains grouped into blends.

These are beneficial bacteria that live in your digestive tract and are meant to help restore balance to your gut flora. The inactive ingredients are microcrystalline cellulose (a binder), the capsule itself, and medium chain triglycerides.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: relieve occasional constipation and support colon health.
  • We looked for evidence on: Constipation, Antibiotic-associated diarrhea, Clostridioides difficile infection, Irritable bowel syndrome (IBS), Inflammatory bowel disease (IBD), Lactose intolerance — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Constipation, Inflammatory bowel disease (IBD), Radiation-induced diarrhea, Lactose intolerance, and more.

The Lactobacillus acidophilus strains in this product are rated possibly effective for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis, based on the evidence we hold. They're rated possibly ineffective for atopic disease, and there isn't enough reliable evidence to rate them for acute respiratory distress syndrome.

The effectiveness of the other bacterial strains in this blend hasn't been rated in our data.

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children. Some people taking Lactobacillus acidophilus with other probiotics have reported uncommon gastrointestinal side effects like stomach discomfort, abdominal pain, indigestion, gas, bloating, diarrhea, vomiting, and burping.

In rare cases, these probiotic bacteria have been found in bloodstream infections and serious conditions, though this typically happens in people whose immune system is compromised and the bacteria traveled from somewhere else in the body. There's no pregnancy or breastfeeding safety data on file for these ingredients, so talk with your doctor or pharmacist for personalized advice if you're pregnant or breastfeeding.

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotic drugs, separate them from this probiotic by at least a few hours — antibiotics can kill the live beneficial bacteria before they have a chance to work. We couldn't check the interaction data for most of the other probiotic strains in this product, so use the medication checker on this page for your specific prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic is a good fit if you're dealing with IBS, antibiotic-related diarrhea, or similar digestive concerns and want to restore beneficial bacteria. If you take antibiotics, time your doses a few hours apart from this product so the antibiotic doesn't kill the live cultures.

Since we couldn't check most of the other bacterial strains, ask your pharmacist to review your specific medications before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 12 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 27, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ultimate Flora Colon Care Probiotic 80 Billion, straight from the product label.

Brand Renew Life
Net contents 30 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jul 27, 2021
DSLD ID 250865
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ultimate Flora Colon Care Probiotic 80 Billion by Renew Life, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
IngredientAmount% DV
Lactobacillus acidophilus NCFM0 NP--
Bifidobacterium lactis HN0190 NP--
Lactobacillus plantarum Lp-1150 NP--
Lactobacillus rhamnosus GG0 NP--
Bifidobacterium lactis BI-040 NP--
Bifidobacterium infantis Bi-260 NP--
Lactobacillus casei Lc-110 NP--
Lactobacillus brevis Lbr-350 NP--
Colon Care Probiotic Culture Blend241 mg--
Bifidobacterium lactis Bi-070 NP--
Lactobacillus paracasei Lpc-370 NP--
Lactobacillus acidophillus La-140 NP--
Lactococcus lactis Ll-230 NP--
Bifido Probiotic blend0 NP--
Lacto Probiotic blend0 NP--

Other ingredients: Microcrystalline Cellulose, Capsule, Medium Chain Triglycerides

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

#1 Most studied strain More clinically studied strains than the leading brand Relieves occasional constipation

Potency, quality and purity guaranteed through expiration

Made in the USA of global ingredients.

At Renew Life, we are 100% devoted to your well-being. That's why we use more clinically studied strains than the leading brand. For over 20 years, Renew Life has been a pioneer in gut wellness.

We've improved Renew Life probiotics with world-class strains to help your natural rhythms thrive. Inside, you can find: - Digestive and immune health support - The #1 most-studied probiotic strain - A Non-GMO Project Verified formula - Smaller, easier-to-swallow capsules - And a recyclable bottle

We don't compromise on quality, you trust us with your health and we take that seriously, which is why Renew Life Colon Care probiotic guarantees: - A formula containing world-class strains backed by science - Potency through expiration - A blend of 12 different strains to support digestive and immune health - Delayed-release capsules that help the probiotics reach your gut alive

Non GMO

A gluten, dairy and soy-free formula

Formula

80 Billion live cultures 12 Probiotic strains

FDA Statement of Identity

Probiotic Supplement

Seals/Symbols

Non GMO Project Verified nongmoproject.org

Suggested/Recommended/Usage/Directions

Directions: For best results, take one (1) capsule daily, with or without food.

Storage

Store at 77 degrees Fahrenheit (25 degrees Celsius) or below. Best if refrigerated.

Precautions

Keep out of reach of children.

Consult your physician prior to using this or any product if you are pregnant, nursing, taking any medication or have a medical condition.

Brand IP Statement(s)

Copyright 2019 Patents: www.renewlife.com/patents

General Statements

Our guarantee We stand by our products. Visit renewlife.com/customer-service for our 60-day satisfaction guarantee.

L. rhamnosus GG strain, PubMed Clinical Trials

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ultimate Flora Colon Care Probiotic 80 Billion by Renew Life label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ultimate Flora Colon Care Probiotic 80 Billion label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ultimate Flora Colon Care Probiotic 80 Billion by Renew Life

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Colon Care Probiotic Culture Blend

241 mg per serving
  • › Bifido Probiotic blend
  • › Lacto Probiotic blend

Other (inactive) ingredients: Microcrystalline Cellulose, Capsule, Medium Chain Triglycerides. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ultimate Flora Colon Care Probiotic 80 Billion by Renew Life Drug Interactions

Want to check YOUR meds against Ultimate Flora Colon Care Probiotic 80 Billion?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Individual Drug Interactions

The ingredients in Ultimate Flora Colon Care Probiotic 80 Billion interact with 182 drugs. Click any drug to see the details.

0 of the 2 ingredients in Ultimate Flora Colon Care Probiotic 80 Billion interact with drugs. Each result below shows which ingredient is responsible.

Each ingredient & the kinds of drugs it affects

For each ingredient in Ultimate Flora Colon Care Probiotic 80 Billion with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

The maker

Brand information

Manufacturer and brand details for Ultimate Flora Colon Care Probiotic 80 Billion, from the product label.

Renew Life

Name
Renew Life Formulas, Inc.
City
Palm Harbor
State
FL
ZipCode
34683
Phone Number
1-800-830-1800
Web Address
www.renewlife.com
Pharmacist Counseling Corner

Ultimate Flora Colon Care Probiotic 80 Billion by Renew Life: Common Questions

Does Ultimate Flora Colon Care Probiotic 80 Billion by Renew Life interact with any medications?
Yes. Based on its ingredients, Ultimate Flora Colon Care Probiotic 80 Billion has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ultimate Flora Colon Care Probiotic 80 Billion contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this probiotic work if I'm taking antibiotics?
It'll work better if you separate them. Since antibiotics kill bacteria — the good ones included — taking them at the same time as your probiotic can reduce how well the probiotic does its job. Space them out by a few hours if you can, and talk to your pharmacist about the best timing for your specific antibiotic.
What are these probiotic strains for?
The Lactobacillus and Bifidobacterium strains here are meant to restore healthy bacteria in your gut and colon. They're possibly effective for IBS, antibiotic-associated diarrhea, bacterial vaginosis, and Helicobacter pylori infection, based on the evidence we have.
Can I take this if I'm pregnant or breastfeeding?
We don't have safety data on file for these probiotic strains during pregnancy or breastfeeding. Talk with your doctor or pharmacist — they can give you personalized advice based on your situation.
What side effects might I notice?
Most people tolerate this well, but some experience uncommon digestive upset like gas, bloating, stomach discomfort, or loose stools when first taking probiotics with other strains. These usually settle down. Rash or itching has been reported very rarely in clinical trials, though it wasn't clear if the probiotic or another ingredient caused it.
How many live bacteria am I getting per dose?
The name says 80 billion, which refers to the total CFU count of the live organisms in each capsule. That's a substantial dose of beneficial bacteria.
Is this safe for kids?
Lactobacillus acidophilus is generally well tolerated in children. For the other strains and for your child's individual situation, check with your pediatrician or pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ultimate Flora Colon Care Probiotic 80 Billion label
Sources

Sources & How We Checked

Ultimate Flora Colon Care Probiotic 80 Billion's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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