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Dietary supplement

Centered Mind Ingredients & Drug Interactions

by Pure Prescriptions

Centered Mind label
See full label image
Capsule Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Centered Mind against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Centered Mind is a dietary supplement by Pure Prescriptions with 2 active ingredients. Its ingredients are commonly taken for immune support, fatigue and general well-being, stress and sleep.Based on those ingredients, 747 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are AlphaWave, Reishi Mushroom extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Centered Mind by Pure Prescriptions

Ask about any prescription or over-the-counter medication and we check it for interactions with Centered Mind by Pure Prescriptions — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Centered Mind by Pure Prescriptions

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Centered Mind has two active ingredients. Reishi mushroom extract is a fungal product used in traditional medicine for relaxation and immune support.

Theanine (branded here as AlphaWave) is an amino acid naturally found in tea leaves, included for its potential to support focus and calm without drowsiness. The capsule also contains inactive ingredients — hypromellose, silicon dioxide, stearic acid, and microcrystalline cellulose — which are standard binders and fillers.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: focus and relaxation without drowsiness.
  • We looked for evidence on: Attention deficit-hyperactivity disorder (ADHD), Cognitive function, Cognitive impairment, Generalized anxiety disorder (GAD), Stress, Insomnia — and 4 related terms.
  • The strongest evidence on file: Theanine is rated "Possibly Effective" for Cognitive function (Natural Medicines).
  • Also on file: Reishi Mushroom is rated "Insufficient Reliable Evidence To Rate" for Insomnia, Stress, Psychological well-being.
  • Also on file: Theanine is rated "Insufficient Reliable Evidence To Rate" for Generalized anxiety disorder (GAD), Attention deficit-hyperactivity disorder (ADHD), Cognitive impairment.

The evidence for these ingredients is mixed. Theanine is rated Possibly Effective for cognitive function — it may help with focus and mental clarity.

For reishi mushroom, the data is thinner: it's rated Possibly Ineffective for cholesterol, and there's Insufficient Evidence for altitude sickness, Alzheimer's disease, and athletic performance. If you're looking for cognitive support, theanine has some backing; reishi's specific benefits here aren't well established in the data we hold.

The evidence, ingredient by ingredient Reishi Mushroom Theanine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both reishi and theanine are generally well tolerated when used short-term. Reishi may cause dizziness, dry mouth, itching, nausea, rash, stomach upset, sore throat, or runny nose — and rarely, insomnia or headache.

Some people can develop a respiratory allergy to reishi spores. Theanine may cause headaches, drowsiness, or increased dream activity.

Neither ingredient has enough safety data in pregnancy or while breastfeeding — the safety data advises against both in those situations.

Side effects, ingredient by ingredient Reishi Mushroom Theanine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Reishi Mushroom, Theanine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 747 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Centered Mind, double-check these medication types with your pharmacist or the search tool below: blood pressure medication (Moderate risk from both ingredients), blood thinners or aspirin-like drugs (Moderate risk from reishi at higher doses), diabetes medication (Moderate risk from reishi), and sedatives or CNS depressants (Minor risk from theanine). Also mention any antidepressants that work on serotonin (Minor risk from theanine, though no serotonin syndrome cases have been reported).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you take blood pressure medication, diabetes medication, blood thinners, or sedatives, check your exact drugs with the tool below before starting Centered Mind. If you're pregnant or breastfeeding, talk to your pharmacist or doctor first — there isn't enough data to recommend either ingredient in those situations.

Both ingredients are generally well tolerated for short-term use, but we don't know much about using them long-term.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Centered Mind, straight from the product label.

Brand Pure Prescriptions
Barcode (UPC) 852980001627
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Aug 22, 2024
DSLD ID 317092
Product type Botanical With Nutrients
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Centered Mind by Pure Prescriptions, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
852980001627
IngredientAmount% DV
Reishi Mushroom extract700 mg--
AlphaWave200 mg--

Other ingredients: Hypromellose, Silicon Dioxide, Stearic Acid, Microcrystalline Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

L-theanine triggers the release of alpha brain waves, which has shown to enhance relaxation, focus, and creativity. Combined with Reishi, this powerful mushroom works as an adptogen, helping to balance hormones and the body's stress responses.

Centered Mind featuring: Organic Reishi Mushroom + L-Theanine

Suggested/Recommended/Usage/Directions

Directions: Adults take as a dietary supplement, 2 capsules per day, with food or as directed by your healthcare provider.

Precautions

Read first: Keep out of reach of children.

Consult with your doctor if you are pregnant or nursing.

Storage

Store in a cool, dry place.

General Statements

Natural Health Solutions

Formulation

Professional grade For the support of concentration without drowsiness

Centered Mind featuring: Organic Reishi Mushroom + L-Theanine

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Centered Mind by Pure Prescriptions label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Centered Mind label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Centered Mind by Pure Prescriptions

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Reishi Mushroom extract

Interacts with
375 drugs
700 mg per serving

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits...

Reishi Mushroom extract monograph & interactions

AlphaWave

Interacts with
565 drugs
200 mg per serving Form: L-Theanine

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong dro...

AlphaWave monograph & interactions

Other (inactive) ingredients: Hypromellose, Silicon Dioxide, Stearic Acid, Microcrystalline Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Centered Mind by Pure Prescriptions Drug Interactions

Want to check YOUR meds against Centered Mind?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
747Drugs
375 Moderate 372 Minor

Ingredients driving the most interactions

AlphaWave 565
Reishi Mushroom extract 375

Individual Drug Interactions

The ingredients in Centered Mind interact with 747 drugs. Click any drug to see the details.

2 of the 2 ingredients in Centered Mind interact with drugs. Each result below shows which ingredient is responsible. AlphaWave Reishi Mushroom extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Centered Mind with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

AlphaWave3 drug types · 565 drugs

Antihypertensive Drugs

Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.
Animal research shows that theanine can lower blood pressure in spontaneously hypertensive animals. Theoretically, concomitant use of theanine and antihypertensive drugs might potentiate the antihypertensive activity.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Theoretically, theanine may compete with glutamate and/or increase plasma gamma-aminobutyric acid (GABA) levels, which could cause CNS depression. In one clinical study, some subjects taking oral theanine reported drowsiness.

Likelihood Unlikely Evidence D
Serotonergic Drugs

Clinical studies regarding the effects of L-theanine on serotonin levels are conflicting. Some studies suggest it can increase serotonin levels in the brain while others report that it may decrease them. Nevertheless, there have been no reports of l-theanine being a causative agent in serotonergic-related side effects or serotonin syndrome.

Likelihood Unlikely Evidence C
AlphaWave full monograph & interactions

Reishi Mushroom extract3 drug types · 375 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
A dose of 1.5 grams daily of reishi mushroom does not seem to decrease platelet aggregation, but a higher dose of 3 grams daily does.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Animal research suggests that reishi mushroom decreases blood sugar. However, in patients with type 2 diabetes, taking reishi mushroom does not reduce fasting glucose levels, and its effects on glycated hemoglobin are inconsistent.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Reishi mushroom has shown hypotensive activity in animal research. Clinical evidence suggests that reishi mushroom reduces blood pressure in some, but not all, patients with hypertension.

Likelihood Possible Evidence D
Reishi Mushroom extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Centered Mind, from the product label.

Pure Prescriptions

See all Pure Prescriptions products
Name
Pure Prescriptions, Inc.
Street Address
5670 El Camino Real, Suite D
City
Carlsbad
State
CA
ZipCode
92008
Phone Number
1.800.860.9583
Web Address
www.PurePrescriptions.com
Pharmacist Counseling Corner

Centered Mind by Pure Prescriptions: Common Questions

Does Centered Mind by Pure Prescriptions interact with any medications?
Yes. Based on its ingredients, Centered Mind has a known interaction with 747 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Centered Mind contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does reishi mushroom do?
Reishi is a fungal extract traditionally used for relaxation and immune support. The evidence that it's effective for specific conditions like cholesterol or altitude sickness is weak or absent in our data.
What's theanine, and how does it differ from caffeine?
Theanine is an amino acid from tea that's included for mental focus and calm. Unlike caffeine, it doesn't typically cause jitters or energy crashes — in fact, it may cause mild drowsiness in some people.
Can I take Centered Mind if I'm pregnant?
Neither reishi nor theanine has enough safety data in pregnancy. The safety data advises against both during pregnancy. Talk to your pharmacist or doctor to decide what's right for you.
What side effects should I watch for?
The most common are dizziness, dry mouth, nausea, headaches, and drowsiness. Reishi can also cause itching, rash, stomach upset, or sore throat. Respiratory allergies to reishi spores are possible but less common.
Is this product safe long-term?
Both reishi and theanine are generally well tolerated for short-term use, but long-term safety hasn't been well studied for either one. If you plan to take it regularly, ask your pharmacist.
Does Centered Mind contain any fillers or other inactive ingredients?
Yes — the capsule contains hypromellose, silicon dioxide, stearic acid, and microcrystalline cellulose as inactive ingredients to hold and protect the active ingredients.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Centered Mind label
Go deeper

The Full Monographs Behind Centered Mind’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Reishi Mushroom

Interacts with 375 drugs

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits is limited or low-quality, so it should...

Read the full Reishi Mushroom monograph → Herb & supplement monograph

Theanine

Interacts with 565 drugs

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong drowsiness. Early research suggests it may...

Read the full Theanine monograph →
Sources

Sources & How We Checked

Centered Mind's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 23 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Reishi Mushroom 17 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Tao J, Feng KY. Experimental and clinical studies on inhibitory effect of ganoderma lucidum on platelet aggregation. J Tongji Med Univ 1990;10:240-3. PubMed
  3. Singh AB, Gupta SK, Pereira BM, Prakash D. Sensitization to Ganoderma lucidum in patients with respiratory allergy in India. Clin Exp Allergy 1995;25:440-7.
  4. Lee SY, Rhee HM. Cardiovascular effects of mycelium extract of Ganoderma lucidum: inhibition of sympathetic outflow as a mechanism of its hypotensive action. Chem Pharm Bull (Tokyo) 1990;38:1359-64. PubMed
  5. Kwok Y, Ng KFJ, Li, CCF, et al. A prospective, randomized, double-blind, placebo-controlled study of the platelet and global hemostatic effects of Ganoderma lucidum (Ling-Zhi) in healthy volunteers. Anesth Analg 2005;101:423-6. PubMed
  6. Wanmuang, H., Leopairut, J., Kositchaiwat, C., Wananukul, W., and Bunyaratvej, S. Fatal fulminant hepatitis associated with Ganoderma lucidum (Lingzhi) mushroom powder. J Med Assoc Thai. 2007;90(1):179-181.
  7. Seto, S. W., Lam, T. Y., Tam, H. L., Au, A. L., Chan, S. W., Wu, J. H., Yu, P. H., Leung, G. P., Ngai, S. M., Yeung, J. H., Leung, P. S., Lee, S. M., and Kwan, Y. W. Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db
  8. Chu, T. T., Benzie, I. F., Lam, C. W., Fok, B. S., Lee, K. K., and Tomlinson, B. Study of potential cardioprotective effects of Ganoderma lucidum (Lingzhi): results of a controlled human intervention trial. Br.J.Nutr. 2012;107(7):1017-1027.
  9. Jin, X., Ruiz, Beguerie J., Sze, D. M., and Chan, G. C. Ganoderma lucidum (Reishi mushroom) for cancer treatment. Cochrane.Database.Syst.Rev. 2012;6:CD007731.
  10. Kabir, Y., Kimura, S., and Tamura, T. Dietary effect of Ganoderma lucidum mushroom on blood pressure and lipid levels in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol.(Tokyo) 1988;34(4):433-438. PubMed
  11. Kanmatsuse, K., Kajiwara, N., Hayashi, K., Shimogaichi, S., Fukinbara, I., Ishikawa, H., and Tamura, T. [Studies on Ganoderma lucidum. I. Efficacy against hypertension and side effects]. Yakugaku Zasshi 1985;105(10):942-947. PubMed
  12. Gao, Y., Lan, J., Dai, X., Ye, J., and Zhou, S. A Phase I/II Study of Ling Zhi Mushroom Ganoderma lucidum(W.Curt: Fr.) Lloyd (Aphyllophoromycetideae) Extract in Patients with Type II Diabetes Mellitus. International Journal of Medicinal Mushrooms 2004;6. DOI
  13. Jin H, Zhang G, Cao X, and et al. Treatment of hypertension by linzhi combined with hypotensor and its effects on arterial, arteriolar and capillary pressure and microcirculation. In: Niimi H, Xiu RJ, Sawada T, and et al. Microcirculatory Approach to Asi
  14. Klupp NL, Chang D, Hawke F, Kiat H, Cao H, Grant SJ, Bensoussan A. Ganoderma lucidum mushroom for the treatment of cardiovascular risk factors. Cochrane Database Syst Rev. 2015 Feb 17;2:CD007259. PubMed
  15. Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X. Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial. Evid Based Complement Alternat Med. 2012;2012:809614.
  16. Pazzi F, Adsuar JC, Domínguez-Muñoz FJ, García-Gordillo MA, Gusi N, Collado-Mateo D. Ganoderma lucidum effects on mood and health-related quality of life in women with fibromyalgia. Healthcare (Basel) 2020;8(4):520. PubMed
  17. Kogure T, Koiwai A, Fukushi D, et al. Hypereosinophilia with hepatic nodule formation caused by Ganoderma lucidum. Intern Med 2021;60(24):3897-3903.

See these in context on the Reishi Mushroom monograph →

Theanine 6 references
  1. Yokogoshi H, Kobayashi M. Hypotensive effect of gamma-glutamylethylamide in spontaneously hypertensive rats. Life Sci 1998;62:1065-8.
  2. Haskell, C. F., Kennedy, D. O., Milne, A. L., Wesnes, K. A., and Scholey, A. B. The effects of L-theanine, caffeine and their combination on cognition and mood. Biol.Psychol. 2008;77(2):113-122. PubMed
  3. Yokogoshi, H., Kato, Y., Sagesaka, Y. M., Takihara-Matsuura, T., Kakuda, T., and Takeuchi, N. Reduction effect of theanine on blood pressure and brain 5-hydroxyindoles in spontaneously hypertensive rats. Biosci.Biotechnol.Biochem. 1995;59(4):615-618. PubMed
  4. Lyon MR, Kapoor MP, Juneja LR. The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial. Altern Med Rev. 2011;16(4):348-
  5. Hidese S, Ota M, Wakabayashi C, et al. Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study. Acta Neuropsychiatr 2017;29(2):72-9.
  6. Tsuchiya T, Honda H, Oikawa M, et al. Oral administration of the amino acids cystine and theanine attenuates the adverse events of S-1 adjuvant chemotherapy in gastrointestinal cancer patients. Int J Clin Oncol 2016;21(6):1085-90. PubMed

See these in context on the Theanine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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