Interactions on record — worth a quick check against your medications. Based on 9 of 13 ingredients. Check your meds →
Dietary supplement

Ultra Natural Prostate Ingredients & Drug Interactions

by Life Extension

Ultra Natural Prostate label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ultra Natural Prostate against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Ultra Natural Prostate is a dietary supplement by Life Extension with 13 active ingredients. Its ingredients are commonly taken for high cholesterol, enlarged prostate (bph), heart health.Based on those ingredients, 616 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Flax (seed) Lignan extracts, Saw Palmetto CO2 extract, Dwarf Nettle extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Ultra Natural Prostate by Life Extension

Ask about any prescription or over-the-counter medication and we check it for interactions with Ultra Natural Prostate by Life Extension — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Ultra Natural Prostate by Life Extension

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 9 of its 13 active ingredients.
  • “Proprietary Enterolactone Precursors Blend” is a proprietary blend — the label gives one combined amount (20.15 mg) without saying how much of each component you get.
  • “Saw Palmetto CO2 extract” is listed as a grouped ingredient — the label gives one combined amount (320 mg) without saying how much of each component you get.
  • “Stinging And Dwarf Nettle Extracts Blend” is a proprietary blend — the label gives one combined amount (240 mg) without saying how much of each component you get.

Ultra Natural Prostate contains 13 active ingredients focused on prostate and urinary health. The main components include beta-sitosterol (a plant sterol for benign prostate enlargement), pygeum extract (African cherry bark), lycopene (a carotenoid from tomatoes), two nettle extracts, pumpkin seed oil, boron, and frankincense extract.

You'll also find proprietary blends of enterolactone precursors, fatty acids, and saw palmetto—plus flower pollen extract and lignan compounds from Norway spruce and flax seed. The softgels are filled with inactive ingredients like gelatin, sunflower oil, and glycerin.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: prostate health and urinary function support.
  • We looked for evidence on: Benign prostatic hyperplasia (BPH), Non-neurogenic lower urinary tract symptoms (LUTS), Chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS), Prostate enlargement, Urinary flow, Prostate inflammation.
  • The strongest evidence on file: Pygeum is rated "Likely Effective" for Benign prostatic hyperplasia (BPH) (Natural Medicines).
  • Also on file: Beta-sitosterol is rated "Likely Effective" for Benign prostatic hyperplasia (BPH).
  • Also on file: Pumpkin is rated "Possibly Effective" for Benign prostatic hyperplasia (BPH).

Beta-sitosterol is likely effective for benign prostate hyperplasia (BPH)—that's enlarged prostate—and possibly effective for high cholesterol and heart disease. Pygeum extract is also likely effective for BPH.

Lycopene is possibly effective for prostate cancer prevention. Pumpkin seed oil is possibly effective for BPH.

For the other ingredients in this product—nettle, boron, and the proprietary blends—the evidence in our data is either insufficient to rate or shows possibly ineffective results. Talk with your doctor about whether this formula targets your specific concern.

The evidence, ingredient by ingredient Beta-sitosterol Pygeum Boron Lycopene Flaxseed Saw Palmetto Stinging Nettle Frankincense

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most active ingredients in this product are generally well tolerated when used as directed. Beta-sitosterol, pygeum, nettle, and pumpkin seed commonly cause mild gastrointestinal side effects like gas, diarrhea, or constipation.

Boron is safe at low doses but can be toxic at high amounts. Lycopene supplements may cause similar digestive upset.

One rare case linked lycopene to chest pain in a pregnant woman, and a handful of cases have reported liver issues or severe nausea with certain herbal products containing nettle. Avoid this product during pregnancy—beta-sitosterol, pygeum, boron, and nettle all lack adequate safety data in pregnancy, and boron in high amounts may harm the fetus.

Similarly, safety during breastfeeding is not established for most of these ingredients, so check with your doctor first.

Side effects, ingredient by ingredient Beta-sitosterol Pygeum Boron Lycopene Flaxseed Saw Palmetto Stinging Nettle Frankincense

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 7 matched ingredients can interact with medications — Lycopene, Stinging Nettle, Pumpkin, Flaxseed.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 605 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting Ultra Natural Prostate, check your medications against these types: blood thinners and blood-clotting drugs (moderate interaction with lycopene and nettle), diabetes medications (moderate), water pills or diuretics (moderate), and lithium (moderate). These four drug categories interact at Moderate severity with ingredients in this product.

No interactions are documented for the data we hold on several other ingredients.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a multi-ingredient prostate supplement aimed at BPH and urinary health, with beta-sitosterol and pygeum as the most evidence-backed components. If you take a blood thinner, diabetes medication, water pill, or lithium, you need to verify your specific medications before starting—nettle and pumpkin are particular concerns.

Pregnant or nursing women should avoid it. Talk to your pharmacist before adding it to your routine, especially if you're on any prescription medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 13 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ultra Natural Prostate, straight from the product label.

Brand Life Extension
Barcode (UPC) 737870189862
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Jun 24, 2016
DSLD ID 60789
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult Male (18-50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ultra Natural Prostate by Life Extension, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
30
UPC/BARCODE
737870189862
IngredientAmount% DV
Phospholipids160 mg--
Beta-Sitosterol180 mg--
Pygeum extract100 mg--
Boron3 mg--
Lycopene10 mg--
Proprietary Enterolactone Precursors Blend20.15 mg--
Total Fatty Acids272 mg--
Saw Palmetto CO2 extract320 mg--
Stinging And Dwarf Nettle Extracts Blend240 mg--
Dwarf Nettle extract0 NP--
Graminex Flower Pollen extract252 mg--
AprèsFlex Indian Frankincense (Boswellia serrata) extract70 mg--
AKBA14 mg--
Pumpkin seed Oil200 mg--
Stinging (Nettle extract)0 NP--
HMRlignan Norway Spruce (Picea abies) (knot wood) extract0 NP--
Flax (seed) Lignan extracts0 NP--

Other ingredients: Gelatin, Sunflower Oil, Glycerin, Soy Lecithin, Medium Chain Triglycerides, purified Water, Carob color, Maltodextrin, Beeswax, Rosemary extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Scan for product info

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Comprehensive Support for Aging Prostate Glands

General

QE01898B

Suggested/Recommended/Usage/Directions

Read the entire label and follow the directions carefully prior to use. Directions: Take two (2) softgels daily divided between morning and evening, with or without food, or as recommended by a healthcare practitioner.

Storage

Store tightly closed in a cool, dry place.

Precautions

Warnings: - Keep out of reach of children.

- Do not exceed recommended dose. - Do not purchase if outer seal is broken or damaged.

- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

Contains soybeans.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

ApresFlex is a registered trademark of Laila Nutraceuticals exclusively licensed to PL Thomas – Laila Nutra LLC. U.S. Patent No. 8,551,496 and other patents pending. HMRlignan is a trademark used under sublicense from Linnea S.A. Albion is a registered trademark of Albion Laboratories, Inc.

FDA Statement of Identity

Dietary Supplement

Formula

Contains soybeans.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ultra Natural Prostate by Life Extension label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ultra Natural Prostate label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ultra Natural Prostate by Life Extension

These are the 13 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Phospholipids

160 mg per serving

Beta-Sitosterol

No known
interactions
180 mg per serving

Beta-sitosterol is a plant sterol that may modestly lower LDL ('bad') cholesterol and may help ease urinary symptoms from an enlarged prostate. Eviden...

Beta-Sitosterol monograph & interactions

Pygeum extract

No known
interactions
100 mg per serving

Pygeum is an extract from the bark of the African cherry tree that is most often used to ease urinary symptoms linked to an enlarged prostate. Some st...

Pygeum extract monograph & interactions

Boron

No known
interactions
3 mg per serving Form: Albion Bororganic Glycine

Boron is a trace mineral found in many plant foods and sold as a supplement, mainly promoted for bone, joint, and hormone health. The human evidence f...

Boron monograph & interactions

Lycopene

Interacts with
122 drugs
10 mg per serving Form: natural Tomato extract

Lycopene is a red plant pigment and antioxidant found mainly in tomatoes and other red fruits. Eating lycopene-rich foods is linked with possible hear...

Lycopene monograph & interactions

Proprietary Enterolactone Precursors Blend

20.15 mg per serving

Saw Palmetto CO2 extract

Interacts with
174 drugs
320 mg per serving

Saw palmetto is a plant extract most often used for urinary symptoms linked to an enlarged prostate (BPH). The best research suggests it works no bett...

Saw Palmetto CO2 extract monograph & interactions
  • › Total Fatty Acids

Stinging And Dwarf Nettle Extracts Blend

240 mg per serving

Graminex Flower Pollen extract

252 mg per serving Form: Rye

AprèsFlex Indian Frankincense (Boswellia serrata) extract

No known
interactions
70 mg per serving

Frankincense is the aromatic resin of the Boswellia tree and is best known for its boswellic acids, which may help with inflammation and joint pain. E...

AprèsFlex Indian Frankincense (Boswellia serrata) extract monograph & interactions
  • › AKBA

Pumpkin seed Oil

Interacts with
1 drug
200 mg per serving

Pumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The...

Pumpkin seed Oil monograph & interactions

Other (inactive) ingredients: Gelatin, Sunflower Oil, Glycerin, Soy Lecithin, Medium Chain Triglycerides, Purified Water, Carob color, Maltodextrin, Beeswax, Rosemary extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ultra Natural Prostate by Life Extension Drug Interactions

Want to check YOUR meds against Ultra Natural Prostate?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
616Drugs
616 Moderate

Ingredients driving the most interactions

Flax (seed) Lignan extracts 597
Saw Palmetto CO2 extract 174
Dwarf Nettle extract 164
Lycopene 122
Pumpkin seed Oil 1

Individual Drug Interactions

The ingredients in Ultra Natural Prostate interact with 616 drugs. Click any drug to see the details.

5 of the 13 ingredients in Ultra Natural Prostate interact with drugs. Each result below shows which ingredient is responsible. Flax (seed) Lignan extracts Saw Palmetto CO2 extract Dwarf Nettle extract Lycopene Pumpkin seed Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Ultra Natural Prostate with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Flax (seed) Lignan extracts5 drug types · 597 drugs

Antibiotic Drugs

Theoretically, antibiotics might interfere with the metabolism of flaxseed constituents, which could potentially alter the effects of flaxseed.
Some potential benefits of flaxseed are thought to be due to its lignan content. Secoisolariciresinol diglucoside (SDG), a major lignan precursor, is found in high concentrations in flaxseed. SDG is converted by bacteria in the colon to the lignans enterolactone and enterodiol. Antibiotics alter the flora of the colon, which could theoretically alter the metabolism of flaxseed.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, using flaxseed in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Some clinical evidence suggests that the oil contained in flaxseed can decrease platelet aggregation.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, flaxseed might have additive effects when used with antidiabetes drugs and increase the risk for hypoglycemia.
Some clinical research suggests that flaxseed can lower blood glucose levels.

Likelihood Probable Evidence B
Antihypertensive Drugs

Theoretically, flaxseed might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Clinical research shows that daily flaxseed consumption, especially for longer than 12 weeks, modestly reduces blood pressure.

Likelihood Possible Evidence D
Estrogens

Theoretically, taking flaxseed might decrease the effects of estrogens.
Flaxseed contains lignans with mild estrogenic and possible antiestrogenic effects. The lignans seem to compete with circulating endogenous estrogen and might reduce estrogen binding to estrogen receptors, resulting in an anti-estrogen effect. It is unclear if this effect transfers to exogenously administered estrogens.

Likelihood Possible Evidence D
Flax (seed) Lignan extracts full monograph & interactions

Saw Palmetto CO2 extract3 drug types · 174 drugs

Anticoagulant/Antiplatelet Drugs

Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Saw palmetto is reported to prolong bleeding time. Theoretically, it might increase the risk of bleeding when used concomitantly with anticoagulant or antiplatelet drugs.

Likelihood Possible Evidence D
Contraceptive Drugs

Saw palmetto might reduce the effectiveness of contraceptive drugs.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with contraceptive drugs taken concomitantly.

Likelihood Possible Evidence B
Estrogens

Saw palmetto might reduce the effectiveness of estrogens.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with estrogens taken concomitantly.

Likelihood Possible Evidence B
Saw Palmetto CO2 extract full monograph & interactions

Dwarf Nettle extract4 drug types · 164 drugs

Antidiabetes Drugs

Theoretically, stinging nettle might have additive effects with antidiabetes drugs.
Clinical research shows that stinging nettle might decrease blood glucose levels in patients with diabetes.

Likelihood Possible Evidence B
Diuretic Drugs

Theoretically, combining stinging nettle with diuretic drugs may have additive effects.
Animal research suggests that the above ground parts and roots of stinging nettle may have a diuretic effect.

Likelihood Possible Evidence D
Lithium

Theoretically, stinging nettle might reduce excretion and increase levels of lithium.
Animal research suggests that stinging nettle has diuretic and natriuretic properties, which could alter the excretion of lithium. The dose of lithium might need to be decreased.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is some concern that stinging nettle might decrease the effects of anticoagulant drugs such as warfarin.
Stinging nettle contains a significant amount of vitamin K. When taken in large quantities, this might interfere with the activity of warfarin.

Likelihood Possible Evidence D
Dwarf Nettle extract full monograph & interactions

Lycopene1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
In vitro research shows that lycopene has antiplatelet effects.

Likelihood Possible Evidence D
Lycopene full monograph & interactions

Pumpkin seed Oil1 drug type · 1 drug

Lithium

Pumpkin might reduce excretion and increase levels of lithium.
Pumpkin is thought to have diuretic properties. Theoretically, this might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Pumpkin seed Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Ultra Natural Prostate, from the product label.

Life Extension

See all Life Extension products
Name
Quality Supplements and Vitamins, Inc.
City
Ft. Lauderdale
State
FL
ZipCode
33309
Phone Number
1-866-280-2852
Web Address
LifeExtension.com
Pharmacist Counseling Corner

Ultra Natural Prostate by Life Extension: Common Questions

Does Ultra Natural Prostate by Life Extension interact with any medications?
Yes. Based on its ingredients, Ultra Natural Prostate has a known interaction with 616 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ultra Natural Prostate contains 13 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on a blood thinner like warfarin?
Not without checking with your pharmacist first. The nettle extracts in this product contain vitamin K, which can interfere with warfarin's effectiveness. Lycopene may also increase bleeding risk with blood thinners. Your doctor may need to adjust your dose or monitor you more closely.
Is it safe to take while pregnant?
No. Beta-sitosterol, pygeum, boron, and nettle all lack adequate safety data in pregnancy. Boron at high doses may harm the fetus. Avoid this product unless your doctor specifically advises otherwise.
What does beta-sitosterol actually do?
It's a plant sterol that's likely effective for benign prostate hyperplasia—that enlarged prostate condition that causes trouble with urinating. It's also possibly helpful for high cholesterol and heart health.
What are the most common side effects?
Mild digestive issues: gas, diarrhea, constipation, and indigestion are the most common. These typically happen with several of the ingredients in this blend, especially beta-sitosterol and nettle.
Will this work for prostate cancer?
Lycopene in this product is possibly effective for prostate cancer prevention, but the evidence isn't strong. This isn't a cancer treatment—it's a supplement for prostate health and BPH. Talk to your oncologist if you're dealing with cancer.
Can I take this if I'm on diabetes medication?
Possibly, but you need to check first. The nettle extracts may lower blood sugar, so taking them alongside diabetes drugs could cause your blood sugar to drop too low. Your doctor or pharmacist can advise whether it's safe for you and whether your dose needs adjusting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Ultra Natural Prostate is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ultra Natural Prostate label
Go deeper

The Full Monographs Behind Ultra Natural Prostate’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Beta-sitosterol

Beta-sitosterol is a plant sterol that may modestly lower LDL ('bad') cholesterol and may help ease urinary symptoms from an enlarged prostate. Evidence is moderate for these uses and weaker...

Read the full Beta-sitosterol monograph → Herb & supplement monograph

Pygeum

Pygeum is an extract from the bark of the African cherry tree that is most often used to ease urinary symptoms linked to an enlarged prostate. Some studies suggest modest benefit for these s...

Read the full Pygeum monograph → Herb & supplement monograph

Boron

Boron is a trace mineral found in many plant foods and sold as a supplement, mainly promoted for bone, joint, and hormone health. The human evidence for most of these uses is limited or prel...

Read the full Boron monograph → Herb & supplement monograph

Lycopene

Interacts with 122 drugs

Lycopene is a red plant pigment and antioxidant found mainly in tomatoes and other red fruits. Eating lycopene-rich foods is linked with possible heart and prostate benefits, but evidence fr...

Read the full Lycopene monograph → Herb & supplement monograph

Flaxseed

Interacts with 597 drugs

Flaxseed is a nutritious food rich in fiber, omega-3 fats (ALA), and plant compounds called lignans. It is most reliably helpful for constipation and may modestly lower cholesterol, but evid...

Read the full Flaxseed monograph → Herb & supplement monograph

Saw Palmetto

Interacts with 174 drugs

Saw palmetto is a plant extract most often used for urinary symptoms linked to an enlarged prostate (BPH). The best research suggests it works no better than a placebo for most men, though i...

Read the full Saw Palmetto monograph → Herb & supplement monograph

Stinging Nettle

Interacts with 164 drugs

Stinging nettle is a common plant used as food and in traditional medicine, most often for prostate symptoms, allergies, and joint pain. The evidence is mixed and mostly preliminary, so it i...

Read the full Stinging Nettle monograph → Herb & supplement monograph

Frankincense

Frankincense is the aromatic resin of the Boswellia tree and is best known for its boswellic acids, which may help with inflammation and joint pain. Early research is promising for condition...

Read the full Frankincense monograph → Herb & supplement monograph

Pumpkin

Interacts with 1 drug

Pumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The evidence for these uses is limited and...

Read the full Pumpkin monograph →
Sources

Sources & How We Checked

Ultra Natural Prostate's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 115 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Beta-sitosterol 7 references
  1. Berges RR, Windeler J, Trampisch HJ, et al. Randomised, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia. Beta-sitosterol Study Group. Lancet 1995;345:1529-32.
  2. Klippel KF, Hiltl DM, Schipp B. A multicentric, placebo-controlled, double-blind clinical trial of beta-sitosterol (phytosterol) for the treatment of benign prostatic hyperplasia. Br J Urol 1997;80:427-32.
  3. Wilt TJ, MacDonald R, Ishani A. beta-sitosterol for the treatment of benign prostatic hyperplasia: a systematic review. BJU Int 1999;83:976-83. PubMed
  4. Oster P, Schlierf G, Heuck CC, et al. [Sitosterol in familial hyperlipoproteinemia type II. A randomized, double-blind, cross-over study]. Dtsch Med Wochenschr 1976;101:1308-11.
  5. Becker M, Staab D, Von Bergman K. Long-term treatment of severe familial hypercholesterolemia in children: effect of sitosterol and bezafibrate. Pediatrics 1992;89:138-42. DOI
  6. Prager N, Bickett K, French N, Marcovici G. A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia. J Altern Complement Med 2002
  7. Lorenze A, Hsueh W, Nasr J. Beta-sitosterol-induced acute pancreatitis: A case report and review of the literature. Cureus. 2020;12(3):e7407. PubMed

See these in context on the Beta-sitosterol monograph →

Pygeum 3 references
  1. Ishani A, MacDonald R, Nelson D, et al. Pygeum africanum for the treatment of patients with benign prostatic hyperplasia: a systematic review and quantitative meta-analysis. Am J Med 2000;109:654-64.. PubMed
  2. Wilt T, Ishani A, Mac Donald R, et al. Pygeum africanum for benign prostatic hyperplasia. Cochrane Database Syst Rev 2002;CD001044.. PubMed
  3. Andro M and Riffaud J. Pygeum africanum extract for the treatment of patients with benign prostatic hyperplasia: a review of 25 years of published experience. Curr Ther Res 1995;56(8):796-817. DOI

See these in context on the Pygeum monograph →

Boron 6 references
  1. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  3. Thai L, Hart LL. Boric acid vaginal suppositories. Ann Pharmacother 1993;27:1355-7.
  4. Acs N, Banhidy F, Puho E, Czeizel AE. Teratogenic effects of vaginal boric acid treatment during pregnancy. Int J Gynaecol Obstet 2006;93:55-6. PubMed
  5. Garabrant, D. H., Bernstein, L., Peters, J. M., and Smith, T. J. Respiratory and eye irritation from boron oxide and boric acid dusts. J Occup Med 1984;26(8):584-586. PubMed
  6. Hjelm C, Harari F, Vahter M. Pre- and postnatal environmental boron exposure and infant growth: results from a mother-child cohort in northern Argentina. Environ Res 2019;171:60-8. PubMed

See these in context on the Boron monograph →

Lycopene 10 references
  1. Sharma, J. B., Kumar, A., Kumar, A., Malhotra, M., Arora, R., Prasad, S., and Batra, S. Effect of lycopene on pre-eclampsia and intra-uterine growth retardation in primigravidas. Int J Gynaecol.Obstet. 2003;81(3):257-262. PubMed
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Saw Palmetto 22 references
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  14. Mantovani, F. Serenoa repens in benign prostatic hypertrophy: analysis of 2 Italian studies. Minerva Urol.Nefrol. 2010;62(4):335-340.
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Stinging Nettle 23 references
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Frankincense 2 references
  1. Acebo, E., Raton, J. A., Sautua, S., Eizaguirre, X., Trebol, I., and Perez, J. L. Allergic contact dermatitis from Boswellia serrata extract in a naturopathic cream. Contact Dermatitis 2004;51(2):91-92.
  2. Buonomo M, Hylwa S. Allergic contact dermatitis from Boswellia carterii (frankincense) oil. Contact Dermatitis 2021;85(4):465-467.

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Pumpkin 5 references
  1. Marks L, Partin AW, Epstein JI, et al. Effects of a saw palmetto herbal blend in men with symptomatic benign prostatic hyperplasia. J Urol 2000;163:1451-6. DOI
  2. Cho YH, Lee SY, Jeong DW, et al. Effect of pumpkin seed oil on hair growth in men with androgenetic alopecia: a randomized, double-blind, placebo-controlled trial. Evid Based Complement Alternat Med 2014;2014:549721. PubMed
  3. Vahlensieck W, Theurer C, Pfitzer E, Patz B, Banik N, Engelmann U. Effects of pumpkin seed in men with lower urinary tract symptoms due to benign prostatic hyperplasia in the one-year, randomized, placebo-controlled GRANU study. Urol Int 2015;94(3):286-95 PubMed
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Flaxseed 37 references
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