Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

Ultra Probiotic Complex Ingredients & Drug Interactions

by Puritan's Pride

Ultra Probiotic Complex label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ultra Probiotic Complex against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Ultra Probiotic Complex is a dietary supplement by Puritan's Pride with 3 active ingredients. Its ingredients are commonly taken for digestive health and regularity, diarrhea (including antibiotic-related), irritable bowel syndrome (ibs) symptoms.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bifidobacterium bifidum SD-5857, Lactobacillus acidophilus La-14. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Ultra Probiotic Complex by Puritan's Pride

Ask about any prescription or over-the-counter medication and we check it for interactions with Ultra Probiotic Complex by Puritan's Pride — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Ultra Probiotic Complex by Puritan's Pride

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 24, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Ultra Probiotic Complex” is a proprietary blend — the label gives one combined amount (768 mg) without saying how much of each component you get.

Ultra Probiotic Complex contains three active probiotic ingredients: Bifidobacterium bifidum SD-5857, Lactobacillus acidophilus La-14, and Bifidobacterium animalis lactis Bl-04. These are live microorganisms that support digestive and immune function.

The capsule also contains inactive ingredients — cellulose, maltodextrin, silica, and magnesium stearate — which serve as fillers and binders.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Antibiotic-associated diarrhea — rated "Possibly Effective" (Lactobacillus Acidophilus) (Natural Medicines).
  • On file: Bacterial vaginosis — rated "Possibly Effective" (Lactobacillus Acidophilus) (Natural Medicines).
  • On file: Helicobacter pylori — rated "Possibly Effective" (Lactobacillus Acidophilus) (Natural Medicines).
  • On file: Irritable bowel syndrome (IBS) — rated "Possibly Effective" (Lactobacillus Acidophilus) (Natural Medicines).
  • On file: Respiratory tract infections — rated "Possibly Effective" (Bifidobacterium Bifidum) (Natural Medicines).

Bifidobacterium bifidum is possibly effective for irritable bowel syndrome (IBS) and respiratory tract infections. The evidence for hay fever and other conditions is not yet established.

Lactobacillus acidophilus is possibly effective for IBS, Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis, but the evidence for acute respiratory distress syndrome is not yet established. We have no effectiveness data on file for Bifidobacterium animalis lactis Bl-04.

The evidence, ingredient by ingredient Bifidobacterium Bifidum Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both Bifidobacterium bifidum and Lactobacillus acidophilus are generally well tolerated in healthy people. Those with weakened immune systems should be cautious and talk with their doctor first.

Bloating, flatulence, and mild digestive discomfort can occur when taking probiotics in combination, though these are uncommon. One rare case of vomiting and fever was reported in a child taking both ingredients together, though it is not clear the probiotics caused it.

Because these are live organisms, there is a small theoretical concern about infection in critically ill or severely immunocompromised patients, but such cases are very rare. Check with your doctor or pharmacist before starting, especially if you have a weakened immune system.

Side effects, ingredient by ingredient Bifidobacterium Bifidum Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Lactobacillus Acidophilus, Bifidobacterium Bifidum.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Antibiotic drugs are the main medication type to check before taking this product. Because these probiotics contain live organisms, antibiotics can kill them and make the probiotics less effective.

Separate the timing of the two — your doctor or pharmacist can help you space them out properly.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with IBS and certain digestive or immune concerns, based on the evidence for its bacterial strains. The main thing to watch for is timing with antibiotics — they'll interfere with each other, so separate them by a few hours.

If you have a weakened immune system or take antibiotics regularly, talk it over with your doctor or pharmacist before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ultra Probiotic Complex, straight from the product label.

Brand Puritan's Pride
Barcode (UPC) 025077549016
Net contents 30 Rapid Release Capsule(s)
Market status On market
Date entered into DSLD May 24, 2023
DSLD ID 285444
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ultra Probiotic Complex by Puritan's Pride, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
025077549016
IngredientAmount% DV
Bifidobacterium bifidum SD-58570 NP--
Lactobacillus acidophilus La-140 NP--
Bifidobacterium animalis lactis Bl-040 NP--
Ultra Probiotic Complex768 mg--

Other ingredients: Cellulose, Maltodextrin, Silica, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Warning: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

Do not use if seal under cap is broken or missing.

Contains milk ingredients.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

Guaranteed quality and CFU through expiration when continuously stored in the original packaging as directed. Store in a cool, dry place away from direct sunlight.

General Statements

To reorder item #54901 www.puritan.com 1-800-645-1030

Brand IP Statement(s)

Copyright 2020 Puritan's Pride, Inc.

Seals/Symbols

QA Quality Assured

Formula

80 billion live cultures Friendly bacteria for the digestive and immune systems

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: For adults, take one (1) capsule daily, with or without a meal.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ultra Probiotic Complex by Puritan's Pride label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ultra Probiotic Complex label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ultra Probiotic Complex by Puritan's Pride

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Ultra Probiotic Complex

768 mg per serving

Other (inactive) ingredients: Cellulose, Maltodextrin, Silica, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ultra Probiotic Complex by Puritan's Pride Drug Interactions

Want to check YOUR meds against Ultra Probiotic Complex?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Bifidobacterium bifidum SD-5857 182
Lactobacillus acidophilus La-14 182

Individual Drug Interactions

The ingredients in Ultra Probiotic Complex interact with 182 drugs. Click any drug to see the details.

2 of the 3 ingredients in Ultra Probiotic Complex interact with drugs. Each result below shows which ingredient is responsible. Bifidobacterium bifidum SD-5857 Lactobacillus acidophilus La-14

Each ingredient & the kinds of drugs it affects

For each ingredient in Ultra Probiotic Complex with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bifidobacterium bifidum SD-58571 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium. bifidum with antibiotic drugs might decrease the effectiveness of B. bifidum.
Since B. bifidum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. bifidum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium bifidum SD-5857 full monograph & interactions

Lactobacillus acidophilus La-141 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus La-14 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Ultra Probiotic Complex, from the product label.

Puritan's Pride

See all Puritan's Pride products
Name
Puritan's Pride, Inc.
City
Ronkonkoma
State
NY
ZipCode
11779
Phone Number
1-800-645-1030
Web Address
www.puritan.com
Pharmacist Counseling Corner

Ultra Probiotic Complex by Puritan's Pride: Common Questions

Does Ultra Probiotic Complex by Puritan's Pride interact with any medications?
Yes. Based on its ingredients, Ultra Probiotic Complex has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ultra Probiotic Complex contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this with antibiotics?
Not at the same time. Antibiotics kill the live bacteria in probiotics, making them less effective. Talk with your doctor or pharmacist about spacing them a few hours apart so each can do its job.
Does this actually work for IBS?
The Bifidobacterium bifidum and Lactobacillus acidophilus in this product are possibly effective for IBS based on the evidence we have. Results vary from person to person, and you may want to give it a few weeks to see if it helps your symptoms.
Is this safe if I have a weak immune system?
People with weakened immune systems should be cautious with live probiotics. Talk with your doctor or pharmacist first — they can assess whether this product is right for you.
What side effects might I notice?
Bloating, gas, and mild belly discomfort can happen when you start probiotics, though these are usually uncommon and often settle down. One rare case of vomiting and fever was reported, but it's unclear whether the probiotics caused it.
Is this safe during pregnancy?
Bifidobacterium bifidum and Lactobacillus acidophilus are both rated possibly safe in pregnancy, but evidence is limited. Talk with your doctor before starting, especially if you're pregnant or planning to become pregnant.
What's in this besides the live bacteria?
The capsule contains cellulose, maltodextrin, silica, and magnesium stearate as inactive ingredients to hold it together and keep it stable.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Ultra Probiotic Complex is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ultra Probiotic Complex label
Go deeper

The Full Monographs Behind Ultra Probiotic Complex’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bifidobacterium Bifidum

Interacts with 182 drugs

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance. Some evidence suggests probiotics may he...

Read the full Bifidobacterium Bifidum monograph → Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Ultra Probiotic Complex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 22 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bifidobacterium Bifidum 7 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed
  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

See these in context on the Bifidobacterium Bifidum monograph →

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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