Interactions on record — worth a quick check against your medications. Based on 2 of 6 ingredients. Check your meds →
Dietary supplement

UltraBiotic 100 Ingredients & Drug Interactions

by HoltraCeuticals

UltraBiotic 100 label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking UltraBiotic 100 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

UltraBiotic 100 is a dietary supplement by HoltraCeuticals with 6 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus (La-14), Bifidobacterium bifidum (Bb-02). Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against UltraBiotic 100 by HoltraCeuticals

Ask about any prescription or over-the-counter medication and we check it for interactions with UltraBiotic 100 by HoltraCeuticals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of UltraBiotic 100 by HoltraCeuticals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 24, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 6 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

UltraBiotic 100 is a 6-ingredient probiotic blend in a vegetable capsule. The active ingredients are live bacterial strains: Lactobacillus paracasei, Lactobacillus acidophilus, Lactobacillus plantarum, Bifidobacterium bifidum, Bifidobacterium lactis, and Lactobacillus rhamnosus.

These are meant to support your gut flora. The capsule also contains inactive ingredients—microcrystalline cellulose, silicon dioxide, and magnesium stearate—which are standard fillers and binders.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Antibiotic-associated diarrhea — rated "Possibly Effective" (Lactobacillus Acidophilus) (Natural Medicines).
  • On file: Bacterial vaginosis — rated "Possibly Effective" (Lactobacillus Acidophilus) (Natural Medicines).
  • On file: Helicobacter pylori — rated "Possibly Effective" (Lactobacillus Acidophilus) (Natural Medicines).
  • On file: Irritable bowel syndrome (IBS) — rated "Possibly Effective" (Lactobacillus Acidophilus) (Natural Medicines).
  • On file: Respiratory tract infections — rated "Possibly Effective" (Bifidobacterium Bifidum) (Natural Medicines).

The Lactobacillus acidophilus in this product is rated possibly effective for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis. Bifidobacterium bifidum is also possibly effective for IBS and respiratory tract infections.

For other conditions—such as hay fever, Alzheimer disease, and anxiety—the evidence we hold is insufficient to rate. The other strains in the blend have no effectiveness ratings in our data.

The evidence, ingredient by ingredient Lactobacillus Acidophilus Bifidobacterium Bifidum

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both Lactobacillus acidophilus and Bifidobacterium bifidum are generally well tolerated in healthy adults and children. Because these contain live organisms, there is a small theoretical risk of infection in people with severely weakened immune systems; check with your doctor before use if that applies to you.

Uncommon gastrointestinal side effects—such as abdominal discomfort, bloating, flatulence, and diarrhea—have been reported. In one trial, a rash and itching appeared, though it's unclear whether the probiotics caused it.

For pregnancy, both strains are rated possibly safe; for breastfeeding, no safety data are on file. Talk it over with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Lactobacillus Acidophilus Bifidobacterium Bifidum

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Lactobacillus Acidophilus, Bifidobacterium Bifidum.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotic drugs, check with your doctor or pharmacist before adding this product. The live bacteria in UltraBiotic 100 may be killed by antibiotics taken at the same time, reducing the supplement's effectiveness.

You may need to separate doses by several hours.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

UltraBiotic 100 is a multi-strain probiotic that may help with IBS, infectious diarrhea, and some other conditions—though evidence is modest and strain-specific. If you take antibiotics, you'll need to space them apart from this supplement.

People with healthy immune systems generally tolerate it well, but those with severely compromised immunity should check with their doctor first. Run your exact medications through the interaction checker before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about UltraBiotic 100, straight from the product label.

Brand HoltraCeuticals
Barcode (UPC) 615033604746
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Sep 22, 2022
DSLD ID 274451
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for UltraBiotic 100 by HoltraCeuticals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
615033604746
IngredientAmount% DV
Proprietary Blend0 NP--
Lactobacillus paracasei Lpc-370 NP--
Lactobacillus acidophilus (La-14)0 NP--
Lactobacillus plantarum (Lp-115)0 NP--
Bifidobacterium bifidum (Bb-02)0 NP--
Bifidobacterium lactis (Bl-04)0 NP--
Lactobacillus rhamnosus (GG)0 NP--

Other ingredients: natural Vegetable Capsules, Microcrystalline Cellulose, Silicon Dioxide, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: 1 capsule per day or as recommended by your health care professional.

Formulation

Formulated to be free of allergens derived from: Gluten, corn, yeast, artificial colors and flavors.

This product was sealed for your protection. Do not use if outer logoed neck seal or inner-seal is missing or damaged.

Promotes healthy intestinal health microbial balance

Vcaps

Precautions

If you are pregnant or nursing, consult your physician before taking this product.

As with all dietary supplements, some individuals may not tolerate or may be allergic to the ingredients used. Please read the ingredient panel carefully prior to ingestion. Cease taking this product and consult your physician if you have a negative reaction upon ingestion.

Caution: This product contains a desiccant. For best results, keep the desiccant in the bottle until all contents are consumed. Do not eat desiccant.

Keep out of reach of children.

Storage

Keep container tightly closed. Store at room temperature.

General Statements

To reorder visit Holtraceuticals.com

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Vcaps

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

UltraBiotic 100 by HoltraCeuticals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

UltraBiotic 100 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in UltraBiotic 100 by HoltraCeuticals

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

0 NP per serving

Other (inactive) ingredients: Natural Vegetable Capsules, Microcrystalline Cellulose, Silicon Dioxide, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

UltraBiotic 100 by HoltraCeuticals Drug Interactions

Want to check YOUR meds against UltraBiotic 100?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus acidophilus (La-14) 182
Bifidobacterium bifidum (Bb-02) 182

Individual Drug Interactions

The ingredients in UltraBiotic 100 interact with 182 drugs. Click any drug to see the details.

2 of the 6 ingredients in UltraBiotic 100 interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus (La-14) Bifidobacterium bifidum (Bb-02)

Each ingredient & the kinds of drugs it affects

For each ingredient in UltraBiotic 100 with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus (La-14)1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus (La-14) full monograph & interactions

Bifidobacterium bifidum (Bb-02)1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium. bifidum with antibiotic drugs might decrease the effectiveness of B. bifidum.
Since B. bifidum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. bifidum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium bifidum (Bb-02) full monograph & interactions
The maker

Brand information

Manufacturer and brand details for UltraBiotic 100, from the product label.

HoltraCeuticals

See all HoltraCeuticals products
Name
Holtorf Medical Group
Street Address
2232 E. Maple Ave.
City
El Segundo
State
CA
ZipCode
90245
Web Address
HoltraCeuticals.com
Pharmacist Counseling Corner

UltraBiotic 100 by HoltraCeuticals: Common Questions

Does UltraBiotic 100 by HoltraCeuticals interact with any medications?
Yes. Based on its ingredients, UltraBiotic 100 has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
UltraBiotic 100 contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this probiotic while I'm on antibiotics?
Not at the same time. Antibiotics kill the live bacteria in this supplement, which defeats the purpose. Your doctor or pharmacist can advise you on how far apart to space them—often at least a few hours.
Is this safe if I have a weakened immune system?
People with healthy immune systems generally tolerate it well, but if your immune system is severely compromised, you should talk with your doctor first before starting. There is a small theoretical risk of infection from live organisms.
Will this help my IBS?
Both Lactobacillus acidophilus and Bifidobacterium bifidum in this product are rated possibly effective for IBS. That means some evidence supports it, but results aren't guaranteed. Your own response may vary.
What are the inactive ingredients?
The capsule is made from vegetable material, and the blend contains microcrystalline cellulose, silicon dioxide, and magnesium stearate—standard fillers and binders. There are no other major additives.
Is it safe to take this while pregnant or breastfeeding?
Both Lactobacillus acidophilus and Bifidobacterium bifidum are rated possibly safe in pregnancy. For breastfeeding, the safety data on file is incomplete. Talk it over with your doctor or pharmacist before starting, especially if you're pregnant or nursing.
What side effects can probiotics cause?
Most people don't experience them, but some report mild gastrointestinal discomfort—bloating, gas, loose stools, or mild pain. In rare cases, a rash or itching has appeared, though it's unclear if the probiotics caused it. Start with a lower dose if your stomach is sensitive.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if UltraBiotic 100 is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

UltraBiotic 100 label
Go deeper

The Full Monographs Behind UltraBiotic 100’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Bifidobacterium Bifidum

Interacts with 182 drugs

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance. Some evidence suggests probiotics may he...

Read the full Bifidobacterium Bifidum monograph →
Sources

Sources & How We Checked

UltraBiotic 100's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 22 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Bifidobacterium Bifidum 7 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed
  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

See these in context on the Bifidobacterium Bifidum monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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