Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Uva Ursi 500 mg Ingredients & Drug Interactions

by NOW

Uva Ursi 500 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Uva Ursi 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Uva Ursi 500 mg is a dietary supplement by NOW with 1 active ingredient. Its ingredients are commonly taken for urinary tract infections, urinary discomfort, mild diuretic.Based on those ingredients, 803 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Uva Ursi. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Uva Ursi 500 mg by NOW

Ask about any prescription or over-the-counter medication and we check it for interactions with Uva Ursi 500 mg by NOW — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Uva Ursi 500 mg by NOW

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 24, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: uva ursi (also called bearberry leaf), a plant traditionally used for urinary tract support. The supplement comes in a capsule with gelatin and magnesium stearate as inactive ingredients.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: urinary tract health support.
  • We looked for evidence on: Urinary tract infections (UTIs), urinary discomfort, urinary antiseptic.
  • The closest evidence on file: Uva Ursi is rated "Possibly Ineffective" for Urinary tract infections (UTIs) (Natural Medicines).

The evidence on uva ursi's actual effectiveness is limited. For urinary tract infections (UTIs), the data suggests it's possibly ineffective.

For bronchitis and benign prostatic hyperplasia (enlarged prostate), there simply isn't enough reliable evidence to know whether it works. So while it has a long history of use, we don't have strong proof it does what many people take it for.

The evidence, ingredient by ingredient Uva Ursi

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Uva ursi is generally well tolerated when you take it at low doses for a short time. The most common side effects are diarrhea, nausea, stomach upset, and vomiting.

However, high doses or long-term use can be toxic — at very high doses (20 grams or more of dried herb), it's been reported to cause serious effects like convulsions, delirium, shortness of breath, and collapse. Doses of 30 grams or more may be fatal.

Don't take this during pregnancy; the safety data advises against it because it may stimulate the uterus. There isn't enough safety information to use it while breastfeeding either, so talk with your doctor or pharmacist before doing so if you're nursing.

Side effects, ingredient by ingredient Uva Ursi

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Uva Ursi.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: lithium.
  • For scale: 804 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Uva Ursi, check with your doctor or pharmacist if you're on any of these medication types: drugs metabolized by CYP2C19 or CYP3A4 (a very large group including many heart, blood pressure, antidepressant, and antihistamine medications), lithium, drugs cleared through glucuronidation, medications that acidify your urine, or P-glycoprotein substrates. The first four are Moderate severity concerns; the last is Minor.

Most of these effects are theoretical (shown in the lab, not yet confirmed in people), but they're worth checking out with your own healthcare provider.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Uva ursi is traditionally used for urinary tract health, but evidence for effectiveness is weak or absent, and it carries real risks at high doses or with prolonged use. It interacts with a broad range of medications by affecting how your liver and kidneys handle them.

If you're on any prescription medications — especially those for mood, heart, blood pressure, or other chronic conditions — run them through the checker on this page and talk with your doctor or pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Uva Ursi 500 mg, straight from the product label.

Brand NOW
Barcode (UPC) 733739047656
Net contents 100 Capsule(s)
Market status On market
Date entered into DSLD Feb 25, 2013
DSLD ID 13995
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Uva Ursi 500 mg by NOW, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
50
UPC/BARCODE
733739047656
IngredientAmount% DV
Total Carbohydrates0.8 g1%
Uva Ursi1 g--

Other ingredients: Gelatin, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General

CODE 4765 V1

Seals/Symbols

GMP QUALITY ASSURED

Formulation

Contains no sugar, salt, yeast, wheat, gluten, soy, corn, milk or preservatives.

General Statements

HERBAL SUPPLEMENT

Uva Ursi, also known as bearberry, has been used by herbalists for over 1,000 years in China. Marco Polo reported its use in the 13th century and helped to bring the use of Uva Ursi to western Europe. Native Americans have also used Uva Ursi for hundreds of years.

FDA Statement of Identity

A Dietary Supplement

Suggested/Recommended/Usage/Directions

SUGGESTED USAGE: As a dietary supplement, take 2 capsules 1-3 times daily as needed, preferably with meals.

Precautions

Caution: Not for prolonged use without consulting a health practitioner. May cause green color in urine. Discontinue use if nausea or upset stomach occurs. Contraindicated in kidney disorders and irritated digestive conditions.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Uva Ursi 500 mg by NOW label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Uva Ursi 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Uva Ursi 500 mg by NOW

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.

Uva Ursi

Interacts with
803 drugs
1 g per serving

Uva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have antimicrobial...

Uva Ursi monograph & interactions

Other (inactive) ingredients: Gelatin, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Uva Ursi 500 mg by NOW Drug Interactions

Want to check YOUR meds against Uva Ursi 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
803Drugs
740 Moderate 63 Minor

Ingredients driving the most interactions

Uva Ursi 803

Individual Drug Interactions

The ingredients in Uva Ursi 500 mg interact with 803 drugs. Click any drug to see the details.

1 of the 1 ingredient in Uva Ursi 500 mg interact with drugs. Each result below shows which ingredient is responsible. Uva Ursi

Each ingredient & the kinds of drugs it affects

For each ingredient in Uva Ursi 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Uva Ursi6 drug types · 803 drugs

Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, uva ursi may decrease the metabolism of CYP2C19 substrates.
In vitro, uva ursi appears to inhibit cytochrome CYP2C19. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.
In vitro, uva ursi appears to inhibit CYP3A4. This effect has not been reported in humans.

Likelihood Possible Evidence D
Glucuronidated Drugs

Theoretically, uva ursi may increase levels of drugs metabolized by glucuronidation.
In vitro, uva ursi extract appears to strongly inhibit UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1). However, uva ursi extract does not appear to inhibit UGT1A1 in animal models. This effect has not been reported in humans.

Likelihood Possible Evidence D
Lithium

Theoretically, uva ursi may increase lithium levels, necessitating a decrease in dose.
Uva ursi may have diuretic properties. Diuretics may increase lithium reabsorption with sodium in the proximal tubule of the kidney. Theoretically, uva ursi might reduce excretion and increase levels of lithium.

Likelihood Probable Evidence D
Urinary Acidifying Agents

Effects of uva ursi in the urinary tract may be reduced by urinary acidifying agents.
Uva ursi seems to work best in alkaline urine. Theoretically, taking uva ursi with medications known to acidify the urine may decrease any effects of uva ursi on the urinary tract.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, uva ursi may alter the levels of drugs transported by P-glycoprotein.
In vitro, uva ursi appears to inhibit the multi-drug transporter protein, P-glycoprotein. This effect has not been reported in humans.

Likelihood Possible Evidence D
Uva Ursi full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Uva Ursi 500 mg, from the product label.

NOW

See all NOW products
Name
NOW FOODS
City
BLOOMINGDALE
State
IL
ZipCode
60108
Pharmacist Counseling Corner

Uva Ursi 500 mg by NOW: Common Questions

Does Uva Ursi 500 mg by NOW interact with any medications?
Yes. Based on its ingredients, Uva Ursi 500 mg has a known interaction with 803 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Uva Ursi 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No — uva ursi is rated likely unsafe in pregnancy because it may stimulate the uterus and safety data is lacking. If you're breastfeeding, there isn't enough safety information either, so avoid it. Talk with your doctor or pharmacist about alternatives if you need urinary tract support during these times.
What are the side effects?
At normal doses, the most common ones are diarrhea, nausea, stomach upset, and vomiting. At very high doses (20+ grams), serious effects like convulsions, delirium, and shortness of breath have been reported. Doses of 30 grams or more may be fatal.
How long can I take this safely?
Uva ursi is meant for short-term use only. Prolonged use or high doses can be toxic, so don't take it long-term without talking to your doctor or pharmacist first.
Does it actually work for urinary tract infections?
The evidence suggests it's possibly ineffective. For bronchitis and enlarged prostate, there isn't enough reliable data to say whether it helps. So while it's been used traditionally, we don't have strong proof it does what many people take it for.
What's in the capsule besides uva ursi?
Just gelatin (the capsule itself) and magnesium stearate (a flow agent). No fillers beyond that.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Uva Ursi 500 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Uva Ursi 500 mg label
Go deeper

The Full Monographs Behind Uva Ursi 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Uva Ursi

Interacts with 803 drugs

Uva ursi is a traditional herb used mainly for urinary tract infections, and its leaves contain a compound called arbutin that may have antimicrobial effects in the urine. Evidence in people...

Read the full Uva Ursi monograph →
Sources

Sources & How We Checked

Uva Ursi 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Uva Ursi 8 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Schulz V, Hansel R, Tyler VE. Rational Phytotherapy: A Physician's Guide to Herbal Medicine. Terry C. Telger, transl. 3rd ed. Berlin, GER: Springer, 1998.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Wang L, Del Priore LV. Bull's-eye maculopathy secondary to herbal toxicity from uva ursi. Am J Ophthalmol 2004;137:1135-7. PubMed
  5. Beaux, D., Fleurentin, J., and Mortier, F. Effect of extracts of Orthosiphon stamineus Benth, Hieracium pilosella L., Sambucus nigra L. and Arctostaphylos uva-ursi (L.) Spreng. in rats. Phytother.Res 1999;13(3):222-225.
  6. de Arriba SG, Naser B, Nolte KU. Risk assessment of free hydroquinone derived from Arctostaphylos Uva-ursi folium herbal preparations. Int J Toxicol. 2013;32(6):442-453.
  7. Park JB, Kim D, Min JS, et al. Identification and characterization of in vitro inhibitors against UDP-glucuronosyltransferase 1A1 in uva-ursi extracts and evaluation of in vivo uva-ursi-drug interactions. Food Chem Toxicol. 2018;120:651-661. PubMed
  8. Chauhan B, Yu C, Krantis A, et al. In vitro activity of uva-ursi against cytochrome P450 isoenzymes and P-glycoprotein. Can J Physiol Pharmacol. 2007;85(11):1099-107.

See these in context on the Uva Ursi monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team