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Dietary supplement

Vanadyl Sulfate 2 mg Ingredients & Drug Interactions

by The Vitamin Shoppe

Vanadyl Sulfate 2 mg label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Oct 7, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Vanadyl Sulfate 2 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Vanadyl Sulfate 2 mg is a dietary supplement by The Vitamin Shoppe with 1 active ingredient. Its ingredients are commonly taken for blood sugar and diabetes support, athletic performance and muscle building, lowering cholesterol.Based on those ingredients, 208 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vanadium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Vanadyl Sulfate 2 mg by The Vitamin Shoppe

Ask about any prescription or over-the-counter medication and we check it for interactions with Vanadyl Sulfate 2 mg by The Vitamin Shoppe — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Vanadyl Sulfate 2 mg by The Vitamin Shoppe

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 24, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: vanadium, supplied as vanadyl sulfate at 2 mg per tablet. Vanadium is a trace mineral your body needs in small amounts.

The tablet also contains several inactive ingredients—dicalcium phosphate, microcrystalline cellulose, stearic acid, magnesium stearate, croscarmellose sodium, purified water, hydroxypropyl methylcellulose, and polyethylene glycol—which help form and stabilize the tablet.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Vanadium's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: glucose metabolism support.
  • We looked for evidence on: Diabetes, Impaired glucose tolerance (prediabetes), blood sugar regulation, insulin sensitivity.
  • The closest evidence on file: Vanadium is rated "Insufficient Reliable Evidence To Rate" for Diabetes (Natural Medicines).
  • Also on file: Vanadium is rated "Insufficient Reliable Evidence To Rate" for Impaired glucose tolerance (prediabetes).

Vanadium is rated likely effective for vanadium deficiency, which is rare in people eating a typical diet. For athletic performance, diabetes, high cholesterol (hyperlipidemia), and cancer, the evidence we hold is insufficient to rate its effectiveness.

This means either very few studies exist, the studies are small, or the results don't yet point clearly in one direction.

The evidence, ingredient by ingredient Vanadium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

At or below the tolerable upper intake level of 1.8 mg daily, vanadium is generally well tolerated. This product is 2 mg, so it's slightly above that threshold.

At higher doses, the most common side effects are gastrointestinal—abdominal discomfort, diarrhea, gas, and nausea. Rare but serious adverse effects from long-term high-dose use include kidney damage.

Allergic reactions to vanadium, including rashes and contact dermatitis, have been reported in people exposed to vanadium metal or compounds. During pregnancy, the safety data advises against supplement doses of vanadium.

While breastfeeding, safety is unknown, so it's best to avoid vanadium supplements. Talk with your doctor or pharmacist about whether this product is right for you if you're pregnant or breastfeeding.

Side effects, ingredient by ingredient Vanadium

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vanadium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 208 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Vanadyl Sulfate 2 mg, double-check if you're on blood thinners or antiplatelet drugs (such as warfarin, aspirin, or clopidogrel)—vanadium may increase bleeding risk. Also confirm your diabetes medications with your doctor or pharmacist, since vanadium might lower blood glucose further and raise the risk of low blood sugar.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This supplement is for people looking to address vanadium deficiency, which is uncommon. If you take blood thinners, antiplatelet drugs, or diabetes medications, you'll need to check with your own doctor or pharmacist before starting it—the interaction risk is real and moderate.

Pregnant or breastfeeding? Skip it until you've talked it through with your healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Vanadyl Sulfate 2 mg, straight from the product label.

Brand The Vitamin Shoppe
Barcode (UPC) 766536013388
Net contents 100 Tablet(s)
Market status On market
Date entered into DSLD Apr 25, 2014
DSLD ID 32138
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Vanadyl Sulfate 2 mg by The Vitamin Shoppe, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
766536013388
IngredientAmount% DV
Vanadium2 mg--

Other ingredients: Dicalcium Phosphate, Microcrystalline Cellulose, Stearic Acid, Magnesium Stearate, Croscarmellose Sodium, purified Water, Hydroxypropyl Methylcellulose, Polyethylene Glycol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

V SUITABLE FOR MOST VEGETARIANS

Formulation

Does not contain: Yeast, Corn, Wheat, Gluten, Sugar, Salt, Soy, Starch, Dairy, Citrus, Fish, Animal Derivatives, Preservatives, Artificial Colors or Flavors.

gluten free dairy free soy free nut free

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Suggested/Recommended/Usage/Directions

DIRECTIONS: As a dietary supplement, take one (1) tablet daily, preferably with a meal.

FDA Statement of Identity

dietary supplement

General Statements

trace mineral

glucose metabolism

{tablets} actual size

Visit www.vitaminshoppe.com or call 1-800-223-1216 for more information and to reorder.

mineral

Precautions

WARNING: Consult your healthcare provider prior to use if you are pregnant, nursing, taking any medication or have any medical conditions.

KEEP OUT OF REACH OF CHILDREN.

TAMPER EVIDENT Do not use if outer seal is broken or missing.

Storage

STORE IN A COOL, DRY PLACE.

General

Item No. VS-1338 1045273 BO 1

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Vanadyl Sulfate 2 mg by The Vitamin Shoppe label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Vanadyl Sulfate 2 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Vanadyl Sulfate 2 mg by The Vitamin Shoppe

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Vanadium

Interacts with
208 drugs
2 mg per serving Form: Vanadyl Sulfate

Vanadium is a trace mineral found in tiny amounts in food, and people get plenty from a normal diet. Supplement claims for diabetes, weight, and athle...

Vanadium monograph & interactions

Other (inactive) ingredients: Dicalcium Phosphate, Microcrystalline Cellulose, Stearic Acid, Magnesium Stearate, Croscarmellose Sodium, Purified Water, Hydroxypropyl Methylcellulose, Polyethylene Glycol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Vanadyl Sulfate 2 mg by The Vitamin Shoppe Drug Interactions

Want to check YOUR meds against Vanadyl Sulfate 2 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
208Drugs
208 Moderate

Ingredients driving the most interactions

Vanadium 208

Individual Drug Interactions

The ingredients in Vanadyl Sulfate 2 mg interact with 208 drugs. Click any drug to see the details.

1 of the 1 ingredient in Vanadyl Sulfate 2 mg interact with drugs. Each result below shows which ingredient is responsible. Vanadium

Each ingredient & the kinds of drugs it affects

For each ingredient in Vanadyl Sulfate 2 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vanadium2 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, vanadium might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
In vitro research shows that the sodium orthovanadate form of vanadium prolongs clotting time, likely through inhibition of thrombin and factor Xa.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, vanadium might increase the risk of hypoglycemia when taken with antidiabetes drugs.
A few very small clinical studies in patients with type 2 diabetes show that the vanadyl sulfate form of vanadium increases insulin sensitivity and might lower blood glucose levels.

Likelihood Probable Evidence B
Vanadium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Vanadyl Sulfate 2 mg, from the product label.

The Vitamin Shoppe

See all The Vitamin Shoppe products
Name
Vitamin Shoppe, Inc.
City
Secaucus
State
NJ
ZipCode
07094
Phone Number
1-800-223-1216
Web Address
www.vitaminshoppe.com
Pharmacist Counseling Corner

Vanadyl Sulfate 2 mg by The Vitamin Shoppe: Common Questions

Does Vanadyl Sulfate 2 mg by The Vitamin Shoppe interact with any medications?
Yes. Based on its ingredients, Vanadyl Sulfate 2 mg has a known interaction with 208 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Vanadyl Sulfate 2 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is 2 mg of vanadium safe to take daily?
The tolerable upper intake level is 1.8 mg daily, so this product is slightly above that. At or below 1.8 mg, vanadium is generally well tolerated. Doses above the upper limit may cause stomach upset, and long-term high-dose use carries a rare risk of kidney damage. Talk with your doctor or pharmacist about whether this dose is right for you.
Can I take this if I'm pregnant or breastfeeding?
The safety data advises against vanadium supplements during pregnancy. While breastfeeding, safety is unknown, so it's best to avoid it. Speak with your doctor or pharmacist about your individual situation before taking this product.
Does vanadium actually work for diabetes?
A small number of very small clinical trials suggest vanadyl sulfate may help your body use insulin better and lower blood glucose in type 2 diabetes, but the overall evidence is insufficient to rate how well it works. More research is needed.
What are the side effects I should watch for?
The most common side effects at higher doses are gastrointestinal: belly discomfort, diarrhea, gas, and nausea. Allergic reactions like itchy rashes and contact dermatitis have been reported, though they're uncommon. If you notice any of these, stop taking it and talk with your pharmacist.
What is vanadium, and why would I need a supplement?
Vanadium is a trace mineral your body needs in tiny amounts, and it's found in food. Vanadium deficiency is rare. This supplement is most useful if you've been diagnosed with a deficiency by your doctor.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Vanadyl Sulfate 2 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Vanadyl Sulfate 2 mg label
Go deeper

The Full Monographs Behind Vanadyl Sulfate 2 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vanadium

Interacts with 208 drugs

Vanadium is a trace mineral found in tiny amounts in food, and people get plenty from a normal diet. Supplement claims for diabetes, weight, and athletic performance are not well proven, and...

Read the full Vanadium monograph →
Sources

Sources & How We Checked

Vanadyl Sulfate 2 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vanadium 15 references
  1. Harland BF, Harden-Williams BA. Is vanadium of human nutritional importance yet? J Am Diet Assoc 1994;94:891-4. PubMed
  2. Sitprija V, Tungsanga K, Tosukhowong P, et al. Metabolic problems in northeastern Thailand: possible role of vanadium. Mineral Electrolyte Metab 1998;19:51-6.
  3. Funakoshi T, Shimada H, Kojima S, et al. Anticoagulant action of vanadate. Chem Pharmaceut Bull 1992;40:174-6. PubMed
  4. Halberstam M, Cohen N, Shlimovich P, et al. Oral vanadyl sulfate improves insulin sensitivity in NIDDM but not in obese nondiabetic subjects. Diabetes 1996;45:659-66. PubMed
  5. Cohen N, Halberstam M, Shlimovich P, et al. Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus. J Clin Invest 1995;95:2501-9. PubMed
  6. Boden G, Chen X, Ruiz J, et al. Effects of vanadyl sulfate on carbohydrate and lipid metabolism in patients with non-insulin-dependent diabetes mellitus. Metabolism 1996;45:1130-5.
  7. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  8. Goldfine AB, Simonson DC, Folli F, et al. Metabolic effects of sodium metavanadate in humans with insulin-dependent and noninsulin-dependent diabetes mellitus in vivo and in vitro studies. J Clin Endocrinol Metab 1995;80:3311-20. PubMed
  9. Cusi K, Cukier S, DeFronzo RA, et al. Vanadyl sulfate improves hepatic and muscle insulin sensitivity in type 2 diabetes. J Clin Endocrinol Metab 2001;86:1410-7.
  10. Peat F, Coomber R, Rana A, Vince A. Vanadium allergy following total knee arthroplasty. BMJ Case Rep 2018;2018. pii: bcr-2017-222092. doi: 10.1136/bcr-2017-222092. PubMed
  11. Jin S, Xia W, Jiang Y, et al. Urinary vanadium concentration in relation to premature rupture of membranes: A birth cohort study. Chemosphere 2018;210:1035-41. doi: 10.1016/j.chemosphere.2018.07.110. PubMed
  12. Garcia-Nunez I, Algaba-Marmol MA, Suarez-Vergara M, et al. Vanadium contact dermatitis: case report and studies performed. Contact Dermatitis 2019;80(2):127-8. PubMed
  13. Zhou Y, Zhu Q, Ma W, et al. Prenatal vanadium exposure, cytokine expression, and fetal growth: a gender-specific analysis in Shanghai MCPC study. Sci Total Environ 2019;685:1152-9. PubMed
  14. Jiang S, Zhou S, Liu H, et al. Concentrations of vanadium in urine with hypertension prevalence and blood pressure levels. Ecotoxicol Environ Saf 2021;213:112028. PubMed
  15. Zhang W, Chen H, Zeng Q, Xu S, Xia W, Li Y. Prenatal and postnatal exposure to vanadium and the immune function of children. J Trace Elem Med Biol 2021;67:126787. PubMed

See these in context on the Vanadium monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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