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Dietary supplement

Vanadyl Sulfate Spray Ingredients & Drug Interactions

by Douglas Laboratories

Vanadyl Sulfate Spray label
See full label image
Liquid Category: Mineral
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Vanadyl Sulfate Spray against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Vanadyl Sulfate Spray is a dietary supplement by Douglas Laboratories with 1 active ingredient. Its ingredients are commonly taken for blood sugar and diabetes support, athletic performance and muscle building, lowering cholesterol.Based on those ingredients, 208 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vanadium Sulfate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Vanadyl Sulfate Spray by Douglas Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with Vanadyl Sulfate Spray by Douglas Laboratories — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Vanadyl Sulfate Spray by Douglas Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Vanadyl Sulfate Spray is a single-ingredient product. Its active ingredient is vanadium sulfate, a mineral form of vanadium.

The spray also contains several inactive ingredients — purified water, fructose, citric acid, glycerine, sodium bisulfate, sodium benzoate, and cherry flavor — which are used to deliver and preserve the formula.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Vanadium's overall clinical evidence instead.

Strong

Strong clinical evidence supports Vanadium for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Vanadium deficiency — rated "Likely Effective" (Natural Medicines).

The evidence we have supports vanadium for vanadium deficiency, rated Likely Effective. For other uses listed — athletic performance, cancer, diabetes, and high cholesterol — the evidence is not established enough to rate.

Small studies suggest vanadium may help with blood sugar control in type 2 diabetes, but larger, stronger evidence is needed before we can say it works for that purpose.

The evidence, ingredient by ingredient Vanadium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vanadium is well tolerated when taken in small amounts — up to 1.8 mg daily. Higher doses can cause stomach upset, including nausea, diarrhea, abdominal discomfort, and gas.

Long-term use at high doses has rarely caused kidney damage. Allergic reactions to vanadium are uncommon but have occurred; they can include itching, rashes, and skin irritation.

The safety data advises against vanadium supplements during pregnancy and while breastfeeding, because there isn't enough information to know they're safe in those situations.

Side effects, ingredient by ingredient Vanadium

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vanadium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 208 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before using this product if you take blood thinners or antiplatelet drugs (Moderate risk of increased bleeding) or diabetes medications (Moderate risk of low blood sugar). These are the medication types with documented interactions with vanadium.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This product is designed for people who may be deficient in vanadium, though such deficiency is rare in the general population. If you take blood thinners, antiplatelet drugs, or diabetes medications, talk with your pharmacist before starting — the interactions are real and worth checking against your specific prescriptions.

Stick to the label dose and watch for stomach symptoms or unusual bleeding or bruising.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 26, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Vanadyl Sulfate Spray, straight from the product label.

Brand Douglas Laboratories
Barcode (UPC) 310539017586
Net contents 4 oz.
Market status On market
Date entered into DSLD Apr 26, 2012
DSLD ID 8015
Product type Mineral
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Vanadyl Sulfate Spray by Douglas Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
8 Spray(s)
Maximum serving Sizes:
8 Spray(s)
Servings per container
100
UPC/BARCODE
310539017586
IngredientAmount% DV
Vanadium Sulfate25 mg--

Other ingredients: purified Water, Fructose, Citric Acid, Glycerine, sodium bisulfate, Sodium Benzoate, Cherry flavor

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

A Dietary Supplement

Formulation

This product contains NO yeast, wheat gluten, soy protein, milk/dairy, corn, sodium, sugar, starch, artificial coloring, preservatives or flavoring.

Suggested/Recommended/Usage/Directions

Suggested Usage: As a dietary supplement, adults take 1 dose orally (8 pumps) daily or as directed by your healthcare professional.

Precautions

KEEP OUT OF REACH OF CHILDREN.

Tamper resistant package, do not use if outer seal is missing.

Storage

For optimal storage conditions, store in a cool, dry place. (59°-77°F/15°-25°C) (35-65% relative humidity)

General

Formula #7031

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Vanadyl Sulfate Spray by Douglas Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Vanadyl Sulfate Spray label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Vanadyl Sulfate Spray by Douglas Laboratories

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size8 Spray(s) Dosage formLiquid Servings per container100 Amounts shown are per serving.

Vanadium Sulfate

Interacts with
208 drugs
25 mg per serving

Vanadium is a trace mineral found in tiny amounts in food, and people get plenty from a normal diet. Supplement claims for diabetes, weight, and athle...

Vanadium Sulfate monograph & interactions

Other (inactive) ingredients: Purified Water, Fructose, Citric Acid, Glycerine, Sodium bisulfate, Sodium Benzoate, Cherry flavor. These complete the product’s ingredient list but are not active constituents.

Interaction report

Vanadyl Sulfate Spray by Douglas Laboratories Drug Interactions

Want to check YOUR meds against Vanadyl Sulfate Spray?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
208Drugs
208 Moderate

Ingredients driving the most interactions

Vanadium Sulfate 208

Individual Drug Interactions

The ingredients in Vanadyl Sulfate Spray interact with 208 drugs. Click any drug to see the details.

1 of the 1 ingredient in Vanadyl Sulfate Spray interact with drugs. Each result below shows which ingredient is responsible. Vanadium Sulfate

Each ingredient & the kinds of drugs it affects

For each ingredient in Vanadyl Sulfate Spray with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vanadium Sulfate2 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, vanadium might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
In vitro research shows that the sodium orthovanadate form of vanadium prolongs clotting time, likely through inhibition of thrombin and factor Xa.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, vanadium might increase the risk of hypoglycemia when taken with antidiabetes drugs.
A few very small clinical studies in patients with type 2 diabetes show that the vanadyl sulfate form of vanadium increases insulin sensitivity and might lower blood glucose levels.

Likelihood Probable Evidence B
Vanadium Sulfate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Vanadyl Sulfate Spray, from the product label.

Douglas Laboratories

See all Douglas Laboratories products
Name
Douglas Laboratories
Street Address
600 Boyce Road
City
Pittsburgh
State
PA
ZipCode
15205
Web Address
www.douglaslabs.com
Pharmacist Counseling Corner

Vanadyl Sulfate Spray by Douglas Laboratories: Common Questions

Does Vanadyl Sulfate Spray by Douglas Laboratories interact with any medications?
Yes. Based on its ingredients, Vanadyl Sulfate Spray has a known interaction with 208 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Vanadyl Sulfate Spray contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is vanadium supposed to do?
Vanadium is a mineral your body needs in small amounts. This product is supported by evidence for vanadium deficiency. It's also been studied for diabetes, athletic performance, and high cholesterol, but the evidence for those uses isn't strong enough for us to say it works.
Can I take this while pregnant or breastfeeding?
The safety data advises against vanadium supplements during pregnancy and while breastfeeding because there isn't enough information to know they're safe. Talk with your doctor or pharmacist for personalized advice.
What side effects might I experience?
At normal doses, vanadium is well tolerated. Higher doses can cause stomach problems — nausea, diarrhea, gas, and belly discomfort. Allergic skin reactions (rashes, itching) are rare but possible. Long-term use at very high doses has rarely caused kidney damage.
Is there a safe upper limit for vanadium?
Yes. Vanadium is well tolerated when taken at or below 1.8 mg daily. Doses above that level are more likely to cause side effects, so it's important to stick to the label dose.
Why is this a spray instead of a pill?
The facts don't say. Ask your pharmacist or Douglas Laboratories — they can explain why this delivery form works best for this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Vanadyl Sulfate Spray is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Vanadyl Sulfate Spray label
Go deeper

The Full Monographs Behind Vanadyl Sulfate Spray’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vanadium

Interacts with 208 drugs

Vanadium is a trace mineral found in tiny amounts in food, and people get plenty from a normal diet. Supplement claims for diabetes, weight, and athletic performance are not well proven, and...

Read the full Vanadium monograph →
Sources

Sources & How We Checked

Vanadyl Sulfate Spray's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vanadium 15 references
  1. Harland BF, Harden-Williams BA. Is vanadium of human nutritional importance yet? J Am Diet Assoc 1994;94:891-4. PubMed
  2. Sitprija V, Tungsanga K, Tosukhowong P, et al. Metabolic problems in northeastern Thailand: possible role of vanadium. Mineral Electrolyte Metab 1998;19:51-6.
  3. Funakoshi T, Shimada H, Kojima S, et al. Anticoagulant action of vanadate. Chem Pharmaceut Bull 1992;40:174-6. PubMed
  4. Halberstam M, Cohen N, Shlimovich P, et al. Oral vanadyl sulfate improves insulin sensitivity in NIDDM but not in obese nondiabetic subjects. Diabetes 1996;45:659-66. PubMed
  5. Cohen N, Halberstam M, Shlimovich P, et al. Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus. J Clin Invest 1995;95:2501-9. PubMed
  6. Boden G, Chen X, Ruiz J, et al. Effects of vanadyl sulfate on carbohydrate and lipid metabolism in patients with non-insulin-dependent diabetes mellitus. Metabolism 1996;45:1130-5.
  7. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  8. Goldfine AB, Simonson DC, Folli F, et al. Metabolic effects of sodium metavanadate in humans with insulin-dependent and noninsulin-dependent diabetes mellitus in vivo and in vitro studies. J Clin Endocrinol Metab 1995;80:3311-20. PubMed
  9. Cusi K, Cukier S, DeFronzo RA, et al. Vanadyl sulfate improves hepatic and muscle insulin sensitivity in type 2 diabetes. J Clin Endocrinol Metab 2001;86:1410-7.
  10. Peat F, Coomber R, Rana A, Vince A. Vanadium allergy following total knee arthroplasty. BMJ Case Rep 2018;2018. pii: bcr-2017-222092. doi: 10.1136/bcr-2017-222092. PubMed
  11. Jin S, Xia W, Jiang Y, et al. Urinary vanadium concentration in relation to premature rupture of membranes: A birth cohort study. Chemosphere 2018;210:1035-41. doi: 10.1016/j.chemosphere.2018.07.110. PubMed
  12. Garcia-Nunez I, Algaba-Marmol MA, Suarez-Vergara M, et al. Vanadium contact dermatitis: case report and studies performed. Contact Dermatitis 2019;80(2):127-8. PubMed
  13. Zhou Y, Zhu Q, Ma W, et al. Prenatal vanadium exposure, cytokine expression, and fetal growth: a gender-specific analysis in Shanghai MCPC study. Sci Total Environ 2019;685:1152-9. PubMed
  14. Jiang S, Zhou S, Liu H, et al. Concentrations of vanadium in urine with hypertension prevalence and blood pressure levels. Ecotoxicol Environ Saf 2021;213:112028. PubMed
  15. Zhang W, Chen H, Zeng Q, Xu S, Xia W, Li Y. Prenatal and postnatal exposure to vanadium and the immune function of children. J Trace Elem Med Biol 2021;67:126787. PubMed

See these in context on the Vanadium monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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